Research output per year
Research output per year
Personal profile
Education/Academic qualification
Chemistry, M.Sc., University of Helsinki
Award Date: 1 Jun 2017
Radiopharmaceutical Chemistry, Ph.D., University of Helsinki
22 Aug 2017 → …
Fields of Science
- 116 Chemical sciences
- molecular imaging
- positron emission tomography
- preclinical
- radiopharmaceutical chemistry
- biological radiopharmaceutics
- click chemistry
- bioorthogonal chemistry
International and National Collaboration
Publications and projects within past five years.
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Radiolabelling of peptides with tetrazine ligation based on the inverse electron-demand Diels-Alder reaction: rapid, catalyst-free and mild conversion of 1,4-dihydropyridazines to pyridazines
Otaru, S., Martinmaki, T., Kuurne, I., Paulus, A., Helariutta, K., Sarparanta, M. & Airaksinen, A., 19 Jul 2023, In: RSC Advances. 13, 32, p. 22606-22615 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Biocompatible and Selective 18F-Fluorination Reagents for the Development of Biological Radiotracers for Positron Emission Tomography
Otaru, S., 2022, Helsinki: Helsingin yliopisto.Research output: Thesis › Doctoral Thesis › Collection of Articles
Open Access -
Development of [18F]AmBF3 Tetrazine for Radiolabeling of Peptides: Preclinical Evaluation and PET Imaging of [18F]AmBF3-PEG7-Tyr3-Octreotide in an AR42J Pancreatic Carcinoma Model
Otaru, S., Paulus, A., Imlimthan, S., Kuurne, I., Virtanen, H., Liljenbäck, H., Tolvanen, T., Auchynnikava, T., Roivainen, A., Helariutta, K., Sarparanta, M. & Airaksinen, A., 16 Jun 2022, In: Bioconjugate Chemistry. 33, 7, p. 1393-1404 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Evaluation of Organo [F-18]Fluorosilicon Tetrazine as a Prosthetic Group for the Synthesis of PET Radiotracers
Otaru, S., Imlimthan, S., Sarparanta, M., Helariutta, K., Wähälä, K. & Airaksinen, A., 1 Mar 2020, In: Molecules. 25, 5, 17 p., 1208.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Metabolism of a Bioorthogonal PET Tracer Candidate [F-19/F-18]SiFA-Tetrazine in Mouse Liver Microsomes: Biotransformation Pathways and Defluorination Investigated by UHPLC-HRMS
Otaru, S., Niemikoski, H., Sarparanta, M. & Airaksinen, A. J., 3 Aug 2020, In: Molecular Pharmaceutics. 17, 8, p. 3106-3115 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
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Click-on-Chip
Otaru, S., Sikanen, T., Haapala, M. & Li, T. R.
01/01/2022 → 31/12/2023
Project: Business Finland
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Efficient, biocompatible and selective [18F]-fluorination reagents for kit production of PET radiopharmaceuticals.
Otaru, S., Airaksinen, A. & Keinänen, O.
01/10/2016 → 30/09/2018
Project: Research project
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PRERAPHA: Pretargeted radiopharmaceuticals for imaging
Airaksinen, A., Sarparanta, M., Lumen, D., Lambidis, E. & Otaru, S.
01/09/2016 → 31/08/2020
Project: Research project
Activities
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23rd International Symposium on Radiopharmaceutical Sciences (ISRS) (Poster presentation): "Investigation of the Metabolic Stability of New Silicon-Based Fluoride Acceptor 18F-Tracers"
Sofia Otaru (Poster Presentation)
26 May 2019 → 1 Jun 2019Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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17th Nordic Mass Spectrometry Conference (Oral presentation): High-resolution mass spectrometry-based investigation of defluorination of a novel PET radiotracer
Sofia Otaru (Speaker)
26 Aug 2019 → 28 Aug 2019Activity: Talk or presentation types › Oral presentation
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Medicinal Chemistry Meets Pharmacology Symposium
Sofia Otaru (Attendee)
24 Apr 2018 → 25 Apr 2018Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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Ph.D. representative in the steering group of doctoral program in Chemistry and Molecular Sciences (CHEMS) 2018- (Event)
Sofia Otaru (Member)
1 Jan 2018 → 31 Dec 2019Activity: Membership types › Membership or other role in research network
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XIV Turku PET Symposium (Poster presentation): "Synthesis of a 18F-Labeled Tetrazine via Isotopic Exchange for Pretargeted PET Imaging"
Sofia Otaru (Poster Presentation)
27 May 2017 → 30 May 2017Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars