20162020

Research output per year

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Personal profile

Description of research and teaching

I am currently pursuing my Ph.D. degree at the Doctoral Programme for Chemistry and Molecular Sciences (CHEMS-DP) in The TRacers for Molecular Imaging Team (TRIM Team). The project I am working on is an Academy of Finland Key project (Prof. Airaksinen) on KIT-ra­diola­bel­ing of bio­mo­lecules with flu­or­ine-18 under the supervision of Prof. Airaksinen and Dr. Sarparanta. My research interests are on targeted biopharmaceutics, personalized medicines and studying cancer and its differentiation from benign conditions. Thus, the main focus of my PhD is on developing efficient radiolabeling methods for functionalized biopharmaceuticals. The aim in my project is on the utilization of the radiolabeled analogues of these selected biomolecules to target and evaluate the biomolecular tracers in a variety of cancers in murine xenograft and allograft tumor models. In my research I use biological evaluations and positron emission tomography (PET) with fluorine-18 radiolabeled biomolecules for the detection of cancers in a molecular and cellular level. 

Fields of Science

  • 116 Chemical sciences

International and National Collaboration Publications and projects within past five years.

Publications

Evaluation of Organo [F-18]Fluorosilicon Tetrazine as a Prosthetic Group for the Synthesis of PET Radiotracers

Otaru, S., Imlimthan, S., Sarparanta, M., Helariutta, K., Wähälä, K. & Airaksinen, A., 1 Mar 2020, In : Molecules. 25, 5, 17 p., 1208.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Radiolabeled Molecular Imaging Probes for the in Vivo Evaluation of Cellulose Nanocrystals for Biomedical Applications

Imlimthan, S., Otaru, S., Keinänen, O., Correia, A., Lintinen, K., Almeida Santos, H., Airaksinen, A., Kostiainen, M. & Sarparanta, M., Feb 2019, In : Biomacromolecules. 20, 2, p. 674–683 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Projects

Activities

  • 4 Organisation and participation in conferences, workshops, courses, seminars
  • 1 Membership or other role in research network
  • 1 Oral presentation

23rd International Symposium on Radiopharmaceutical Sciences (ISRS) (Poster presentation): "Investigation of the Metabolic Stability of New Silicon-Based Fluoride Acceptor 18F-Tracers"

Sofia Otaru (Poster Presentation)

26 May 20191 Jun 2019

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Ph.D. representative in the steering group of doctoral program in Chemistry and Molecular Sciences (CHEMS) 2018- (Event)

Sofia Otaru (Member)

1 Jan 201831 Dec 2019

Activity: Membership typesMembership or other role in research network

Medicinal Chemistry Meets Pharmacology Symposium

Sofia Otaru (Attendee)

24 Apr 201825 Apr 2018

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

XIV Turku PET Symposium (Poster presentation): "Synthesis of a 18F-Labeled Tetrazine via Isotopic Exchange for Pretargeted PET Imaging"

Sofia Otaru (Poster Presentation)

27 May 201730 May 2017

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars