Research output per year
Research output per year
- 18 results
Search results
-
2024
Disruption of KLHL6 Fuels Oncogenic Antigen Receptor Signaling in B-Cell Lymphoma
Meriranta, L., Sorri, S., Huse, K., Liu, X., Spasevska, I., Zafar, S., Chowdhury, I., Dufva, O., Sahlberg, E., Tandaric, L., Karjalainen-Lindsberg, M.-L., Hyytiäinen, M., Varjosalo, M., Myklebust, J. H. & Leppä, S., 3 Sept 2024, In: Blood cancer discovery. 5, 5, p. 331-352 22 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
GNAS mutation inhibits growth and induces phosphodiesterase 4D expression in colorectal cancer cell lines
Nummela, P., Zafar, S., Veikkolainen, E., Ukkola, I., Cinella, V., Ayo, A., Asghar, M. Y., Välimäki, N., Törnquist, K., Karhu, A., Laakkonen, P., Aaltonen, L. A. & Ristimäki, A., Feb 2024, In: International Journal of Cancer. 154, 11, p. 1987-1998 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Overcoming effector T cell exhaustion in ovarian cancer ascites with a novel adenovirus encoding for a MUC1 bispecific antibody engager and IL-2 cytokine
Basnet, S., Van der Heijden, M., Quixabeira, D. C. A., Jirovec, E., Grönberg-Vähä-Koskela, S. A. M., Clubb, J. H. A., Kanerva, A., Pakola, S., Haybout, L., Arias, V., Hemminki, O., Kudling, T., Zafar, S., Santos, J. M. & Hemminki, A., 2024, In: Molecular therapy. 32, 9, p. 3114-3127 14 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
2023
N-Glycomic Profiling of Microsatellite Unstable Colorectal Cancer
Ukkola, I., Nummela, P., Heiskanen, A., Holm, M., Zafar, S., Kero, M., Haglund, C., Satomaa, T., Kytola, S. & Ristimäki, A., Jul 2023, In: Cancers. 15, 14, 17 p., 3571.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access -
Proliferation and migration of ML1 follicular thyroid cancer cells are inhibited by IU1 targeting USP14: role of proteasome and autophagy flux
Srinivasan, V., Asghar, M. Y., Zafar, S., Törnquist, K. & Lindholm, D., 30 Aug 2023, In: Frontiers in Cell and Developmental Biology. 11, 14 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
2021
Ad5/3 is able to avoid neutralization by binding to erythrocytes and lymphocytes
Zafar, S., Quixabeira, D. C. A., Kudling, T. V., Cervera-Carrascon, V., Santos, J. M., Grönberg-Vähä-Koskela, S., Zhao, F., Aronen, P., Heiniö, C., Havunen, R., Sorsa, S., Kanerva, A. & Hemminki, A., May 2021, In: Cancer Gene Therapy. 28, 5, p. 442-454 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Adenovirus Armed With TNFa and IL2 Added to aPD-1 Regimen Mediates Antitumor Efficacy in Tumors Refractory to aPD-1
Cervera-Carrascon, V., Quixabeira, D. C. A., Santos, J. M., Havunen, R., Milenova, I., Verhoeff, J., Heinio, C., Zafar, S., Garcia-Vallejo, J. J., van Beusechem, V. W., de Gruijl, T. D., Kalervo, A., Sorsa, S., Kanerva, A. & Hemminki, A., 23 Jul 2021, In: Frontiers in Immunology. 12, 12 p., 706517.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Armed oncolytic immunotherapies for overcoming tumor induced immune suppression
Zafar, S., 2021, Helsinki: Helsingin yliopisto. 79 p.Research output: Thesis › Doctoral Thesis › Collection of Articles
Open Access -
Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Microenvironment and Confers Enhanced Tumor Control
Quixabeira, D. C. A., Zafar, S., Santos, J. M., Cervera-Carrascon, V., Havunen, R., Kudling, T. V., Basnet, S., Anttila, M., Kanerva, A. & Hemminki, A., 18 May 2021, In: Frontiers in Immunology. 12, 13 p., 674400.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Oncolytic Adenovirus Type 3 Coding for CD40L Facilitates Dendritic Cell Therapy of Prostate Cancer in Humanized Mice and Patient Samples
Zafar, S., Basnet, S., Launonen, I.-M., Quixabeira, D. C. A., Santos, J., Hemminki, O., Malmstedt, M., Cervera-Carrascon, V., Aronen, P., Kalliokoski, R., Havunen, R., Rannikko, A., Mirtti, T., Matikainen, M., Kanerva, A. & Hemminki, A., 1 Feb 2021, In: Human Gene Therapy. 32, 3-4, p. 192-202 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Systemic Delivery of Oncolytic Adenovirus to Tumors Using Tumor-Infiltrating Lymphocytes as Carriers
Santos, J., Heiniö, C., Quixabeira, D., Zafar, S., Clubb, J., Pakola, S., Cervera-Carrascon, V., Havunen, R., Kanerva, A. & Hemminki, A., May 2021, In: Cells. 10, 5, 14 p., 978.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
2020
Comparison of clinically relevant oncolytic virus platforms for enhancing T-cell therapy of solid tumors
Cervera-Carrascon, V., Quixabeira, D. C. A., Havunen, R., Santos, J. M., Kutvonen, E., Clubb, J. H. A., Siurala, M., Heiniö, C., Zafar, S., Koivula, T., Lumen, D., Vaha, M., Garcia-Horsman, A., Airaksinen, A. J., Sorsa, S., Anttila, M., Hukkanen, V., Kanerva, A. & Hemminki, A., 26 Jun 2020, In: Molecular Therapy - Oncolytics. 17, p. 47-60 14 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity
Santos, J. M., Heiniö, C., Cervera-Carrascon, V., Quixabeira, D. C. A., Siurala, M., Havunen, R., Butzow, R., Zafar, S., de Gruijl, T., Lassus, H., Kanerva, A. & Hemminki, A., Jan 2020, In: Journal for Immunotherapy of Cancer. 8, 1, 15 p., 000188.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition
Cervera-Carrascon, V., Quixabeira, D. C. A., Santos, J. M., Havunen, R., Zafar, S., Hemminki, O., Heiniö, C., Munaro, E., Siurala, M., Sorsa, S., Mirtti, T., Järvinen, P., Mildh, M., Nisen, H., Rannikko, A., Anttila, M., Kanerva, A. & Hemminki, A., 2020, In: OncoImmunology. 9, 1, 12 p., e1761229.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
2019
Effect of Genetic Modifications on Physical and Functional Titers of Adenoviral Cancer Gene Therapy Constructs
Heiniö, C., Sorsa, S., Siurala, M., Grönberg-Vähä-Koskela, S., Havunen, R., Haavisto, E., Koski, A., Hemminki, O., Zafar, S., Cervera-Carrascon, V., Munaro, E., Kanerva, A. & Hemminki, A., 1 Jun 2019, In: Human Gene Therapy. 30, 6, p. 740-752 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
2018
Adenovirus Coding for Interleukin-2 and Tumor Necrosis Factor Alpha Replaces Lymphodepleting Chemotherapy in Adoptive T Cell Therapy
Santos, J. M., Cervera-Carrascon, V., Havunen, R., Zafar, S., Siurala, M., Sorsa, S., Anttila, M., Kanerva, A. & Hemminki, A., 5 Sept 2018, In: Molecular therapy. 26, 9, p. 2243-2254 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
CD40L coding oncolytic adenovirus allows long-term survival of humanized mice receiving dendritic cell therapy
Zafar, S., Sorsa, S., Siurala, M., Hemminki, O., Havunen, R., Cervera-Carrascon, V., Santos, J. M., Wang, H., Lieber, A., De Gruijl, T., Kanerva, A. & Hemminki, A., 2018, In: OncoImmunology. 7, 10, 10 p., 1490856.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
2017
CD40L coding oncolytic adenovirus 3 is a potent facilitator of dendritic cell therapy.
Zafar, S., Siurala, M. O., Sorsa, S., Hemminki, O. J., Havunen, R. S. A., Tähtinen, S., Bramante, S., Vassilev, L., Wang, H., Lieber, A., Hemmi, S., de Gruijl, T., Kanerva, A.-M. & Hemminki, A. E., 2017.Research output: Conference materials › Poster