Photo of Reijo Käkelä

Reijo Käkelä

  • P.O. Box 65 (Viikinkaari 1)

    00014 University of Helsinki


  • PL 65 (Viikinkaari 1)



  • Viikinkaari 5, Biocenter 2

    00790 Helsinki



Research output per year

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Personal profile

Description of research and teaching

Research of Dr Käkelä focuses on the roles of lipids and fatty acids in cellular functions, pathogenesis of human diseases, aquatic food webs, and environmental adaptation of animals. Basic research and applied projects are carried out. The main methods are mass spectrometry-based lipidomics and several chromatographic techniques. Käkelä is responsible for the study courses: BSc Seminar in Physiology and Neuroscience, Animal Ecophysiology, Physiological Ecotoxicology and Functional Lipidomics Seminar, and contributes to several other courses as well e.g. the course Membranes, Carbohydrates and Lipids. He is supervising several MSc and PhD students, and runs a core facility Helsinki University Lipidomics Unit. The resources of the Lipidomics Unit are used for undergraduate and postgraduate student training.


Fields of Science

  • 1182 Biochemistry, cell and molecular biology
  • Lipids and membranes
  • Fatty acid metabolism
  • Mass spectrometry
  • Chromatography
  • 1184 Genetics, developmental biology, physiology
  • Lipid metabolism
  • 1181 Ecology, evolutionary biology
  • Foraging ecology
  • Temperature adaptation
  • 3111 Biomedicine
  • Metabolic syndromes
  • Cardiovascular diseases
  • 3112 Neurosciences
  • Neurodegeneration

International and National Collaboration Publications and projects within past five years.


ANGPTL3 deficiency alters the lipid profile and metabolism of cultured hepatocytes and human lipoproteins

Ruhanen, H., Haridas, P. A. N., Minicocci, I., Taskinen, J. H., Palmas, F., di Costanzo, A., D'Erasmo, L., Metso, J., Partanen, J., Dalli, J., Zhou, Y., Arca, M., Jauhiainen, M., Käkelä, R. & Olkkonen, V. M., Jul 2020, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1865, 7, 11 p., 158679.

Research output: Contribution to journalArticleScientificpeer-review

Changes in thiamine concentrations, fatty acid composition, and some other lipid-related biochemical indices in Baltic Sea Atlantic salmon (Salmo salar) during the spawning run and pre-spawning fasting

Vuorinen, P. J., Rokka, M., Ritvanen, T., Käkelä, R., Nikonen, S., Pakarinen, T. & Keinänen, M., 28 Aug 2020, In : Helgoland Marine Research. 74, 10, 24 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism

Matilainen, J., Mustonen, A-M., Rilla, K., Kakela, R., Sihvo, S. P. & Nieminen, P., 13 Apr 2020, In : Lipids in Health and Disease. 19, 1, 15 p., 70.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

The Diapause Lipidomes of Three Closely Related Beetle Species Reveal Mechanisms for Tolerating Energetic and Cold Stress in High-Latitude Seasonal Environments

Lehmann, P., Westberg, M., Tang, P., Lindstrom, L. & Kakela, R., 25 Sep 2020, In : Frontiers in Physiology. 11, 17 p., 576617.

Research output: Contribution to journalArticleScientificpeer-review

Open Access



  • 1 Assessment of candidates for academic posts
  • 1 Oral presentation

Environmental effects of fish introductions in small, high-latitude lakes

Marco Milardi (Speaker), , Reijo Tapio Käkelä (Speaker), , Jan Björn Weckström (Speaker), & Kimmo Kahilainen (Speaker)


Activity: Talk or presentation typesOral presentation

University of Oulu (External organisation)

Reijo Käkelä (Assessment)

5 May 20068 May 2006

Activity: Membership typesAssessment of candidates for academic posts