Samuli Ripatti

Publications

Research output per year 1998 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 2022 2023 2024 2024

• 366 Article
• 10 Review Article
• 8 Meeting Abstract
• 2 Chapter
• 7 More
  • 2 Letter
  • 1 Anthology or special issue
  • 1 Conference contribution
  • 1 Paper
  • 1 Comment/debate
  • 1 Editorial

Research output per year

Research output per year

Search results

• 2024

  A genomic mutational constraint map using variation in 76,156 human genomes

  Genome Aggregation Database Consortium, Chen, S., Francioli, L. C., Goodrich, J. K., Färkkilä, M., Groop, L., Holi, M. M., Kaprio, J., Koskinen, S., Palotie, A., Ripatti, S., Suvisaari, J., Tuomi, T., Vartiainen, E., Wessman, M., Daly, M. J. & Neale, B. M., 4 Jan 2024, In: Nature. 625, 7993, p. 92-100 27 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• A unified framework for estimating country-specific cumulative incidence for 18 diseases stratified by polygenic risk

  Jermy, B., Läll, K., Wolford, B. N., Wang, Y., Zguro, K., Cheng, Y., Kanai, M., Kanoni, S., Yang, Z., Hartonen, T., Monti, R., Wanner, J., Youssef, O., Lippert, C., van Heel, D., Okada, Y., McCartney, D. L., Hayward, C., Marioni, R. E. & Furini, S. & 10 others, Renieri, A., Martin, A. R., Neale, B. M., Hveem, K., Mägi, R., Palotie, A., Heyne, H., Mars, N., Ganna, A. & Ripatti, S., 2024, In: Nature Communications. 15, 1, 14 p., 5007.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Comprehensive Inherited Risk Estimation for Risk-Based Breast Cancer Screening in Women

  Mars, N., Kerminen, S., Tamlander, M., Pirinen, M., Jakkula, E., Aaltonen, K., Meretoja, T., Heinävaara, S., Widén, E. & Ripatti, S., 1 May 2024, In: Journal of Clinical Oncology. 42, 13, p. 1477-1487 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Evaluation of polygenic scoring methods in five biobanks shows larger variation between biobanks than methods and finds benefits of ensemble learning

  Monti, R., Eick, L., Hudjashov, G., Läll, K., Kanoni, S., Wolford, B. N., Wingfield, B., Pain, O., Wharrie, S., Jermy, B., McMahon, A., Hartonen, T., Heyne, H., Mars, N., Lambert, S., Hveem, K., Inouye, M., van Heel, D. A., Mägi, R. & Marttinen, P. & 3 others, Ripatti, S., Ganna, A. & Lippert, C., 21 Jun 2024, In: American Journal of Human Genetics. 111, 7, p. 1431-1447 17 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Exploring machine learning strategies for predicting cardiovascular disease risk factors from multi-omic data

  Drouard, G., Mykkänen, J., Heiskanen, J., Pohjonen, J., Ruohonen, S., Pahkala, K., Lehtimäki, T., Wang, X., Ollikainen, M., Ripatti, S., Pirinen, M., Raitakari, O. & Kaprio, J., 2 May 2024, In: BMC Medical Informatics and Decision Making. 24, 1, 18 p., 116.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Exploring Synaptic Pathways in Traumatic Brain Injury: A Cross-Phenotype Genomics Approach

  Genetic Associations Neurotrauma GAIN Consortium, Ctr TBI TRACK TBI CABI MGB & TBIcare Studies, Prapiadou, S., Mayerhofer, E., Georgakis, M. K., Kals, M., Radmanesh, F., Izzy, S., Richardson, S., Okonkwo, D., Puccio, A., Temkin, N., Palotie, A., Ripatti, S., Diaz-Arrastia, R., Stein, M. B., Manley, G., Menon, D. K., Rosand, J. & Parodi, L. & 1 others, Anderson, C. D., 7 Oct 2024, In: Journal of Neurotrauma. 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Genetic Analysis of Obstructive Sleep Apnea and Its Relationship with Severe COVID-19

  FinnGen, Strausz, S., Agafonova, E., Tiullinen, V., Kiiskinen, T., Broberg, M., Ruotsalainen, S. E., Koskela, J., Bachour, A., Sofer, T., Gottlieb, D. J., Palotie, A., Palotie, T., Ripatti, S. & Ollila, H. M., Jun 2024, In: Proceedings of the American Thoracic Society. 21, 6, p. 961-970 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Genetic and functional analysis of Raynaud's syndrome implicates loci in vasculature and immunity

  Tervi, A., Ramste, M., Abner, E., Lammi, V., Strausz, S., Riikonen, J., Gu, W., FinnGen, Estonian Biobank research team, Pirinen, M., Palotie, A., Ripatti, S., Sinnott-Armstrong, N., Daly, M., Heckman, C. A., Jones, S. E. & Ollila, H. M., 2024, In: Cell genomics. 4, 9, 23 p., 100630.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

  Million Veteran Program, LifeLines Cohort Study, CHARGE Consortium, ICBP Consortium, Keaton, J. M., Kamali, Z., Xie, T., Kristiansson, K., Tuomilehto, J., Salomaa, V., Lehtimäki, T. & Raitakari, O. T., 1 May 2024, In: Nature Genetics. 56, 5, p. 778-791 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Genome-wide polygenic risk scores for colorectal cancer have implications for risk-based screening

  FinnGen, Tamlander, M., Jermy, B., Seppälä, T. T., Färkkilä, M., Widén, E., Ripatti, S. & Mars, N., 2024, In: British Journal of Cancer. 130, 4, p. 651-659 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Genome-Wide Polygenic Score for Muscle Strength Predicts Risk for Common Diseases and Lifespan: A Prospective Cohort Study

  FinnGen, Herranen, P., Koivunen, K., Palviainen, T., Kujala, U. M., Ripatti, S., Kaprio, J. & Sillanpää, E., 1 Apr 2024, In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 79, 4, 8 p., glae064.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• High Burden of Ileus and Pneumonia in Clozapine-Treated Individuals With Schizophrenia: A Finnish 25-Year Follow-Up Register Study

  FinnGen, SUPER-Finland, Partanen, J. J., Häppölä, P., Kämpe, A., Ahola-Olli, A., Hellsten, A., Rask, S. M., Haaki, W., Hietala, J., Kampman, O., Tiihonen, J., Tanskanen, A. J., Daly, M. J., Ripatti, S., Palotie, A., Taipale, H., Lähteenvuo, M. & Koskela, J. T., 1 Oct 2024, In: The American journal of psychiatry. 181, 10, p. 879-892 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• High-Resolution Genotyping of Formalin-Fixed Tissue Accurately Estimates Polygenic Risk Scores in Human Diseases

  FinnGen, Youssef, O., Loukola, A., Zidi-Mouaffak, Y. H. S., Tamlander, M., Ruotsalainen, S., Kilpeläinen, E., Mars, N., Ripatti, S., Palotie, A., Donner, K. & Carpén, O., Apr 2024, In: Laboratory Investigation. 104, 4, 27 p., 100325.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Imputation of missing values in lipidomic datasets

  Frölich, N., Klose, C., Widén, E., Ripatti, S. & Gerl, M. J., 2024, In: Proteomics. 24, 15, 11 p., 2300606.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Inferring compound heterozygosity from large-scale exome sequencing data

  gnomAD Project Consortium, Guo, M. H., Francioli, L. C., Stenton, S. L., Goodrich, J. K., Watts, N. A., Singer-Berk, M., Groopman, E., Darnowsky, P. W., Solomonson, M., Baxter, S., Tiao, G., Neale, B. M., Hirschhorn, J. N., Rehm, H. L., Daly, M. J., O'Donnell-Luria, A., Karczewski, K. J., MacArthur, D. G. & Samocha, K. E. & 13 others, Palotie, A., Färkkilä, M., Kaprio, J., Groop, L., Ripatti, S., Tuomi, T., Wessman, M., Holi, M. M., Kallela, M., Koskinen, S., Vartiainen, E., Salomaa, V. & Suvisaari, J., 2024, In: Nature Genetics. 56, 1, p. 152–161 18 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Marital status and genetic liability independently predict coronary heart disease incidence

  Silventoinen, K., Lahtinen, H., Korhonen, K., Smith, G. D., Ripatti, S., Morris, T. & Martikainen, P., Feb 2024, In: Scandinavian Journal of Public Health. 52, 1, p. 1-4 4 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Nightmares share genetic risk factors with sleep and psychiatric traits

  Ollila, H. M., Sinnott-Armstrong, N., Kantojärvi, K., Broberg, M., Palviainen, T., Jones, S., Ripatti, V., Pandit, A., Rong, R., Kristiansson, K., Sandman, N., Valli, K., Hublin, C., Ripatti, S., Widen, E., Kaprio, J., Saxena, R. & Paunio, T., 2024, In: Translational Psychiatry. 14, 1, 6 p., 123.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• One-year employment outcome prediction after traumatic brain injury: A CENTER-TBI study

  Van Deynse, H., Cools, W., De Deken, V. J., Depreitere, B., Hubloue, I., Tisseghem, E., Putman, K., the CENTER-TBI Collaborators, Åkerlund, C., Amrein, K., Andelic, N., Andreassen, L., Anke, A., Antoni, A., Audibert, G., Azouvi, P., Azzolini, M. L., Bartels, R., Barzó, P. & Beauvais, R. & 31 others, Beer, R., Bellander, B. M., Belli, A., Benali, H., Berardino, M., Beretta, L., Blaabjerg, M., Bragge, P., Brazinova, A., Brinck, V., Brooker, J., Brorsson, C., Buki, A., Bullinger, M., Cabeleira, M., Caccioppola, A., Calappi, E., Calvi, M. R., Cameron, P., Lozano, G. C., Carbonara, M., Cavallo, S., Chevallard, G., Chieregato, A., Jiang, J.-Y., Oresic, M., Palotie, A., Piippo-Karjalainen, A., Pirinen, M., Raj, R. & Ripatti, S., 2024, In: Disability and Health Journal. 7 p., 101716.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Oral and non-oral lichen planus show genetic heterogeneity and differential risk for autoimmune disease and oral cancer

  FinnGen, Reeve, M. P., Vehviläinen, M., Luo, S., Ritari, J., Karjalainen, J., Gracia-Tabuenca, J., Mehtonen, J., Padmanabhuni, S. S., Kolosov, N., Artomov, M., Siirtola, H., Olilla, H. M., Graham, D., Partanen, J., Xavier, R. J., Daly, M. J., Ripatti, S., Salo, T. & Siponen, M., 6 Jun 2024, In: American Journal of Human Genetics. 111, 6, p. 1047-1060 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Patterns of reproductive health in inflammatory rheumatic diseases and other immune-mediated diseases: a nationwide registry study

  Kerola, A. M., Palomäki, A., Laivuori, H., Laitinen, T., Färkkilä, M., Eklund, K. K., Ripatti, S., Perola, M., Ganna, A., Lindbohm, J. V. & Mars, N., 20 Mar 2024, In: Rheumatology. 63, 10, p. 2701–2710 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• Polygenic scores for complex traits are associated with changes in concentration of circulating lipid species

  Tabassum, R., Mars, N., Briotta Parolo, P. D., Gerl, M. J., Klose, C., FinnGen Consortium, Pirinen, M., Simons, K., Widén, E. & Ripatti, S., Sept 2024, In: PLoS Biology. 22, 9, 19 p., e3002830.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Socio-demographic and genetic risk factors for drug adherence and persistence across 5 common medication classes

  FinnGen, Estonian Biobank Research Team, Cordioli, M., Corbetta, A., Kariis, H. M., Jukarainen, S., Vartiainen, P., Kiiskinen, T., Ferro, M., Ganna, A., Ripatti, S., Perola, M., Hudjashov, G., Nelis, M., Mägi, R., Esko, T., Milani, L., Metspalu, A., Niemi, M. & Ripatti, S. & 2 others, Lehto, K. & Ganna, A., Dec 2024, In: Nature Communications. 15, 1, 13 p., 9156.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• 2023

  A second update on mapping the human genetic architecture of COVID-19

  Covid 19 Host Genetics Initiative, Kanai, M., Andrews, S., Cordioli, M., Stevens, C., Neale, B. M., Daly, M. J., Ganna, A., Kanai, M., Andrews, S., Cordioli, M., Pathak, G. A., Iwasaki, A., Karjalainen, J., Mehtonen, J., Pirinen, M., Marttila, M. M., Mondal, S., Nakanishi, T. & Niemi, M. E. K. & 21 others, Cordioli, M., Pigazzini, S., Nakanishi, T., Wong, I., Corbetta, A., Niemi, M. E. K., Corbetta, A., Ripatti, S., Jermy, B., Ruotsalainen, S., Kristiansson, K., Koskelainen, S., Perola, M., Donner, K., Kivinen, K., Palotie, A., Kaunisto, M., Bishop, L., Ding, Y., Nakanishi, T. & Zhou, W., 7 Sept 2023, In: Nature. 621, 7977, p. E7–E26 23 p.

  Research output: Contribution to journal › Letter › Scientific › peer-review

  Open Access

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• Association between genetic risk of alcohol consumption and alcohol‐related morbidity and mortality under different alcohol policy conditions: evidence from the Finnish alcohol price reduction of 2004

  Lahtinen, H., Moustgaard, H., Ripatti, S. & Martikainen, P., Apr 2023, In: Addiction. 118, 4, p. 678-685 8 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Effect of biological sex on human circulating lipidome: An overview of the literature

  Tabassum, R., Widen, E. & Ripatti, S., Nov 2023, In: Atherosclerosis. 384, 10 p., 117274.

  Research output: Contribution to journal › Review Article › peer-review

  Open Access

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• Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata

  Sliz, E., Tyrmi, J. S., Rahmioglu, N., Zondervan, K. T., Becker, C. M., Uimari, O., Kettunen, J., Palotie, A., Daly, M., Riley-Gills, B., Jacob, H., Paul, D., Matakidou, A., Platt, A., Runz, H., John, S., Okafo, G., Lawless, N., Salminen-Mankonen, H. & Plenge, R. & 306 others, Maranville, J., McCarthy, M., Ehm, M. G., Auro, K., Longerich, S., Fox, C., Malarstig, A., Klinger, K., Chatelain, C., Gossel, M., Estrada, K., Graham, R., Yang, R., O'Donnell, C., Mäkelä, T. P., Kaprio, J., Virolainen, P., Hakanen, A., Kilpi, T., Perola, M., Partanen, J., Pitkäranta, A., Raivio, T., Serpi, R., Laitinen, T., Kosma, V.-M., Laukkanen, J., Hautalahti, M., Tuovila, O., Pakkanen, R., Waring, J., Riley-Gillis, B., Rahimov, F., Tachmazidou, I., Chen, C.-Y., Ding, Z., Jung, M., Biswas, S., Pendergrass, R., Pulford, D., Raghavan, N., Huertas-Vazquez, A., Sul, J.-H., Hu, X., Hedman, A., Rivas, M., Waterworth, D., Renaud, N., Obeidat, M., Ripatti, S., Schleutker, J., Arvas, M., Carpen, O., Hinttala, R., Mannermaa, A., Aalto-Setala, K., Kahonen, M., Mäkelä, J., Kalviainen, R., Julkunen, V., Soininen, H., Remes, A., Hiltunen, M., Peltola, J., Raivio, M., Tienari, P., Rinne, J., Kallionpaa, R., Partanen, J., Abbasi, A., Ziemann, A., Smaoui, N., Lehtonen, A., Eaton, S., Lahdenpera, S., Bowers, N., Teng, E., Xu, F., Addis, L., Eicher, J., Li, Q. S., He, K., Khramtsova, E., Färkkilä, M., Koskela, J., Pikkarainen, S., Jussila, A., Kaukinen, K., Blomster, T., Kiviniemi, M., Voutilainen, M., Lu, T., McCarthy, L., Hart, A., Guan, M., Miller, J., Kalpala, K., Miller, M., Eklund, K., Palomaki, A., Isomaki, P., Pirila, L., Kaipiainen-Seppanen, O., Huhtakangas, J., Mars, N., Lertratanakul, A., Hochfeld, M., Gordillo, J. E., Farias, F., Bing, N., Pelkonen, M., Kauppi, P., Kankaanranta, H., Harju, T., Lahesmaa, R., Lassi, G., Chen, H., Betts, J., Mishra, R., Mouded, M., Ngo, D., Niiranen, T., Vaura, F., Salomaa, V., Metsarinne, K., Aittokallio, J., Hernesniemi, J., Gordin, D., Sinisalo, J., Taskinen, M.-R., Tuomi, T., Elliott, A., Reeve, M. P., Ruotsalainen, S., Challis, B., Chu, A., Reilly, D., Mendelson, M., Parkkinen, J., Meretoja, T., Joensuu, H., Mattson, J., Salminen, E., Auranen, A., Karihtala, P., Auvinen, P., Elenius, K., Pitkänen, E., Popovic, R., Schutzman, J., Kulkarni, D., Porello, A., Loboda, A., Lehtonen, H., McDonough, S., Vuoti, S., Kaarniranta, K., Turunen, J. A., Ollila, T., Uusitalo, H., Karjalainen, J., Liu, M., Loomis, S., Strauss, E., Chen, H., Tasanen, K., Huilaja, L., Hannula-Jouppi, K., Salmi, T., Peltonen, S., Koulu, L., Choy, D., Wu, Y., Pussinen, P., Salminen, A., Salo, T., Rice, D., Nieminen, P., Palotie, U., Siponen, M., Suominen, L., Mäntylä, P., Gursoy, U., Anttonen, V., Sipila, K., Laivuori, H., Kurra, V., Kotaniemi-Talonen, L., Heikinheimo, O., Kalliala, I., Aaltonen, L., Jokimaa, V., Vaarasmaki, M., Morin-Papunen, L., Niinimaki, M., Piltonen, T., Kivinen, K., Widen, E., Tukiainen, T., Välimäki, N., Laakkonen, E., Silven, H., Arffman, R., Savukoski, S., Laisk, T., Pujol, N., Kumar, J., Hovatta, I., Isometsä, E., Ollila, H., Suvisaari, J., Als, T. D., Mäkitie, A., Bizaki-Vallaskangas, A., Toppila-Salmi, S., Willberg, T., Saarentaus, E., Aarnisalo, A., Rahikkala, E., Aittomaki, K., Åberg, F., Kurki, M., Havulinna, A., Mehtonen, J., Palta, P., Hassan, S., Parolo, P. D. B., Zhou, W., Maasha, M., Lemmela, S., Liu, A., Lehisto, A., Ganna, A., Llorens, V., Heyne, H., Rämö, J., Rodosthenous, R., Strausz, S., Palotie, T., Palin, K., Garcia-Tabuenca, J., Siirtola, H., Kiiskinen, T., Lee, J., Tsuo, K., Kristiansson, K., Hyvarinen, K., Ritari, J., Pylkas, K., Karjalainen, M., Mantere, T., Kangasniemi, E., Heikkinen, S., Pitkanen, N., Lessard, S., Chatelain, C., Terho, P., Wahlfors, T., Punkka, E., Siltanen, S., Kuopio, T., Jalanko, A., Shen, H.-Y., Kajanne, R., Aavikko, M., Palin, H., Linna, M.-M., Kanai, M., Zheng, Z., Lahtela, L. E., Kaunisto, M., Kilpeläinen, E., Sipila, T. P., Dada, O. A., Ghazal, A., Kytölä, A., Weldatsadik, R., Donner, K., Loukola, A., Laiho, P., Sistonen, T., Kaiharju, E., Laukkanen, M., Jarvensivu, E., Lahteenmaki, S., Mannikko, L., Wong, R., Toivola, A., Brunfeldt, M., Mattsson, H., Koskelainen, S., Hiekkalinna, T., Paajanen, T., Pärn, K., Kals, M., Luo, S., Padmanabhuni, S. S., Niemi, M., Gracia-Tabuenca, J., Helminen, M., Luukkaala, T., Vahatalo, I., Tammerluoto, J., Smith, S., Southerington, T. & Lehto, P., 1 Feb 2023, In: Nature Communications. 14, 542, 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• FinnGen provides genetic insights from a well-phenotyped isolated population

  FinnGen, Kurki, M. I., Karjalainen, J., Palta, P., Sipilä, T. P., Kristiansson, K., Donner, K. M., Reeve, M. P., Laivuori, H., Aavikko, M., Kaunisto, M. A., Loukola, A., Mattsson, H., Laiho, P., Della Briotta Parolo, P., Lehisto, A. A., Mars, N., Rämö, J., Kiiskinen, T. & Heyne, H. O. & 63 others, Rüeger, S., Lemmelä, S., Zhou, W., Ruotsalainen, S., Pärn, K., Hiekkalinna, T., Koskelainen, S., Paajanen, T., Llorens, V., Gracia-Tabuenca, J., Auro, K., Carpen, O., Dada, O. A., Eklund, K., Färkkilä, M., Ganna, A., Ghazal, A., Hovatta, I., Joensuu, H., Julkunen, V., Kajanne, R., Kaprio, J., Kettunen, J., Kilpeläinen, E., Kurra, V., Laukkanen, J., Liu, A., Mäkelä, J., Mäkitie, A., Meretoja, T., Niemi, M. E. K., Niemi, M., Niiranen, T., Ollila, H. M., Palomäki, A., Palotie, T., Partanen, J., Pelkonen, M., Pitkäranta, A., Punkka, E., Pussinen, P., Rodosthenous, R., Saarentaus, E., Salminen, A., Salminen, E., Shen, H.-Y., Silander, K., Soini, S., Tienari, P., Toppila-Salmi, S., Tukiainen, T., Tuomi, T., Turunen, J. A., Vaura, F., Havulinna, A. S., Perola, M., Ripatti, S., Jalanko, A., Laitinen, T., Mäkelä, T. P., Daly, M. J., Palotie, A. & Kanai, M., 19 Jan 2023, In: Nature. 613, 7944, p. 508-+ 20 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Genetic analyses implicate complex links between adult testosterone levels and health and disease

  FinnGen Consortium, Leinonen, J. T., Mars, N., Lehtonen, L. E., Ahola-Olli, A., Ruotsalainen, S., Lehtimäki, T., Kähönen, M., Raitakari, O., Piltonen, T., Tuomi, T., Daly, M., Ripatti, S., Tukiainen, T. & Pirinen, M., 18 Jan 2023, In: Communications Medicine. 3, 1, 15 p., 4.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Genetic prediction of medication use patterns in cardiometabolic disease

  Kiiskinen, T. & Ripatti, S., Jan 2023, In: Nature Medicine. 29, 1, p. 43-44 2 p.

  Research output: Contribution to journal › Editorial › Scientific

  Open Access

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• Genetic predictors of lifelong medication-use patterns in cardiometabolic diseases

  Kiiskinen, T., Helkkula, P., Krebs, K., Karjalainen, J., Saarentaus, E., Mars, N., Lehisto, A., Zhou, W., Cordioli, M., Jukarainen, S., Rämö, J. T., Mehtonen, J., Veerapen, K., Räsänen, M., Ruotsalainen, S., Maasha, M., Niiranen, T., Tuomi, T., Salomaa, V. & Kurki, M. & 7 others, Pirinen, M., Palotie, A., Daly, M., Ganna, A., Havulinna, A. S., Milani, L. & Ripatti, S., Jan 2023, In: Nature Medicine. 29, 1, p. 209–218 28 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy

  FINNPEC Study Grp, Estonian Biobank Research Team, FinnGen, Tyrmi, J. S., Kaartokallio, T., Lokki, A. I., Jääskeläinen, T., Kortelainen, E., Ruotsalainen, S., Karjalainen, J., Ripatti, S., Kivioja, A., Laisk, T., Kettunen, J., Pouta, A., Kivinen, K., Kajantie, E., Heinonen, S., Kere, J. & Laivuori, H. & 3 others, Kaprio, J., Mäkitie, A. & Tienari, P., Jul 2023, In: JAMA cardiology. 8, 7, p. 674-683 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity

  HUNT All In Stroke, CADISP group, International Consortium for Blood Pressure, The International Headache Genetics Consortium, International Stroke Genetics Consortium (ISGC), Bakker, M. K., Kanning, J. P., Abraham, G., Zhou, W., Metso, A. J., Metso, T., Tatlisumak, T., Havulinna, A. S., Jousilahti, P., Kristiansson, K., Niiranen, T., Palotie, A., Perola, M., Ripatti, S. & Sarin, A. P. & 21 others, Tuomilehto, J., Anttila, V., Palta, P., Muona, M., Wedenoja, J., Färkkilä, M., Artto, V., Kaunisto, M., Vepsäläinen, S., Kurki, M. I., Pärn, K., Hämäläinen, E., Eriksson, J. G., Heikkilä, K., Kaprio, J., Wessman, M., Daly, M. J., Neale, B. M., Jääskeläinen, J. E., Lindgren, A. & Niemelä, M., 1 Mar 2023, In: Stroke. 54, 3, p. 810-818 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Genome-wide association analysis of plasma lipidome identifies 495 genetic associations

  Ottensmann, L., Tabassum, R., Ruotsalainen, S. E., Gerl, M. J., Klose, C., Widén, E., Simons, K., Ripatti, S. & Pirinen, M., 31 Oct 2023, In: Nature Communications. 14, 1, 15 p., 6934.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Genome-wide association study of varicose veins identifies a protective missense variant in GJD3 enriched in the Finnish population

  Helkkula, P., Hassan, S., Saarentaus, E., Vartiainen, E. A. H., Ruotsalainen, S., Leinonen, J., Palotie, A., Karjalainen, J. M., Kurki, M. I., Ripatti, S. & Tukiainen, T., 18 Jan 2023, In: Communications Biology. 6, 1, 12 p., 71.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Genome-wide screen of otosclerosis in population biobanks: 27 loci and shared associations with skeletal structure

  FinnGen, Rämö, J. T., Kiiskinen, T., Seist, R., Krebs, K., Kanai, M., Karjalainen, J., Kurki, M., Hämäläinen, E., Häppölä, P. S., Havulinna, A. S., Hautakangas, H., Mägi, R., Palta, P., Esko, T., Metspalu, A., Pirinen, M. J., Karczewski, K. J., Ripatti, S. & Milani, L. M. & 4 others, Stankovic, K., Mäkitie, A., Daly, M. & Palotie, A., 18 Jan 2023, In: Nature Communications. 14, 1, 14 p., 157.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation

  FinnGen, Saarentaus, E. C., Karjalainen, J. T., Rämö, J. T., Kiiskinen, T., Havulinna, A., Mehtonen, J., Hautakangas, H., Ruotsalainen, S., Tamlander, M., Mars, N., Toppila-Salmi, S., Pirinen, M., Kurki, M., Ripatti, S., Daly, M., Palotie, T., Mäkitie, A. & Palotie, A., 18 Jan 2023, In: Nature Communications. 14, 1, 15 p., 83.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Integration of Biomarker Polygenic Risk Score Improves Prediction of Coronary Heart Disease

  FinnGen Study, Lin, J., Mars, N., Fu, Y., Ripatti, P., Kiiskinen, T., Tukiainen, T., Ripatti, S. & Pirinen, M., Dec 2023, In: JACC: Basic to Translational Science. 8, 12, p. 1489-1499 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins

  BIOS Consortium, BBMRI-NL Metabolomics Consortium, Drouard, G., Hagenbeek, F. A., Whipp, A., Pool, R., Hottenga, J. J., Jansen, R., Hubers, N., Afonin, A., Willemsen, G., de Geus, E. J. C., Ripatti, S., Pirinen, M., Kanninen, K. M., Boomsma, D. I., van Dongen, J. & Kaprio, J., 21 Dec 2023, In: BMC Medicine. 21, 21 p., 508.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• Narcolepsy risk loci outline role of T cell autoimmunity and infectious triggers in narcolepsy

  FinnGen, Palotie, A., Kytölä, A., Ganna, A., Jalanko, A., Liu, A., Lehisto, A., Ghazal, A., Kilpeläinen, E., Widen, E., Saarentaus, E., Pitkänen, E., Ollila, H. M., Laivuori, H., Heyne, H., Shen, H.-Y., Kaprio, J., Rämö, J., Karjalainen, J. M. & Mehtonen, J. M. F. & 31 others, Pitkänen, J., Pärn, K., Donner, K., Kivinen, K., Lahtela, L. E., Niemi, M. E., Kaunisto, M., Mars, N., Dada, O. A., Della Briotta Parolo, P., Palta, P., Weldatsadik, R., Kajanne, R., Rodosthenous, R., Ripatti, S., Ruotsalainen, S., Strausz, S. J., Hassan, S., Padmanabhuni, S. S., Luo, S., Lemmelä, S., Tukiainen, T., Sipilä, T., Kiiskinen, T., Llorens, V., Daly, M., Lee, J., Kurki, M. I., Havulinna, A., Mäkitie, A. & Tienari, P., 15 May 2023, In: Nature Communications. 14, 1, 13 p., 2709.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Nationwide health, socio-economic and genetic predictors of COVID-19 vaccination status in Finland

  FinnGen, Estonian Biobank Research Team, Hartonen, T., Jermy, B., Sonajalg, H., Vartiainen, P., Krebs, K., Vabalas, A., Leino, T., Nohynek, H., Sivelä, J., Mägi, R., Daly, M., Ollila, H. M., Milani, L., Perola, M., Ripatti, S. & Ganna, A., Jul 2023, In: Nature Human Behaviour. 7, 7, p. 1069-+ 25 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Novel Finnish-enriched variants causing severe hypercholesterolemia and their clinical impact on coronary artery disease

  FinnGen, Junna, N., Ruotsalainen, S., Ripatti, P., Ripatti, S. & Widén, E., Dec 2023, In: Atherosclerosis. 386, 10 p., 117327.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

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• OTTERS: a powerful TWAS framework leveraging summary-level reference data

  eQTLGen Consortium, Dai, Q., Zhou, G., Zhao, H., Võsa, U., Franke, L., Battle, A., Teumer, A., Lehtimäki, T., Raitakari, O. T., Esko, T., Agbessi, M., Ahsan, H., Alves, I., Andiappan, A. K., Arindrarto, W., Awadalla, P., Beutner, F., Jan Bonder, M. & Boomsma, D. I. & 31 others, Christiansen, M. W., Claringbould, A., Deelen, P., Favé, M. J., Frayling, T., Gharib, S. A., Gibson, G., Heijmans, B. T., Hemani, G., Jansen, R., Kähönen, M., Kalnapenkis, A., Kasela, S., Kettunen, J., Kim, Y., Kirsten, H., Kovacs, P., Krohn, K., Kronberg, J., Kukushkina, V., Kutalik, Z., Lee, B., Loeffler, M., Marigorta, U. M., Mei, H., Milani, L., Perola, M., Pervjakova, N., Ripatti, S., Rüeger, S. & Seppälä, I., Dec 2023, In: Nature Communications. 14, 1, 1271.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Prognostic Models for Global Functional Outcome and Post-Concussion Symptoms Following Mild Traumatic Brain Injury: A Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study

  the CENTER-TBI participants and investigators, Mikolić, A., Steyerberg, E. W., Polinder, S., Oresic, M., Palotie, A., Piippo-Karjalainen, A., Pirinen, M., Raj, R. & Ripatti, S., 1 Aug 2023, In: Journal of Neurotrauma. 40, 15-16, p. 1651-1670 20 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Response to Li and Hopper

  Mars, N., Lindbohm, J. V., Parolo, P. D. B., Widen, E., Kaprio, J., Palotie, A. & Ripatti, S., 6 Jul 2023, In: American Journal of Human Genetics. 110, 7, p. 1224-1225 2 p.

  Research output: Contribution to journal › Letter › Scientific
• 2022

  A genome-wide association study of outcome from traumatic brain injury

  Genetic Assoc Neurotrauma Gain Con, CENTER-TBI, CABI, MGB, TBIcare Studies, Kals, M., Kunzmann, K., Parodi, L., Palotie, A., Ripatti, S. & Menon, D. K., Mar 2022, In: EBioMedicine. 77, 12 p., 103933.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

  Million Veterans Program, Global Lipids Genetics Consortium, Ramdas, S., Judd, J., Graham, S. E., Surakka, I., Havulinna, A. S., Weir, D. R., Ruotsalainen, S. E., Loukola, A., Bollepalli, S., Kaprio, J., Koistinen, H. A., Kivimäki, M., Ripatti, S., Widén, E., Tuomilehto, J., Jousilahti, P., Sun, Y. V. & Ikeda, D. D. & 1 others, Iha, H., 4 Aug 2022, In: American Journal of Human Genetics. 109, 8, p. 1366-1387 23 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

• Article Multiomics and digital monitoring during lifestyle changes reveal independent dimensions of human biology and health

  Marabita, F., James, T., Karhu, A., Virtanen, H., Kettunen, K., Stenlund, H., Boulund, F., Hellstrom, C., Neiman, M., Mills, R., Perheentupa, T., Laivuori, H., Helkkula, P., Byrne, M., Jokinen, I., Honko, H., Kallonen, A., Ermes, M., Simila, H. & Lindholm, M. & 9 others, Widen, E., Ripatti, S., Perala-Heape, M., Engstrand, L., Nilsson, P., Moritz, T., Miettinen, T., Sallinen, R. & Kallioniemi, O., 16 Mar 2022, In: Cell Systems. 13, 3, p. 241-+ 23 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• A saturated map of common genetic variants associated with human height

  23andMe Res Team, VA Million Vet Program, DiscovEHR DiscovEHR MyCode Communi, eEMERGE Elect Med Records Genomics, LifeLines Cohort Study, PRACTICAL Consortium, Understanding Soc Sci Grp, Yengo, L., Vedantam, S., Marouli, E., Bollepalli, S., Havulinna, A. S., Ruotsalainen, S. E., Kaprio, J., Kivimäki, M., Koistinen, H. A., Ripatti, S., Tuomi, T., Tuomilehto, J. & Widen, E., 27 Oct 2022, In: Nature. 610, 7933, p. 704-+ 35 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Common Genetic Variation And Age at Onset Of Anorexia Nervosa

  Watson, H. J., Thornton, L. M., Yilmaz, Z., Baker, J. H., Coleman, J. R., Adan, R. A., Alfredsson, L., Andreassen, O. A., Ask, H., Berrettini, W. H., Boehnke, M., Boehm, I., Boni, C., Buehren, K., Bulant, J., Burghardt, R., Chang, X., Cichon, S., Cone, R. D. & Courtet, P. & 156 others, Crow, S., Crowley, J. J., Danner, U. N., de Zwaan, M., Dedoussis, G., DeSocio, J. E., Dick, D. M., Dikeos, D., Dina, C., Djurovic, S., Dmitrzak-Weglarz, M., Docampo-Martinez, E., Duriez, P., Egberts, K., Ehrlich, S., Eriksson, J. G., Escaramís, G., Esko, T., Estivill, X., Farmer, A., Fernández-Aranda, F., Fichter, M. M., Föcker, M., Foretova, L., Forstner, A. J., Frei, O., Gallinger, S., Giegling, I., Giuranna, J., Gonidakis, F., Gorwood, P., Gratacòs, M., Guillaume, S., Guo, Y., Hakonarson, H., Hauser, J., Havdahl, A., Hebebrand, J., Helder, S. G., Herms, S., Herpertz-Dahlmann, B., Herzog, W., Hinney, A., Hudson, J. I., Imgart, H., Jamain, S., Janout, V., Jiménez-Murcia, S., Jones, I. R., Julià, A., Kalsi, G., Kaminská, D., Kaprio, J., Karhunen, L., Kas, M. J., Keel, P. K., Kennedy, J. L., Keski-Rahkonen, A., Kiezebrink, K., Klareskog, L., Klump, K. L., Knudsen, G. P. S., La Via, M. C., Le Hellard, S., Leboyer, M., Li, D., Lilenfeld, L., Lin, B., Lissowska, J., Luykx, J., Magistretti, P., Maj, M., Marsal, S., Marshall, C. R., Mattingsdal, M., Meulenbelt, I., Micali, N., Mitchell, K. S., Monteleone, A. M., Monteleone, P., Myers, R., Navratilova, M., Ntalla, I., O'Toole, J. K., Ophoff, R. A., Padyukov, L., Pantel, J., Papežová, H., Pinto, D., Raevuori, A., Ramoz, N., Reichborn-Kjennerud, T., Ricca, V., Ripatti, S., Ripke, S., Ritschel, F., Roberts, M., Rotondo, A., Rujescu, D., Rybakowski, F., Scherag, A., Scherer, S. W., Schmidt, U., Scott, L. J., Seitz, J., Silén, Y., Šlachtová, L., Slagboom, P. E., Slof-Op 't Landt, M. C., Slopien, A., Sorbi, S., Świątkowska, B., Tortorella, A., Tozzi, F., Treasure, J., Tsitsika, A., Tyszkiewicz-Nwafor, M., Tziouvas, K., van Elburg, A. A., van Furth, E. F., Walton, E., Widen, E., Zerwas, S., Zipfel, S., Bergen, A. W., Boden, J. M., Brandt, H., Crawford, S., Halmi, K. A., Horwood, L. J., Johnson, C., Kaplan, A. S., Kaye, W. H., Mitchell, J. E., Olsen, C. M., Pearson, J. F., Pedersen, N. L., Strober, M., Werge, T., Whiteman, D. C., Woodside, D. B., Gordon, S., Maguire, S., Larsen, J. T., Parker, R., Petersen, L. V., Jordan, J., Kennedy, M., Wade, T. D., Birgegård, A., Lichtenstein, P., Landén, M., Martin, N. G., Mortensen, P. B., Breen, G. & Bulik, C. M., Oct 2022, In: Biological Psychiatry Global Open Science. 2, 4, p. 368-378 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

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• Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors

  Mullins, N., Kang, J., Campos, A. I., Coleman, J. R. I., Edwards, A. C., Galfalvy, H., Levey, D. F., Lori, A., Shabalin, A., Starnawska, A., Su, M.-H., Watson, H. J., Adams, M., Awasthi, S., Gandal, M., Hafferty, J. D., Hishimoto, A., Kim, M., Okazaki, S. & Otsuka, I. & 814 others, Ripke, S., Ware, E. B., Bergen, A. W., Berrettini, W. H., Bohus, M., Brandt, H., Chang, X., Chen, W. J., Chen, H.-C., Crawford, S., Crow, S., DiBlasi, E., Duriez, P., Fernández-Aranda, F., Fichter, M. M., Gallinger, S., Glatt, S. J., Gorwood, P., Guo, Y., Hakonarson, H., Halmi, K. A., Hwu, H.-G., Jain, S., Jamain, S., Jiménez-Murcia, S., Johnson, C., Kaplan, A. S., Kaye, W. H., Keel, P. K., Kennedy, J. L., Klump, K. L., Li, D., Liao, S.-C., Lieb, K., Lilenfeld, L., Liu, C.-M., Magistretti, P. J., Marshall, C. R., Mitchell, J. E., Monson, E. T., Myers, R. M., Pinto, D., Powers, A., Ramoz, N., Roepke, S., Rozanov, V., Scherer, S. W., Schmahl, C., Sokolowski, M., Strober, M., Thornton, L. M., Treasure, J., Tsuang, M. T., Witt, S. H., Woodside, D. B., Yilmaz, Z., Zillich, L., Adolfsson, R., Agartz, I., Air, T. M., Alda, M., Alfredsson, L., Andreassen, O. A., Anjorin, A., Appadurai, V., Soler Artigas, M., der Auwera, S. V., Azevedo, M. H., Bass, N., Bau, C. H. D., Baune, B. T., Bellivier, F., Berger, K., Biernacka, J. M., Bigdeli, T. B., Binder, E. B., Boehnke, M., Boks, M. P., Bosch, R., Braff, D. L., Bryant, R., Budde, M., Byrne, E. M., Cahn, W., Casas, M., Castelao, E., Cervilla, J. A., Chaumette, B., Cichon, S., Corvin, A., Craddock, N., Craig, D., Degenhardt, F., Djurovic, S., Edenberg, H. J., Fanous, A. H., Foo, J. C., Forstner, A. J., Frye, M., Fullerton, J. M., Gatt, J. M., Gejman, P. V., Giegling, I., Grabe, H. J., Green, M. J., Grevet, E. H., Grigoroiu-Serbanescu, M., Gutierrez, B., Guzman-Parra, J., Hamilton, S. P., Hamshere, M. L., Hartmann, A., Hauser, J., Heilmann-Heimbach, S., Hoffmann, P., Ising, M., Jones, I., Jones, L. A., Jonsson, L., Kahn, R. S., Kelsoe, J. R., Kendler, K. S., Kloiber, S., Koenen, K. C., Kogevinas, M., Konte, B., Krebs, M.-O., Landén, M., Lawrence, J., Leboyer, M., Lee, P. H., Levinson, D. F., Liao, C., Lissowska, J., Lucae, S., Mayoral, F., McElroy, S. L., McGrath, P., McGuffin, P., McQuillin, A., Medland, S. E., Mehta, D., Melle, I., Milaneschi, Y., Mitchell, P. B., Molina, E., Morken, G., Mortensen, P. B., Müller-Myhsok, B., Nievergelt, C. M., Nimgaonkar, V., Nöthen, M. M., O’Donovan, M. C., Ophoff, R. A., Owen, M. J., Pato, C., Pato, M. T., Penninx, B. W. J. H., Pimm, J., Pistis, G., Potash, J. B., Power, R. A., Preisig, M., Quested, D., Ramos-Quiroga, J. A., Reif, A., Ribasés, M., Richarte, V., Rietschel, M., Rivera, M., Roberts, A., Roberts, G., Rouleau, G. A., Rovaris, D. L., Rujescu, D., Sánchez-Mora, C., Sanders, A. R., Schofield, P. R., Schulze, T. G., Scott, L. J., Serretti, A., Shi, J., Shyn, S. I., Sirignano, L., Sklar, P., Smeland, O. B., Smoller, J. W., Sonuga-Barke, E. J. S., Spalletta, G., Strauss, J. S., Świątkowska, B., Trzaskowski, M., Turecki, G., Vilar-Ribó, L., Vincent, J. B., Völzke, H., Walters, J. T. R., Shannon Weickert, C., Weickert, T. W., Weissman, M. M., Williams, L. M., Wray, N. R., Zai, C. C., Ashley-Koch, A. E., Beckham, J. C., Hauser, E. R., Hauser, M. A., Kimbrel, N. A., Lindquist, J. H., McMahon, B., Oslin, D. W., Qin, X., Mattheisen, M., Abdellaoui, A., Adams, M. J., Agerbo, E., Andlauer, T. F. M., Bacanu, S.-A., Bækvad-Hansen, M., Beekman, A. T. F., Bryois, J., Buttenschøn, H. N., Bybjerg-Grauholm, J., Cai, N., Christensen, J. H., Clarke, T.-K., Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Crawford, G. E., Davies, G., Derks, E. M., Direk, N., Dolan, C. V., Dunn, E. C., Eley, T. C., Escott-Price, V., Hassan Kiadeh, F. F., Finucane, H. K., Frank, J., Gaspar, H. A., Gill, M., Goes, F. S., Gordon, S. D., Weinsheimer, S. M., Wellmann, J., Willemsen, G., Wu, Y., Xi, S., Yang, J., Zhang, F., Arolt, V., Boomsma, D. I., Dannlowski, U., de Geus, E. J. C., Depaulo, J. R., Domenici, E., Domschke, K., Esko, T., Grove, J., Hall, L. S., Hansen, C. S., Hansen, T. F., Herms, S., Hickie, I. B., Homuth, G., Horn, C., Hottenga, J.-J., Hougaard, D. M., Howard, D. M., Jansen, R., Jorgenson, E., Knowles, J. A., Kohane, I. S., Kraft, J., Kretzschmar, W. W., Kutalik, Z., Li, Y., Lind, P. A., MacIntyre, D. J., MacKinnon, D. F., Maier, R. M., Maier, W., Marchini, J., Mbarek, H., Middeldorp, C. M., Mihailov, E., Milani, L., Mondimore, F. M., Montgomery, G. W., Mostafavi, S., Nauck, M., Ng, B., Nivard, M. G., Nyholt, D. R., O’Reilly, P. F., Oskarsson, H., Hayward, C., Heath, A. C., Lewis, G., Li, Q. S., Madden, P. A. F., Magnusson, P. K., Martin, N. G., McIntosh, A. M., Metspalu, A., Mors, O., Nordentoft, M., Paciga, S. A., Pedersen, N. L., Painter, J. N., Pedersen, C. B., Pedersen, M. G., Peterson, R. E., Peyrot, W. J., Posthuma, D., Quiroz, J. A., Qvist, P., Rice, J. P., Riley, B. P., Mirza, S. 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