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Prson Gautam

  • PL 20 (Tukholmankatu 8)

    00014

    Finland

20132019
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Publications 2013 2019

2019

Network pharmacology modeling identifies synergistic Aurora B and ZAK interaction in triple-negative breast cancer

Tang, J., Gautam, P., Gupta, A., He, L., Timonen, S., Akimov, Y., Wang, W., Szwajda, A., Jaiswal, A., Turei, D., Yadav, B., Kankainen, M., Saarela, J., Saez-Rodriguez, J., Wennerberg, K. & Aittokallio, T., 2019, In : npj Systems Biology and Applications. 5, 1

Research output: Contribution to journalArticleScientificpeer-review

Phenotypic Screening Combined with Machine Learning for Efficient Identification of Breast Cancer-Selective Therapeutic Targets

Gautam, P., Jaiswal, A., Aittokallio, T., Al-Ali, H. & Wennerberg, K., 18 Jul 2019, In : Cell chemical biology. 26, 7, p. 970-+ 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2018

Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions

Tang, J., Tanoli, Z-R., Ravikumar, B., Alam, Z., Rebane, A., Vähä-Koskela, M., Peddinti, G., van Adrichem, A. J., Wakkinen, J., Jaiswal, A., Karjalainen, E., Gautam, P., He, L., Parri, E., Khan, S., Gupta, A., Ali, M., Yetukuri, L., Gustavsson, A-L., Seashore-Ludlow, B. & 6 othersHersey, A., Leach, A. R., Overington, J. P., Repasky, G., Wennerberg, K. & Aittokallio, T., 15 Feb 2018, In : Cell chemical biology. 25, 2, p. 224-+ 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Genomic perturbations reveal distinct regulatory networks in intrahepatic cholangiocarcinoma

Nepal, C., O'Rourke, C. J., Oliveira, D. V. N. P., Taranta, A., Shema, S., Gautam, P., Calderaro, J., Barbour, A., Raggi, C., Wennerberg, K., Wang, X. W., Lautem, A., Roberts, L. R. & Andersen, J. B., Sep 2018, In : Hepatology. 68, 3, p. 949-963 15 p.

Research output: Contribution to journalArticleScientificpeer-review

KRAS Suppression-Induced Degradation of MYC Is Antagonized by a MEK5-ERK5 Compensatory Mechanism

Vaseva, A. V., Blake, D. R., Gilbert, T. S. K., Ng, S., Hostetter, G., Azam, S. H., Ozkan-Dagliyan, I., Gautam, P., Bryant, K. L., Pearce, K. H., Herring, L. E., Han, H., Graves, L. M., Witkiewicz, A. K., Knudsen, E. S., Pecot, C., Rashid, N., Houghton, P. J., Wennerberg, K., Cox, A. D. & 1 othersDer, C. J., 12 Nov 2018, In : Cancer Cell. 34, 5, p. 807-+ 23 p.

Research output: Contribution to journalArticleScientificpeer-review

2017

Chemical systems biology studies of triple negative breast cancer cell lines

Gautam, P., 2017, Helsinki: Helsingin yliopisto. 94 p.

Research output: ThesisDoctoral ThesisCollection of Articles

Open Access
2016

Consistency in drug response profiling

Mpindi, J. P., Yadav, B., Ostling, P., Gautam, P., Malani, D., Murumagi, A., Hirasawa, A., Kangaspeska, S., Wennerberg, K., Kallioniemi, O. & Aittokallio, T., 1 Dec 2016, In : Nature. 540, 7631, p. E5-E6 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Identification of selective cytotoxic and synthetic lethal drug responses in triple negative breast cancer cells

Gautam, P., Karhinen, L., Szwajda, A., Jha, S. K., Yadav, B., Aittokallio, T. & Wennerberg, K., 10 May 2016, In : Molecular Cancer. 15, 16 p., 34.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression

Hayes, T. K., Neel, N. F., Hu, C., Gautam, P., Chenard, M., Long, B., Aziz, M., Kassner, M., Bryant, K. L., Pierobon, M., Marayati, R., Kher, S., George, S. D., Xu, M., Wang-Gillam, A., Samatar, A. A., Maitra, A., Wennerberg, K., Petricoin, E. F., Yin, H. H. & 4 othersNelkin, B., Cox, A. D., Yeh, J. J. & Der, C. J., 11 Jan 2016, In : Cancer Cell. 29, 1, p. 75-89 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2015

Bioluminescent, Nonlytic, Real-Time Cell Viability Assay and Use in Inhibitor Screening

Duellman, S. J., Zhou, W., Meisenheimer, P., Vidugiris, G., Cali, J. J., Gautam, P., Wennerberg, K. & Vidugiriene, J., 1 Oct 2015, In : Assay and drug development technologies. 13, 8, p. 456-465 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Endothelial destabilization by angiopoietin-2 via integrin beta 1 activation

Hakanpaa, L., Sipila, T., Leppanen, V-M., Gautam, P., Nurmi, H., Jacquemet, G., Eklund, L., Ivaska, J., Alitalo, K. & Saharinen, P., Jan 2015, In : Nature Communications. 6, 12 p., 5962.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth

Al-Ali, H., Lee, D-H., Danzi, M. C., Nassif, H., Gautam, P., Wennerberg, K., Zuercher, B., Drewry, D. H., Lee, J. K., Lemmon, V. P. & Bixby, J. L., Aug 2015, In : ACS Chemical Biology. 10, 8, p. 1939-1951 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Systematic Mapping of Kinase Addiction Combinations in Breast Cancer Cells by Integrating Drug Sensitivity and Selectivity Profiles

Szwajda, A., Gautam, P., Karhinen, L., Jha, S. K., Saarela, J., Shakyawar, S., Turunen, L., Yadav, B., Tang, J., Wennerberg, K. & Aittokallio, T., 20 Aug 2015, In : Chemistry & Biology. 22, 8, p. 1144-1155 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Bioluminescent Cell-Based NAD(P)/NAD(P)H Assays for Rapid Dinucleotide Measurement and Inhibitor Screening

Vidugiriene, J., Leippe, D., Sobol, M., Vidugiris, G., Zhou, W., Meisenheimer, P., Gautam, P., Wennerberg, K. & Cali, J. J., 1 Dec 2014, In : Assay and drug development technologies. 12, 9-10, p. 514-526 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Donor Simvastatin Treatment Prevents Ischemia-Reperfusion and Acute Kidney Injury by Preserving Microvascular Barrier Function

Tuuminen, R., Nykänen, A., Saharinen, P., Gautam, P., Keränen, M. A. I., Arnaudova, R., Rouvinen, E., Helin, H., Tammi, R., Rilla, K., Krebs, R. & Lemström, K. B., Aug 2013, In : American Journal of Transplantation. 13, 8, p. 2019-2034 16 p.

Research output: Contribution to journalArticleScientificpeer-review