Photo of Reijo Käkelä

Reijo Käkelä

  • P.O. Box 65 (Viikinkaari 1)

    00014 University of Helsinki

    Finland

  • PL 65 (Viikinkaari 1)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

19962019
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Publications 1996 2019

1996

Site-specific fatty acid composition in adipose tissues of several northern aquatic and terrestrial mammals

Kakela, R. & Hyvarinen, H., 1996, In : Comparative Biochemistry and Physiology. Part B: Biochemistry & Molecular Biology. 115, p. 501-514 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2000

Muscle fatty acids as indicators of niche and habitat in Malawian cichlids

Kuusipalo, L. & Kakela, R., 2000, In : Limnology and Oceanography: Methods. 45, p. 996-1000 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Plasma leptin and thyroxine of mink (Mustela vison) vary with gender, diet and subchronic exposure to PCBs

Nieminen, P., Hyvarinen, H., Kakela, R. & Asikainen, J., 2000, In : Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology. 127, p. 515-522 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

Phospholipid molecular species profiles of tectiviruses infecting Gram-negative and Gram-positive hosts

Laurinavicius, S., Kakela, R., Somerharju, P. & Bamford, DH., 1 May 2004, In : Virology. 322, 2, p. 328-336 9 p.

Research output: Contribution to journalArticleScientificpeer-review

The origin of phospholipids of the enveloped bacteriophage phi6

Laurinavicius, S., Kakela, R., Bamford, DH. & Somerharju, P., 15 Aug 2004, In : Virology. 326, 1, p. 182-190 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Automated quantitative analysis of complex lipidomes by liquid chromatography/mass spectrometry

Hermansson, M., Uphoff, A., Käkelä, R. & Somerharju, P., 2005, In : Analytical Chemistry. 77, p. 2166-2175 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Fatty acid composition of blubber of the Baikal seal Phoca sibifica and its marine relative, the ringed seal P-hispida

Grahl-Nielsen, O., Halvorsen, A. K., Bodoev, N., Averina, L., Radnaeva, L., Pronin, N., Käkelä, R. & Petrov, E., 2005, In : Marine Ecology. Progress Series. 305, p. 261-274 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Fatty acid signatures in plasma of captive herring gulls as indicators of demersal or pelagic fish diet

Käkelä, R., Käkelä, A., Kahle, S., Becker, P. H., Kelly, A. & Furness, R. W., 2005, In : Marine Ecology. Progress Series. 293, p. 191-200 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Overexpression of OSBP-related protein 2 (ORP2) in CHO cells induces alterations of phospholipid species composition

Käkelä, R., Tanhuanpää, K., Laitinen, S., Somerharju, P. & Olkkonen, V., 2005, In : Biochemistry and Cell Biology. 83, p. 677-683 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Overexpression of OSBP-related protein 2 (ORP2) induces changes in cellular cholesterol metabolism and enhances endocytosis

Hynynen, R., Laitinen, S., Käkelä, R., Tanhuanpää, K., Lusa, S., Ehnholm, C., Somerharju, P., Ikonen, E. & Olkkonen, V. M., 2005, In : Biochemical Journal. 390, p. 273-283 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Fatty acid signatures as indicators of diet in great skuas Stercorarius skua, Shetland

Käkelä, A., Crane, J., Votier, S. C., Furness, R. W. & Käkelä, R., 2006, In : Marine Ecology. Progress Series. 319, p. 297-310 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Selective fatty acid mobilization in the American mink (Mustela vison) during food deprivation

Nieminen, P., Käkelä, R., Pyykonen, T. & Mustonen, A-M., 2006, In : Comparative Biochemistry and Physiology. Part B: Biochemistry & Molecular Biology. 145, 1, p. 81-93 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Techniques to link individual migration patterns of seabirds with diet specialization, condition and breeding performance

Furness, R. W., Crane, J. E., Bearhop, S., Garthe, S., Käkelä, A., Käkelä, R., Kelly, A., Kubetzki, U., Votier, S. C. & Waldron, S., 2006, In : Ardea. 94, 3, p. 631-638 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Different fatty acid composition in central and peripheral adipose tissues of the American mink (Mustela vison)

Mustonen, A-M., Kakela, R. & Nieminen, P., 2007, In : Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology. 147, 4, p. 903-910 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Fatty acid signatures and stable isotopes as dietary indicators in North Sea seabirds

Käkelä, A., Furness, R. W., Kelly, A., Strandberg, U., Waldron, S. & Käkelä, R., 2007, In : Marine Ecology. Progress Series. 342, p. 291-301 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Lipid metabolism in the adipose tissues of a carnivore, the raccoon dog, during prolonged fasting

Mustonen, A-M., Käkelä, R., Käkelä, A., Pyykönen, T., Aho, J. & Nieminen, P., 2007, In : Experimental Biology and Medicine (Maywood). 232, p. 58-69 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Accumulation of bis(monoacylglycero)phosphate and gangliosides in mouse models of neuronal ceroid lipofuscinosis

Jabs, S., Quitsch, A., Käkelä, R., Koch, B., Tyynelä, J., Brade, H., Glatzel, M., Walkley, S., Saftig, P., Vanier, M. & Braulke, T., 2008, In : Journal of Neurochemistry. 106, p. 1415-1425 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Seasonal acclimatization of brain lipidome in a eurythermal fish (Carassius carassius) is mainly determined by temperature

Käkelä, R., Mattila, M., Hermansson, M., Haimi, P., Uphoff, A., Paajanen, V., Somerharju, P. & Vornanen, M., 2008, In : American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 294, p. R1716-R1728

Research output: Contribution to journalArticleScientificpeer-review

Stratification, composition, and function of marine mammal blubber: The ecology of fatty acids in marine mammals

Strandberg, U., Käkelä, A., Lydersen, C., Kovacs, K. M., Grahl-Nielsen, O., Hyvarinen, H. & Käkelä, R., 2008, In : Physiological and Biochemical Zoology. 81, 4, p. 473-485 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Chlamydial and periodontal pathogens induce hepatic inflammation and fatty acid imbalance in apolipoprotein E-deficient mice

Hyvärinen, K., Tuomainen, A., Laitinen, S., Bykov, I. L., Tormakangas, L., Lindros, K., Käkelä, R., Alfthan, G., Salminen, I., Jauhiainen, M., Kovanen, P., Leinonen, M., Saikku, P. & Pussinen, P., 2009, In : Infection and Immunity. 77, 8, p. 3442-3449 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Fatty acid signatures in seabird plasma are a complex function of diet composition: a captive feeding trial with herring gulls

Käkelä, R., Furness, R. W., Kahle, S., Becker, P. H. & Käkelä, A., 2009, In : Functional Ecology. 23, 1, p. 141-149 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Selective Fatty Acid Mobilization from Adipose Tissues of the Pheasant (Phasianus colchicus mongolicus) during Food Deprivation

Mustonen, A-M., Käkelä, R., Asikainen, J. & Nieminen, P., 2009, In : Physiological and Biochemical Zoology. 82, p. 531-540 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Fatty acid signature analysis confirms foraging resources of a globally endangered Mediterranean seabird species: calibration test and application to the wild

Käkelä, R., Käkelä, A., Martinez-Abrain, A., Sarzo, B., Louzao, M., Gerique, C., Villuendas, E., Strandberg, U., Furness, R. W. & Oro, D., 2010, In : Marine Ecology. Progress Series. 398, p. 245-258 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Murine cathepsin D deficiency is associated with dysmyelination/myelin disruption and accumulation of cholesteryl esters in the brain

Mutka, A-L., Haapanen, A., Käkelä, R., Lindfors, M., Wright, A. K., Inkinen, T., Hermansson, M., Rokka, A., Corthals, G., Jauhiainen, M., Gillingwater, T. H., Ikonen, E. & Tyynelä, J., 2010, In : Journal of Neurochemistry. 112, 1, p. 193-203 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Activity of BKCa channel is modulated by membrane cholesterol content and association with Na+/K+-ATPase in human melanoma IGR39 cells

Tajima, N., Itokazu, Y., Korpi, E. R., Somerharju, P. & Käkelä, R., 2011, In : Journal of Biological Chemistry. 286, 7, p. 5624-5638 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Experimental infection of the deer ked (Lipoptena cervi) has no negative effects on the physiology of the captive reindeer (Rangifer tarandus tarandus)

Paakkonen, T., Mustonen, A-M., Käkelä, R., Kiljander, T., Kynkäänniemi, S-M., Laaksonen, S., Solismaa, M., Aho, J., Kortet, R., Puukka, K., Saarela, S., Härkönen, L., Kaitala, A., Ylönen, H. & Petteri, N., 2011, In : Veterinary Parasitology. 179, 1-3, p. 180-188 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Fatty acid profiles in different fish species in Lake Baikal

Grahl-Nielsen, O., Averina, E., Pronin, N., Radnaeva, L. & Käkelä, R., 2011, In : Aquatic Biology. 13, 1, p. 1-10 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Lipid body formation during maturation of human mast cells

Dichlberger, A., Schlager, S., Lappalainen, J., Käkelä, R., Hattula, K., Butcher, S. J., Schneider, W. J. & Kovanen, P. T., 2011, In : Journal of Lipid Research. 52, 12, p. 2198-2208 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Vertical fatty acid profiles in blubber of a freshwater ringed seal - Comparison to a marine relative

Strandberg, U., Sipilä, T., Koskela, J., Kunnasranta, M. & Käkelä, R., 2011, In : Journal of Experimental Marine Biology and Ecology. 407, 2, p. 256-265 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Fatty acid mobilization in voles-Model species for rapid fasting response and fatty liver

Mustonen, A-M., Käkelä, R., Halonen, T., Kärjä, V., Vartiainen, E. & Nieminen, P., Sep 2012, In : Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology. 163, 1, p. 152-160 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice

Kollmann, K., Damme, M., Markmann, S., Morelle, W., Schweizer, M., Hermans-Borgmeyer, I., Röchert, A. K., Pohl, S., Luebke, T., Michalski, J-C., Käkelä, R., Walkley, S. U. & Braulke, T., Sep 2012, In : Brain : a journal of neurology. 135, 9, p. 2661-2675 15 p.

Research output: Contribution to journalArticleScientificpeer-review

The effects of an abundant ectoparasite, the deer ked (Lipoptena cervi), on the health of moose (Alces alces) in Finland

Paakkonen, T., Mustonen, A-M., Käkelä, R., Laaksonen, S., Solismaa, M., Aho, J., Puukka, K. & Nieminen, P., Sep 2012, In : Parasitology Research. 111, 3, p. 1223-1232 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality

Kilpinen, L., Tigistu-Sahle, F., Oja, S., Greco, D., Parmar, A., Saavalainen, P. M., Nikkilä, J. T., Korhonen, M., Lehenkari, P., Käkelä, R. & Laitinen, S., Mar 2013, In : Journal of Lipid Research. 54, 3, p. 622-635 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Fatty acid modifications during autumnal cold-hardening in an obligatory ectoparasite, the deer ked (Lipoptena cervi)

Nieminen, P., Käkelä, R., Paakkonen, T., Halonen, T. & Mustonen, A-M., Jun 2013, In : Journal of Insect Physiology. 59, 6, p. 631-637 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Modification of the lipidome in RAW264.7 macrophage subjected to stable silencing of oxysterol-binding proteins

Vihervaara, T., Käkelä, R., Liebisch, G., Tarasov, K., Schmitz, G. & Olkkonen, V. M., Mar 2013, In : Biochimie. 95, 3, p. 538-547 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Modified Lipoprotein-Derived Lipid Particles Accumulate in Human Stenotic Aortic Valves

Lehti, S., Käkelä, R., Horkko, S., Kummu, O., Helske-Suihko, S., Kupari, M., Werkkala, K., Kovanen, P. T. & Öörni, K., 7 Jun 2013, In : PLoS One. 8, 6, p. Article Number: e65810 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2014

Gill tissue lipids of salmon (Salmo salar L.) presmolts and smolts from anadromous and landlocked populations

Itokazu, Y., Käkelä, R., Piironen, J., Guan, X. L., Kiiskinen, P. & Vornanen, M., 2014, In : Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology. 172, p. 39-45 7 p.

Research output: Contribution to journalArticleScientificpeer-review

PNPLA3 mediates hepatocyte triacylglycerol remodeling

Ruhanen, H., Perttila, J., Holtta-Vuori, M., Zhou, Y., Yki-Jarvinen, H., Ikonen, E., Kakela, R. & Olkkonen, V. M., Apr 2014, In : Journal of Lipid Research. 55, 4, p. 739-746 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2015

Expert answers to children's science questions, Helsingin Sanomat, 2014-2015

Käkelä, R. T., 2015, In : Helsingin Sanomat.

Research output: Contribution to journalArticleGeneral public

Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe

Mattila, J., Havula, E., Suominen, E., Teesalu, M., Surakka, I., Hynynen, R., Kilpinen, H., Vaananen, J., Hovatta, I., Kakela, R., Ripatti, S., Sandmann, T. & Hietakangas, V., 13 Oct 2015, In : Cell Reports. 13, 2, p. 350-364 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Sorptive Capacity of Membrane Lipids, Storage Lipids, and Proteins: A Preliminary Study of Partitioning of Organochlorines in Lean Fish from A PCB-Contaminated Freshwater Lake

Mäenpää, K., Leppänen, M. T., Figueiredo, K., Tigistu-Sahle, F. & Käkelä, R., 2015, In : Archives of Environmental Contamination and Toxicology. 68, 1, p. 193-203 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

A2B5+/GFAP+ Cells of Rat Spinal Cord Share a Similar Lipid Profile with Progenitor Cells: A Comparative Lipidomic Study

Itokazu, Y., Tajima, N., Kerosuo, L., Somerharju, P., Sariola, H., Yu, R. K. & Kakela, R., Jul 2016, In : Neurochemical Research. 41, 7, p. 1527-1544 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Energy and lipid metabolism during direct and diapause development in a pierid butterfly

Lehmann, P., Pruisscher, P., Posledovich, D., Carlsson, M., Kakela, R., Tang, P., Nylin, S., Nylin, S., Wheat, C. W., Wiklund, C. & Gotthard, K., 1 Oct 2016, In : Journal of Experimental Biology. 219, 19, p. 3049-3060 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Terrestrial prey fuels the fish population of a small, high-latitude lake

Milardi, M., Käkelä, R., Weckström, J. & Kahilainen, K. K., Oct 2016, In : Aquatic Sciences. 78, 4, p. 695-706 12 p.

Research output: Contribution to journalArticleScientificpeer-review

UNSTABLE LDL - NOVEL MECHANISM OF ATHEROGENESIS AND LINK TO CARDIOVASCULAR DEATHS

Ruuth, M., Nguyen, S. D., Vihervaara, T., Laajala, T. D., Uusitupa, M., Schwab, U., Savolainen, M., Sinisalo, J., Aittokallio, T., Kakela, R., Jauhiainen, M., Kovanen, P. & Oorni, K., Sep 2016, In : Atherosclerosis. 252, p. E208-E208 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications

Robciuc, M. R., Kivela, R., Williams, I. M., de Boer, J. F., van Dijk, T. H., Elamaa, H., Tigistu-Sahle, F., Molotkov, D., Leppanen, V-M., Kakela, R., Eklund, L., Wasserman, D. H., Groen, A. K. & Alitalo, K., 12 Apr 2016, In : Cell Metabolism. 23, 4, p. 712-724 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2017

Depletion of TM6SF2 disturbs membrane lipid composition and dynamics in HuH7 hepatoma cells.

Ruhanen, H., Haridas, P. A. N., Eskelinen, E-L., Eriksson, O., Olkkonen, V. M. & Käkelä, R., May 2017, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1862, 7, p. 676-685 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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