Research output per year
Research output per year
Personal profile
Curriculum vitae
Background and interests: Vascular biologist / genetic engineer. Interested in organ-specific characteristics blood and lymphatic vasculature in development and disease.
Keywords: Obesity; diabetes; blood and lymphatic vessels; inflammation; vascular leakage; intravital imaging; single-cell and bulk RNA sequencing.
See ORCID record for all (45) publications: https://orcid.org/0000-0002-0719-1773
Education information
B.Sc. Molecular Biology and Genetics, Istanbul Technical University, 2006
M.Sc. Molecular Biology-Genetics & Biotechnology, Istanbul Technical University, 2008
Dr. sc. ETH Zurich (Ph.D.) Swiss Federal Institute of Technology Zurich (ETH Zurich), 2012
Docent of Cell and Molecular Biology, Faculty of Medicine, University of Helsinki, 2018
Education/Academic qualification
Ph.D., Docent
External positions
Principal Investigator, Wihuri Reasearch Institute
1 Sept 2020 → …
Team Leader, Wihuri Research Institute
1 Feb 2018 → 31 Aug 2020
Fields of Science
- 3111 Biomedicine
- 1182 Biochemistry, cell and molecular biology
International and National Collaboration
Publications and projects within past five years.
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Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology
Antila, S., Chilov, D., Nurmi, H., Li, Z., Näsi, A., Gotkiewicz, M., Sitnikova, V., Jäntti, H., Acosta, N., Koivisto, H., Ray, J., Keuters, M. H., Sultan, I., Scoyni, F., Trevisan, D., Wojciechowski, S., Kaakinen, M., Dvořáková, L., Singh, A., Jukkola, J., & 7 others, 2024, In: Nature Cardiovascular Research. 3, p. 474–491 41 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Bexmarilimab-induced macrophage activation leads to treatment benefit in solid tumors: The phase I/II first-in-human MATINS trial
Rannikko, J. H., Verlingue, L., de Miguel, M., Pasanen, A., Robbrecht, D., Skytta, T., Iivanainen, S., Shetty, S., Ma, Y. T., Graham, D. M., Arora, S. P., Jaakkola, P., Yap, C., Xiang, Y., Mandelin, J., Karvonen, M. K., Jalkanen, J., Karaman, S., Koivunen, J. P., Minchom, A., & 2 others, 19 Dec 2023, In: Cell Reports Medicine. 4, 12, 17 p., 101307.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation
Li, Z., Antila, S., Nurmi, H., Chilov, D., Korhonen, E. A., Fang, S., Karaman, S., Engelhardt, B. & Alitalo, K., 14 Apr 2023, In: Science immunology. 8, 82, 18 p., eabq0375.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
DLL4/Notch3/WNT5B axis mediates bidirectional prometastatic crosstalk between melanoma and lymphatic endothelial cells
Alve, S., Gramolelli, S., Jukonen, J., Juteau, S., Pink, A., Manninen, A. A., Hänninen, S., Monto, E., Lackman, M. H., Carpen, O., Saharinen, P., Karaman, S., Vaahtomeri, K. & Ojala, P. M., 16 Nov 2023, In: JCI INSIGHT. 9, 1, 21 p., e171821.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium
Anisimov, A., Fang, S., Hemanthakumar, K. A., Örd, T., van Avondt, K., Chevre, R., Toropainen, A., Singha, P., Gilani, H., Nguyen, S. D., Karaman, S., Korhonen, E. A., Adams, R. H., Augustin, H. G., Öörni, K., Soehnlein, O., Kaikkonen, M. U. & Alitalo, K., 2023, In: Nature Cardiovascular Research. 2, 3, p. 307-321 15 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile
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Endothelial regulation of adipocyte phenotypes
01/09/2024 → 31/08/2028
Project: Research Council of Finland: Academy Project
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Adipose tissue endothelial cells in obesity: mechanisms of vessel dysfunction and capillary rarefaction
Karaman, S., Mäkelä, A., Paavonsalo, S. P., Pakarinen, E. & Yildiz, S.
Suomen Akatemia Projektilaskutus
01/09/2023 → 31/08/2025
Project: Research Council of Finland: Academy Research Fellow's research expenses
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DIABETES FOUNDATION 2023 KARAMAN SINEM
Karaman, S., Neupane, N. & Yildiz, S.
01/07/2023 → 31/12/2024
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
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JUSELIUS 2023 KARAMAN SINEM
01/05/2023 → 31/12/2024
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
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WALDEMAR VON FRENCKELL 2023/LACKMAN MADE
Waldemar von Frenckells stiftelse c/o Nordea Private Banking
01/06/2023 → 29/02/2024
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
Prizes
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Academy Research Fellow: Research costs
Karaman, Sinem (Recipient), Sept 2020
Prize: Prizes and awards
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Early Career Researcher (Faculty of Medicine)
Karaman, Sinem (Recipient), Nov 2018
Prize: Prizes and awards
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Activities
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Emma Viittala's thesis supervisory board member
Sinem Karaman (Supervisor)
2023 → …Activity: Examination types › Member of doctoral thesis committee / follow-up group
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Pre-examiner of Sina Tadayon's doctoral thesis
Sinem Karaman (Supervisor)
15 Feb 2022 → 8 Mar 2022Activity: Examination types › Pre-examiner of doctoral thesis
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Invited talk at Bioscience Research Group Seminar at University of Hertfordshire - Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance
Sinem Karaman (Speaker)
23 Feb 2022Activity: Talk or presentation types › Invited talk
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Supervising Erasmus+ intern Gizem Demirci
Sinem Karaman (Teacher)
29 Jul 2022 → 21 Oct 2022Activity: Other activity types › Types for other activities - Other
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Supervising Erasmus+ intern Selvin Yildiz
Sinem Karaman (Teacher)
5 Aug 2022 → 1 Nov 2022Activity: Other activity types › Types for other activities - Other