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Personal profile

Description of research and teaching

https://www.helsinki.fi/en/researchgroups/synaptic-plasticity-and-development

 

My research group focuses on studying the molecular mechanisms guiding activity-dependent development of glutamatergic circuitry in the limbic system and in particular, the roles of ionotropic glutamate receptors in this process. So far, we have identified several novel features related to functions and regulation of AMPA and kainate-type glutamate receptors at the developing synapses. Our current research aims to understand in detail how these mechanisms contribute to development and fine-tuning of the neural circuits underlying behavior under physiological and aberrant conditions, such as early life stress.  

Our experimental approach involves the use of in vitro electrophysiological techniques in combination with pharmacological and local genetic manipulation in various neuronal preparations.

 

 

Keywords

  • 3112 Neurosciences

International and National Collaboration Publications and projects within past five years.

Publications 1993 2019

GluA4 Dependent Plasticity Mechanisms Contribute to Developmental Synchronization of the CA3-CA1 Circuitry in the Hippocampus

Atanasova, T., Kharybina, Z., Kaarela, T. A. M., Huupponen, J. T., Luchkina, N., Taira, T. P. & Lauri, S. E., Mar 2019, In : Neurochemical Research. 44, 3, p. 562–571 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Plasma etched carbon microelectrode arrays for bioelectrical measurements

Heikkinen, J. J., Kaarela, T., Ludwig, A., Sukhanova, T., Khakipoor, S., Kim, S. I., Han, J. G., Huttunen, H. J., Rivera, C., Lauri, S. E., Taira, T., Jokinen, V. & Franssila, S., Nov 2018, In : Diamond and Related Materials. 90, p. 126-134 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Depolarizing γ-aminobutyric acid contributes to glutamatergic network rewiring in epilepsy

Kourdougli, N., Pellegrino, C., Renko, J-M., Khirug, S., Chazal, G., Kukko-Lukjanov, T-K., Lauri, S. E., Gaiarsa, J-L., Zhou, L., Peret, A., Castrén, E., Tuominen, R. K., Crepel, V. & Rivera Baeza, C., Feb 2017, In : Annals of Neurology. 81, 2, p. 251-265 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

Antila, H., Ryazantseva, M., Popova, D., Sipilä, P., Guirado, R., Kohtala, S., Yalcin, I., Lindholm, J., Vesa, L., Sato, V., Cordeira, J., Autio, H., Kislin, M., Rios, M., Joca, S., Casarotto, P., Khiroug, L., Lauri, S., Taira, T., Castren, E. & 1 othersRantamäki, T., 10 Aug 2017, In : Scientific Reports. 7, 12 p., 7811.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Molecular mechanisms controlling synaptic recruitment of GluA4 subunit-containing AMPA-receptors critical for functional maturation of CA1 glutamatergic synapses

Luchkina, N. V., Coleman, S. K., Huupponen, J., Cai, C., Kivistö, A., Taira, T., Keinänen, K. & Lauri, S. E., Jan 2017, In : Neuropharmacology. 112, p. 46-56 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Activities 2004 2019

Nordic Neuroscience

Sari Lauri (Member of organizing committee)
12 Jun 201914 Jun 2019

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Supervisor, MSc thesis: Marta Saez-Garcia

Sari Lauri (Supervisor)
2018

Activity: Examination typesSupervision of other thesis (Master's, Licentiate)

Society of Biological Psychiatry and the 61st Annual Meeting of the Japanese Society for Neurochemistry

Juzoh Umemori (Speaker: Presenter), Frederike Winkel (Attendee), Giuliano Didio (Attendee), Maria Llach Pou (Attendee), Hanna Antila (Attendee), Chloé Buj (Attendee), Ramon Guirado (Attendee), Tomi Petteri Taira (Attendee), Sari Elina Lauri (Attendee), Eero Castrén (Attendee)
6 Sep 20188 Sep 2018

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Member of the thesis committee

Sari Lauri (Member of thesis committee / follow-up group)
2018 → …

Activity: Examination typesMember of doctoral thesis committee / follow-up group

Supervisor of doctoral thesis : Simo Ojanen

Sari Lauri (Supervisor)
2018 → …

Activity: Examination typesSupervisor or co-supervisor of doctoral thesis