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Personal profile

Curriculum vitae

Division of Pharmacology and Pharmacotherapy, Faculty of Pharmacy; Viikinkaari 5e, P.O.Box 27, 00014 University of Helsinki

                      Tel. (358) 400483660                                                         E-mail: reinis.svarcbahs@helsinki.fi

 

EMPLOYMENT

2013-Present Doctoral student in Pharmacology, University of Helsinki

I work as a part of adjunct prof. Timo Myöhänen’s group researching the role of prolyl oligopeptidase (PREP) and alpha synuclein interaction in Parkinson’s disease and role of PRPE inhibitors as possible therapy for treatment of Parkinson’s disease.  

2010–2012 Laboratory Assistant, Pharmacology department at University of Latvia, Latvia

In vivo memory retention and cognition experiments; acute and chronic stress models; Parkinson's and Alzheimer's neurodegeneration models (Passive and Active Avoidance Response; Elevated O maze; Y maze; Open field; Porsolt forced swim test; immobilization tests; apomorphine induced rotations)

 

EDUCATION AND TRAINING

 

2014 (October-December) Visiting researcher, Optogenetics and Transgenic Technology Core (OTTC), the National Institute of Drug Research of the Intramural Research Program (NIDA IRP), Baltimore, USA

I worked as a part of Dr. Brandon Harvey’s lab where I learned to design and construct plasmids and AAV virus vectors for gene editing.

2011–2013 Health Sciences Master’s Degree in Pharmacy (qualification with distinction), University of Latvia, Latvia

2013 (January-June) ERASMUS exchange concerning Master’s Thesis, University of Helsinki

I visited Department of Pharmacology and worked with in vivo 6-OHDA Parkinson's model in rats, epilepsy model of status epilepticus in rats.

2012 (September) the ABC of Animal Experiments category C competence course for researchers, University of Latvia, Latvia

2011–2012 Pharmaceutical Bioinformatics, Uppsala University, Sweden

2009–2010 Volunteer at Latvian Biomedical Research and Study Centre, Latvia

2008–2011 Health Sciences Bachelor’s Degree in Pharmacy (qualification with distinction), University of Latvia, Latvia

 

 

PROJECTS

The effects of Prolyl Oligopeptidase (POP) and its inhibition on alpha-synuclein aggregation and Parkinson's disease. Myöhänen, T., Savolainen, M. & Svarcbahs, R. 01/09/2013 → 31/08/2018

Prolyylioligopeptidaasin (POP) tehtävät ja estäminen alfa-synukleiinin kertymisessä ja Parkinsonin taudinmalleissa. Myöhänen, T., Savolainen, M. & Svarcbahs, R. 01/01/2014 → 31/08/2016

Latvian Council of Science Project Nr. Z-6214. Multi Heterocyclic chemistry development to acquire novel biologically active compounds, 2010-2012.

 

PUBLICATIONS                                                                                                             

Svarcbahs R, Julku UH, Myöhänen TT (2016) Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the α-Synuclein Virus Vector–Based Parkinson's Disease Mouse Model by Decreasing α-Synuclein Oligomeric Species in Mouse Brain. The Journal of Neuroscience 36:12485-12497.

Antidepressant use in Latvia: national trends, regional differences and pharmacists observations. Medicina (Kaunas) 2011; 47 Suppl 2: 97-104.

 

CONFERENCES

 

Prolyl Oligopeptidase (PREP), a novel modulator of PI3K class III regulated autophagy pathway.  Program No. 310.04. 2016 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2016.

Autophagy in Stress, Development & Disease, From the Basics in the Signalling and Molecular Aspect of Autophagy to the Identification of Therapeutic Targets. Prolyl Oligopeptidase (PREP), a novel modulator of PI3K class III regulated autophagy pathway. Gordon Research Conference. 20-25, 2016, Ventura, CA.      

Intracranial chronic administration of prolyl oligopeptidase inhibitor, KYP-2047, counters the behavioural effects and alpha-synuclein overexpression after nigral AAV-alpha-synuclein injection. Program No. 132.09. 2015 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience, 2015. Online.

Prolyl oligopeptidase (PREP) is a novel negative regulator of autophagy and small-molecule PREP inhibitor enhances beclin1-mediated autophagy. 4th Annual Conference Nordic Autophagy Network, pp.48, June 5-7, 2015, Helsinki, Finland.

Prolyl oligopeptidase inhibitor increases the formation of autophagosomes. Keystone Symposia, Autophagy: Fundamentals to Disease, May 23-28, 2014, Austin, Texas, USA.

Comparative effects of different compounds on stress–induced behavioural responses. 17th Multidisciplinary International Conference on Neuroscience and Biological Psychiatry “Stress and Behaviour”, pp.27, May 16-19, 2012, St-Petersburg, Russia.

Influence of propargyl- or adamanthyl-group containing 1,4-dihydropyridine derivatives on behaviour in old animals. International Conference in Pharmacology. April 20-21, 2012, Riga, Latvia. Abstract OP8.

Influence of mildronate, an aza-butyrobetaine analogue, on the expression of trained-rat hippocampal proteins. 7th International Symposium on Neuroprotection and Neurorepair May 2-5, 2012 Potsdam. Abstract-XCD, PIII-33.

Mildronate, a small molecule, enhances memory and adult hippocampal neurogenesis in rats. Australian Neuroscience Society 31st Annual Meeting, 31 Jan – 3 Feb, 2011, Auckland, New Zealand. Poster POS-WED-108.

Education/Academic qualification

Pharmacy, Health Sciences Master’s Degree in Pharmacy (qualification with distinction)

Sep 2011Jun 2013

Laboratory Assistant, University of Latvia

20102012

Pharmacy, Health Sciences Bachelor’s Degree in Pharmacy (qualification with distinction), University of Latvia

Sep 2008Jun 2011

Keywords

  • 317 Pharmacy

International and National Collaboration Publications and projects within past five years.

Publications 2017 2019

New tricks of prolyl oligopeptidase inhibitors - A common drug therapy for several neurodegenerative diseases

Svarcbahs, R., Julku, U., Kilpelainen, T., Kyyrö, M., Jäntti, M. & Myohänen, T. T., Mar 2019, In : Biochemical Pharmacology. 161, p. 113-120 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Prolyl Oligopeptidase Regulates Dopamine Transporter Phosphorylation in the Nigrostriatal Pathway of Mouse

Julku, U. H., Panhelainen, A. E., Tiilikainen, S. E., Svarcbahs, R., Tammimäki, A. E., Piepponen, T. P., Savolainen, M. H. & Myöhänen, T. T., Jan 2018, In : Molecular Neurobiology. 55, 1, p. 470-482 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo

Svarcbahs, R., Julku, U. H., Norrbacka, S. & Myöhänen, T. T., 2018, In : Scientific Reports. 8, 1, 18 p., 1552.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Prolyylioligopeptidaasin estäjällä Parkinsonin tautia vastaan?

Svarcbahs, R., Julku, U. & Myöhänen, T. T., Jan 2017, In : Duodecim. 133, 1, p. 89 1 p.

Research output: Contribution to journalArticleProfessional

Projects 2013 2018

Activities 2013 2016

Society for Neuroscience 2016

Reinis Svarcbahs (Attendee)
11 Nov 201616 Nov 2016

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Autophagy in Stress, Development & Disease 2016 Gordon Research Conference

Reinis Svarcbahs (Attendee)
20 Mar 201625 Mar 2016

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Society for Neuroscience 2015

Reinis Svarcbahs (Attendee)
17 Oct 201521 Oct 2015

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

4th Annual Conference Nordic Autophagy Network, 2015

Reinis Svarcbahs (Attendee)
5 Jun 20157 Jun 2015

Activity: Participating in or organising an event typesPublic Talks

ULLA Summer school 2015

Reinis Svarcbahs (Attendee)
4 Jul 201511 Jul 2015

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars