Photo of Riikka Kivelä
  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

  • Finland

20032020

Research output per year

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Publications

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Altered REDD1, myostatin, and Akt/mTOR/FoxO/MAPK signaling in streptozotocin-induced diabetic muscle atrophy

Hulmi, J. J., Silvennoinen, M., Lehti, M., Kivelä, M. R. & Kainulainen, H., 2012, In : American Journal of Physiology: Endocrinology and Metabolism. 302, 3, p. E307-E315 9 p.

Research output: Contribution to journalArticleScientificpeer-review

A single bout of exercise with high mechanical loading induces the expression of Cyr61/CCN1 and CTGF/CCN2 in human skeletal muscle

Kivelä, M. R., Kyröläinen, H., Selänne, H., Komi, P. V., Kainulainen, H. & Vihko, V., 2007, In : Journal of Applied Physiology. 103, p. 1395-1401 7 p.

Research output: Contribution to journalArticleScientificpeer-review

CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3-Mediated Vascular Endothelial Growth Factor-C Activation

Jeltsch, M., Jha, S. K., Tvorogov, D., Anisimov, A., Leppanen, V-M., Holopainen, T., Kivela, R., Ortega, S., Karpanen, T. & Alitalo, K., 13 May 2014, In : Circulation . 129, 19, p. 1962-1971 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of acute exercise, exercise training, and diabetes on the expression of lymphangiogenic growth factors and lymphatic vessels in skeletal muscle

Kivela, R., Silvennoinen, M., Lehti, M., Kainulainen, H. & Vihko, V., 2007, In : American Journal of Physiology: Heart and Circulatory Physiology. 293, p. H2573-H2579 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of exhaustive stretch-shortening cycle exercise on muscle blood flow during exercise

Laaksonen, M. S., Kivela, R., Kyrolainen, H., Sipila, S., Selanne, H., Lautamaki, R., Nuutila, P., Knuuti, J., Kalliokoski, K. K. & Komi, P. V., 2006, In : Acta Physiologica. 186, p. 261-270 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of experimental type 1 diabetes and exercise training on angiogenic gene expression and capillarization in skeletal muscle

Kivela, R., Silvennoinen, M., Touvra, A-M., Lehti, T. M., Kainulainen, H. & Vihko, V., 2006, In : FASEB Journal. 20, p. 1570-+ 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of fatiguing jumping exercise on mRNA expression of titin-complex proteins and calpains

Lehti, M., Kivela, R., Komi, P., Komulainen, J., Kainulainen, H. & Kyrolainen, H., 2009, In : Journal of Applied Physiology. 106, p. 1419-1424 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of high-fat diet and physical activity on pyruvate dehydrogenase kinase-4 in mouse skeletal muscle

Rinnankoski-Tuikka, R., silvennoinen, M., Torvinen, S., Hulmi, J. J., Lehti, M., Kivelä, R., Reunanen, H. & Kainulainen, H., 2012, In : Nutrition & Metabolism. 9, 53.

Research output: Contribution to journalArticleScientificpeer-review

Effects of streptozotocin-induced diabetes and physical training on gene expression of extracellular matrix proteins in mouse skeletal muscle

Lehti, T. M., Silvennoinen, M., Kivela, R., Kainulainen, H. & Komulainen, J., 2006, In : American Journal of Physiology: Endocrinology and Metabolism. 290, p. E900-E907 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of streptozotocin-induced diabetes and physical training on gene expression of titin-based stretch-sensing complexes in mouse striated muscle

Lehti, T. M., Silvennoinen, M., Kivela, R., Kainulainen, H. & Komulainen, J., 2007, In : American Journal of Physiology: Endocrinology and Metabolism. 292, p. E533-E542 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling

Holopainen, T., Rasanen, M., Anisimov, A., Tuomainen, T., Zheng, W., Tvorogov, D., Hulmi, J. J., Andersson, L. C., Cenni, B., Tavi, P., Mervaala, E., Kivela, R. & Alitalo, K., 20 Oct 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. 13063-13068 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Endothelial Cells Regulate Physiological Cardiomyocyte Growth via VEGFR2-Mediated Paracrine Signaling

Kivelä, R., Hemanthakumar, K. A., Vaparanta, K., Robciuc, M., Izumiya, Y., Kidoya, H., Takakura, N., Peng, X., Sawyer, D. B., Elenius, K., Walsh, K. & Alitalo, K., 28 May 2019, In : Circulation . 139, 22, p. 2570-2584 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Exercise-induced expression of angiogenic growth factors in skeletal muscle and in capillaries of healthy and diabetic mice

Kivela, R., Silvennoinen, M., Lehti, M., Jalava, S., Vihko, V. & Kainulainen, H., 2008, In : Cardiovascular Diabetology. 7, p. - 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Exercise training improves adipose tissue metabolism and vasculature regardless of baseline glucose tolerance and sex

Honkala, S. M., Motiani, P., Kivelä, R., Hemanthakumar, K. A., Tolvanen, E., Motiani, K. K., Eskelinen, J-J., Virtanen, K. A., Kemppainen, J., Heiskanen, M. A., Loyttyniemi, E., Nuutila, P., Kalliokoski, K. K. & Hannukainen, J. C., Jan 2020, In : BMJ Open Diabetes Research and Care. 8, 1, 14 p., 000830.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Flow-Induced Transcriptomic Remodeling of Endothelial Cells Derived From Human Induced Pluripotent Stem Cells

Korvenranta, E., Ampuja, M., Antola, L. M. & Kivelä, R., 15 Oct 2020, In : Frontiers in Physiology.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk

Kivela, R., Silvennoinen, M., Lehti, M., Rinnankoski-Tuikka, R., Purhonen, T., Ketola, T., Pullinen, K., Vuento, M., Mutanen, N., Sartor, M. A., Reunanen, H., Koch, L. G., Britton, S. L. & Kainulainen, H., 2010, In : FASEB Journal. 24, 11, p. 4565-4574 10 p.

Research output: Contribution to journalArticleScientificpeer-review

High-fat feeding induces angiogenesis in skeletal muscle and activates angiogenic pathways in capillaries

Silvennoinen, M., Rinnankoski-Tuikka, R., Vuento, M., Hulmi, J. J., Torvinen, S., Lehti, M., Kivela, R. & Kainulainen, H., Apr 2013, In : Angiogenesis. 16, 2, p. 297-307 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Interrelationships between muscle structure, muscle strength, and running economy

Kyrolainen, H., Kivela, R., Koskinen, S., McBride, J., Andersen, J. L., Takala, T., Sipila, S. & Komi, P. V., 2003, In : Medicine and Science in Sports and Exercise. 35, p. 45-49 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice

Dijkstra, M. H., Pirinen, E., Huusko, J., Kivelä, R., Schenkwein, D., Alitalo, K. & Yla-Herttuala, S., 29 Aug 2014, In : Scientific Reports. 4, 7 p., 6238.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Liikunnan hyödyt ilman liikuntaa?

Hulmi, J. & Kivelä, R., 2015, In : Liikunta & Tiede. 52, 1, p. 22-27 6 p.

Research output: Contribution to journalArticleProfessional

Open Access

Liikunta vähentää diabeteksen haittoja verisuonissa

Kivelä, R., 2008, In : Liikunta & Tiede. 2-3, p. 16-17 2 p.

Research output: Contribution to journalArticleProfessional

Lipid droplet-associated proteins in high-fat fed mice with the effects of voluntary running and diet change

Rinnankoski-Tuikka, R., Hulmi, J. J., Torvinen, S., Silvennoinen, M., Lehti, M., Kivela, R., Reunanen, H., Kujala, U. M. & Kainulainen, H., Aug 2014, In : Metabolism, clinical and experimental. 63, 8, p. 1031-1040 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Localisation of lymphatic vessels and vascular endothelial growth factors-C and -D in human and mouse skeletal muscle with immunohistochemistry

Kivela, R., Havas, E. & Vihko, V., 2007, In : Histochemistry and Cell Biology. 127, p. 31-40 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Molecular adaptations of voltage-gated sodium ion channel related proteins after fatiguing stretch-shortening cycle exercise

Piitulainen, H., Kivela, R., Komi, P., Kainulainen, H. & Kyrolainen, H., 2008, In : Scandinavian Journal of Medicine & Science in Sports. 18, p. 636-642 7 p.

Research output: Contribution to journalArticleScientificpeer-review

mTORC1 Regulates Mitochondrial Integrated Stress Response and Mitochondrial Myopathy Progression

Khan, N., Nikkanen, J., Yatsuga, S., Jackson, C., Wang, L., Pradhan, S., Kivelä, R., Pessia, A., Velagapudi, V. & Suomalainen, A., 1 Aug 2017, In : Cell Metabolism. 26, 2, p. 419–428 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy

Kärpänen, T., Bry, M., Ollila, H., Seppänen-Laakso, T., Liimatta, E., Leskinen, H., Kivelä, R., Helkamaa, T., Merentie, M., Jeltsch, M., Paavonen, K., Andersson, L. C., Mervaala, E., Hassinen, I., Ylä-Herttuala, S., Oresic, M. & Alitalo, K., 2008, In : Circulation Research. 103, 9, p. 1018-1026 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Prevention of chemotherapy-induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle

Hulmi, J. J., Nissinen, T. A., Räsänen, M., Degerman, J., Lautaoja, J. H., Hemanthakumar, K. A., Backman, J. T., Ritvos, O., Silvennoinen, M. & Kivelä, R., Apr 2018, In : Journal of cachexia, sarcopenia and muscle. 9, 2, p. 417-432 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Rasvojen ja liikunnan vaikutukset lihaksen aineenvaihduntaan ja tyypin 2 diabeteksen syntyyn

Kainulainen, H., Kivelä, R., Lehti, M., Rahkila, P., Reunanen, H., Rinnankoski, R. & Silvennoinen, M., 2007, In : Solubiologi. 25, 1, p. 46-53 8 p.

Research output: Contribution to journalArticleProfessional

Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes

Nissinen, T. A., Degerman, J., Räsänen, M., Poikonen, A. R., Koskinen, S., Mervaala, E., Pasternack, A., Ritvos, O., Kivela, R. & Hulmi, J. J., 26 Sep 2016, In : Scientific Reports. 6, 16 p., 32695.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The sinus venosus contributes to coronary vasculature through VEGFC-stimulated angiogenesis

Chen, H. I., Sharma, B., Akerberg, B. N., Numi, H. J., Kivela, R., Saharinen, P., Aghajanian, H., Mckay, A. S., Bogard, P. E., Chang, A. H., Jacobs, A. H., Epstein, J. A., Stankunas, K., Alitalo, K. & Red-Horse, K., Dec 2014, In : Development. 141, 23, p. 4500-4512 13 p.

Research output: Contribution to journalArticleScientificpeer-review

The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation

Kivela, R., Salmela, I., Nguyen, Y. H., Petrova, T. V., Koistinen, H. A., Wiener, Z. & Alitalo, K., 12 Oct 2016, In : Nature Communications. 7, 11 p., 13124.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Treating cachexia using soluble ACVR2B improves survival, alters mTOR localization, and attenuates liver and spleen responses

Nissinen, T. A., Hentilä, J., Penna, F., Lampinen, A., Lautaoja, J. H., Fachada, V., Holopainen, T., Ritvos, O., Kivelä, R. & Hulmi, J. J., Jun 2018, In : Journal of cachexia, sarcopenia and muscle. 9, 3, p. 514-529 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation

Bry, M., Kivelä, R., Holopainen, T., Anisimov, A., Tammela, T., Soronen, J., Silvola, J., Saraste, A., Jeltsch, M., Korpisalo, P., Carmeliet, P., Lemström, K. B., Shibuya, M., Yla-Herttuala, S., Alhonen, L., Mervaala, E., Andersson, L. C., Knuuti, J. & Alitalo, K., 2010, In : Circulation . 122, 17, p. 1725-1733 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Vascular Endothelial Growth Factor-B Induces a Distinct Electrophysiological Phenotype in Mouse Heart

Naumenko, N., Huusko, J., Tuomainen, T., Koivumaki, J. T., Merentie, M., Gurzeler, E., Alitalo, K., Kivela, R., Yla-Herttuala, S. & Tavi, P., 31 May 2017, In : Frontiers in Physiology. 8, 10 p., 373.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Vascular Endothelial Growth Factor-B Overexpressing Hearts Are Not Protected From Transplant-Associated Ischemia-Reperfusion Injury

Raissadati, A., Tuuminen, R., Dashkevich, A., Bry, M., Kivela, R., Anisimov, A., Syrjälä, S., Arnaudova, R., Rouvinen, E., Keränen, M. A. I., Krebs, R., Nykänen, A. & Lemstrom, K. B., Apr 2017, In : Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation. 15, 2, p. 203-212 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

VEGFB/VEGFR1-Induced Expansion of Adipose Vasculature Counteracts Obesity and Related Metabolic Complications

Robciuc, M. R., Kivela, R., Williams, I. M., de Boer, J. F., van Dijk, T. H., Elamaa, H., Tigistu-Sahle, F., Molotkov, D., Leppanen, V-M., Kakela, R., Eklund, L., Wasserman, D. H., Groen, A. K. & Alitalo, K., 12 Apr 2016, In : Cell Metabolism. 23, 4, p. 712-724 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection

Rasanen, M., Degerman, J., Nissinen, T. A., Miinalainen, I., Kerkela, R., Siltanen, A., Backman, J. T., Mervaala, E., Hulmi, J., Kivela, R. & Alitalo, K., 15 Nov 2016, In : Proceedings of the National Academy of Sciences of the United States of America. 113, 46, p. 13144-13149 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

VEGF-B-induced vascular growth leads to metabolic reprogramming and ischemia resistance in the heart

Kivelä, M. R., Bry, M., Robciuc, M. R., Räsänen, M., Taavitsainen, M., Silvola, J. M. U., Saraste, A., Hulmi, J. J., Anisimov, A., Mayranpaa, M. I., Lindeman, J. H., Eklund, L., Hellberg, S., Hlushchuk, R., Zhuang, Z. W., Simons, M., Djonov, V., Knuuti, J., Mervaala, E. & Alitalo, K., Mar 2014, In : EMBO molecular medicine. 6, 3, p. 307-321 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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VEGF-C and aortic cardiomyocytes guide coronary artery stem development

Chen, H. I., Poduri, A., Numi, H., Kivela, R., Saharinen, P., McKay, A. S., Raftrey, B., Churko, J., Tian, X., Zhou, B., Wu, J. C., Alitalo, K. & Red-Horse, K., Nov 2014, In : Journal of Clinical Investigation. 124, 11, p. 4899-4914 16 p.

Research output: Contribution to journalArticleScientificpeer-review