Photo of Reijo Käkelä
  • Finland

  • P.O. Box 65 (Viikinkaari 1)

    00014 University of Helsinki

    Finland

  • PL 65 (Viikinkaari 1)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

19962019
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Publications 1996 2019

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2019

Anterior cruciate ligament transection alters the n-3/n-6 fatty acid balance in the lapine infrapatellar fat pad

Mustonen, A-M., Käkelä, R., Finnilä, M. A. J., Sawatsky, A., Korhonen, R. K., Saarakkala, S., Herzog, W., Paakkonen, T. & Nieminen, P., 18 Mar 2019, In : Lipids in Health and Disease. 18, 67, 9 p., 67.

Research output: Contribution to journalArticleScientificpeer-review

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Complementary methods assessing short and long-term prey of a marine top predator - Application to the grey seal-fishery conflict in the Baltic Sea

Tverin, M., Esparza-Salas, R., Strömberg, A., Tang, P., Kokkonen, I., Herrero, A., Kauhala, K., Karlsson, O., Tiilikainen, R., Vetemaa, M., Sinisalo, T., Käkelä, R. & Lundström, K., 2 Jan 2019, In : PLoS One. 14, 1, 26 p., 0208694.

Research output: Contribution to journalArticleScientificpeer-review

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Dedifferentiation of Primary Hepatocytes is Accompanied with Reorganization of Lipid Metabolism Indicated by Altered Molecular Lipid and miRNA Profiles

Kiamehr, M., Heiskanen, L., Laufer, T., Duesterloh, A., Kahraman, M., Kakela, R., Laaksonen, R. & Aalto-Setala, K., 2 Jun 2019, In : International Journal of Molecular Sciences. 20, 12, 20 p., 2910.

Research output: Contribution to journalArticleScientificpeer-review

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Distinct fatty acid signatures in infrapatellar fat pad and synovial fluid of patients with osteoarthritis versus rheumatoid arthritis

Mustonen, A-M., Käkelä, R., Lehenkari, P., Huhtakangas, J., Turunen, S., Joukainen, A., Kaariainen, T., Paakkonen, T., Kroger, H. & Nieminen, P., 22 May 2019, In : Arthritis research & therapy. 21, 11 p., 124.

Research output: Contribution to journalArticleScientificpeer-review

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Factors affecting the degree of vertical stratification of fatty acids in grey seal blubber

Tverin, M., Westberg, M., Kokkonen, I., Tang, P., Lehmann, P., Lundström, K. & Kakelä, R., Aug 2019, In : Marine Biology. 166, 8, 22 p., 105.

Research output: Contribution to journalArticleScientificpeer-review

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Lipid mediators in platelet concentrate and extracellular vesicles: Molecular mechanisms from membrane glycerophospholipids to bioactive molecules

Valkonen, S., Holopainen, M., Colas, R. A., Impola, U., Dalli, J., Käkelä, R., Siljander, P. R-M. & Laitinen, S., Aug 2019, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1864, 8, p. 1168-1182 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Lysosomal proteome analysis reveals that CLN3-defective cells have multiple enzyme deficiencies associated with changes in intracellular trafficking

Schmidtke, C., Tiede, S., Thelen, M., Käkelä, R., Jabs, S., Makrypidi, G., Sylvester, M., Schweizer, M., Braren, I., Brocke-Ahmadinejad, N., Cotman, S. L., Schulz, A., Gieselmann, V. & Braulke, T., 14 Jun 2019, In : Journal of Biological Chemistry. 294, 24, p. 9592-9604 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization

Le Joncour, V., Filppu, P., Hyvönen, M., Holopainen, M., Turunen, S. P., Sihto, H., Burghardt, I., Joensuu, H., Tynninen, O., Jääskeläinen, J., Weller, M., Lehti, K., Käkelä, R. & Laakkonen, P., Jun 2019, In : EMBO molecular medicine. 11, 6, 21 p., 9034.

Research output: Contribution to journalArticleScientificpeer-review

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2018

A retrospective study of fatty acid composition in Baltic herring (Clupea harengus membras) caught at three locations in the Baltic Sea (1973-2009)

Lind, Y., Huovila, T. & Käkelä, R., 2018, In : ICES Journal of Marine Science. 75, 1, p. 330-339 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Extracellular Lipids Accumulate in Human Carotid Arteries as Distinct Three-Dimensional Structures and Have Proinflammatory Properties

Lehti, S., Nguyen, S. D., Belevich, I., Vihinen, H., Heikkilä, H. M., Soliymani, R., Käkelä, R., Saksi, J., Jauhiainen, M., Grabowski, G. A., Kummu, O., Hörkkö, S., Baumann, M., Lindsberg, P. J., Jokitalo, E., Kovanen, P. T. & Öörni, K., Feb 2018, In : The American Journal of Pathology. 188, 2, p. 525-538 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Fatty acid signatures connect thiamine deficiency with the diet of the Atlantic salmon (Salmo salar) feeding in the Baltic Sea

Keinänen, M., Käkelä, R., Ritvanen, T., Pönni, J., Harjunpää, H., Myllylä, T. & Vuorinen, P. J., Oct 2018, In : Marine Biology. 165, 10, 17 p., 161.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Lipid composition of membrane microdomains isolated detergent-free from PUFA supplemented RAW264.7 macrophages

Hellwing, C., Tigistu-Sahle, F., Fuhrmann, H., Käkelä, R. & Schumann, J., Mar 2018, In : Journal of Cellular Physiology. 233, 3, p. 2602-2612 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Mesenchymal Stromal Cells and Their Extracellular Vesicles Enhance the Anti-Inflammatory Phenotype of Regulatory Macrophages by Downregulating the Production of Interleukin (IL)-23 and IL-22

Hyvärinen, K., Holopainen, M., Skirdenko, V., Ruhanen, H., Lehenkari, P., Korhonen, M., Käkelä, R., Laitinen, S. & Kerkelä, E., 12 Apr 2018, In : Frontiers in Immunology. 9, 13 p., 771.

Research output: Contribution to journalArticleScientificpeer-review

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Phospholipid composition of packed red blood cells and that of extracellular vesicles show a high resemblance and stability during storage

Lauren, E., Tigistu-Sahle, F., Valkonen, S., Westberg, M., Valkeajarvi, A., Eronen, J., Siljander, P., Pettila, V., Kakela, R., Laitinen, S. & Kerkela, E., Jan 2018, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1863, 1, p. 1-8 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Phospholipolysis Caused by Different Types of Bacterial Phospholipases During Cold Storage of Bovine Raw Milk Is Prevented by N2 Gas Flushing

Munsch-Alatossava, P., Käkelä, R., Ibarra, D., Youbi-Idrissi, M. & Alatossava, T., 19 Jun 2018, In : Frontiers in Microbiology. 9, 16 p., 1307.

Research output: Contribution to journalArticleScientificpeer-review

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Physiological differences between female limited, alternative life history strategies: the Alba phenotype in the butterfly Colias croceus

Woronik, A., Stefanescu, C., Käkelä, R., Wheat, C. W. & Lehmann, P., 2018, In : Journal of Insect Physiology. 107

Research output: Contribution to journalArticleScientificpeer-review

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Preservation of fatty acid signatures in three vertebrate species after six months of storage at various temperatures

Nieminen, P., Käkelä, R., Mäkinen, T., Laine, O., Takalo, T. & Mustonen, A-M., 17 Sep 2018, In : PLoS One. 13, 9, 11 p., 0204207.

Research output: Contribution to journalArticleScientificpeer-review

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Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths

Ruuth, M., Nguyen, S. D., Vihervaara, T. M., Hilvo, M., Laajala, T. D., Kondadi, P. K., Gistera, A., Lähteenmäki, H., Kittilä, T., Huusko, J., Uusitupa, M., Schwab, U., Savolainen, M. J., Sinisalo, J., Lokki, M-L., Nieminen, M. S., Jula, A., Perola, M., Ylä-Herttula, S., Rudel, L. & 12 othersÖörni, A., Baumann, M., Baruch, A., Laaksonen, R., Ketelhuth, D. F. J., Aittokallio, T., Jauhiainen, M., Käkelä, R., Boren, J., Williams, K. J., Kovanen, P. T. & Öörni, K., 14 Jul 2018, In : European Heart Journal. 39, 27, p. 2562-2573 13 p.

Research output: Contribution to journalArticleScientificpeer-review

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2017

Depletion of TM6SF2 disturbs membrane lipid composition and dynamics in HuH7 hepatoma cells.

Ruhanen, H., Haridas, P. A. N., Eskelinen, E-L., Eriksson, O., Olkkonen, V. M. & Käkelä, R., May 2017, In : Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids. 1862, 7, p. 676-685 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Fatty acid composition in the white muscle of Cottoidei fishes of Lake Baikal reflects their habitat depth

Radnaeva, L. D., Popov, D. V., Grahl-Nielsen, O., Khanaev, I. V., Bazarsadueva, S. V. & Kakela, R., Dec 2017, In : Environmental Biology of Fishes. 100, 12, p. 1623-1641 19 p.

Research output: Contribution to journalArticleScientificpeer-review

Fatty acid composition of sprat (Sprattus sprattus) and herring (Clupea harengus) in the Baltic Sea as potential prey for salmon (Salmo salar)

Keinanen, M., Kakela, R., Ritvanen, T., Myllyla, T., Ponni, J. & Vuorinen, P. J., 20 Mar 2017, In : Helgoland Marine Research. 71, p. 1-16 16 p., 4.

Research output: Contribution to journalArticleScientificpeer-review

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Lipidomic profiling of patient-specific iPSC-derived hepatocyte-like cells

Kiamehr, M., Viiri, L. E., Vihervaara, T., Koistinen, K. M., Hilvo, M., Ekroos, K., Kakela, R. & Aalto-Setala, K., 1 Sep 2017, In : Disease Models & Mechanisms. 10, 9, p. 1141-1153 13 p.

Research output: Contribution to journalArticleScientificpeer-review

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Metabolism and phospholipid assembly of polyunsaturated fatty acids in human bone marrow mesenchymal stromal cells

Tigistu-Sahle, F., Lampinen, M., Kilpinen, L., Holopainen, M., Lehenkari, P., Laitinen, S. & Käkelä, R., Jan 2017, In : Journal of Lipid Research. 58, 1, p. 92-110 19 p.

Research output: Contribution to journalArticleScientificpeer-review

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2016

A2B5+/GFAP+ Cells of Rat Spinal Cord Share a Similar Lipid Profile with Progenitor Cells: A Comparative Lipidomic Study

Itokazu, Y., Tajima, N., Kerosuo, L., Somerharju, P., Sariola, H., Yu, R. K. & Kakela, R., Jul 2016, In : Neurochemical Research. 41, 7, p. 1527-1544 18 p.

Research output: Contribution to journalArticleScientificpeer-review

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Energy and lipid metabolism during direct and diapause development in a pierid butterfly

Lehmann, P., Pruisscher, P., Posledovich, D., Carlsson, M., Kakela, R., Tang, P., Nylin, S., Nylin, S., Wheat, C. W., Wiklund, C. & Gotthard, K., 1 Oct 2016, In : Journal of Experimental Biology. 219, 19, p. 3049-3060 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Terrestrial prey fuels the fish population of a small, high-latitude lake

Milardi, M., Käkelä, R., Weckström, J. & Kahilainen, K. K., Oct 2016, In : Aquatic Sciences. 78, 4, p. 695-706 12 p.

Research output: Contribution to journalArticleScientificpeer-review

VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications

Robciuc, M. R., Kivela, R., Williams, I. M., de Boer, J. F., van Dijk, T. H., Elamaa, H., Tigistu-Sahle, F., Molotkov, D., Leppanen, V-M., Kakela, R., Eklund, L., Wasserman, D. H., Groen, A. K. & Alitalo, K., 12 Apr 2016, In : Cell Metabolism. 23, 4, p. 712-724 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2015

Expert answers to children's science questions, Helsingin Sanomat, 2014-2015

Käkelä, R. T., 2015, In : Helsingin Sanomat.

Research output: Contribution to journalArticleGeneral public

Mondo-Mlx Mediates Organismal Sugar Sensing through the Gli-Similar Transcription Factor Sugarbabe

Mattila, J., Havula, E., Suominen, E., Teesalu, M., Surakka, I., Hynynen, R., Kilpinen, H., Vaananen, J., Hovatta, I., Kakela, R., Ripatti, S., Sandmann, T. & Hietakangas, V., 13 Oct 2015, In : Cell Reports. 13, 2, p. 350-364 15 p.

Research output: Contribution to journalArticleScientificpeer-review

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Sorptive Capacity of Membrane Lipids, Storage Lipids, and Proteins: A Preliminary Study of Partitioning of Organochlorines in Lean Fish from A PCB-Contaminated Freshwater Lake

Mäenpää, K., Leppänen, M. T., Figueiredo, K., Tigistu-Sahle, F. & Käkelä, R., 2015, In : Archives of Environmental Contamination and Toxicology. 68, 1, p. 193-203 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Gill tissue lipids of salmon (Salmo salar L.) presmolts and smolts from anadromous and landlocked populations

Itokazu, Y., Käkelä, R., Piironen, J., Guan, X. L., Kiiskinen, P. & Vornanen, M., 2014, In : Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology. 172, p. 39-45 7 p.

Research output: Contribution to journalArticleScientificpeer-review

PNPLA3 mediates hepatocyte triacylglycerol remodeling

Ruhanen, H., Perttila, J., Holtta-Vuori, M., Zhou, Y., Yki-Jarvinen, H., Ikonen, E., Kakela, R. & Olkkonen, V. M., Apr 2014, In : Journal of Lipid Research. 55, 4, p. 739-746 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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2013

Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality

Kilpinen, L., Tigistu-Sahle, F., Oja, S., Greco, D., Parmar, A., Saavalainen, P. M., Nikkilä, J. T., Korhonen, M., Lehenkari, P., Käkelä, R. & Laitinen, S., Mar 2013, In : Journal of Lipid Research. 54, 3, p. 622-635 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Fatty acid modifications during autumnal cold-hardening in an obligatory ectoparasite, the deer ked (Lipoptena cervi)

Nieminen, P., Käkelä, R., Paakkonen, T., Halonen, T. & Mustonen, A-M., Jun 2013, In : Journal of Insect Physiology. 59, 6, p. 631-637 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Modification of the lipidome in RAW264.7 macrophage subjected to stable silencing of oxysterol-binding proteins

Vihervaara, T., Käkelä, R., Liebisch, G., Tarasov, K., Schmitz, G. & Olkkonen, V. M., Mar 2013, In : Biochimie. 95, 3, p. 538-547 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Modified Lipoprotein-Derived Lipid Particles Accumulate in Human Stenotic Aortic Valves

Lehti, S., Käkelä, R., Horkko, S., Kummu, O., Helske-Suihko, S., Kupari, M., Werkkala, K., Kovanen, P. T. & Öörni, K., 7 Jun 2013, In : PLoS One. 8, 6, p. Article Number: e65810 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2012

Fatty acid mobilization in voles-Model species for rapid fasting response and fatty liver

Mustonen, A-M., Käkelä, R., Halonen, T., Kärjä, V., Vartiainen, E. & Nieminen, P., Sep 2012, In : Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology. 163, 1, p. 152-160 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Lysosomal dysfunction causes neurodegeneration in mucolipidosis II 'knock-in' mice

Kollmann, K., Damme, M., Markmann, S., Morelle, W., Schweizer, M., Hermans-Borgmeyer, I., Röchert, A. K., Pohl, S., Luebke, T., Michalski, J-C., Käkelä, R., Walkley, S. U. & Braulke, T., Sep 2012, In : Brain : a journal of neurology. 135, 9, p. 2661-2675 15 p.

Research output: Contribution to journalArticleScientificpeer-review

The effects of an abundant ectoparasite, the deer ked (Lipoptena cervi), on the health of moose (Alces alces) in Finland

Paakkonen, T., Mustonen, A-M., Käkelä, R., Laaksonen, S., Solismaa, M., Aho, J., Puukka, K. & Nieminen, P., Sep 2012, In : Parasitology Research. 111, 3, p. 1223-1232 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Activity of BKCa channel is modulated by membrane cholesterol content and association with Na+/K+-ATPase in human melanoma IGR39 cells

Tajima, N., Itokazu, Y., Korpi, E. R., Somerharju, P. & Käkelä, R., 2011, In : Journal of Biological Chemistry. 286, 7, p. 5624-5638 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Experimental infection of the deer ked (Lipoptena cervi) has no negative effects on the physiology of the captive reindeer (Rangifer tarandus tarandus)

Paakkonen, T., Mustonen, A-M., Käkelä, R., Kiljander, T., Kynkäänniemi, S-M., Laaksonen, S., Solismaa, M., Aho, J., Kortet, R., Puukka, K., Saarela, S., Härkönen, L., Kaitala, A., Ylönen, H. & Petteri, N., 2011, In : Veterinary Parasitology. 179, 1-3, p. 180-188 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Fatty acid profiles in different fish species in Lake Baikal

Grahl-Nielsen, O., Averina, E., Pronin, N., Radnaeva, L. & Käkelä, R., 2011, In : Aquatic Biology. 13, 1, p. 1-10 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Lipid body formation during maturation of human mast cells

Dichlberger, A., Schlager, S., Lappalainen, J., Käkelä, R., Hattula, K., Butcher, S. J., Schneider, W. J. & Kovanen, P. T., 2011, In : Journal of Lipid Research. 52, 12, p. 2198-2208 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Vertical fatty acid profiles in blubber of a freshwater ringed seal - Comparison to a marine relative

Strandberg, U., Sipilä, T., Koskela, J., Kunnasranta, M. & Käkelä, R., 2011, In : Journal of Experimental Marine Biology and Ecology. 407, 2, p. 256-265 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Fatty acid signature analysis confirms foraging resources of a globally endangered Mediterranean seabird species: calibration test and application to the wild

Käkelä, R., Käkelä, A., Martinez-Abrain, A., Sarzo, B., Louzao, M., Gerique, C., Villuendas, E., Strandberg, U., Furness, R. W. & Oro, D., 2010, In : Marine Ecology. Progress Series. 398, p. 245-258 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Murine cathepsin D deficiency is associated with dysmyelination/myelin disruption and accumulation of cholesteryl esters in the brain

Mutka, A-L., Haapanen, A., Käkelä, R., Lindfors, M., Wright, A. K., Inkinen, T., Hermansson, M., Rokka, A., Corthals, G., Jauhiainen, M., Gillingwater, T. H., Ikonen, E. & Tyynelä, J., 2010, In : Journal of Neurochemistry. 112, 1, p. 193-203 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Chlamydial and periodontal pathogens induce hepatic inflammation and fatty acid imbalance in apolipoprotein E-deficient mice

Hyvärinen, K., Tuomainen, A., Laitinen, S., Bykov, I. L., Tormakangas, L., Lindros, K., Käkelä, R., Alfthan, G., Salminen, I., Jauhiainen, M., Kovanen, P., Leinonen, M., Saikku, P. & Pussinen, P., 2009, In : Infection and Immunity. 77, 8, p. 3442-3449 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Fatty acid signatures in seabird plasma are a complex function of diet composition: a captive feeding trial with herring gulls

Käkelä, R., Furness, R. W., Kahle, S., Becker, P. H. & Käkelä, A., 2009, In : Functional Ecology. 23, 1, p. 141-149 9 p.

Research output: Contribution to journalArticleScientificpeer-review