1993 …2019
If you made any changes in Pure these will be visible here soon.

Personal profile

Description of research and teaching

Diabetic nephropathy, the serious renal complication of diabetes, starts with albuminuria and can lead to end stage renal disease. Insulin resistance is associated with an increased risk for the development of diabetic nephropathy. Interestingly, the glomerular epithelial cells or podocytes have recently been shown to be insulin responsive and to increase their glucose uptake upon insulin stimulation. It has also been shown that filamentous actin cytoskeleton is required for the insulin response and further, nephrin, a key structural component of podocytes, is essential for insulin action in these cells. Our group aims to characterize the pathophysiological mechanims involved in the early stages of diabetic nephropathy and the development of albuminuria. Specifically, we are interested in analyzing the role of insulin signaling and glucose transport and the regulation of actin cytoskeleton in podocytes.

Keywords

  • 3111 Biomedicine
  • kidney
  • podocyte
  • diabetic nephropathy

International and National Collaboration Publications and projects within past five years.

Publications 1993 2019

Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity

Polianskyte-Prause, Z., Tolvanen, T. A., Lindfors, S., Dumont, V., Van, M., Wang, H., Dash, S. N., Berg, M., Naams, J-B., Hautala, L. C., Nisen, H., Mirtti, T., Groop, P-H., Wähälä, K., Tienari, J. & Lehtonen, S., Feb 2019, In : FASEB Journal. 33, 2, p. 2858-2869 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Glucose Transporters in Diabetic Kidney Disease-Friends or Foes?

Wasik, A. A. & Lehtonen, S., 9 Apr 2018, In : Frontiers in Endocrinology. 9, 12 p., 155.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis

Saurus, P., Tolvanen, T. A., Lindfors, S., Kuusela, S., Holthofer, H., Lehtonen, E. & Lehtonen, S., 6 Sep 2017, In : Scientific Reports. 7, 14 p., 10731.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Metformin and the catalytic activity of SHIP2

Berg, M. E. A., Tolvanen, T. A., Polianskyte-Prause, Z., Lindfors, S. H., Wähälä, K. & Lehtonen, S. H., 27 Aug 2017, p. 125. 1 p.

Research output: Conference materialsPosterResearch

PACSIN2 accelerates nephrin trafficking and is up-regulated in diabetic kidney disease

Dumont, V., Tolvanen, T. A., Kuusela, S., Wang, H., Nyman, T. A., Lindfors, S., Tienari, J., Nisén, H., Suetsugu, S., Plomann, M., Kawachi, H. & Lehtonen, S., Sep 2017, In : FASEB Journal. 31, 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Projects 2017 2019

SHIBNESS: Business from SHIP2 inhibitors TEKES

Lehtonen, S. H. & Wähälä, K.

01/09/201731/08/2019

Project: Research project

Activities 1991 2019

The Paulo Foundation (External organisation)

Sanna Lehtonen (Board member)
2019 → …

Activity: Membership typesMembership or other role in national/international committee, council, board

Amr Elseragy's thesis supervisory board member

Sanna Lehtonen (Supervisor)
2019 → …

Activity: Examination typesMember of doctoral thesis committee / follow-up group

Evaluator, final examination/Amudhala Karthik, TRANSMED MSc programme (Event)

Sanna Lehtonen (Board member)
11 Jun 2018

Activity: Membership typesMembership or other role in review committee

thesis supervisor of Rim Bouslama

Sanna Lehtonen (Supervisor)
2018 → …

Activity: Examination typesSupervisor or co-supervisor of doctoral thesis

Press / Media

Short communication in Duodecim, section In press

Sanna Helena Lehtonen

21/12/2018

1 media contribution

Press/Media: Press / Media

Interview in Helsingin Sanomat

Sanna Helena Lehtonen

25/10/2018

1 media contribution

Press/Media: Press / Media

Interview in Apteekkari, section Lääkeuutiset

Sanna Helena Lehtonen

15/12/2017

1 media contribution

Press/Media: Press / Media

Interview for Europa-newsletter Ajassa

Sanna Helena Lehtonen

01/01/2016

1 media contribution

Press/Media: Press / Media

Interview at MTV-lava, Pori

Sanna Helena Lehtonen

15/07/2015

1 media contribution

Press/Media: Press / Media