Photo of Sanna Lehtonen

Sanna Lehtonen

Professor

  • PL 21 (Haartmaninkatu 3)

    00014

    Finland

1993 …2020

Research output per year

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Personal profile

Description of research and teaching

Diabetic nephropathy, the serious renal complication of diabetes, starts with albuminuria and can lead to end stage renal disease. Insulin resistance is associated with an increased risk for the development of diabetic nephropathy. Interestingly, the glomerular epithelial cells or podocytes have recently been shown to be insulin responsive and to increase their glucose uptake upon insulin stimulation. It has also been shown that filamentous actin cytoskeleton is required for the insulin response and further, nephrin, a key structural component of podocytes, is essential for insulin action in these cells. Our group aims to characterize the pathophysiological mechanims involved in the early stages of diabetic nephropathy and the development of albuminuria. Specifically, we are interested in analyzing the role of insulin signaling and glucose transport and the regulation of actin cytoskeleton in podocytes.

Fields of Science

  • 3111 Biomedicine
  • kidney
  • podocyte
  • diabetic nephropathy

International and National Collaboration Publications and projects within past five years.

Publications

Elevated TLR5 expression in vivo and loss of NF-κΒ activation via TLR5 in vitro detected in HPV-negative oropharyngeal squamous cell carcinoma

Kylmä, A. K., Tolvanen, T. A., Carpén, T., Haglund, C., Mäkitie, A., Mattila, P. S., Grenman, R., Jouhi, L., Sorsa, T., Lehtonen, S. & Hagström, J., 30 Mar 2020, In : Experimental and Molecular Pathology.

Research output: Contribution to journalArticleScientificpeer-review

Novel Sulfonanilide Inhibitors of SHIP2 Enhance Glucose Uptake into Cultured Myotubes

Berg, M. E. A., Naams, J-B., Hautala, L., Tolvanen, T., Ahonen, J., Lehtonen, S. & Wähälä, K., 28 Jan 2020, In : ACS Omega. 5, 3, p. 1430-1438 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

SHIPping out diabetes-Metformin, an old friend among new SHIP2 inhibitors

Lehtonen, S., Jan 2020, In : Acta Physiologica. 228, 1, 22 p., 13349.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1 alpha PARylation in db/db mice

Wang, H., Kuusela, S., Rinnankoski-Tuikka, R., Dumont, V., Bouslama, R., Ramadan, U. A., Waaler, J., Linden, A-M., Chi, N-W., Krauss, S., Pirinen, E. & Lehtonen, S., 21 Apr 2020, In : International Journal of Obesity. 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Editorial: Podocyte Pathology and Nephropathy-An Update

Lehtonen, S. & Lewko, B., 30 Jul 2019, In : Frontiers in Endocrinology. 10, 3 p., 528.

Research output: Contribution to journalEditorialScientificpeer-review

Open Access
File

Projects

Activities

Press / Media

Short communication in Duodecim, section In press

Sanna Lehtonen

21/12/2018

1 Media contribution

Press/Media: Press / Media

Interview in Helsingin Sanomat

Sanna Lehtonen

25/10/2018

1 Media contribution

Press/Media: Press / Media

Interview in Apteekkari, section Lääkeuutiset

Sanna Lehtonen

15/12/2017

1 Media contribution

Press/Media: Press / Media

Interview for Europa-newsletter Ajassa

Sanna Lehtonen

01/01/2016

1 Media contribution

Press/Media: Press / Media

Interview at MTV-lava, Pori

Sanna Lehtonen

15/07/2015

1 Media contribution

Press/Media: Press / Media