Research output per year
Research output per year
Personal profile
Research interests
Sarah O’Keefe is a postdoctoral researcher at the University of Helsinki with over ten years of experience working at the biology/chemistry interface; first as a medicinal chemist and later as a biochemist and cell biologist. Sarah joined the University in 2022 to investigate how proteins are synthesised at the endoplasmic reticulum in parasites that infect and cause disease in humans. She uses biochemical, chemical and structural biology approaches to develop small molecule inhibitors that can be used to probe the mechanisms of parasitic protein production. These molecules are leads for the development of new drugs to treat parasitic diseases, such as leishmaniasis and malaria.
Education/Academic qualification
Biochemistry, PhD, Small molecule inhibitors targeting protein biogenesis at the endoplasmic reticulum, University of Manchester
Sept 2015 → Sept 2019
Medicinal Chemistry, MChem, Chemistry with Medicinal Chemistry, University of Manchester
Sept 2010 → Jul 2015
Fields of Science
- 1182 Biochemistry, cell and molecular biology
International and National Collaboration
Publications and projects within past five years.
-
Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis
Chang, J., Pickard, A., Herrera, J., O'Keefe, S., Hartshorn, M., Garva, R., Hoyle, A., Dingle, L., Zeltz, C., Wong, J., Reid, A., Venkateswaran, R., Lu, Y., Caswell, P., High, S., Gullberg, D. & Kadler, K., 3 Apr 2024, In: eLife.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access -
Dual action of eeyarestatin 24 on Sec-dependent protein secretion and bacterial DNA
Schäfer, A.-B., Steenhuis, M., Jim, K., Neef, J., O'Keefe, S., Whitehead, R., Swanton, E., Wang, B., Halbedel, S., High, S., van Dijl, J., Luirink, J. & Wenzel, M., 13 Jan 2023, In: ACS Infectious Diseases. 9, 2, p. 253-269 17 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity
Stewart, H., Lu, Y., O'Keefe, S., Valpadashi, A., Cruz-Zaragoza, L., Michel, H., Nguyen, S., Carnell, G., Lukhovitskaya, N., Milligan, R., Jungreis, I., Lulla, V., Davidson, A., Matthews, D., High, S., Rehling, P., Emmott, E., Heeney, J., Edgar, J. & Smith, G. & 1 others, , 17 Nov 2023, In: iScience. 26, 11Research output: Contribution to journal › Article › Scientific › peer-review
Open Access -
Proteomics identifies substrates and a novel component in hSnd2-dependent ER protein targeting
Tirincsi, A., O'Keefe, S., Nguyen, D., Sicking, M., Dudek, J., Förster, F., Jung, M., Hadzibeganovic, D., Helms, V., High, S., Zimmermann, R. & Lang, S., 19 Sept 2022, In: Cells. 11, 18, 34 p., 2925.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access -
Synthesis, Biological Evaluation and Docking Studies of Ring-Opened Analogues of Ipomoeassin F
O'Keefe, S., Bhadra, P., Duah, K. B., Zong, G., Tenay, L., Andrews, L. E., Schneider, H., Anderson, A., Hu, Z., Aljewari, H., Hall, B., Simmonds, R., Helms, V., High, S. & Shi, W. Q., 10 Jul 2022, In: Molecules. 27, 14, 21 p., 4419.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
Projects
- 5 Active
-
Instruct-ERIC pilot R&D / O'Keefe Sarah
O'Keefe, S. (Project manager)
Instruct-ERIC Hub Oxford House
01/08/2024 → 31/07/2025
Project: Other funder
-
Battersby SKR
Battersby, B. (Project manager) & O'Keefe, S. (Project manager)
01/03/2024 → 28/02/2026
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
-
MITOGUARDER
Battersby, B. (Project manager), O'Keefe, S. (Project manager), Juhola, L. M. (Participant), Ng, K. Y. (Participant) & Quirin, T. (Participant)
Innovaatiorahoituskeskus Business Finland
01/01/2024 → 31/12/2025
Project: Business Finland
-
ER proteiinihomeostaasin säätely tutkiminen kemiallisen biologian keinoin
Paavilainen, V. (Project manager), Hyytinen, M. (Participant), Kiesewetter, L. (Participant), Nordlin, K. P. (Participant), O'Keefe, S. (Participant) & Tranter, D. (Participant)
Suomen Akatemia Projektilaskutus
01/09/2021 → 31/08/2025
Project: Research Council of Finland: Academy Project
-
Jane ja Aatos Erkon säätiö/Paavilainen
Paavilainen, V. (Project manager), Andelkovic, A. (Participant), Collin, P. M. (Participant), Dekere, Z. (Participant), Green, M. (Participant), Hyytinen, M. (Participant), Karki, S. (Participant), Kellosalo, J. (Participant), Nanekar, R. (Participant), O'Keefe, S. (Participant), Paatero, A. (Participant), Rosti, K. (Participant) & Tranter, D. (Participant)
01/09/2020 → 31/12/2025
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)