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Raimo K. Tuominen

  • PL56 (Viikinkaari 5)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1983 …2019
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Publications 1983 2019

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2019

Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson's disease

Albert, K., Voutilainen, M. H., Domanskyi, A., Piepponen, T. P., Ahola, S., Tuominen, R. K., Richie, C., Harvey, B. K. & Airavaara, M., Mar 2019, In : Journal of Neuroscience Research. 97, 3, p. 346-361 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson's Disease

Huotarinen, A., Penttinen, A-M., Bäck, S., Voutilainen, M. H., Julku, U., Piepponen, T. P., Männistö, P. T., Saarma, M., Tuominen, R., Laakso, A. & Airavaara, M., 15 Mar 2018, In : Neuroscience. 374, p. 250-263 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke

Tseng, K-Y., Anttila, J. E., Khodosevich, K., Tuominen, R. K., Lindahl, M., Domanskyi, A. & Airavaara, M., 3 Jan 2018, In : Molecular therapy. 26, 1, p. 238-255 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Open Access
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Pre-α-pro-GDNF and Pre-β-pro-GDNF Isoforms Are Neuroprotective in the 6-hydroxydopamine Rat Model of Parkinson's Disease

Penttinen, A-M., Parkkinen, I., Voutilainen, M. H., Koskela, M., Bäck, S., Their, A., Richie, C. T., Domanskyi, A., Harvey, B. K., Tuominen, R. K., Nevalaita, L., Saarma, M. & Airavaara, M., 20 Jun 2018, In : Frontiers in neurology. 9, 14 p., 457.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Protein kinase C-activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations

Sarajärvi, T., Jäntti, M., Paldanius, K. M. A., Natunen, T., Wu, J. C., Mäkinen, P., Tarvainen, I., Tuominen, R. K., Talman, V. & Hiltunen, M., Oct 2018, In : Neuropharmacology. 141, p. 76-88 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Depolarizing γ-aminobutyric acid contributes to glutamatergic network rewiring in epilepsy

Kourdougli, N., Pellegrino, C., Renko, J-M., Khirug, S., Chazal, G., Kukko-Lukjanov, T-K., Lauri, S. E., Gaiarsa, J-L., Zhou, L., Peret, A., Castrén, E., Tuominen, R. K., Crepel, V. & Rivera Baeza, C., Feb 2017, In : Annals of Neurology. 81, 2, p. 251-265 15 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Labelling, molecular modelling and biological evaluation of vardenafil: a potential agent for diagnostic evaluation of erectile dysfunction

El-Kawy, O. A., Garcia-Horsman, J. A. & Tuominen, R. K., Dec 2016, In : Applied Radiation and Isotopes. 118, p. 258-265 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Beyond the affinity for protein kinase C: exploring 2-phenyl-3-hydroxypropyl pivalate analogues as C1 domain-targeting ligands

Rossi, D., Talman, V., Boije af Gennäs, G., Marra, A., Picconi, P., Nasti, R., Serra, M., Ann, J., Amadio, M., Pascale, A., Tuominen, R. K., Yli-Kauhaluoma, J., Lee, J. & Collina, S., 2015, In : MedChemComm. 6, 4, p. 547-554 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Evidence for a role of MRCK in mediating HeLa cell elongation induced by the C1 domain ligand HMI-1a3

Talman, V., Gateva, G., Ahti, M., Ekokoski, E., Lappalainen, P. & Tuominen, R. K., 2014, In : European Journal of Pharmaceutical Sciences. 55, p. 46-57 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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Protein Kinase C and its Inhibitors in the Regulation of Inflammation: Inducible Nitric Oxide Synthase as an Example

Leppanen, T., Tuominen, R. K. & Moilanen, E., 2014, In : Basic & Clinical Pharmacology & Toxicology. 114, 1, p. 37-43 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Down-regulation of protein kinase Cdelta inhibits inducible nitric oxide synthase expression through IRF1

Leppänen, T., Korhonen, R., Laavola, M., Nieminen, R., Tuominen, R. K. & Moilanen, E., 2013, In : PLoS One. 8, 1, 12 p., e52741.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease

Bäck, S., Peränen, J., Galli, E., Pulkkila, P., Lonka-Nevalaita, L., Tamminen, T., Voutilainen, M. H., Raasmaja, A., Saarma, M., Männistö, P. T. & Tuominen, R. K., Mar 2013, In : Brain and Behavior. 3, 2, p. 75-88 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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High correlation between in vivo [123I]β-CIT SPECT/CT imaging and post-mortem immunohistochemical findings in the evaluation of lesions induced by 6-OHDA in rats

Bäck, S., Raki, M., Tuominen, R. K., Raasmaja, A., Bergström, K. & Männistö, P. T., 2013, In : EJNMMI Research. 3, 10 p., 46.

Research output: Contribution to journalArticleScientificpeer-review

Nicotine-morphine interactions at α4β2, α7 and α3⁎ nicotinic acetylcholine receptors.

Talka, R., Salminen, O., Whiteaker, P., Lukas, R. J. & Tuominen, R. K., 2013, In : European Journal of Pharmacology. 701, 1-3, p. 57-64 8 p.

Research output: Contribution to journalArticleScientificpeer-review

The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells

Talman, V., Amadio, M., Osera, C., Sorvari, S., Boije af Gennäs, G., Yli-Kauhaluoma, J., Rossi, D., Govoni, S., Collina, S., Ekokoski, E., Tuominen, R. K. & Pascale, A., 2013, In : Pharmacological Research. 73, p. 44-54 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery After MPTP Treatment in Mice

Airavaara, M., Harvey, B. K., Voutilainen, M. H., Shen, H., Chou, J., Lindholm, P., Lindahl, M., Tuominen, R. K., Saarma, M., Hoffer, B. & Wang, Y., 2012, In : Cell Transplantation. 21, 6, p. 1213-1223 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Comprehensive medication reviews for elderly patients: Findings and recommendations to physicians

Leikola, S. N. S., Virolainen, J., Tuomainen, L., Tuominen, R. K. & Airaksinen, M. S. A., 2012, In : Journal of the American Pharmacists Association. 52, 5, p. 630-633 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Effect of Catechol-O-methyltransferase deficiency on reinforcing effects of cocaine (experimental study)

Mus, L. V., Dravolina, O. A., Bespalov, A. I., Käenmäki, M., Talka, R., Salminen, O., Tuominen, R. K., Männistö, P. T. & Zvartau, E. E., 2012, In : Zhurnal Nevropatologii i Psikhiatrii im. S.S. Korsakova. 112, 7, p. 48-52 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Kinetics of PKC epsilon Activating and Inhibiting Llama Single Chain Antibodies and Their Effect on PKC epsilon Translocation in HeLa Cells

Summanen, M., Granqvist, N., Tuominen, R. K., Yliperttula, M., Verrips, C. T., Boonstra, J., Blanchetot, C. & Ekokoski, E., 2012, In : PLoS One. 7, p. - 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Minocycline protects SH-SY5Y cells from 6-hydroxydopamine by inhibiting both caspase-dependent and -independent programmed cell death

Ossola, B., Lantto, T. A., Katja, P., Tuominen, R. K., Raasmaja, A. & Männistö, P., 2012, In : Journal of Neuroscience Research. 90, 3, p. 682-690 9 p.

Research output: Contribution to journalArticleScientificpeer-review

The Effect of MII alpha-Conotoxin and Its N-Terminal Derivatives on Ca2+- and Na+-Signals Induced by Nicotine in SH-SY5Y Neuroblastoma Cells

Surin, A. M., Kryukova, E. V., Strukov, A. S., Zhmak, M. N., Talka, R., Tuominen, R., Salminen, O., Khiroug, L. S., Kasheverov, I. E. & Tsetlin, V. I., 2012, In : Russian Journal of Bioorganic Chemistry. 38, 2, p. 184-191 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Влияние дефицита катехол-О-метилтрансферазы на подкреп­ляющие эффекты кокаина (экспериментальное исследование)

Translated title of the contribution: Effect of Catechol-O-methyltransferase deficiency on reinforcing effects of cocaine (experimental study)Mus, L. V., Dravolina, O. A., Bespalov, A. Y., Kaenmaki, M., Talka, R., Salminen, O., Tuominen, R. K., Mannisto, P. T. & Zvartau, E. E., 2012, In : Zhurnal nevrologii i psikhiatrii imeni s s korsakova. 112, 7, p. 48-52 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Amantadine protects dopamine neurons by a dual action: Reducing activation of microglia and inducing expression of GNDF in astroglia

Ossola, B., Schendzielorz, N., Chen, S-H., Bird, G. S., Tuominen, R. K., Männistö, P. T. & Hong, J-S., 2011, In : Clinical Neuropharmacology. 61, 4, p. 574-582 9 p.

Research output: Contribution to journalArticleScientificpeer-review

C1 Domain-Targeted Isophthalate Derivatives Induce Cell Elongation and Cell Cycle Arrest in HeLa Cells

Talman, V., Tuominen, R. K., Boije af Gennäs, G., Yli-Kauhaluoma, J. & Ekokoski, E., 2011, In : PLoS One. 6, 5, p. e20053 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery After MPTP Treatment n Mice

Airavaara, M., Harvey, B. K., Voutilainen, M. H., Chou, J., Lindholm, P., Lindahl, M., Tuominen, R. K., Saarma, M., Wang, Y. & Hoffer, B., 2011, In : Cell Transplantation. 20, Supplement 1, p. 544-545 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease

Voutilainen, M. H., Back, S., Peranen, J., Lindholm, P., Raasmaja, A., Mannisto, P. T., Saarma, M. & Tuominen, R. K., 2011, In : Experimental Neurology. 228, 1, p. 99-108 10 p.

Research output: Contribution to journalArticleScientificpeer-review

INHIBITION OF CLASSICAL PROTEIN KINASE C ISOENZYMES DOWNREGULATES STAT1 ACTIVATION AND NITRIC OXIDE PRODUCTION IN ACTIVATED MACROPHAGES

Leppanen, T., Sareila, O., Jalonen, U., Kankaanranta, H., Tuominen, R. K. & Moilanen, E., 2011, In : Scandinavian Journal of Rheumatology. 40, p. 245-246 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Liikehäiriösairauksien hoidon tulevaisuuden toiveita: Löytyykö hermokasvutekijöistä yhdessä kantasolujen tai solusiirrännäisten kanssa uusi hoitomahdollisuus?

Translated title of the contribution: Future hopes for the treatment of movement disordersTuominen, R. K. & Männistö, P. T., Jan 2011, In : Parkinson-postia. 24, 1, p. 46-47 2 p.

Research output: Contribution to journalArticleGeneral public

Stereoselective synthesis of (3-aminodecahydro-1,4-methanonaphthalen-2-yl) methanols targeted to the C1 domain of protein kinase C

Kiriazis, A., Boije af Gennäs, G., Talman, V., Ekokoski, E., Ruotsalainen, T., Kylänlahti, I., Rüffer, T., Wissel, G., Xhaard, H., Lang, H., Tuominen, R. K. & Yli-Kauhaluoma, J., 11 Nov 2011, In : Tetrahedron. 67, 45, p. 8665-8670 6 p.

Research output: Contribution to journalArticleScientificpeer-review

The development of activating and inhibiting camelid VHH domains against human protein kinase C epsilon

Paalanen, M. M. I., Ekokoski, E., El Khattabi, M., Tuominen, R. K., Verrips, C. T., Boonstra, J. & Blanchetot, C., 2011, In : European Journal of Pharmaceutical Sciences. 42, 4, p. 332-339 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

HIV-1 Tat-peptide inhibits protein kinase C and protein kinase A through substrate competition

Ekokoski, E., Aitio, O., Tornquist, K., Yli-Kauhaluoma, J. T. & Tuominen, R. K., 2010, In : European Journal of Pharmaceutical Sciences. 40, 5, p. 404-411 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Inhibition of protein kinase C delta reduces tristetraprolin expression by destabilizing its mRNA in activated macrophages

Leppanen, T., Jalonen, U., Korhonen, R., Tuominen, R. K. & Moilanen, E., 2010, In : European Journal of Pharmacology. 628, 1-3, p. 220-225 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Medium-throughput computer aided micro-island method to assay embryonic dopaminergic neuron cultures in vitro

Planken, A., Porokuokka, L., Hänninen, A-L., Tuominen, R. & Andressoo, J-O., 2010, In : Journal of Neuroscience Methods. 194, 1, p. 122-131 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Nicotine exposure throughout early development promotes nicotine self-administration in adolescent mice and induces long-lasting behavioural changes

Chistyakov, V., Patkina, N., Tammimaki, A., Talka, R., Salminen, O., Belozertseva, I., Galankin, T., Tuominen, R. & Zvartau, E., 2010, In : European Journal of Pharmacology. 640, p. 87-93 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C

Boije af Gennäs, G., Talman, V., Aitio, O., Ekokoski, E., Finel, M., Tuominen, R. K. & Yli-Kauhaluoma, J., 2009, In : Journal of Medicinal Chemistry. 52, 13, p. 3969-3981 13 p.

Research output: Contribution to journalArticleScientificpeer-review

File

Mesencephalic astrocyte-derived neurotrophic factor is neurorestorative in rat model of Parkinson's Disease

Voutilainen, M., Bäck, S., Pörsti, E., Toppinen, L., Lindgren, L., Lindholm, P., Peränen, J., Saarma, M. & Tuominen, R. K., 2009, In : Journal of Neuroscience. 29, 30, p. 9651-9659 9 p.

Research output: Contribution to journalArticleScientificpeer-review

PROTEIN KINASE C ISOENZYMES REGULATE THE EXPRESSION OF ARTHRITIS SUPPRESSOR GENE TTP IN ACTIVATED MACROPHAGES

Leppanen, T., Jalonen, U., Kankaanranta, H., Tuominen, R. K. & Moilanen, E., 2009, In : Scandinavian Journal of Rheumatology. 38, p. 406-406 1 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Chronic nicotine modifies the effects of morphine on extracellular striatal dopamine and ventral tegmental GABA

Vihavainen, T., Relander, T., Leiviskä, R., Airavaara, M., Tuominen, R. K., Ahtee, L. & Piepponen, T. P., 2008, In : Journal of Neurochemistry. 107, 3, p. 844-854 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Inhibition of protein kinase C beta II downregulates tristetraprolin expression in activated macrophages

Leppaenen, T., Jalonen, U., Kankaanranta, H., Tuominen, R. & Moilanen, E., May 2008, In : Inflammation Research. 57, 5, p. 230-240 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Morphine-nicotine interaction in conditioned place preference in mice after chronic nicotine exposure

Vihavainen, T., Piltonen, M., Tuominen, R. K., Korpi, E. R. & Ahtee, L., 2008, In : European Journal of Pharmacology. 587, 1/3, p. 169-174 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Ovatko hermokasvutekijät tulevaisuuden Parkinson-lääkkeitä?

Tuominen, R. K. & Gordin, A., 2008, In : Parkinson-postia. 21, 5, p. 36

Research output: Contribution to journalArticleGeneral public

2007

Increased catechol-O-methyltransferase activity and protein expression in OX-42-positive cells in the substantia nigra after lipopolysaccharide microinfusion

Helkamaa, T., Reenilä, I., Tuominen, R. K., Soinila, S., Väänänen, A., Tilgmann, C. & Rauhala, P., 2007, In : Neurochemistry International. 51, 6-7, p. 412-423 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo

Lindholm, P., Voutilainen, M., Lauren, J., Peränen, J., Leppänen, V-M., Andressoo, J-O., Lindahl, M., Janhunen, S., Kalkkinen, N., Timmusk, T., Tuominen, R. K. & Saarma, M., 2007, In : Nature. 448, 7147, p. 73-78 6 p.

Research output: Contribution to journalArticleScientificpeer-review