Pia Heikkilä

Publications

Research output per year 1997 1997 1999 2000 2002 2003 2004 2005 2006 2011 2018 2020 2021 2022 2023 2023

• 15 Article
• 1 Conference contribution
• 1 Meeting Abstract
• 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2023

  Active Matrix Metalloproteinase-8 (aMMP-8) Versus Total MMP-8 in Periodontal and Peri-Implant Disease Point-of-Care Diagnostics

  Räisänen, I. T., Aji, N. R. A. S., Sakellari, D., Grigoriadis, A., Rantala, I., Pätilä, T., Heikkilä, P., Gupta, S. & Sorsa, T., Nov 2023, In: Biomedicines. 11, 11, 10 p., 2885.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access
• 2022

  Oral health associated with incident diabetes but not other chronic diseases: A register-based cohort study

  Heikkilä, P., Niskanen, L., But, A., Sorsa, T. & Haukka, J., 2022, In: Frontiers in Oral Health . 3, 12 p., 956072.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2021

  Active matrix metalloproteinase-8 and interleukin-6 detect periodontal degeneration caused by radiotherapy of head and neck cancer: a pilot study

  Keskin, M., Lähteenmäki, H., Rathnayake, N., Räisänen, I. T., Tervahartiala, T., Pärnänen, P., Senisik, A. M., Karacetin, D., Balkanay, A. Y., Heikkilä, P., Hagström, J., Rautava, J., Haglund, C., Gursoy, U. K., Silbereisen, A., Bostanci, N. & Sorsa, T., 8 Jan 2021, In: Expert review of proteomics.. 17, 10, p. 777-784 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2020

  Periodontal disease and targeted prevention using aMMP-8 point-of-care oral fluid analytics in the COVID-19 era

  Räisänen, I. T., Umeizudike, K. A., Pärnänen, P., Heikkilä, P., Tervahartiala, T., Nwhator, S. O., Grigoriadis, A., Sakellari, D. & Sorsa, T., Nov 2020, In: Medical Hypotheses. 144, 6 p., 110276.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2018

  Periodontitis and cancer mortality: Register-based cohort study of 68,273 adults in 10-year follow-up

  Heikkila, P., But, A., Sorsa, T. & Haukka, J., 1 Jun 2018, In: International Journal of Cancer. 142, 11, p. 2244-2253 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2011

  Selective Gelatinase Inhibitor Peptide Is Effective in Targeting Tongue Carcinoma Cell Tumors In Vivo

  Suojanen, J., Vilen, S-T., Nyberg, P., Heikkila, P., Penate-Medina, O., Saris, P. E. J., Hagstrom, J., Ranta, T-M., Salo, T., Sorsa, T. & Reunanen, J., 2011, In: Anticancer Research. 31, 11, p. 3659-3664 6 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• 2006

  Human tongue carcinoma growth is inhibited by selective antigelatinolytic peptides

  Heikkilä, P., Suojanen, J., Pirilä, E., Väänänen, A., Koivunen, E., Sorsa, T. & Salo, T., 2006, In: International Journal of Cancer. 118, p. 2202-2209 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2005

  Effects of bisphosphonates and small cyclic peptides on matrix metalloproteinases and human cancer cells

  Heikkilä, P., 2005, Helsinki: [P. Heikkilä]. 93 p.

  Research output: Thesis › Doctoral Thesis › Collection of Articles

• Generation of biologically active endostatin fragments from human collagen XVIII by distinct matrix metalloproteases

  Heljasvaara, R., Nyberg, P., Luostarinen, J., Parikka, M., Heikkilä, P., Rehn, M., Sorsa, T., Salo, T. & Pihlajaniemi, T., 2005, In: Experimental Cell Research. 307, 2, p. 292-304 13 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2004

  Malignancy in pheochromocytomas

  Salmenkivi, K., Heikkila, P., Haglund, C. & Arola, J., 2004, In: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. 112, p. 551-559 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• 2003

  Inhibition of matrix metalloproteinase-14 in osteosarcoma cells by clodronate

  Heikkilä, P., Teronen, O., Hirn, M. Y., Sorsa, T., Tervahartiala, T., Salo, T., Konttinen, Y. T., Halttunen, T., Moilanen, M., Hanemaaijer, R. & Laitinen, M., 2003, In: Journal of Surgical Research. 111, 1, p. 45-52 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review
• 2002

  Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20), but not urokinase-type plasminogen activator, and diminish invasion and migration of human malignant and endothelial cell lines

  Heikkila, P., Teronen, O., Moilanen, M., Konttinen, Y. T., Hanemaaijer, R., Laitinen, M., Maisi, P., van der Pluijm, G., Bartlett, J. D., Salo, T. & Sorsa, T., 2002, In: Anti-Cancer Drugs. 13, p. 245-254 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Bisphosphonates inhibit stromelysin-1 (MMP-3), matrix metalloelastase (MMP-12), collagenase-3 (MMP-13) and enamelysin (MMP-20) but not urokinase-type plasminogen activator (uPA) and diminish invasion and migration of human malignant and endothelial cell lines.

  Heikkila, P., Teronen, O., Moilanen, M., Konttinen, YT., Hanemaaijer, R., Laitinen, M., Maisi, P., Pluijm, VDG., Bartlett, JD., Salo, T. & Sorsa, T., Mar 2002, In: Journal of Dental Research. 81, p. A130-A130 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

• 2000

  Inhibition of matrix metalloproteinases by bisphosphonates may in part explain their effects in the treatment of multiple myeloma

  Teronen, O., Laitinen, M., Salo, T., Hanemaaijer, R., Heikkilä, P., Konttinen, Y. T. & Sorsa, T., 2000, In: Blood. 96, p. 4006-4007 2 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• 1999

  MMP inhibition and downregulation by bisphosphonates

  Teronen, O., Heikkila, P., Konttinen, YT., Laitinen, M., Salo, T., Hanemaaijer, R., Teronen, A., Maisi, P. & Sorsa, T., 1999, INHIBITION OF MATRIX METALLOPROTEINASES: THERAPEUTIC APPLICATIONS. Greenwald, RA., Zucker, S. & Golub, LM. (eds.). The New York Academy of Sciences, p. 453-465 13 p. (Annals of the New York Academy of Sciences; vol. 878).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

• Tumor targeting with a selective gelatinase inhibitor

  Koivunen, E., Arap, W., Valtanen, H., Rainisalo, A., Medina, O. P., Heikkila, P., Kantor, C., Gahmberg, C. G., Salo, T., Konttinen, Y. T., Sorsa, T., Ruoslahti, E. & Pasqualini, R., 1999, In: Nature Biotechnology. 17, p. 768-774 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• 1997

  Activation of type IV procollagenases by human tumor-associated trypsin-2

  Sorsa, T., Salo, T., Koivunen, E., Tyynela, J., Konttinen, Y. T., Bergmann, U., Tuuttila, A., Niemi, E., Teronen, O., Heikkila, P., Tschesche, H., Leinonen, J., Osman, S. & Stenman, U. H., 1997, In: Journal of Biological Chemistry. 272, p. 21067-21074 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Decrease in and polarization of dental caries occurrence among child and youth populations, 1976-1993

  Vehkalahti, M., Tarkkonen, L., Varsio, S. & Heikkilä, P., 1997, In: Caries Research. 31, 7, p. 161-165

  Research output: Contribution to journal › Article › Scientific › peer-review