Photo of Pirjo Laakkonen
  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

1990 …2020

Research output per year

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Publications

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1990

A SINGLE AMINO-ACID CHANGE IN E3 OF TS1 MUTANT INHIBITS THE INTRACELLULAR-TRANSPORT OF SFV ENVELOPE PROTEIN COMPLEX

Laakkonen, P. M., PERANEN, J., SUOMALAINEN, M., KERANEN, S. & KAARIAINEN, L., 1990, In : Virology. 179, p. 658-666 9 p.

Research output: Contribution to journalArticleScientificpeer-review

1994

EXPRESSION OF SEMLIKI FOREST VIRUS NSP1-SPECIFIC METHYLTRANSFERASE IN INSECT CELLS AND IN ESCHERICHIA-COLI

LAAKKONEN, P., HYVONEN, M., PERANEN, J. & KAARIAINEN, L., 1994, In : Journal of Virology. 68, p. 7418-7425 8 p.

Research output: Contribution to journalArticleScientificpeer-review

1995

THE ALPHAVIRUS REPLICASE PROTEIN NSP1 IS MEMBRANE-ASSOCIATED AND HAS AFFINITY TO ENDOCYTIC ORGANELLES

PERANEN, J., LAAKKONEN, P., HYVONEN, M. & KAARIAINEN, L., 1995, In : Virology. 208, p. 610-620 11 p.

Research output: Contribution to journalArticleScientificpeer-review

1996

Synthesis of Semliki Forest virus RNA polymerase components nsP1 through nsP4 in Saccharomyces cerevisiae by expression of cDNA encoding the nonstructural polyprotein

Russo, P., Laakkonen, P., Ahola, T. & Kaariainen, L., 1996, In : Journal of Virology. 70, p. 4086-4089 4 p.

Research output: Contribution to journalArticleScientificpeer-review

The effects of palmitoylation on membrane association of Semliki Forest virus RNA capping enzyme

Laakkonen, P., Ahola, T. & Kaariainen, L., 1996, In : Journal of Biological Chemistry. 271, p. 28567-28571 5 p.

Research output: Contribution to journalArticleScientificpeer-review

1997

Critical residues of Semliki Forest virus RNA capping enzyme involved in methyltransferase and guanylyltransferase-like activities

Ahola, T., Laakkonen, P., Vihinen, H. & Kaariainen, L., 1997, In : Journal of Virology. 71, p. 392-397 6 p.

Research output: Contribution to journalArticleScientificpeer-review

1998

Alphavirus replicase protein NSP1 induces filopodia and rearrangement of actin filaments

Laakkonen, P., Auvinen, P., Kujala, P. & Kaariainen, L., 1998, In : Journal of Virology. 72, p. 10265-10269 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2000

Effects of palmitoylation of replicase protein nsP1 on alphavirus infection

Ahola, T., Kujala, P., Tuittila, M., Blom, T., Laakkonen, P., Hinkkanen, A. & Auvinen, P., 2000, In : Journal of Virology. 74, p. 6725-6733 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2001

Solution structures and integrin binding activities of an RGD peptide with two isomers

Assa-Munt, N., Jia, X., Laakkonen, P. & Ruoslahti, E., 2001, In : Biochemistry. 40, 8, p. 2373-2378 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2002

A fragment of the HMGN2 protein homes to the nuclei of tumor cells and tumor endothelial cells in vivo

Porkka, K., Laakkonen, P., Hoffman, J. A., Bernasconi, M. & Ruoslahti, E., 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, p. 7444-7449 6 p.

Research output: Contribution to journalArticleScientificpeer-review

A tumor-homing peptide with a targeting specificity related to lymphatic vessels

Laakkonen, P., Porkka, K., Hoffman, J. A. & Ruoslahti, E., 2002, In : Nature Medicine. 8, p. 751-755 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Nanocrystal targeting in vivo

Akerman, M. E., Chan, W. C. W., Laakkonen, P., Bhatia, S. N. & Ruoslahti, E., 2002, In : Proceedings of the National Academy of Sciences of the United States of America. 99, p. 12617-12621 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2003

Lymphatic microvessels in the rat remnant kidney model of renal fibrosis: Aminopeptidase P and podoplanin are discriminatory markers for endothelial cells of blood and lymphatic vessels

Matsui, K., Nagy-Bojarsky, K., Laakkonen, P., Krieger, S., Mechtler, K., Uchida, S., Geleff, S., Kang, D. H., Johnson, R. J. & Kerjaschki, D., 2003, In : Journal of the American Society of Nephrology. 14, p. 1981-1989 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Nucleolin expressed at the cell surface is a marker of endothelial cells in angiogenic blood vessels

Christian, S., Pilch, J., Akerman, M. E., Porkka, K., Laakkonen, P. & Ruoslahti, E., 2003, In : Journal of Cell Biology. 163, p. 871-878 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis

Joyce, J. A., Laakkonen, P., Bernasconi, M., Bergers, G., Ruoslahti, E. & Hanahan, D., 2003, In : Cancer Cell. 4, p. 393-403 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells

Laakkonen, P., Akerman, M. E., Biliran, H., Yang, M., Ferrer, F., Karpanen, T., Hoffman, R. M. & Ruoslahti, E., 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, p. 9381-9386 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates

Kerjaschki, D., Regele, H. M., Moosberger, I., Nagy-Bojarski, K., Watschinger, B., Soleiman, A., Birner, P., Krieger, S., Hovorka, A., Silberhumer, G., Laakkonen, P., Petrova, T., Langer, B. & Raab, I., 2004, In : Journal of the American Society of Nephrology. 15, p. 603-612 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Identification of breast cancer metastasis and chronic myeloid leukemia-specific cell surface proteins

Karhemo, P., Goodison, S., Porkka, K. & Laakkonen, P., 2005, In : Molecular & Cellular Proteomics. 4, 8 Suppl. 1, p. S114-S114 1 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Characterization of the Rab8-specific membrane traffic route linked to protrusion formation

Hattula, K., Furuhjelm, J., Tikkanen, J., Tanhuanpää, K., Laakkonen, P. M. & Peränen, J., 2006, In : Journal of Cell Science. 119, p. 4866-4877 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

A heparan sulfate-targeted conditionally replicative adenovirus, Ad5.pk7-Delta 24, for the treatment of advanced breast cancer

Ranki, T., Kanerva, A., Ristimaki, A., Hakkarainen, T., Sarkioja, M., Kangasniemi, L., Raki, M., Laakkonen, P., Goodison, S. & Hemminki, A., 2007, In : Gene Therapy (Basingstoke). 14, p. 58-67 10 p.

Research output: Contribution to journalArticleScientificpeer-review

p53-kasvurajoitereitin aktivaatio - uusi mahdollisuus virusperäisen lymfooman hoitoon: [J Clin Invest in press]

Sarek, G., Kurki, S., Enbäck, J., Iotzova, G., Haas, J., Laakkonen, P. M., Laiho, M. & Ojala, P. M., 2007, In : Duodecim. 123, 8, p. 869-870 2 p.

Research output: Contribution to journalArticleScientific

Reactivation of the p53 pathway as a treatment modality for KSHV-induced lymphomas

Sarek, G., Kurki, S., Enbäck, J., Iotzova, G., Haas, J., Laakkonen, P. M., Laiho, M. & Ojala, P., 2007, In : Journal of Clinical Investigation. 117, 4, p. 1019-1028 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Tumour-homing peptides: tools for targeting, imaging and destruction

Enback, J. & Laakkonen, P., 2007, In : Biochemical Society Transactions. 35, p. 780-783 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth

Laakkonen, P., Waltari, M., Holopainen, T., Takahashi, T., Pytowski, B., Steiner, P., Hicklin, D., Persaud, K., Tonra, J. R., Witte, L. & Alitalo, K., 2007, In : Cancer Research. 67, 2, p. 593-599 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation: [letters]

Tammela, T., Zarkada, G., Wallgard, E., Murtomäki, A., Suchting, S., Wirzenius, M., Waltari, M., Hellström, M., Schomber, T., Peltonen, R., Freitas, C., Duarte, A., Isoniemi, H., Laakkonen, P., Christofori, G., Ylä-Herttuala, S., Shibuya, M., Pytowski, B., Eichmann, A., Betsholtz, C. & 1 others, Alitalo, K., 2008, In : Nature. 31, 454(7204), p. 656-660 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Development of peptides specifically modulating the activity of KLK2 and KLK3

Koistinen, H., Närvänen, A., Pakkala, M., Helim, C., Mattsson, J., Zhu, L., Laakkonen, P. M. & Stenman, U-H., 2008, In : Biological Chemistry. 389, 6, p. 633-642 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Gene expression changes associated with the anti-angiogenic activity of kallikrein-related peptidase 3 (KLK3) on human umbilical vein endothelial cells

Mattsson, J., Laakkonen, P. M., Kilpinen, S., Stenman, U-H. & Koistinen, H., 2008, In : Biological Chemistry. 389, 6, p. 765-771 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Glycodelin reduces breast cancer xenograft growth in vivo

Hautala, L. C., Koistinen, R., Seppälä, M., Butzow, R., Stenman, U-H., Laakkonen, P. & Koistinen, H., 2008, In : International Journal of Cancer. 123, 10, p. 2279-2284 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Structural characterization and anti-angiogenic properties of prostate-specific antigen isoforms in seminal fluid

Mattsson, J., Valmu, L., Laakkonen, P. M., Stenman, U-H. & Koistinen, H., 2008, In : Prostate. 68, 9, p. 945-954 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Tumor targeting of baculovirus displaying a lymphatic homing peptide

Makela, A. R., Enback, J., Laakkonen, J. P., Vihinen-Ranta, M., Laakkonen, P. & Oker-Blom, C., 2008, In : Journal of Gene Medicine. 10, p. 1019-1031 13 p.

Research output: Contribution to journalArticleScientificpeer-review

VEGFR-3 expression is restricted to blood and lymphatic vessels in solid tumors: [correspondence]

Petrova, T., Bono, P., Holnthoner, W., Chesnes, J., Pytowski, B., Sihto, H., Laakkonen, P., Heikkilä, P., Joensuu, H. & Alitalo, K., 2008, In : Cancer Cell. 13, 6, p. 554-556 3 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Antiangiogenic properties of prostate-specific antigen (PSA)

Mattsson, J. M., Laakkonen, P., Stenman, U-H. & Koistinen, H., 2009, In : Scandinavian Journal of Clinical & Laboratory Investigation. 69, 4, p. 447-451 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Complex Formation Between Human Prostate-Specific Antigen and Protease Inhibitors in Mouse Plasma

Hekim, C., Riipi, T., Zhu, L., Laakkonen, P., Stenman, U. H. & Koistinen, H., 2010, In : Prostate. 70, 5, p. 482-490 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Homing peptides as targeted delivery vehicles

Laakkonen, P. & Vuorinen, K., 2010, In : Integrative Biology. 2, p. 326-337 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Identification of Novel p53 Pathway Activating Small-Molecule Compounds Reveals Unexpected Similarities with Known Therapeutic Agents

Peltonen, K., Colis, L., Liu, H., Jaamaa, S., Moore, H. M., Enback, J., Laakkonen, P., Vaahtokari, A., Jones, R. J., af Hallstrom, T. M. & Laiho, M., 2010, In : PLoS One. 5, 9, p. Article Number: e12996 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

In vivo SPECT/CT imaging of human orthotopic ovarian carcinoma xenografts with In-111-labeled monoclonal antibodies

Huhtala, T., Laakkonen, P., Sallinen, H., Yla-Herttuala, S. & Narvanen, A., 2010, In : Nuclear Medicine and Biology. 37, p. 957-964 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Loss of Endothelial Tie1 Receptor Impairs Lymphatic Vessel Development-Brief Report

D Amico Lago, G. V., Korhonen, E. A., Waltari, M., Saharinen, P., Laakkonen, P. & Alitalo, K., 2010, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 30, 2, p. 207-209 3 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

An extensive tumor array analysis supports tumor suppressive role for nucleophosmin in breast cancer

Karhemo, P-R., Rivinoja, A., Lundin, J. E., Hyvönen, M., Chernenko, A., Lammi, J., Sihto, H., Lundin, M. E., Heikkilä, P., Joensuu, H., Bono, P. & Laakkonen, P. M., 2011, In : The American Journal of Pathology. 179, 2, p. 1004-1014 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Identification of homing peptides using the in vivo phage display technology

Rivinoja, A. & Laakkonen, P. M., 2011, In : Methods in molecular biology. 683, p. 401-415

Research output: Contribution to journalArticleScientificpeer-review

2012

An optimized isolation of biotinylated cell surface proteins reveals novel players in cancer metastasis

Karhemo, P-R., Ravela, S., Laakso, M., Ritamo, I., Tatti, O., Mäkinen, S., Goodison, S., Stenman, U. H., Hölttä, E. J., Hautaniemi, S., Valmu, L., Lehti, K. I. & Laakkonen, P. M., 2012, In : Journal of Proteomics. 77, p. 87-100 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Metastasis-associated cell surface oncoproteomics

Karhemo, P-R., Hyvönen, M. & Laakkonen, P. M., 2012, In : Frontiers in Pharmacology. 3, 8 p., 192.

Research output: Contribution to journalArticleScientificpeer-review

Tumour Targeting with Rationally Modified Cell-Penetrating Peptides

Mae, M., Rautsi, O., Enback, J., Hallbrink, M., Aizman, K. R., Lindgren, M., Laakkonen, P. & Langel, U., 1 Dec 2012, In : International Journal of Peptide Research and Therapeutics. 18, 4, p. 361-371 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Kaposi's sarcoma herpesvirus lytic replication compromises apoptotic response to p53 reactivation in virus-induced lymphomas

Sarek, G., Ma, L., Enback, J., Järviluoma, A., Moreau, P., Haas, J., Gessain, A., Koskinen, P. J., Laakkonen, P. & Ojala, P. M., 28 Feb 2013, In : Oncogene. 32, 9, p. 1091-1098 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Peptide-Based Glioma-Targeted Drug Delivery Vector gHoPe2

Eriste, E., Kurrikoff, K., Suhorutsenko, J., Osokolkov, N., Copolovici, D. M., Jones, S., Laakkonen, P., Howl, J. & Langel, U., Mar 2013, In : Bioconjugate Chemistry. 24, 3, p. 305-313 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Tumour homing peptide-functionalized porous silicon nanovectors for cancer therapy

Kinnari, P. J., Hyvönen, M. L. K., Mäkilä, E. M., Kaasalainen, M. H., Rivinoja, A., Salonen, J. J., Hirvonen, J. T., Laakkonen, P. M. & Santos, H. A., Dec 2013, In : Biomaterials. 34, 36, p. 9134–9141 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Novel Target for Peptide-Based Imaging and Treatment of Brain Tumors

Hyvönen, M., Enback, J., Huhtala, T., Lammi, J., Sihto, H., Weisell, J., Joensuu, H., Rosenthal-Aizman, K., El-Andaloussi, S., Langel, U., Narvanen, A., Bergers, G. & Laakkonen, P., Apr 2014, In : Molecular Cancer Therapeutics. 13, 4, p. 996-1007 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Multifunctional porous silicon nanoparticles for cancer theranostics

Wang, C-F., Sarparanta, M. P., Mäkilä, E. M., Hyvönen, M. L. K., Laakkonen, P. M., Salonen, J. J., Hirvonen, J. T., Airaksinen, A. J. & Santos, H. A., Apr 2015, In : Biomaterials. 48, p. 108-118 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Fibroblast spheroids as a model to study sustained fibroblast quiescence and their crosstalk with tumor cells

Salmenperä, P., Karhemo, P-R., Rasanen, K., Laakkonen, P. & Vaheri, A., 1 Jul 2016, In : Experimental Cell Research. 345, 1, p. 17-24 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Gene expression analyses of primary melanomas reveal CTHRC1 as an important player in melanoma progression

Eriksson, J., Le Joncour, V., Nummela, P., Jahkola, T., Virolainen, S., Laakkonen, P., Saksela, O. & Hölttä, E., 22 Mar 2016, In : Oncotarget. 7, 12, p. 15065-15092 28 p.

Research output: Contribution to journalArticleScientificpeer-review