Research output per year
Research output per year
Personal profile
Curriculum vitae
Background and interests: Vascular biologist / genetic engineer. Interested in organ-specific characteristics blood and lymphatic vasculature in development and disease.
Keywords: Obesity; diabetes; blood and lymphatic vessels; inflammation; vascular leakage; intravital imaging; single-cell and bulk RNA sequencing.
See ORCID record for all (47) publications: https://orcid.org/0000-0002-0719-1773
Education information
B.Sc. Molecular Biology and Genetics, Istanbul Technical University, 2006
M.Sc. Molecular Biology-Genetics & Biotechnology, Istanbul Technical University, 2008
Dr. sc. ETH Zurich (Ph.D.) Swiss Federal Institute of Technology Zurich (ETH Zurich), 2012
Docent of Cell and Molecular Biology, Faculty of Medicine, University of Helsinki, 2018
Education/Academic qualification
Ph.D., Docent
External positions
Principal Investigator, Wihuri Reasearch Institute
1 Sept 2020 → …
Team Leader, Wihuri Research Institute
1 Feb 2018 → 31 Aug 2020
Fields of Science
- 3111 Biomedicine
- 1182 Biochemistry, cell and molecular biology
International and National Collaboration
Publications and projects within past five years.
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Multi-omics characterization of lymphedema-induced adipose tissue resulting from breast cancer-related surgery
Karaman, S., Lehti, S., Zhang, C., Taskinen, M.-R., Käkelä, R., Mardinoglu, A., Brorson, H., Alitalo, K. & Kivelä, R., 31 Oct 2024, In: FASEB Journal. 38, 20, 13 p., e70097.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology
Antila, S., Chilov, D., Nurmi, H., Li, Z., Näsi, A., Gotkiewicz, M., Sitnikova, V., Jäntti, H., Acosta, N., Koivisto, H., Ray, J., Keuters, M. H., Sultan, I., Scoyni, F., Trevisan, D., Wojciechowski, S., Kaakinen, M., Dvořáková, L., Singh, A. & Jukkola, J. & 7 others, , 2024, In: Nature Cardiovascular Research. 3, p. 474–491 41 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Bexmarilimab-induced macrophage activation leads to treatment benefit in solid tumors: The phase I/II first-in-human MATINS trial
Rannikko, J. H., Verlingue, L., de Miguel, M., Pasanen, A., Robbrecht, D., Skytta, T., Iivanainen, S., Shetty, S., Ma, Y. T., Graham, D. M., Arora, S. P., Jaakkola, P., Yap, C., Xiang, Y., Mandelin, J., Karvonen, M. K., Jalkanen, J., Karaman, S., Koivunen, J. P. & Minchom, A. & 2 others, , 19 Dec 2023, In: Cell Reports Medicine. 4, 12, 17 p., 101307.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation
Li, Z., Antila, S., Nurmi, H., Chilov, D., Korhonen, E. A., Fang, S., Karaman, S., Engelhardt, B. & Alitalo, K., 14 Apr 2023, In: Science immunology. 8, 82, 18 p., eabq0375.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
DLL4/Notch3/WNT5B axis mediates bidirectional prometastatic crosstalk between melanoma and lymphatic endothelial cells
Alve, S., Gramolelli, S., Jukonen, J., Juteau, S., Pink, A., Manninen, A. A., Hänninen, S., Monto, E., Lackman, M. H., Carpen, O., Saharinen, P., Karaman, S., Vaahtomeri, K. & Ojala, P. M., 16 Nov 2023, In: JCI INSIGHT. 9, 1, 21 p., e171821.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile
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FINSKA LÄKARESÄLLSKAPET 2025/LACKMAN MAD
Karaman, S. (Project manager)
01/01/2025 → 31/08/2026
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
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ÅLANDS KS 10/25 LACKMAN
Karaman, S. (Project manager)
Stiftelsen Ålandsfonden för Östersjöns framtid c/o Hotell Arkipelag
01/11/2024 → 31/10/2025
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
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Endothelial regulation of adipocyte phenotypes
Karaman, S. (Project manager) & Neupane, N. (Participant)
01/09/2024 → 31/08/2028
Project: Research Council of Finland: Academy Project
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Adipose tissue endothelial cells in obesity: mechanisms of vessel dysfunction and capillary rarefaction
Karaman, S. (Project manager), Mäkelä, A. (Participant), Neupane, N. (Participant), Paavonsalo, S. P. (Participant), Pakarinen, E. (Participant) & Yildiz, S. (Participant)
Suomen Akatemia Projektilaskutus
01/09/2023 → 31/08/2025
Project: Research Council of Finland: Academy Research Fellow's research expenses
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JUSELIUS 2023 KARAMAN SINEM
Karaman, S. (Project manager)
Sigrid Juséliuksen Säätiö @003701165704@
01/05/2023 → 31/12/2026
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
Prizes
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Early Career Researcher (Faculty of Medicine)
Karaman, S. (Recipient), Nov 2018
Prize: Prizes and awards
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Activities
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Invited talk at Pharmacology Seminar – Organotypic responses of capillaries in metabolic diseases
Karaman, S. (Speaker)
15 Mar 2024Activity: Talk or presentation types › Invited talk
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Pre-examiner of Mustafa Beter's doctoral thesis
Karaman, S. (Supervisor)
10 Jan 2024 → 28 Feb 2024Activity: Examination types › Pre-examiner of doctoral thesis
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Wen Manqing's thesis supervisory board member
Karaman, S. (Supervisor)
2024 → …Activity: Examination types › Member of doctoral thesis committee / follow-up group
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Emma Viittala's thesis supervisory board member
Karaman, S. (Supervisor)
2023 → …Activity: Examination types › Member of doctoral thesis committee / follow-up group
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Invited talks at Metabolism seminar – Organotypic responses of endothelial cells to metabolic challenges
Karaman, S. (Speaker), Subashi, Y. (Speaker) & Lackman, M. H. (Speaker)
20 Dec 2023Activity: Talk or presentation types › Invited talk