20042012
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Publications 2004 2012

2012

Brush border Myosin Ia has tumor suppressor activity in the intestine

Mazzolini, R., Dopeso, H., Mateo-Lozano, S., Chang, W., Rodrigues, P., Bazzocco, S., Alazzouzi, H., Landolfi, S., Hernandez-Losa, J., Andretta, E., Alhopuro, P., Espin, E., Armengol, M., Tabernero, J., Ramon y Cajal, S., Kloor, M., Gebert, J., Mariadason, J. M., Schwartz, S., Aaltonen, L. A. & 2 othersMooseker, M. S. & Arango, D., 31 Jan 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 5, p. 1530-1535 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Candidate driver genes in microsatellite-unstable colorectal cancer

Alhopuro, P. P., Sammalkorpi, H. P., Niittymäki, I., Biström, M., Raitila, A., Saharinen, J. M. N., Nousiainen, K. J., Lehtonen, H., Heliövaara, E., Puhakka, J., Tuupanen, S., Sousa, S., Seruca, R., Ferreira, A. M., Hofstra, R. M. W., Mecklin, J-P., Järvinen, H., Ristimäki, A., Orntoft, T. F., Hautaniemi, S. & 3 othersArango, D., Karhu, A. I. & Aaltonen, L. A., 2012, In : International Journal of Cancer. 130, 7, p. 1558–1566 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Loss of SUFU Function in Familial Multiple Meningioma

Aavikko, M., Li, S-P., Saarinen, S., Alhopuro, P., Kaasinen, E., Morgunova, E., Li, Y., Vesanen, K., Smith, M. J., Evans, D. G. R., Pöyhönen, M., Kiuru, A., Auvinen, A., Aaltonen, L. A., Taipale, J. & Vahteristo, P., 7 Sep 2012, In : American Journal of Human Genetics. 91, 3, p. 520-526 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

The MDM2 Promoter SNP285C/309G Haplotype Diminishes Sp1 Transcription Factor Binding and Reduces Risk for Breast and Ovarian Cancer in Caucasians

Knappskog, S., Bjornslett, M., Myklebust, L. M., Huijts, P. E. A., Vreeswijk, M. P., Edvardsen, H., Guo, Y., Zhang, X., Yang, M., Ylisaukko-oja, S. K., Alhopuro, P., Arola, J., Tollenaar, R. A. E. M., van Asperen, C. J., Seynaeve, C., Staalesen, V., Chrisanthar, R., Lokkevik, E., Salvesen, H. B., Evans, D. G. & 13 othersNewman, W. G., Lin, D., Aaltonen, L. A., Borresen-Dale, A-L., Tell, G. S., Stoltenberg, C., Romundstad, P., Hveem, K., Lillehaug, J. R., Vatten, L., Devilee, P., Dorum, A. & Lonning, P. E., 2011, In : Cancer Cell. 19, 2, p. 273-282 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Mutations in the Circadian Gene CLOCK in Colorectal Cancer

Alhopuro, P., Björklund, M., Sammalkorpi, H. P., Turunen, M., Tuupanen, S. J., Bistrom, M., Niittymäki, I., Lehtonen, H., Kivioja, T., Launonen, V., Saharinen, J. M. N., Nousiainen, K. J., Hautaniemi, S., Nuorva, K., Mecklin, J-P., Järvinen, H., Orntoft, T., Arango, D., Lehtonen, R. J., Karhu, A. I. & 2 othersTaipale, J. & Aaltonen, L. A., 2010, In : Molecular Cancer Research. 8, 7, p. 952-960 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Mutation analysis of MYH11 in acute myeloid leukemia

Sammalkorpi, H., Alhopuro, P., Niittymäki, I., Ørntoft, T. F., Hokland, P., Karhu, A. & Aaltonen, L. A., 2008, In : Leukemia & lymphoma. 49, 9, p. 1829-1831 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Somatic mutation analysis of MYH11 in breast and prostate cancer

Alhopuro, P., Karhu, A., Winqvist, R., Waltering, K., Visakorpi, T. & Aaltonen, L., 2008, In : BMC Cancer. 8, p. 263 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Unregulated smooth-muscle myosin in human intestinal neoplasia

Alhopuro, P., Phichith, D., Tuupanen, S., Sammalkorpi, H., Nybondas, M., Saharinen, J., Robinson, J. P., Yang, Z., Chen, L-Q., Ørntoft, T. F., Mecklin, J-P., Järvinen, H., Eng, C., Moeslein, G., Shibata, D., Houlston, R. S., Lucassen, A., Tomlinson, I. P. M., Launonen, V., Ristimäki, A. & 4 othersArango, D., Karhu, A., Sweeney, H. L. & Aaltonen, L. A., 2008, In : Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5513-5518 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Background mutation frequency in microsatellite-unstable colorectal cancer

Sammalkorpi, H., Alhopuro, P., Lehtonen, R., Tuimala, J., Mecklin, J-P., Järvinen, H. J., Jiricny, J., Karhu, A. & Aaltonen, L. A., 2007, In : Cancer Research. 67, 12, p. 5691-5698 8 p.

Research output: Contribution to journalArticleScientificpeer-review

No evidence for association of NOD2 R702W and G908R with colorectal cancer

Tuupanen, S., Alhopuro, P., Mecklin, J-P., Järvinen, H. J. & Aaltonen, L. A., 2007, In : International Journal of Cancer. 121, 1, p. 76-79 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Novel insights into the molecular genetic background of colorectal tumors

Alhopuro, P., 2007, Helsinki: [P. Alhopuro]. 85 p.

Research output: ThesisDoctoral ThesisCollection of Articles

Tumour selection advantage of non-dominant negative P53 mutations in homozygotic MDM2-SNP309 colorectal cancer cells

Alazzouzi, H., Suriano, G., Guerra, A., Plaja, A., Espin, E., Armengol, M., Alhopuro, P., Velho, S., Shinomura, Y., Gonzales-Aguilera, J. J., Yamamoto, H., Aaltonen, L. A., Moreno, V., Capella, G., Peinado, M. A., Seruca, R., Arango, D. & Schwartz, S., 2007, In : Journal of Medical Genetics. 44, 1, p. 75-80 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

In response: SMAD4 levels and allelic imbalance in 18q21 in colorectal cancer

Arango, D., Alhopuro, P. & Aaltonen, L. A., 2006, In : Clinical Cancer Research. 12, 5, p. 1654-1655 2 p.

Research output: Contribution to journalArticleScientific

MDM2 SNP309 accelerates colorectal tumour formation in women

Bond, G. L., Menin, C., Bertorelle, R., Alhopuro, P., Aaltonen, L. A. & Levine, A. J., 2006, In : Journal of Medical Genetics. 43, 12, p. 950-952 3 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

A novel functionally deficient MYH variant in individuals with colorectal adenomatous polyposis

Alhopuro, P., Parker, A. R., Lehtonen, R., Enholm, S., Järvinen, H. J., Mecklin, J-P., Karhu, A., Eshleman, J. R. & Aaltonen, L. A., 2005, In : Human Mutation. 26, 4, p. 393 9 p.

Research output: Contribution to journalArticleScientificpeer-review

BRAF-V600E is not involved in the colorectal tumorigenesis of HNPCC in patients with functional MLH1 and MSH2 genes

Domingo, E., Niessen, R., Oliveira, C., Alhopuro, P., Moutinho, C., Espin, E., Armengol, M., Sijmons, R. H., Kleibeuker, J. H., Seruca, R., Aaltonen, L. A., Imai, K., Yamamoto, H., Schwartz, S. & Hofstra, R. M. W., 2005, In : Oncogene. 24, 24, p. 3995-3998 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Gene-expression profiling predicts recurrence in Dukes' C colorectal cancer

Arango, D., Laiho, P., Kokko, A., Alhopuro, P., Sammalkorpi, H., Salovaara, R., Nicorici, D., Hautaniemi, S., Alazzouzi, H., Mecklin, J-P., Järvinen, H. J., Hemminki, A. E., Astola, J., Schwartz, S. & Aaltonen, L. A., 2005, In : Gastroenterology. 129, 3, p. 874-884 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Molecular classification of patients with unexplained hamartomatous and hyperplastic polyposis

Sweet, K., Willis, J., Zhou, X-P., Gallione, C., Sawada, T., Alhopuro, P., Khoo, S. K., Patocs, A., Martin, C., Bridgeman, S., Heinz, J., Pilarski, R., Lehtonen, R., Prior, T. W., Frebourg, T., Teh, B. T., Marchuk, D. A., Aaltonen, L. A. & Eng, C., 2005, In : JAMA : The Journal of the American Medical Association. 294, 19, p. 2465-2473 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome

Alhopuro, P., Katajisto, P., Lehtonen, R. J., Ylisaukko-oja, S., Näätäsaari, L., Karhu, A., Westerman, A. M., Wilson, J. H. P., de Rooij, F. W. M., Vogel, T., Moeslein, G., Tomlinson, I. P. M., Aaltonen, L. A., Mäkelä, T. P. & Launonen, V., 2005, In : British Journal of Cancer. 92, 6, p. 1126-1129 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRAD alpha, and MO25 alpha, in Peutz-Jeghers syndrome

Alhopuro, P., Katajisto, P., Lehtonen, R., Ylisaukko-oja, S. K., Näätsaari, L., Karhu, A., Westerman, A. M., Wilson, J. H. P., de Rooij, F. W. M., Vogel, T., Moeslein, G., Tomlinson, I. P., Aaltonen, L. A., Mäkelä, T. P. & Launonen, V., 2005, In : British Journal of Cancer. 92, p. 1126-1129 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutations in two short noncoding mononucleotide repeats in most microsatellite-unstable colorectal cancers

Hienonen, T., Sammalkorpi, H., Enholm, S., Alhopuro, P., Barber, T. D., Lehtonen, R., Nupponen, N. N., Lehtonen, H., Salovaara, R., Mecklin, J-P., Järvinen, H. J., Koistinen, R., Arango, D., Launonen, V., Vogelstein, B., Karhu, A. & Aaltonen, L. A., 2005, In : Cancer Research. 65, 11, p. 4607-4613 7 p.

Research output: Contribution to journalArticleScientificpeer-review

SMAD4 as a prognostic marker in colorectal cancer

Alazzouzi, H., Alhopuro, P., Salovaara, R., Sammalkorpi, H., Järvinen, H. J., Mecklin, J-P., Hemminki, A., Schwartz, S., Aaltonen, L. A. & Arango, D., 2005, In : Clinical Cancer Research. 11, 7, p. 2606-2611 6 p.

Research output: Contribution to journalArticleScientificpeer-review

SMAD4 levels and response to 5-fluorouracil in colorectal cancer

Alhopuro, P., Alazzouzi, H., Sammalkorpi, H., Davalos, V., Salovaara, R., Hemminki, A., Järvinen, H. J., Mecklin, J-P., Schwartz, S., Aaltonen, L. A. & Arango, D., 2005, In : Clinical Cancer Research. 11, 17, p. 6311-6316 6 p.

Research output: Contribution to journalArticleScientificpeer-review

The MDM2 promoter polymorphism SNP309T-->G and the risk of uterine leiomyosarcoma, colorectal cancer, and squamous cell carcinoma of the head and neck

Alhopuro, P., Ylisaukko-oja, S., Koskinen, W., Bono, P., Arola, J., Järvinen, H. J., Mecklin, J-P., Atula, T., Kontio, R., Mäkitie, A., Suominen, S., Leivo, I., Vahteristo, P., Aaltonen, L-M., Aaltonen, L. A. & Suominen, S., 2005, In : Journal of Medical Genetics. 42, 9, p. 694-698 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status

Oliveira, C., Westra, J. L., Arango, D., Ollikainen, M., Domingo, E., Ferreira, A., Velho, S., Niessen, R., Lagerstedt, K., Alhopuro, P., Laiho, P., Veiga, I., Teixeira, M. R., Ligtenberg, M., Kleibeuker, J. H., Sijmons, R. H., Plukker, J. T., Imai, K., Lage, P., Hamelin, R. & 8 othersAlbuquerque, C., Schwartz, S., Lindblom, A., Peltomäki, P., Yamamoto, H., Aaltonen, L. A., Seruca, R. & Hofstra, R. M. W., 2004, In : Human Molecular Genetics. 13, p. 2303-2311 9 p.

Research output: Contribution to journalArticleScientificpeer-review