Photo of Pirjo Laakkonen
  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

1990 …2020

Research output per year

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Publications

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2020

ARX788, a novel anti-HER2 antibody-drug conjugate, shows anti-tumor effects in preclinical models of trastuzumab emtansine-resistant HER2-positive breast cancer and gastric cancer

Barok, M., Le Joncour, V., Martins, A., Isola, J., Salmikangas, M., Laakkonen, P. & Joensuu, H., 2020, In : Cancer Letters. 473, p. 156-163 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Prostate-specific membrane antigen expression in the vasculature of primary lung carcinomas associates with faster metastatic dissemination to the brain

Ramanathan, J. T., Lehtipuro, S., Sihto, H., Tovari, J., Reiniger, L., Teglasi, V., Moldvay, J., Nykter, M., Haapasalo, H., Le Joncour, V. & Laakkonen, P., Jun 2020, In : Journal of Cellular and Molecular Medicine. 24, 12, p. 6916-6927 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Tumor-Targeting Peptides: The Functional Screen of Glioblastoma Homing Peptides to the Target Protein FABP3 (MDGI)

Ayo, A., Figueras, E., Schachtsiek, T., Budak, M., Sewald, N. & Laakkonen, P., Jul 2020, In : Cancers. 12, 7, 19 p., 1836.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2019

Anagrelide for Gastrointestinal Stromal Tumor

Pulkka, O-P., Gebreyohannes, Y. K., Wozniak, A., Mpindi, J-P., Tynninen, O., Icay, K., Cervera, A., Keskitalo, S., Murumägi, A., Kulesskiy, E., Laaksonen, M., Wennerberg, K., Varjosalo, M., Laakkonen, P., Lehtonen, R., Hautaniemi, S., Kallioniemi, O., Schöffski, P., Sihto, H. & Joensuu, H., 1 Mar 2019, In : Clinical Cancer Research. 25, 5, p. 1676-1687 12 p.

Research output: Contribution to journalArticleScientificpeer-review

A Novel Anti-HER2 Antibody-Drug Conjugate XMT-1522 for HER2-Positive Breast and Gastric Cancers Resistant to Trastuzumab Emtansine

Le Joncour, V., Martins, A., Puhka, M., Isola, J., Salmikangas, M., Laakkonen, P., Joensuu, H. & Barok, M., Oct 2019, In : Molecular Cancer Therapeutics. 18, 10, p. 1721-1730 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Octreotide Conjugates for Tumor Targeting and Imaging

Figueras, E., Martins, A., Borbely, A., Le Joncour, V., Cordella, P., Perego, R., Modena, D., Pagani, P., Esposito, S., Auciello, G., Frese, M., Gallinari, P., Laakkonen, P., Steinkuhler, C. & Sewald, N., May 2019, In : Pharmaceutics. 11, 5, 14 p., 220.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish

Le Joncour, V., Karaman, S. & Laakkonen, P. M., 16 Apr 2019, In : Journal of Visualized Experiments. 146, 12 p., 59384.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization

Le Joncour, V., Filppu, P., Hyvönen, M., Holopainen, M., Turunen, S. P., Sihto, H., Burghardt, I., Joensuu, H., Tynninen, O., Jääskeläinen, J., Weller, M., Lehti, K., Käkelä, R. & Laakkonen, P., Jun 2019, In : EMBO molecular medicine. 11, 6, 21 p., 9034.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Seek & Destroy, use of targeting peptides for cancer detection and drug delivery

Le Joncour, V. & Laakkonen, P., 1 Jun 2018, In : Bioorganic & Medicinal Chemistry. 26, 10, p. 2797-2806 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Motility of glioblastoma cells is driven by netrin-1 induced gain of stemness

Ylivinkka, I., Sihto, H., Tynninen, O., Hu, Y., Laakso, A., Kivisaari, R., Laakkonen, P., Keski-Oja, J. & Hyytiäinen, M., 9 Jan 2017, In : Journal of Experimental and Clinical Cancer Research (Online). 36, 18 p., 9.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Fibroblast spheroids as a model to study sustained fibroblast quiescence and their crosstalk with tumor cells

Salmenperä, P., Karhemo, P-R., Rasanen, K., Laakkonen, P. & Vaheri, A., 1 Jul 2016, In : Experimental Cell Research. 345, 1, p. 17-24 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Gene expression analyses of primary melanomas reveal CTHRC1 as an important player in melanoma progression

Eriksson, J., Le Joncour, V., Nummela, P., Jahkola, T., Virolainen, S., Laakkonen, P., Saksela, O. & Hölttä, E., 22 Mar 2016, In : Oncotarget. 7, 12, p. 15065-15092 28 p.

Research output: Contribution to journalArticleScientificpeer-review

PP2A Inhibitor PME-1 Drives Kinase Inhibitor Resistance in Glioma Cells

Kaur, A., Denisova, O. V., Qiao, X., Jumppanen, M., Peuhu, E., Ahmed, S. U., Raheem, O., Haapasalo, H., Eriksson, J., Chalmers, A. J., Laakkonen, P. & Westermarck, J., 1 Dec 2016, In : Cancer Research. 76, 23, p. 7001-7011 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Multifunctional porous silicon nanoparticles for cancer theranostics

Wang, C-F., Sarparanta, M. P., Mäkilä, E. M., Hyvönen, M. L. K., Laakkonen, P. M., Salonen, J. J., Hirvonen, J. T., Airaksinen, A. J. & Santos, H. A., Apr 2015, In : Biomaterials. 48, p. 108-118 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Novel Target for Peptide-Based Imaging and Treatment of Brain Tumors

Hyvönen, M., Enback, J., Huhtala, T., Lammi, J., Sihto, H., Weisell, J., Joensuu, H., Rosenthal-Aizman, K., El-Andaloussi, S., Langel, U., Narvanen, A., Bergers, G. & Laakkonen, P., Apr 2014, In : Molecular Cancer Therapeutics. 13, 4, p. 996-1007 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas

Sarek, G., Ma, L., Enback, J., Järviluoma, A., Moreau, P., Haas, J., Gessain, A., Koskinen, P. J., Laakkonen, P. & Ojala, P. M., 28 Feb 2013, In : Oncogene. 32, 9, p. 1091-1098 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Peptide-Based Glioma-Targeted Drug Delivery Vector gHoPe2

Eriste, E., Kurrikoff, K., Suhorutsenko, J., Osokolkov, N., Copolovici, D. M., Jones, S., Laakkonen, P., Howl, J. & Langel, U., Mar 2013, In : Bioconjugate Chemistry. 24, 3, p. 305-313 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Tumour homing peptide-functionalized porous silicon nanovectors for cancer therapy

Kinnari, P. J., Hyvönen, M. L. K., Mäkilä, E. M., Kaasalainen, M. H., Rivinoja, A., Salonen, J. J., Hirvonen, J. T., Laakkonen, P. M. & Santos, H. A., Dec 2013, In : Biomaterials. 34, 36, p. 9134–9141 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

An optimized isolation of biotinylated cell surface proteins reveals novel players in cancer metastasis

Karhemo, P-R., Ravela, S., Laakso, M., Ritamo, I., Tatti, O., Mäkinen, S., Goodison, S., Stenman, U. H., Hölttä, E. J., Hautaniemi, S., Valmu, L., Lehti, K. I. & Laakkonen, P. M., 2012, In : Journal of Proteomics. 77, p. 87-100 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Metastasis-associated cell surface oncoproteomics

Karhemo, P-R., Hyvönen, M. & Laakkonen, P. M., 2012, In : Frontiers in Pharmacology. 3, 8 p., 192.

Research output: Contribution to journalArticleScientificpeer-review

Tumour Targeting with Rationally Modified Cell-Penetrating Peptides

Mae, M., Rautsi, O., Enback, J., Hallbrink, M., Aizman, K. R., Lindgren, M., Laakkonen, P. & Langel, U., 1 Dec 2012, In : International Journal of Peptide Research and Therapeutics. 18, 4, p. 361-371 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

An extensive tumor array analysis supports tumor suppressive role for nucleophosmin in breast cancer

Karhemo, P-R., Rivinoja, A., Lundin, J. E., Hyvönen, M., Chernenko, A., Lammi, J., Sihto, H., Lundin, M. E., Heikkilä, P., Joensuu, H., Bono, P. & Laakkonen, P. M., 2011, In : The American Journal of Pathology. 179, 2, p. 1004-1014 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Identification of homing peptides using the in vivo phage display technology

Rivinoja, A. & Laakkonen, P. M., 2011, In : Methods in molecular biology. 683, p. 401-415

Research output: Contribution to journalArticleScientificpeer-review

2010

Complex Formation Between Human Prostate-Specific Antigen and Protease Inhibitors in Mouse Plasma

Hekim, C., Riipi, T., Zhu, L., Laakkonen, P., Stenman, U. H. & Koistinen, H., 2010, In : Prostate. 70, 5, p. 482-490 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Homing peptides as targeted delivery vehicles

Laakkonen, P. & Vuorinen, K., 2010, In : Integrative Biology. 2, p. 326-337 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Identification of Novel p53 Pathway Activating Small-Molecule Compounds Reveals Unexpected Similarities with Known Therapeutic Agents

Peltonen, K., Colis, L., Liu, H., Jaamaa, S., Moore, H. M., Enback, J., Laakkonen, P., Vaahtokari, A., Jones, R. J., af Hallstrom, T. M. & Laiho, M., 2010, In : PLoS One. 5, 9, p. Article Number: e12996 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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In vivo SPECT/CT imaging of human orthotopic ovarian carcinoma xenografts with In-111-labeled monoclonal antibodies

Huhtala, T., Laakkonen, P., Sallinen, H., Yla-Herttuala, S. & Narvanen, A., 2010, In : Nuclear Medicine and Biology. 37, p. 957-964 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Loss of Endothelial Tie1 Receptor Impairs Lymphatic Vessel Development-Brief Report

D Amico Lago, G. V., Korhonen, E. A., Waltari, M., Saharinen, P., Laakkonen, P. & Alitalo, K., 2010, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 30, 2, p. 207-209 3 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Antiangiogenic properties of prostate-specific antigen (PSA)

Mattsson, J. M., Laakkonen, P., Stenman, U-H. & Koistinen, H., 2009, In : Scandinavian Journal of Clinical & Laboratory Investigation. 69, 4, p. 447-451 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation: [letters]

Tammela, T., Zarkada, G., Wallgard, E., Murtomäki, A., Suchting, S., Wirzenius, M., Waltari, M., Hellström, M., Schomber, T., Peltonen, R., Freitas, C., Duarte, A., Isoniemi, H., Laakkonen, P., Christofori, G., Ylä-Herttuala, S., Shibuya, M., Pytowski, B., Eichmann, A., Betsholtz, C. & 1 others, Alitalo, K., 2008, In : Nature. 31, 454(7204), p. 656-660 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Development of peptides specifically modulating the activity of KLK2 and KLK3

Koistinen, H., Närvänen, A., Pakkala, M., Helim, C., Mattsson, J., Zhu, L., Laakkonen, P. M. & Stenman, U-H., 2008, In : Biological Chemistry. 389, 6, p. 633-642 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Gene expression changes associated with the anti-angiogenic activity of kallikrein-related peptidase 3 (KLK3) on human umbilical vein endothelial cells

Mattsson, J., Laakkonen, P. M., Kilpinen, S., Stenman, U-H. & Koistinen, H., 2008, In : Biological Chemistry. 389, 6, p. 765-771 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Glycodelin reduces breast cancer xenograft growth in vivo

Hautala, L. C., Koistinen, R., Seppälä, M., Butzow, R., Stenman, U-H., Laakkonen, P. & Koistinen, H., 2008, In : International Journal of Cancer. 123, 10, p. 2279-2284 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Structural characterization and anti-angiogenic properties of prostate-specific antigen isoforms in seminal fluid

Mattsson, J., Valmu, L., Laakkonen, P. M., Stenman, U-H. & Koistinen, H., 2008, In : Prostate. 68, 9, p. 945-954 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Tumor targeting of baculovirus displaying a lymphatic homing peptide

Makela, A. R., Enback, J., Laakkonen, J. P., Vihinen-Ranta, M., Laakkonen, P. & Oker-Blom, C., 2008, In : Journal of Gene Medicine. 10, p. 1019-1031 13 p.

Research output: Contribution to journalArticleScientificpeer-review

VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors: [correspondence]

Petrova, T., Bono, P., Holnthoner, W., Chesnes, J., Pytowski, B., Sihto, H., Laakkonen, P., Heikkilä, P., Joensuu, H. & Alitalo, K., 2008, In : Cancer Cell. 13, 6, p. 554-556 3 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

A heparan sulfate-targeted conditionally replicative adenovirus, Ad5.pk7-Delta 24, for the treatment of advanced breast cancer

Ranki, T., Kanerva, A., Ristimaki, A., Hakkarainen, T., Sarkioja, M., Kangasniemi, L., Raki, M., Laakkonen, P., Goodison, S. & Hemminki, A., 2007, In : Gene Therapy (Basingstoke). 14, p. 58-67 10 p.

Research output: Contribution to journalArticleScientificpeer-review

p53-kasvurajoitereitin aktivaatio - uusi mahdollisuus virusperäisen lymfooman hoitoon: [J Clin Invest in press]

Sarek, G., Kurki, S., Enbäck, J., Iotzova, G., Haas, J., Laakkonen, P. M., Laiho, M. & Ojala, P. M., 2007, In : Duodecim. 123, 8, p. 869-870 2 p.

Research output: Contribution to journalArticleScientific

Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas

Sarek, G., Kurki, S., Enbäck, J., Iotzova, G., Haas, J., Laakkonen, P. M., Laiho, M. & Ojala, P., 2007, In : Journal of Clinical Investigation. 117, 4, p. 1019-1028 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Tumour-homing peptides: tools for targeting, imaging and destruction

Enback, J. & Laakkonen, P., 2007, In : Biochemical Society Transactions. 35, p. 780-783 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth

Laakkonen, P., Waltari, M., Holopainen, T., Takahashi, T., Pytowski, B., Steiner, P., Hicklin, D., Persaud, K., Tonra, J. R., Witte, L. & Alitalo, K., 2007, In : Cancer Research. 67, 2, p. 593-599 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Characterization of the Rab8-specific membrane traffic route linked to protrusion formation

Hattula, K., Furuhjelm, J., Tikkanen, J., Tanhuanpää, K., Laakkonen, P. M. & Peränen, J., 2006, In : Journal of Cell Science. 119, p. 4866-4877 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Identification of breast cancer metastasis and chronic myeloid leukemia-specific cell surface proteins

Karhemo, P., Goodison, S., Porkka, K. & Laakkonen, P., 2005, In : Molecular & Cellular Proteomics. 4, 8 Suppl. 1, p. S114-S114 1 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells

Laakkonen, P., Akerman, M. E., Biliran, H., Yang, M., Ferrer, F., Karpanen, T., Hoffman, R. M. & Ruoslahti, E., 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, p. 9381-9386 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates

Kerjaschki, D., Regele, H. M., Moosberger, I., Nagy-Bojarski, K., Watschinger, B., Soleiman, A., Birner, P., Krieger, S., Hovorka, A., Silberhumer, G., Laakkonen, P., Petrova, T., Langer, B. & Raab, I., 2004, In : Journal of the American Society of Nephrology. 15, p. 603-612 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2003

Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: Aminopeptidase P and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels

Matsui, K., Nagy-Bojarsky, K., Laakkonen, P., Krieger, S., Mechtler, K., Uchida, S., Geleff, S., Kang, D. H., Johnson, R. J. & Kerjaschki, D., 2003, In : Journal of the American Society of Nephrology. 14, p. 1981-1989 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels

Christian, S., Pilch, J., Akerman, M. E., Porkka, K., Laakkonen, P. & Ruoslahti, E., 2003, In : Journal of Cell Biology. 163, p. 871-878 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis

Joyce, J. A., Laakkonen, P., Bernasconi, M., Bergers, G., Ruoslahti, E. & Hanahan, D., 2003, In : Cancer Cell. 4, p. 393-403 11 p.

Research output: Contribution to journalArticleScientificpeer-review