Sinem Karaman

Academy Research Fellow, Title of Docent (Cell and Molecular Biology), Principal Investigator

Title of Docent, Medicum
Academy Research Fellow, INDIVIDRUG - Individualized Drug Therapy
Organotypic Vasculature Lab
Supervisor for doctoral programme, Doctoral Programme in Integrative Life Science
Supervisor for doctoral programme, Doctoral Programme in Biomedicine

https://orcid.org/0000-0002-0719-1773

Phone+358504486436, +358294125526
Emailsinem.karamanhelsinkifi

PL 63 (Haartmaninkatu 8)
00014
Finland
Finland

Research activity per year

22 Article
4 Review Article
1 Chapter
1 Meeting Abstract

28 results

2024

Multi-omics characterization of lymphedema-induced adipose tissue resulting from breast cancer-related surgery
Karaman, S., Lehti, S., Zhang, C., Taskinen, M.-R., Käkelä, R., Mardinoglu, A., Brorson, H., Alitalo, K. & Kivelä, R., 31 Oct 2024, In: FASEB Journal. 38, 20, 13 p., e70097.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
Sustained meningeal lymphatic vessel atrophy or expansion does not alter Alzheimer’s disease-related amyloid pathology
Antila, S., Chilov, D., Nurmi, H., Li, Z., Näsi, A., Gotkiewicz, M., Sitnikova, V., Jäntti, H., Acosta, N., Koivisto, H., Ray, J., Keuters, M. H., Sultan, I., Scoyni, F., Trevisan, D., Wojciechowski, S., Kaakinen, M., Dvořáková, L., Singh, A. & Jukkola, J. & 7 others, Korvenlaita, N., Eklund, L., Koistinaho, J., Karaman, S., Malm, T., Tanila, H. & Alitalo, K., 2024, In: Nature Cardiovascular Research. 3, p. 474–491 41 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
2023

Bexmarilimab-induced macrophage activation leads to treatment benefit in solid tumors: The phase I/II first-in-human MATINS trial
Rannikko, J. H., Verlingue, L., de Miguel, M., Pasanen, A., Robbrecht, D., Skytta, T., Iivanainen, S., Shetty, S., Ma, Y. T., Graham, D. M., Arora, S. P., Jaakkola, P., Yap, C., Xiang, Y., Mandelin, J., Karvonen, M. K., Jalkanen, J., Karaman, S., Koivunen, J. P. & Minchom, A. & 2 others, Hollmén, M. & Bono, P., 19 Dec 2023, In: Cell Reports Medicine. 4, 12, 17 p., 101307.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
Blockade of VEGFR3 signaling leads to functional impairment of dural lymphatic vessels without affecting autoimmune neuroinflammation
Li, Z., Antila, S., Nurmi, H., Chilov, D., Korhonen, E. A., Fang, S., Karaman, S., Engelhardt, B. & Alitalo, K., 14 Apr 2023, In: Science immunology. 8, 82, 18 p., eabq0375.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
DLL4/Notch3/WNT5B axis mediates bidirectional prometastatic crosstalk between melanoma and lymphatic endothelial cells
Alve, S., Gramolelli, S., Jukonen, J., Juteau, S., Pink, A., Manninen, A. A., Hänninen, S., Monto, E., Lackman, M. H., Carpen, O., Saharinen, P., Karaman, S., Vaahtomeri, K. & Ojala, P. M., 16 Nov 2023, In: JCI INSIGHT. 9, 1, 21 p., e171821.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
PACSIN2 Regulates the Inflammatory Response in Diabetic Kidney Disease
Bouslama, R., Polianskyte-Prause, Z., Lehtonen, E., Subashi, Y., Lindfors, S. H., Karaman, S., Plomann, M. & Lehtonen, S., 2023, In: Journal of the American Society of Nephrology. 34, 11S, p. 836-836 1 p.
Research output: Contribution to journal › Meeting Abstract › peer-review
The angiopoietin receptor Tie2 is atheroprotective in arterial endothelium
Anisimov, A., Fang, S., Hemanthakumar, K. A., Örd, T., van Avondt, K., Chevre, R., Toropainen, A., Singha, P., Gilani, H., Nguyen, S. D., Karaman, S., Korhonen, E. A., Adams, R. H., Augustin, H. G., Öörni, K., Soehnlein, O., Kaikkonen, M. U. & Alitalo, K., 2023, In: Nature Cardiovascular Research. 2, 3, p. 307-321 15 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
Whole-mount immunofluorescence staining of blood and lymphatic vessels in murine small intestine
Paavonsalo, S. P., Subashi, Y., Lackman, M. H. & Karaman, S., 16 Jun 2023, In: STAR protocols. 4, 2, 15 p., 102310.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
2022

A closer look at adipose tissue lymphatics and their markers
Lackman, M. H., Subashi, Y. & Karaman, S., May 2022, In: Current Opinion in Hematology. 29, 3, p. 144-150 7 p.
Research output: Contribution to journal › Review Article › peer-review

Open Access
File
Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance
Karaman, S., Paavonsalo, S., Heinolainen, K., Lackman, M. H., Ranta, A., Hemanthakumar, K. A., Kubota, Y. & Alitalo, K., 20 Jan 2022, In: Journal of Experimental Medicine. 219, 3, 25 p., 20210565.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
VEGF-C/VEGFR-3 signalling in macrophages ameliorates acute lung injury
Yamashita, M., Niisato, M., Kawasaki, Y., Karaman, S., Robciuc, M. R., Shibata, Y., Ishida, Y., Nishio, R., Masuda, T., Sugai, T., Ono, M., Tuder, R. M., Alitalo, K. & Yamauchi, K., 1 Apr 2022, In: European Respiratory Journal. 59, 4, 12 p., 2100880.
Research output: Contribution to journal › Article › Scientific › peer-review
2021

3-hydroxy-L-kynurenamine is an immunomodulatory biogenic amine
Clement, C. C., D'Alessandro, A., Thangaswamy, S., Chalmers, S., Furtado, R., Spada, S., Mondanelli, G., Ianni, F., Gehrke, S., Gargaro, M., Manni, G., Lopez Cara, L. C., Runge, P., Tsai, W. L., Karaman, S., Arasa, J., Fernandez-Rodriguez, R., Beck, A., Macchiarulo, A. & Gadina, M. & 15 others, Halin, C., Fallarino, F., Skobe, M., Veldhoen, M., Moretti, S., Formenti, S., Demaria, S., Soni, R. K., Galarini, R., Sardella, R., Lauvau, G., Putterman, C., Alitalo, K., Grohmann, U. & Santambrogio, L., 21 Jul 2021, In: Nature Communications. 12, 1, 17 p., 4447.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
2020

Capillary Rarefaction in Obesity and Metabolic Diseases—Organ-Specificity and Possible Mechanisms
Paavonsalo, S., Hariharan, S., Lackman, M. H. & Karaman, S., 14 Dec 2020, In: Cells. 9, 12, 23 p., 2683.
Research output: Contribution to journal › Review Article › peer-review

Open Access
File
2019

Predicting In Vivo Payloads Delivery using a Blood-brain Tumor-barrier in a Dish
Le Joncour, V., Karaman, S. & Laakkonen, P. M., 16 Apr 2019, In: Journal of Visualized Experiments. 146, 12 p., 59384.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
2018

Stimulation and Inhibition of Lymphangiogenesis Via Adeno-Associated Viral Gene Delivery
Karaman, S., Nurmi, H., Antila, S. & Alitalo, K., 22 Sept 2018, Lymphangiogenesis: Methods and Protocols. Oliver, G. & Kahn, M. (eds.). 1st ed. ed. Humana press, p. 291-300 10 p. ( Methods in Molecular Biology; no. 1846).
Research output: Chapter in Book/Report/Conference proceeding › Chapter › Scientific › peer-review

Open Access
File
Vascular endothelial growth factor signaling in development and disease
Karaman, S., Leppänen, V.-M. & Alitalo, K., 15 Jul 2018, In: Development. 145, 14, 8 p., 151019.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
2017

An Important Role of VEGF-C in Promoting Lymphedema Development
Gousopoulos, E., Proulx, S. T., Bachmann, S. B., Dieterich, L. C., Scholl, J., Karaman, S., Bianchi, R. & Detmar, M., Sept 2017, In: Journal of Investigative Dermatology. 137, 9, p. 1995-2004 10 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
Development and plasticity of meningeal lymphatic vessels
Antila, S., Karaman, S., Nurmi, H., Airavaara, M., Voutilainen, M. H., Mathivet, T., Chilov, D., Li, Z., Koppinen, T., Park, J.-H., Fang, S., Aspelund, A., Saarma, M., Eichmann, A., Thomas, J.-L. & Alitalo, K., Dec 2017, In: Journal of Experimental Medicine. 214, 12, p. 3645-3667 23 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
Lymphangiogenesis guidance by paracrine and pericellular factors
Vaahtomeri, K., Karaman, S., Makinen, T. & Alitalo, K., 15 Aug 2017, In: Genes & Development. 31, 16, p. 1615-1634 20 p.
Research output: Contribution to journal › Review Article › peer-review

Open Access
File
Midkine and Melanoma Metastasis: A Malevolent Mix
Karaman, S. & Alitalo, K., 7 Aug 2017, In: Developmental Cell. 42, 3, p. 205-207 4 p.
Research output: Contribution to journal › Article › Scientific

Open Access
File
ORAI1 Controls the Unique Adjustment of Lymphatics to Fluid Flow
Karaman, S. & Alitalo, K., 28 Apr 2017, In: Circulation Research. 120, 9, p. 1373-1375 3 p.
Research output: Contribution to journal › Article › Scientific

Open Access
Retrograde Lymph Flow Leads to Chylothorax in Transgenic Mice with Lymphatic Malformations
Nitschke, M., Bell, A., Karaman, S., Amouzgar, M., Rutkowski, J. M., Scherer, P. E., Alitalo, K. & McDonald, D. M., Sept 2017, In: The American Journal of Pathology. 187, 9, p. 1984-1997 14 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
VEGFR3 Modulates Vascular Permeability by Controlling VEGF/VEGFR2 Signaling
Heinolainen, K., Karaman, S., D'Amico, G., Tammela, T., Sormunen, R., Eklund, L., Alitalo, K. & Zarkada, G., 28 Apr 2017, In: Circulation Research. 120, 9, p. 1414-+ 19 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
2016

Lymphatic System in Cardiovascular Medicine
Aspelund, A., Robciuc, M. R., Karaman, S., Makinen, T. & Alitalo, K., 5 Feb 2016, In: Circulation Research. 118, 3, p. 515-530 16 p.
Research output: Contribution to journal › Review Article › peer-review
Transgenic overexpression of VEGF-C induces weight gain and insulin resistance in mice
Karaman, S., Hollmen, M., Yoon, S.-Y., Alkan, H. F., Alitalo, K., Wolfrum, C. & Detmar, M., 11 Aug 2016, In: Scientific Reports. 6, 12 p., 31566.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
2015

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
Aspelund, A., Antila, S., Proulx, S. T., Karlsen, T. V., Karaman, S., Detmar, M., Wiig, H. & Alitalo, K., 29 Jun 2015, In: Journal of Experimental Medicine. 212, 7, p. 991-999 9 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
Blockade of VEGF-C and VEGF-D modulates adipose tissue inflammation and improves metabolic parameters under high-fat diet
Karaman, S., Hollmen, M., Robciuc, M. R., Alitalo, A., Nurmi, H., Morf, B., Buschle, D., Alkan, H. F., Ochsenbein, A. M., Alitalo, K., Wolfrum, C. & Detmar, M., Feb 2015, In: Molecular metabolism. 4, 2, p. 93-105 13 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
2013

VEGF-C and VEGF-D Blockade Inhibits Inflammatory Skin Carcinogenesis
Alitalo, A. K., Proulx, S. T., Karaman, S., Aebischer, D., Martino, S., Jost, M., Schneider, N., Bry, M. & Detmar, M., 15 Jul 2013, In: Cancer Research. 73, 14, p. 4212-4221 10 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Sinem Karaman

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