Research output per year
Research output per year
Personal profile
Description of research and teaching
Research of Dr Käkelä focuses on the roles of lipids and fatty acids in cellular functions, pathogenesis of human diseases, aquatic food webs, and environmental adaptation of animals. Basic research and applied projects are carried out. The main methods are mass spectrometry-based lipidomics and several chromatographic techniques. Käkelä is responsible for the study courses: BSc Seminar in Physiology and Neuroscience, Animal Ecophysiology, Physiological Ecotoxicology and Functional Lipidomics Seminar, and contributes to several other courses as well e.g. the course Membranes, Carbohydrates and Lipids. He is supervising several MSc and PhD students, and runs a core facility Helsinki University Lipidomics Unit. The resources of the Lipidomics Unit are used for undergraduate and postgraduate student training.
Fields of Science
- 1182 Biochemistry, cell and molecular biology
- Lipids and membranes
- Fatty acid metabolism
- Mass spectrometry
- Chromatography
- 1184 Genetics, developmental biology, physiology
- Lipid metabolism
- 1181 Ecology, evolutionary biology
- Foraging ecology
- Temperature adaptation
- 3111 Biomedicine
- Metabolic syndromes
- Cardiovascular diseases
- 3112 Neurosciences
- Neurodegeneration
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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ANO7 expression in the prostate modulates mitochondrial function and lipid metabolism
Löf, C., Sultana, N., Goel, N., Heron, S., Wahlström, G., House, A., Holopainen, M., Käkelä, R. & Schleutker, J., 8 Feb 2025, In: Cell Communication and Signaling. 23, 1, 19 p., 71.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Association of aerobic fitness and body composition with protein and major lipid class composition of high-density lipoprotein
Lähteenmäki, E. I., Lehti, S., Jauhiainen, M., Kankaanpää, A., Soliymani, R., Baumann, M., Ruhanen, H., Käkelä, R., Vaara, J., Laakkonen, E. K., Öörni, K., Kyröläinen, H. & Lehti, M., 18 Aug 2025, In: American Journal of Physiology: Endocrinology and Metabolism. 329, 2, p. E368-E381 14 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Glucose-6-phosphate-dehydrogenase on old peroxisomes maintains self-renewal of epithelial stem cells after asymmetric cell division
Bui, H., Andersson, S., Sola-Carvajal, A., De Marchi, T., Vähäkangas, E., Holopainen, M., House, A. H., Rovenko, B. M., Englund, J. I., Kasper, M., Kuuluvainen, E., Käkelä, R., Hietakangas, V., Niméus, E. & Katajisto, P., 26 Apr 2025, In: Nature Communications. 16, 1, 14 p., 3932.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Icosapent ethyl–induced lipoprotein remodeling and its impact on cardiovascular disease risk markers in normolipidemic individuals
Äikäs, L., Kovanen, P. T., Lorey, M. B., Laaksonen, R. M. H., Holopainen, M., Ruhanen, H., Käkelä, R., Jauhiainen, M., Hermansson, M. & Öörni, K., 8 Oct 2025, In: JCI INSIGHT. 10, 19, 23 p., 193637.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Improvement of high-density lipoprotein atheroprotective properties in patients with systemic lupus erythematosus after belimumab treatment
Dedemadi, A., Gkolfinopoulou, C., Nikoleri , D., Nikoloudaki, M., Ruhanen, H., Holopainen, M., Käkelä, R., Christopoulou, G., Bournazos, S., Constantoulakis, P., Sidiropoulos, P., Bertsias, G. & Chroni , A., Feb 2025, In: Rheumatology. 64, 2, p. 648-657 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile
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Browning lakes in the greening Arctic
Weckström, J. (Project manager), Heikkilä, M. (Co-Principal Investigator), Heikkilä, M. (Co-Principal Investigator), Weckström, K. (Co-Principal Investigator), Keva, O. (Participant), Koski, K. J. A. (Participant), Käkelä, R. (Participant), Odé, E. M. (Participant), Strötz, L. M. (Participant), Virtanen, T. (Participant), Weckström, K. (Participant), Orozco, L. (Other), McGowan, S. (CoIlaborator), Meyer-Jacob, C. (CoIlaborator) & Smol, J. (CoIlaborator)
01/09/2023 → 31/08/2027
Project: Research Council of Finland: Academy Project
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Membrec (Membranes and Receptors)
Keinänen, K. (Participant), Finne, J. (Participant), Siljander, P. (Participant), Gahmberg, C. G. (Participant), Käkelä, R. (Participant), Eskelinen, E.-L. (Participant) & Kukkonen, J. (Participant)
01/01/2013 → 31/12/2016
Project: Research project
Activities
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Principles of bioscience omics, Lectures 10 cr, NEU-561
Pietiäinen, V. (Teacher), Käkelä, R. (Teacher) & Palviainen, M. (Teacher)
2022 → …Activity: Other activity types › Types for other activities - External teaching and subject coordination
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Environmental effects of fish introductions in small, high-latitude lakes
Milardi, M. (Speaker), Käkelä, R. T. (Speaker), Weckström, J. B. (Speaker) & Kahilainen, K. (Speaker)
2014Activity: Talk or presentation types › Oral presentation
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University of Oulu (External organisation)
Käkelä, R. (Assessment)
5 May 2006 → 8 May 2006Activity: Membership types › Assessment of candidates for academic posts
Equipment
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Air compressor
Facility/equipment: Registry of appliances: Laboratory equipment › Compressors
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Gas chromatograph
Facility/equipment: Registry of appliances: Laboratory equipment › Chromatographs and their accessories
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Gas chromatograph-MS
Faculty Common Matters (Faculty of Biology and Environmental Sciences)Facility/equipment: Registry of appliances: Laboratory equipment › Chromatographs and their accessories
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Helsinki University Lipidomics Unit (LS-RIA/ Metabo-HiLIFE)
Käkelä, R. (Manager), Ruhanen, H. E. (Operator), Holopainen, M. (Operator) & Somerharju, P. J. (Manager)
Functional Lipidomics GroupFacility/equipment: Core Facility
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Nitrogen regenerator
Facility/equipment: Registry of appliances: Laboratory equipment › Generators