Research output per year
Research output per year
Personal profile
Description of research and teaching
https://www.helsinki.fi/en/researchgroups/synaptic-plasticity-and-development
My research group focuses on studying the molecular mechanisms guiding activity-dependent development of glutamatergic circuitry in the limbic system and in particular, the roles of ionotropic glutamate receptors in this process. So far, we have identified several novel features related to functions and regulation of AMPA and kainate-type glutamate receptors at the developing synapses. Our current research aims to understand in detail how these mechanisms contribute to development and fine-tuning of the neural circuits underlying behavior under physiological and aberrant conditions, such as early life stress.
Our experimental approach involves the use of in vitro electrophysiological techniques in combination with pharmacological and local genetic manipulation in various neuronal preparations.
Fields of Science
- 3112 Neurosciences
International and National Collaboration
Publications and projects within past five years.
-
Aberrant cortical projections to amygdala GABAergic neurons contribute to developmental circuit dysfunction following early life stress
Haikonen, J., Englund, J., Amarilla, S. P., Kharybina, Z., Shintyapina, A., Kegler, K., Garcia, M. S., Atanasova, T., Taira, T., Hartung, H. & Lauri, S. E., 20 Jan 2023, In: iScience. 26, 1, 105724.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access -
Activation of TrkB in Parvalbumin interneurons is required for the promotion of reversal learning in spatial and fear memory by antidepressants
Jetsonen, E., Didio, G., Winkel, F., Pou, M. L., Boj, C., Kuczynski-Noyau, L., Voikar, V., Guirado, R., Taira, T., Lauri, S. E., Castren, E. & Umemori, J., Mar 2023, (E-pub ahead of print) In: Neuropsychopharmacology. 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access -
Antidepressant drugs act by directly binding to TRKB neurotrophin receptors
Casarotto, P. C., Girych, M., Fred, S. M., Kovaleva, V., Moliner, R., Enkavi, G., Biojone, C., Cannarozzo, C., Sahu, M. P., Kaurinkoski, K., Brunello, C. A., Steinzeig, A., Winkel, F., Patil, S., Vestring, S., Serchov, T., Diniz, C. R. A. F., Laukkanen, L., Cardon, I., Antila, H., & 8 others, 4 Mar 2021, In: Cell. 184, 5, p. 1299-+ 34 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Downregulation of kainate receptors regulating GABAergic transmission in amygdala after early life stress is associated with anxiety-like behavior in rodents
Englund, J., Haikonen, J., Shteinikov, V., Amarilla, S. P., Atanasova, T., Shintyapina, A., Ryazantseva, M., Partanen, J., Voikar, V. & Lauri, S. E., 18 Oct 2021, In: Translational Psychiatry. 11, 1, 15 p., 538.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Kainate receptors in the developing neuronal networks
Lauri, S. E., Ryazantseva, M., Orav, E., Vesikansa, A. & Taira, T., 1 Sep 2021, In: Neuropharmacology. 195, 14 p., 108585.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile
Activities
-
Post doctoral mentor: JUn Kyu Rhee
Sari Lauri (Supervisor)
2022 → …Activity: Examination types › Post doctoral mentor
-
pre-examination of doctoral thesis: Iina Korkka
Sari Lauri (Supervisor)
2021Activity: Examination types › Pre-examiner of doctoral thesis
-
Cells (Journal)
Sari Lauri (Member of editorial board)
2020 → …Activity: Publication peer-review and editorial work types › Editor of research journal
-
Supervisor of doctoral thesis: Vasilii Shteinikov
Sari Lauri (Supervisor)
2020 → …Activity: Examination types › Supervisor or co-supervisor of doctoral thesis
-
Post-doctoral mentor: Paola Amarilla
Sari Lauri (Supervisor)
2020 → 2021Activity: Examination types › Post doctoral mentor
Press/Media
-
-UNIVERSITY OF HELSINKI: Eero Castren and Sari Lauri appointed as research directors for Neuroscience Center
30/04/2021
1 item of Media coverage
Press/Media: Press / Media
-
Eero Castrén and Sari Lauri appointed as research directors for Neuroscience Center
29/04/2021
1 item of Media coverage
Press/Media: Press / Media