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Raimo K. Tuominen

  • PL56 (Viikinkaari 5)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1983 …2020
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Publications 1983 2020

2019

Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson's disease

Albert, K., Voutilainen, M. H., Domanskyi, A., Piepponen, T. P., Ahola, S., Tuominen, R. K., Richie, C., Harvey, B. K. & Airavaara, M., Mar 2019, In : Journal of Neuroscience Research. 97, 3, p. 346-361 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Glial cell line-derived neurotrophic factor receptor REarranged during transfection agonist supports dopamine neurons in Vitro and enhances dopamine release In Vivo

Mahato, A. K., Kopra, J., Renko, J-M., Visnapuu, T., Korhonen, I., Pulkkinen, N., Bespalov, M. M., Domanskyi, A., Ronken, E., Piepponen, T. P., Voutilainen, M. H., Tuominen, R. K., Karelson, M., Sidorova, Y. A. & Saarma, M., 16 Dec 2019, In : Movement Disorders. 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Missing Selectivity of Targeted 4β-Phorbol Prodrugs Expected to be Potential Chemotherapeutics

Tarvainen, I., Zimmermann, T., Heinonen, P., Jäntti, M., Yli-Kauhaluoma, J., Talman, V., Franzyk, H., Tuominen, R. K. & Christensen, S. B., 23 Dec 2019, (Accepted/In press) In : ACS Medicinal Chemistry Letters.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson's Disease

Huotarinen, A., Penttinen, A-M., Bäck, S., Voutilainen, M. H., Julku, U., Piepponen, T. P., Männistö, P. T., Saarma, M., Tuominen, R., Laakso, A. & Airavaara, M., 15 Mar 2018, In : Neuroscience. 374, p. 250-263 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Itsehoitolääkkeet osana lääkehoitoa - tunnistammeko riskit?

Salminen, O. & Tuominen, R. K., 2018, In : Duodecim. 134, 20, p. 2024-2030 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke

Tseng, K-Y., Anttila, J. E., Khodosevich, K., Tuominen, R. K., Lindahl, M., Domanskyi, A. & Airavaara, M., 3 Jan 2018, In : Molecular therapy. 26, 1, p. 238-255 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Open Access
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Pre-α-pro-GDNF and Pre-β-pro-GDNF Isoforms Are Neuroprotective in the 6-hydroxydopamine Rat Model of Parkinson's Disease

Penttinen, A-M., Parkkinen, I., Voutilainen, M. H., Koskela, M., Bäck, S., Their, A., Richie, C. T., Domanskyi, A., Harvey, B. K., Tuominen, R. K., Nevalaita, L., Saarma, M. & Airavaara, M., 20 Jun 2018, In : Frontiers in neurology. 9, 14 p., 457.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Protein kinase C-activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations

Sarajärvi, T., Jäntti, M., Paldanius, K. M. A., Natunen, T., Wu, J. C., Mäkinen, P., Tarvainen, I., Tuominen, R. K., Talman, V. & Hiltunen, M., Oct 2018, In : Neuropharmacology. 141, p. 76-88 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Role of CDNF in SOD1-G93A Mouse Model of Amyotrophic Lateral Sclerosis

Voutilainen, M. H., De Lorenzo, F., Montonen, E., Tuominen, R. K., Lindholm, D., Sendtner, M. & Saarma, M., Apr 2018, In : Cell Transplantation. 27, 4, p. 717-718 2 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Open Access
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2017

Depolarizing γ-aminobutyric acid contributes to glutamatergic network rewiring in epilepsy

Kourdougli, N., Pellegrino, C., Renko, J-M., Khirug, S., Chazal, G., Kukko-Lukjanov, T-K., Lauri, S. E., Gaiarsa, J-L., Zhou, L., Peret, A., Castrén, E., Tuominen, R. K., Crepel, V. & Rivera Baeza, C., Feb 2017, In : Annals of Neurology. 81, 2, p. 251-265 15 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Lääkkeiden yhteis- ja haittavaikutukset

Renko, J-M. J., Kononoff, J. P., Salminen, O. S., Vihavainen, T. & Tuominen, R. K., 24 Oct 2016, (In preparation) Farmakoterapian tilanneharjoituksia. 8. ed. Helsinki: Farmasian opettajien ja tutkijoiden yhdistys ry, Vol. 2017. 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

Labelling, molecular modelling and biological evaluation of vardenafil: a potential agent for diagnostic evaluation of erectile dysfunction

El-Kawy, O. A., Garcia-Horsman, J. A. & Tuominen, R. K., Dec 2016, In : Applied Radiation and Isotopes. 118, p. 258-265 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Protein Kinase C Activation as a Potential Therapeutic Strategy in Alzheimer's Disease: Is there a Role for Embryonic Lethal Abnormal Vision-like Proteins?

Talman, V., Pascale, A., Jäntti, M., Amadio, M. & Tuominen, R. K., Aug 2016, In : Basic & Clinical Pharmacology & Toxicology. 119, 2, p. 149-160 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
2015

Beyond the affinity for protein kinase C: exploring 2-phenyl-3-hydroxypropyl pivalate analogues as C1 domain-targeting ligands

Rossi, D., Talman, V., Boije af Gennäs, G., Marra, A., Picconi, P., Nasti, R., Serra, M., Ann, J., Amadio, M., Pascale, A., Tuominen, R. K., Yli-Kauhaluoma, J., Lee, J. & Collina, S., 2015, In : MedChemComm. 6, 4, p. 547-554 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Methadone's effect on nAChRs-a link between methadone use and smoking?

Talka, R., Tuominen, R. K. & Salminen, O., 15 Oct 2015, In : Biochemical Pharmacology. 97, 4, p. 542-549 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Comparison of striatal and nigral administration of CDNF in 6-OHDA rat model of PD

Voutilainen, M. H., Panhelainen, A., Albert, K., Tuominen, R. K., Airavaara, M. & Saarma, M., May 2014, In : Movement Disorders. 29, p. S331-S331 1 p.

Research output: Contribution to journalConference articleScientific

Evidence for a role of MRCK in mediating HeLa cell elongation induced by the C1 domain ligand HMI-1a3

Talman, V., Gateva, G., Ahti, M., Ekokoski, E., Lappalainen, P. & Tuominen, R. K., 2014, In : European Journal of Pharmaceutical Sciences. 55, p. 46-57 12 p.

Research output: Contribution to journalArticleScientificpeer-review

File

Protein Kinase C and its Inhibitors in the Regulation of Inflammation: Inducible Nitric Oxide Synthase as an Example

Leppanen, T., Tuominen, R. K. & Moilanen, E., 2014, In : Basic & Clinical Pharmacology & Toxicology. 114, 1, p. 37-43 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Alkueläimiin vaikuttavat lääkeaineet

Männistö, P. T. & Tuominen, R. K., 2013, Farmakologia ja toksikologia. Koulu, M. & Mervaala, E. (eds.). 9 ed. Kuopio: Medicina, Vol. 2013. p. 975-987 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

Down-regulation of protein kinase Cdelta inhibits inducible nitric oxide synthase expression through IRF1

Leppänen, T., Korhonen, R., Laavola, M., Nieminen, R., Tuominen, R. K. & Moilanen, E., 2013, In : PLoS One. 8, 1, 12 p., e52741.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease

Bäck, S., Peränen, J., Galli, E., Pulkkila, P., Lonka-Nevalaita, L., Tamminen, T., Voutilainen, M. H., Raasmaja, A., Saarma, M., Männistö, P. T. & Tuominen, R. K., Mar 2013, In : Brain and Behavior. 3, 2, p. 75-88 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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High correlation between in vivo [123I]β-CIT SPECT/CT imaging and post-mortem immunohistochemical findings in the evaluation of lesions induced by 6-OHDA in rats

Bäck, S., Raki, M., Tuominen, R. K., Raasmaja, A., Bergström, K. & Männistö, P. T., 2013, In : EJNMMI Research. 3, 10 p., 46.

Research output: Contribution to journalArticleScientificpeer-review

Nicotine-morphine interactions at α4β2, α7 and α3⁎ nicotinic acetylcholine receptors.

Talka, R., Salminen, O., Whiteaker, P., Lukas, R. J. & Tuominen, R. K., 2013, In : European Journal of Pharmacology. 701, 1-3, p. 57-64 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Nikotiini ja neurologiset sairaudet : haitallisellakin aineella voi olla hyödyllisiä ominaisuuksia

Kaakkola, S. & Tuominen, R., 2013, In : Duodecim. 129, 16, p. 1654-1660 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Nukleiinihappoihin vaikuttavat mikrobilääkkeet

Männistö, P. T. & Tuominen, R. K., 2013, Farmakologia ja toksikologia. Koulu, M. & Mervaala, E. (eds.). 9 ed. Kuopio: Medicina, Vol. 2013. p. 919-930 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

Proteiinisynteesiä estävät mikrobilääkkeet

Tuominen, R. K. & Männistö, P. T., 2013, Farmakologia ja toksikologia. Koulu, M. & Mervaala, E. (eds.). 9 ed. Kuopio: Medicina, p. 899-918 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

Sieni-infektioiden hoitoon tarkoitetut lääkeaineet

Männistö, P. T. & Tuominen, R. K., 2013, Farmakologia ja toksikologia. Koulu, M. & Mervaala, E. (eds.). 9 ed. Kuopio: Medicina, Vol. 2013. p. 949-960 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

Soluseinämää heikentävät bakteerilääkkeet

Männistö, P. T. & Tuominen, R. K., 2013, Farmakologia ja toksikologia. Koulu, M. & Mervaala, E. (eds.). 9 ed. Kuopio: Medicina, Vol. 2013. p. 877-897 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells

Talman, V., Amadio, M., Osera, C., Sorvari, S., Boije af Gennäs, G., Yli-Kauhaluoma, J., Rossi, D., Govoni, S., Collina, S., Ekokoski, E., Tuominen, R. K. & Pascale, A., 2013, In : Pharmacological Research. 73, p. 44-54 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Uusien lääkeaineiden vaikutusmekanismit

Translated title of the contribution: Mechanisms of action of novel drugsTuominen, R. K., 2013, In : Duodecim. 129, p. 43-50 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Virustautien hoitoon tarkoitetut mikrobilääkkeet

Männistö, P. T. & Tuominen, R. K., 2013, Farmakologia ja toksikologia. Koulu, M. & Mervaala, E. (eds.). 9 ed. Kuopio: Medicina, p. 961-974 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

Yleistä mikrobilääkkeistä

Männistö, P. T. & Tuominen, R. K., 2013, Farmakologia ja toksikologia. Koulu, M. & Mervaala, E. (eds.). 9 ed. Kuopio: Medicina, Vol. 2013. p. 861-875 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

2012

Alkueläimiin vaikuttavat lääkeaineet

Männistö, P. T. & Tuominen, R. K., 2012, Farmakologia ja toksikologia. Koulu, M., Mervaala, E. & Tuomisto, J. (eds.). 8 ed. Kuopio: Medicina, p. 975-987 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery After MPTP Treatment in Mice

Airavaara, M., Harvey, B. K., Voutilainen, M. H., Shen, H., Chou, J., Lindholm, P., Lindahl, M., Tuominen, R. K., Saarma, M., Hoffer, B. & Wang, Y., 2012, In : Cell Transplantation. 21, 6, p. 1213-1223 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Comprehensive medication reviews for elderly patients: Findings and recommendations to physicians

Leikola, S. N. S., Virolainen, J., Tuomainen, L., Tuominen, R. K. & Airaksinen, M. S. A., 2012, In : Journal of the American Pharmacists Association. 52, 5, p. 630-633 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Effect of Catechol-O-methyltransferase deficiency on reinforcing effects of cocaine (experimental study)

Mus, L. V., Dravolina, O. A., Bespalov, A. I., Käenmäki, M., Talka, R., Salminen, O., Tuominen, R. K., Männistö, P. T. & Zvartau, E. E., 2012, In : Zhurnal Nevropatologii i Psikhiatrii im. S.S. Korsakova. 112, 7, p. 48-52 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Kinetics of PKC epsilon Activating and Inhibiting Llama Single Chain Antibodies and Their Effect on PKC epsilon Translocation in HeLa Cells

Summanen, M., Granqvist, N., Tuominen, R. K., Yliperttula, M., Verrips, C. T., Boonstra, J., Blanchetot, C. & Ekokoski, E., 2012, In : PLoS One. 7, p. - 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Minocycline protects SH-SY5Y cells from 6-hydroxydopamine by inhibiting both caspase-dependent and -independent programmed cell death

Ossola, B., Lantto, T. A., Katja, P., Tuominen, R. K., Raasmaja, A. & Männistö, P., 2012, In : Journal of Neuroscience Research. 90, 3, p. 682-690 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Nukleiinihappoihin vaikuttavat mikrobilääkkeet

Tuominen, R. K. & Männistö, P. T., 2012, Farmakologia ja toksikologia. Koulu, M., Mervaala, E. & Tuomisto, J. (eds.). 8 ed. Kuopio: Medicina, p. 919-930 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

Proteiinisynteesiä estävät lääkeaineet

Tuominen, R. K. & Männistö, P. T., 2012, Farmakologia ja toksikologia. Koulu, M., Mervaala, E. & Tuomisto, J. (eds.). 8 ed. Kuopio: Medicina, Vol. 2012. p. 899-918 18 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

Sieni-infektioiden hoitoon tarkoitetut lääkeaineet

Tuominen, R. K. & Männistö, P. T., 2012, Farmakologia ja toksiologia. 8 ed. Kuopio: Medicina, p. 949-960 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientific