No photo of Susanna Fagerholm
  • PL 56 (Viikinkaari 9)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

19982019
If you made any changes in Pure these will be visible here soon.

Publications 1998 2019

  • 25 Article
  • 7 Review Article
  • 1 Conference contribution
2019

A beta2-Integrin/MRTF-A/SRF Pathway Regulates Dendritic Cell Gene Expression, Adhesion, and Traction Force Generation

Guenther, C., Faisal, I., Uotila, L., Llort Asens, M., Harjunpää, H., Savinko, T., Öhman, T., Yao, S., Moser, M., Morris, S. W., Tojkander, S. & Fagerholm, S., 28 May 2019, In : Frontiers in Immunology. 10, 1138, 13 p., 1138.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Beta2-Integrins and Interacting Proteins in Leukocyte Trafficking, Immune Suppression, and Immunodeficiency Disease

Fagerholm, S. C., Guenther, C., Asens, M. L., Savinko, T. & Uotila, L. M., 19 Feb 2019, In : Frontiers in Immunology. 10, 10 p., 254.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

Cell Adhesion Molecules and Their Roles and Regulation in the Immune and Tumor Microenvironment

Harjunpää, H., Llort Asens, M., Guenther, C. & Fagerholm, S. C., 22 May 2019, In : Frontiers in Immunology. 10, 24 p., 1078.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File
2018

Filamin A Is Required for Optimal T Cell Integrin-Mediated Force Transmission, Flow Adhesion, and T Cell Trafficking

Savinko, T., Guenther, C., Uotila, L. M., Asens, M. L., Yao, S., Tojkander, S. & Fagerholm, S. C., 1 May 2018, In : Journal of Immunology. 200, 9, p. 3109-3116 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2017

Caveolin-1 Influences LFA-1 Redistribution upon TCR Stimulation in CD8 T Cells

Borger, J. G., Morrison, V. L., Filby, A., Garcia, C., Uotila, L. M., Simbari, F., Fagerholm, S. C. & Zamoyska, R., 1 Aug 2017, In : Journal of Immunology. 199, 3, p. 874-884 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Filamin A Regulates Neutrophil Adhesion, Production of Reactive Oxygen Species, and Neutrophil Extracellular Trap Release

Uotila, L. M., Günther, C., Savinko, T., Lehti, T. A. & Fagerholm, S. C., 15 Nov 2017, In : Journal of Immunology. 199, 10, p. 3644-3653 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status

Cameron, A. R., Morrison, V. L., Levin, D., Mohan, M., Forteath, C., Beall, C., McNeilly, A. D., Balfour, D. J. K., Savinko, T., Wong, A. K. F., Viollet, B., Sakamoto, K., Fagerholm, S. C., Foretz, M., Lang, C. C. & Rena, G., 19 Aug 2016, In : Circulation Research. 119, 5, p. 652-665 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Verisolujen integriinit ja taudit

Uotila, L., Savinko, T., Guenther, C. & Fagerholm, S., 2016, In : Duodecim. 132, 20, p. 1865-1873 9 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File
2015

A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells

Cook, P. C., Owen, H., Deaton, A. M., Borger, J. G., Brown, S. L., Clouaire, T., Jones, G-R., Jones, L. H., Lundie, R. J., Marley, A. K., Morrison, V. L., Phythian-Adams, A. T., Wachter, E., Webb, L. M., Sutherland, T. E., Thomas, G. D., Grainger, J. R., Selfridge, J., McKenzie, A. N. J., Allen, J. E. & 5 othersFagerholm, S. C., Maizels, R. M., Ivens, A. C., Bird, A. & MacDonald, A. S., Apr 2015, In : Nature Communications. 6, 11 p., 6920.

Research output: Contribution to journalArticleScientificpeer-review

Functional Beta2-Integrins Restrict Skin Inflammation In Vivo

Savinko, T. S., Morrison, V. L., Uotila, L. M., Wolff, C. H. J., Alenius, H. T. & Fagerholm, S. C., Sep 2015, In : Journal of Investigative Dermatology. 135, 9, p. 2249-2257 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Mice Lacking beta2-Integrin Function Remain Glucose Tolerant in Spite of Insulin Resistance, Neutrophil Infiltration and Inflammation

Meakin, P. J., Morrison, V. L., Sneddon, C. C., Savinko, T., Uotila, L., Jalicy, S. M., Gabriel, J. L., Kang, L., Ashford, M. L. J. & Fagerholm, S. C., 25 Sep 2015, In : PLoS One. 10, 9, 15 p., 0138872.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Optimal T Cell Activation and B Cell Antibody Responses In Vivo Require the Interaction between Leukocyte Function-Associated Antigen-1 and Kindlin-3

Morrison, V. L., Uotila, L. M., Llort Asens, M., Savinko, T. & Fagerholm, S. C., 1 Jul 2015, In : Journal of Immunology. 195, 1, p. 105-115 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

A crucial role for beta 2 integrins in podosome formation, dynamics and Toll-like-receptor-signaled disassembly in dendritic cells

Gawden-Bone, C., West, M. A., Morrison, V. L., Edgar, A. J., McMillan, S. J., Dill, B. D., Trost, M., Prescott, A., Fagerholm, S. C. & Watts, C., 1 Oct 2014, In : Journal of Cell Science. 127, 19, p. 4213-4224 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Kindlin-3 in the immune system

Fagerholm, S. C., Lek, HS. & Morrison, VL., 2014, In : American Journal of Clinical and Experimental Immunology. p. 37-42

Research output: Contribution to journalReview ArticleScientificpeer-review

Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype

Morrison, V. L., James, M. J., Grzes, K., Cook, P., Glass, D. G., Savinko, T., Lek, H. S., Gawden-Bone, C., Watts, C., Millington, O. R., MacDonald, A. S. & Fagerholm, S. C., 2014, In : Nature Communications. 5, 13 p., 5359.

Research output: Contribution to journalArticleScientificpeer-review

2013

The beta 2 integrin-kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo

Morrison, V. L., MacPherson, M., Savinko, T., San Lek, H., Prescott, A. & Fagerholm, S. C., 22 Aug 2013, In : Blood. 122, 8, p. 1428-1436 9 p.

Research output: Contribution to journalArticleScientificpeer-review

The CD11b-integrin (ITGAM) and systemic lupus erythematosus

Fagerholm, S. C., MacPherson, M., James, M. J., Sevier-Guy, C. & Lau, C. S., 2013, In : Lupus. 22, 7, p. 657-663 7 p.

Research output: Contribution to journalArticleScientificpeer-review

The Spontaneously Adhesive Leukocyte Function-associated Antigen-1 (LFA-1) Integrin in Effector T Cells Mediates Rapid Actin- and Calmodulin-dependent Adhesion Strengthening to Ligand under Shear Flow

Lek, H. S., Morrison, V. L., Conneely, M., Campbell, P. A., McGloin, D., Kliche, S., Watts, C., Prescott, A. & Fagerholm, S. C., 24 May 2013, In : Journal of Biological Chemistry. 288, 21, p. 14698-14708 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Protein kinase D isoforms are dispensable for integrin-mediated lymphocyte adhesion and homing to lymphoid tissues

Matthews, S. A., Lek, H. S., Morrison, V. L., Mackenzie, M. G., Zarrouk, M., Cantrell, D. & Fagerholm, S. C., May 2012, In : European Journal of Immunology. 42, 5, p. 1316-1326 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

A Systemic Lupus Erythematosus-associated R77H Substitution in the CD11b Chain of the Mac-1 Integrin Compromises Leukocyte Adhesion and Phagocytosis

MacPherson, M., Lek, H. S., Prescott, A. & Fagerholm, S. C., 13 May 2011, In : Journal of Biological Chemistry. 286, 19, p. 17303-17310 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Regulation of integrin activity and signalling

Gahmberg, C. G., Fagerholm, S. C., Nurmi, S. M., Chavakis, T., Marchesan, S. & Grönholm, M., 2009, In : Biochimica et Biophysica Acta. General Subjects. 1790, 6, p. 431-444 14 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2008

Regulation of LFA-1-dependent inflammatory cell recruitment by Cb1-b and 14-3-3 proteins

Choi, E. Y., Orlova, V. V., Fagerholm, S. C., Nurmi, S. M., Zhang, L., Ballantyne, C. M., Gahmberg, C. G. & Chavakis, T., 1 Apr 2008, In : Blood. 111, 7, p. 3607-3614 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins

Choi, E. Y., Orlova, V. V., Fagerholm, S. C., Nurmi, S. M., Zhang, L., Ballantyne, C. M., Gahmberg, C. G. & Chavakis, T., 2008, In : Blood. 111, 7, p. 3607-3614 8 p.

Research output: Contribution to journalArticleScientificpeer-review

β2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding

Takala, H., Nurminen, E., Nurmi, S. M., Aatonen, M., Strandin, T., Takatalo, M., Kiema, T., Gahmberg, C. G., Ylänne, J. & Fagerholm, S. C., 1 Sep 2008, In : Blood. 112, 5, p. 1853-1862 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2007
2006

14-3-3 proteins bind both filamin and alpha(L)beta(2) integrin in activated T cells

Nurmi, S. M., Gahmberg, C. G. & Fagerholm, S. C., 2006, SIGNAL TRANSDUCTION PATHWAYS, PT A: APOPTOTIC AND EXTRACELLULAR SIGNALING. p. 318-325 8 p. ( ANNALS OF THE NEW YORK ACADEMY OF SCIENCES; vol. 1090).

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

14-3-3 proteins bind both filamin and Lß2 integrin in activated T cells

Nurmi, S. M., Gahmberg, C. G. & Fagerholm, S. C., 2006, In : Annals of the New York Academy of Sciences. 1090, p. 318-325 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Interfering with leukocyte integrin activation: a novel concept in the development of anti-inflammatory drugs

Hilden, T. J., Nurmi, S. M., Fagerholm, S. C. & Gahmberg, C. G., 2006, In : Annals of Medicine. 38, p. 503-511 9 p.

Research output: Contribution to journalArticleScientificpeer-review

α-chain phosphorylation of the human leukocyte CD11b/CD18 (Mac-1) integrin is pivotal for integrin activation to bind ICAMs and leukocyte extravasation

Fagerholm, S. C., Varis, M., Stefanidakis, M., Hilden, T. J. & Gahmberg, C. G., 2006, In : Blood. 108, 10, p. 3379-3386 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Specific integrin alpha and beta chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms

Fagerholm, SC., Hilden, TJ., Nurmi, SM. & Gahmberg, CG., 21 Nov 2005, In : Journal of Cell Biology. 171, 4, p. 705-715 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Specific integrin α and ß chain phosphorylations regulate LFA-1 activation through affinity-dependent and -independent mechanisms

Fagerholm, S. C., Hilden, T. J., Nurmi, S. M. & Gahmberg, C. G., 2005, In : Journal of Cell Biology. 171, 4, p. 705-715 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2004

P marks the spot: site-specific integrin phosphorylation regulates molecular interactions

Fagerholm, S. C., Hilden, T. J. & Gahmberg, C. G., 2004, In : Trends in Biochemical Sciences. 29, 9, p. 504-512 9 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

1998

Leukocyte integrins and inflammation

Gahmberg, CG., Valmu, L., Fagerholm, S., Kotovuori, P., Ihanus, E., Tian, L. & Pessa-Morikawa, T., Jun 1998, In : Cellular and Molecular Life Sciences. 54, 6, p. 549-555 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review