Photo of Reijo Käkelä

Reijo Käkelä

  • P.O. Box 65 (Viikinkaari 1)

    00014 University of Helsinki

    Finland

  • PL 65 (Viikinkaari 1)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

19962020

Research output per year

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Publications

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2020

ANGPTL3 deficiency alters the lipid profile and metabolism of cultured hepatocytes and human lipoproteins

Ruhanen, H., Haridas, P. A. N., Minicocci, I., Taskinen, J. H., Palmas, F., di Costanzo, A., D'Erasmo, L., Metso, J., Partanen, J., Dalli, J., Zhou, Y., Arca, M., Jauhiainen, M., Käkelä, R. & Olkkonen, V. M., Jul 2020, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1865, 7, 11 p., 158679.

Research output: Contribution to journalArticleScientificpeer-review

Changes in thiamine concentrations, fatty acid composition, and some other lipid-related biochemical indices in Baltic Sea Atlantic salmon (Salmo salar) during the spawning run and pre-spawning fasting

Vuorinen, P. J., Rokka, M., Ritvanen, T., Käkelä, R., Nikonen, S., Pakarinen, T. & Keinänen, M., 28 Aug 2020, In : Helgoland Marine Research. 74, 10, 24 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Orotic acid-treated hepatocellular carcinoma cells resist steatosis by modification of fatty acid metabolism

Matilainen, J., Mustonen, A-M., Rilla, K., Kakela, R., Sihvo, S. P. & Nieminen, P., 13 Apr 2020, In : Lipids in Health and Disease. 19, 1, 15 p., 70.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The Diapause Lipidomes of Three Closely Related Beetle Species Reveal Mechanisms for Tolerating Energetic and Cold Stress in High-Latitude Seasonal Environments

Lehmann, P., Westberg, M., Tang, P., Lindstrom, L. & Kakela, R., 25 Sep 2020, In : Frontiers in Physiology. 11, 17 p., 576617.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2019

Anterior cruciate ligament transection alters the n-3/n-6 fatty acid balance in the lapine infrapatellar fat pad

Mustonen, A-M., Käkelä, R., Finnilä, M. A. J., Sawatsky, A., Korhonen, R. K., Saarakkala, S., Herzog, W., Paakkonen, T. & Nieminen, P., 18 Mar 2019, In : Lipids in Health and Disease. 18, 67, 9 p., 67.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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A transposable element insertion is associated with an alternative life history strategy

Woronik, A., Tunstrom, K., Perry, M. W., Neethiraj, R., Stefanescu, C., Celorio-Mancera, M. D. L. P., Brattstrom, O., Hill, J., Lehmann, P., Käkelä, R. & Wheat, C. W., 17 Dec 2019, In : Nature Communications. 10, 11 p., 5757.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Complementary methods assessing short and long-term prey of a marine top predator - Application to the grey seal-fishery conflict in the Baltic Sea

Tverin, M., Esparza-Salas, R., Strömberg, A., Tang, P., Kokkonen, I., Herrero, A., Kauhala, K., Karlsson, O., Tiilikainen, R., Vetemaa, M., Sinisalo, T., Käkelä, R. & Lundström, K., 2 Jan 2019, In : PLoS One. 14, 1, 26 p., 0208694.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Dedifferentiation of Primary Hepatocytes is Accompanied with Reorganization of Lipid Metabolism Indicated by Altered Molecular Lipid and miRNA Profiles

Kiamehr, M., Heiskanen, L., Laufer, T., Duesterloh, A., Kahraman, M., Kakela, R., Laaksonen, R. & Aalto-Setala, K., 2 Jun 2019, In : International Journal of Molecular Sciences. 20, 12, 20 p., 2910.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Distinct fatty acid signatures in infrapatellar fat pad and synovial fluid of patients with osteoarthritis versus rheumatoid arthritis

Mustonen, A-M., Käkelä, R., Lehenkari, P., Huhtakangas, J., Turunen, S., Joukainen, A., Kaariainen, T., Paakkonen, T., Kroger, H. & Nieminen, P., 22 May 2019, In : Arthritis research & therapy. 21, 11 p., 124.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Factors affecting the degree of vertical stratification of fatty acids in grey seal blubber

Tverin, M., Westberg, M., Kokkonen, I., Tang, P., Lehmann, P., Lundström, K. & Kakelä, R., Aug 2019, In : Marine Biology. 166, 8, 22 p., 105.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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hiPSC-derived hepatocytes closely mimic the lipid profile of primary hepatocytes: A future personalised cell model for studying the lipid metabolism of the liver

Kiamehr, M., Alexanova, A., Viiri, L., Heiskanen, L., Vihervaara, T., Kauhanen, D., Ekroos, K., Laaksonen, R., Käkelä, R. & Aalto-Setälä, K., 2019, In : Journal of Cellular Physiology. 234, 4

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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LDL aggregation susceptibility is higher in healthy South Asian compared with white Caucasian men

Ruuth, M., Janssen, L. G. M., Aikas, L., Tigistu-Sahle, F., Nahon, K. J., Ritvos, O., Ruhanen, H., Käkelä, R., Boon, M. R., Öörni, K. & Rensen, P. C. N., Dec 2019, In : Journal of Clinical Lipidology. 13, 6, p. 910-919 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Lipid mediators in platelet concentrate and extracellular vesicles: Molecular mechanisms from membrane glycerophospholipids to bioactive molecules

Valkonen, S., Holopainen, M., Colas, R. A., Impola, U., Dalli, J., Käkelä, R., Siljander, P. R-M. & Laitinen, S., Aug 2019, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1864, 8, p. 1168-1182 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking

Schmidtke, C., Tiede, S., Thelen, M., Käkelä, R., Jabs, S., Makrypidi, G., Sylvester, M., Schweizer, M., Braren, I., Brocke-Ahmadinejad, N., Cotman, S. L., Schulz, A., Gieselmann, V. & Braulke, T., 14 Jun 2019, In : Journal of Biological Chemistry. 294, 24, p. 9592-9604 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Polyunsaturated fatty acids modify the extracellular vesicle membranes and increase the production of proresolving lipid mediators of human mesenchymal stromal cells

Holopainen, M., Colas, R. A., Valkonen, S., Tigistu-Sahle, F., Hyvärinen, K., Mazzacuva, F., Lehenkari, P., Käkelä, R., Dalli, J., Kerkelä, E. & Laitinen, S., Oct 2019, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1864, 10, p. 1350-1362 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Seasonal changes in European whitefish muscle and invertebrate prey fatty acid composition in a subarctic lake

Keva, O., Tang, P., Käkelä, R., Hayden, B., Taipale, S. J., Harrod, C. & Kahilainen, K. K., Nov 2019, In : Freshwater Biology. 64, 11, p. 1908-1920 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization

Le Joncour, V., Filppu, P., Hyvönen, M., Holopainen, M., Turunen, S. P., Sihto, H., Burghardt, I., Joensuu, H., Tynninen, O., Jääskeläinen, J., Weller, M., Lehti, K., Käkelä, R. & Laakkonen, P., Jun 2019, In : EMBO molecular medicine. 11, 6, 21 p., 9034.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

A retrospective study of fatty acid composition in Baltic herring (Clupea harengus membras) caught at three locations in the Baltic Sea (1973-2009)

Lind, Y., Huovila, T. & Käkelä, R., 2018, In : ICES Journal of Marine Science. 75, 1, p. 330-339 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Extracellular Lipids Accumulate in Human Carotid Arteries as Distinct Three-Dimensional Structures and Have Proinflammatory Properties

Lehti, S., Nguyen, S. D., Belevich, I., Vihinen, H., Heikkilä, H. M., Soliymani, R., Käkelä, R., Saksi, J., Jauhiainen, M., Grabowski, G. A., Kummu, O., Hörkkö, S., Baumann, M., Lindsberg, P. J., Jokitalo, E., Kovanen, P. T. & Öörni, K., Feb 2018, In : The American Journal of Pathology. 188, 2, p. 525-538 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Fatty acid signatures connect thiamine deficiency with the diet of the Atlantic salmon (Salmo salar) feeding in the Baltic Sea

Keinänen, M., Käkelä, R., Ritvanen, T., Pönni, J., Harjunpää, H., Myllylä, T. & Vuorinen, P. J., Oct 2018, In : Marine Biology. 165, 10, 17 p., 161.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Lipid composition of membrane microdomains isolated detergent-free from PUFA supplemented RAW264.7 macrophages

Hellwing, C., Tigistu-Sahle, F., Fuhrmann, H., Käkelä, R. & Schumann, J., Mar 2018, In : Journal of Cellular Physiology. 233, 3, p. 2602-2612 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Mesenchymal Stromal Cells and Their Extracellular Vesicles Enhance the Anti-Inflammatory Phenotype of Regulatory Macrophages by Downregulating the Production of Interleukin (IL)-23 and IL-22

Hyvärinen, K., Holopainen, M., Skirdenko, V., Ruhanen, H., Lehenkari, P., Korhonen, M., Käkelä, R., Laitinen, S. & Kerkelä, E., 12 Apr 2018, In : Frontiers in Immunology. 9, 13 p., 771.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Phospholipid composition of packed red blood cells and that of extracellular vesicles show a high resemblance and stability during storage

Lauren, E., Tigistu-Sahle, F., Valkonen, S., Westberg, M., Valkeajarvi, A., Eronen, J., Siljander, P. R-M., Pettila, V., Kakela, R., Laitinen, S. & Kerkela, E., Jan 2018, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1863, 1, p. 1-8 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Phospholipolysis Caused by Different Types of Bacterial Phospholipases During Cold Storage of Bovine Raw Milk Is Prevented by N2 Gas Flushing

Munsch-Alatossava, P., Käkelä, R., Ibarra, D., Youbi-Idrissi, M. & Alatossava, T., 19 Jun 2018, In : Frontiers in Microbiology. 9, 16 p., 1307.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Physiological differences between female limited, alternative life history strategies: the Alba phenotype in the butterfly Colias croceus

Woronik, A., Stefanescu, C., Käkelä, R., Wheat, C. W. & Lehmann, P., 2018, In : Journal of Insect Physiology. 107, p. 257-264 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Preservation of fatty acid signatures in three vertebrate species after six months of storage at various temperatures

Nieminen, P., Käkelä, R., Mäkinen, T., Laine, O., Takalo, T. & Mustonen, A-M., 17 Sep 2018, In : PLoS One. 13, 9, 11 p., 0204207.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths

Ruuth, M., Nguyen, S. D., Vihervaara, T. M., Hilvo, M., Laajala, T. D., Kondadi, P. K., Gistera, A., Lähteenmäki, H., Kittilä, T., Huusko, J., Uusitupa, M., Schwab, U., Savolainen, M. J., Sinisalo, J., Lokki, M-L., Nieminen, M. S., Jula, A., Perola, M., Ylä-Herttula, S., Rudel, L. & 12 others, Öörni, A., Baumann, M., Baruch, A., Laaksonen, R., Ketelhuth, D. F. J., Aittokallio, T., Jauhiainen, M., Käkelä, R., Boren, J., Williams, K. J., Kovanen, P. T. & Öörni, K., 14 Jul 2018, In : European Heart Journal. 39, 27, p. 2562-2573 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Depletion of TM6SF2 disturbs membrane lipid composition and dynamics in HuH7 hepatoma cells.

Ruhanen, H., Haridas, P. A. N., Eskelinen, E-L., Eriksson, O., Olkkonen, V. M. & Käkelä, R., May 2017, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1862, 7, p. 676-685 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Fatty acid composition in the white muscle of Cottoidei fishes of Lake Baikal reflects their habitat depth

Radnaeva, L. D., Popov, D. V., Grahl-Nielsen, O., Khanaev, I. V., Bazarsadueva, S. V. & Kakela, R., Dec 2017, In : Environmental Biology of Fishes. 100, 12, p. 1623-1641 19 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Fatty acid composition of sprat (Sprattus sprattus) and herring (Clupea harengus) in the Baltic Sea as potential prey for salmon (Salmo salar)

Keinanen, M., Kakela, R., Ritvanen, T., Myllyla, T., Ponni, J. & Vuorinen, P. J., 20 Mar 2017, In : Helgoland Marine Research. 71, p. 1-16 16 p., 4.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Lipidomic profiling of patient-specific iPSC-derived hepatocyte-like cells

Kiamehr, M., Viiri, L. E., Vihervaara, T., Koistinen, K. M., Hilvo, M., Ekroos, K., Kakela, R. & Aalto-Setala, K., 1 Sep 2017, In : Disease Models & Mechanisms. 10, 9, p. 1141-1153 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Metabolism and phospholipid assembly of polyunsaturated fatty acids in human bone marrow mesenchymal stromal cells

Tigistu-Sahle, F., Lampinen, M., Kilpinen, L., Holopainen, M., Lehenkari, P., Laitinen, S. & Käkelä, R., Jan 2017, In : Journal of Lipid Research. 58, 1, p. 92-110 19 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

A2B5+/GFAP+ Cells of Rat Spinal Cord Share a Similar Lipid Profile with Progenitor Cells: A Comparative Lipidomic Study

Itokazu, Y., Tajima, N., Kerosuo, L., Somerharju, P., Sariola, H., Yu, R. K. & Kakela, R., Jul 2016, In : Neurochemical Research. 41, 7, p. 1527-1544 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Energy and lipid metabolism during direct and diapause development in a pierid butterfly

Lehmann, P., Pruisscher, P., Posledovich, D., Carlsson, M., Kakela, R., Tang, P., Nylin, S., Nylin, S., Wheat, C. W., Wiklund, C. & Gotthard, K., 1 Oct 2016, In : Journal of Experimental Biology. 219, 19, p. 3049-3060 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Terrestrial prey fuels the fish population of a small, high-latitude lake

Milardi, M., Käkelä, R., Weckström, J. & Kahilainen, K. K., Oct 2016, In : Aquatic Sciences. 78, 4, p. 695-706 12 p.

Research output: Contribution to journalArticleScientificpeer-review

VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications

Robciuc, M. R., Kivela, R., Williams, I. M., de Boer, J. F., van Dijk, T. H., Elamaa, H., Tigistu-Sahle, F., Molotkov, D., Leppanen, V-M., Kakela, R., Eklund, L., Wasserman, D. H., Groen, A. K. & Alitalo, K., 12 Apr 2016, In : Cell Metabolism. 23, 4, p. 712-724 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2015

Expert answers to children's science questions, Helsingin Sanomat, 2014-2015

Käkelä, R. T., 2015, In : Helsingin Sanomat.

Research output: Contribution to journalArticleGeneral public

Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe

Mattila, J., Havula, E., Suominen, E., Teesalu, M., Surakka, I., Hynynen, R., Kilpinen, H., Vaananen, J., Hovatta, I., Kakela, R., Ripatti, S., Sandmann, T. & Hietakangas, V., 13 Oct 2015, In : Cell Reports. 13, 2, p. 350-364 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Sorptive Capacity of Membrane Lipids, Storage Lipids, and Proteins: A Preliminary Study of Partitioning of Organochlorines in Lean Fish from A PCB-Contaminated Freshwater Lake

Mäenpää, K., Leppänen, M. T., Figueiredo, K., Tigistu-Sahle, F. & Käkelä, R., 2015, In : Archives of Environmental Contamination and Toxicology. 68, 1, p. 193-203 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Spatial Distributions of Lipids in Atherosclerosis of Human Coronary Arteries Studied by Time-of-Flight Secondary Ion Mass Spectrometry

Lehti, S., Sjovall, P., Kakela, R., Mayranpaa, M. I., Kovanen, P. T. & Öörni, K., May 2015, In : The American Journal of Pathology. 185, 5, p. 1216-1233 18 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Gill tissue lipids of salmon (Salmo salar L.) presmolts and smolts from anadromous and landlocked populations

Itokazu, Y., Käkelä, R., Piironen, J., Guan, X. L., Kiiskinen, P. & Vornanen, M., 2014, In : Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology. 172, p. 39-45 7 p.

Research output: Contribution to journalArticleScientificpeer-review

PNPLA3 mediates hepatocyte triacylglycerol remodeling

Ruhanen, H., Perttila, J., Holtta-Vuori, M., Zhou, Y., Yki-Jarvinen, H., Ikonen, E., Kakela, R. & Olkkonen, V. M., Apr 2014, In : Journal of Lipid Research. 55, 4, p. 739-746 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2013

Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality

Kilpinen, L., Tigistu-Sahle, F., Oja, S., Greco, D., Parmar, A., Saavalainen, P. M., Nikkilä, J. T., Korhonen, M., Lehenkari, P., Käkelä, R. & Laitinen, S., Mar 2013, In : Journal of Lipid Research. 54, 3, p. 622-635 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Fatty acid modifications during autumnal cold-hardening in an obligatory ectoparasite, the deer ked (Lipoptena cervi)

Nieminen, P., Käkelä, R., Paakkonen, T., Halonen, T. & Mustonen, A-M., Jun 2013, In : Journal of Insect Physiology. 59, 6, p. 631-637 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Modification of the lipidome in RAW264.7 macrophage subjected to stable silencing of oxysterol-binding proteins

Vihervaara, T., Käkelä, R., Liebisch, G., Tarasov, K., Schmitz, G. & Olkkonen, V. M., Mar 2013, In : Biochimie. 95, 3, p. 538-547 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Modified Lipoprotein-Derived Lipid Particles Accumulate in Human Stenotic Aortic Valves

Lehti, S., Käkelä, R., Horkko, S., Kummu, O., Helske-Suihko, S., Kupari, M., Werkkala, K., Kovanen, P. T. & Öörni, K., 7 Jun 2013, In : PLoS One. 8, 6, p. Article Number: e65810 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2012

Fatty acid mobilization in voles-Model species for rapid fasting response and fatty liver

Mustonen, A-M., Käkelä, R., Halonen, T., Kärjä, V., Vartiainen, E. & Nieminen, P., Sep 2012, In : Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology. 163, 1, p. 152-160 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice

Kollmann, K., Damme, M., Markmann, S., Morelle, W., Schweizer, M., Hermans-Borgmeyer, I., Röchert, A. K., Pohl, S., Luebke, T., Michalski, J-C., Käkelä, R., Walkley, S. U. & Braulke, T., Sep 2012, In : Brain : a journal of neurology. 135, 9, p. 2661-2675 15 p.

Research output: Contribution to journalArticleScientificpeer-review