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Personal profile

Curriculum vitae

EDUCATION

Licentiate of Medicine (MD equiv.), University of Helsinki, 31 May 1995

Doctor of Medical Sciences (PhD equiv.), University of Helsinki,14 Dec 1999

Certified specialist in Clinical Microbiology, Univ. of Helsinki, 3 Aug 2001

Docent (Adjunct Professor)  in Medical Microbiology and Immunology, Univ. of Helsinki, 5 Jan 2006

Curriculum vitae

CURRENT POSITIONS

Clinical teacher (Senior lecturer), permanent position Univ. of Helsinki, Finland   1 Aug 2008-

R&D Manager (part-time), United Medix Laboratories Ltd., Espoo                      1 Oct 2009-

Description of research and teaching

Jokiranta research group is a scientific work group lead by T. Sakari Jokiranta at Haartman-institute, University of Helsinki, Finland. The focus of the research is in function of an important arm of innate immunity, the alternative pathway of complement. The main question is how that system leaves the host structures intact while destroying the invading pathogenic microbes.There are two projects to answer to the main question. (1) Protection of the glomerular structures by complement factor H and pathogenesis of the kidney diseases that develop when thend. The focus and main question in this project is how the alternative pathway of complement works as a part of the innate immunity to leave protection is insufficient (membranoproliferative glomerulonephritis type II/ dense deposit disease and atypical haemolytic uremic syndrome). (2) Mechanisms of complement evasion of certain microbes (e.g. Streptococcus pyogenes, Borrelia recurrentis, B. duttonii, Bordetella pertussis) by actively binding host factor H to their surface. The research is currently financed by the Academy of Finland, the Sigrid Juselius Foundation, and Helsinki University Central Hospital Funds.

Keywords

  • 311 Basic medicine
  • Immunology
  • Microbiology
  • Molecular biology
  • Structural biology
  • Structure and function
  • 312 Clinical medicine
  • Nephrology
  • Infectious diseases
  • Clinical microbiology
  • Parasitology

International and National Collaboration Publications and projects within past five years.

Publications 1988 2019

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement

Kajander, T., Lehtinen, M. J., Hyvärinen, S., Bhattacharjee, A., Leung, E., Isenman, D. E., Meri, S., Goldman, A. & Jokiranta, T. S., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 7, p. 2897-2902 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutations of factor H impair regulation of surface-bound C3b by three mechanisms in atypical hemolytic uremic syndrome

Lehtinen, M. J., Rops, A. L., Isenman, D. E., van der Vlag, J. & Jokiranta, T. S., 2009, In : Journal of Biological Chemistry. 284, 23, p. 15650-15658 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Complement factor H allotype 402H is associated with increased C3b opsonization and phagocytosis of Streptococcus pyogenes

Haapasalo, K., Jarva, H., Siljander, T., Tewodros, W., Vuopio-Varkila, J. & Jokiranta, T. S., 2008, In : Molecular Microbiology. 70, 3, p. 583-594 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Successful liver-kidney transplantation in two children with aHUS caused by a mutation in complement factor H

Jalanko, H., Peltonen, S., Koskinen, A., Puntila, J., Isoniemi, H., Holmberg, C., Pinomäki, A., Armstrong, E., Koivusalo, A., Tukiainen, E., Mäkisalo, H., Saland, J., Remuzzi, G., de Cordoba, S. R., Lassila, R., Meri, S. & Jokiranta, S., 2008, In : American Journal of Transplantation. 8, 1, p. 216-221 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Structure of complement factor H carboxyl-terminus reveals molecular basis of atypical haemolytic uremic syndrome

Jokiranta, T. S., Jaakola, V-P., Lehtinen, M. J., Pärepalo, M-J., Meri, S. & Goldman, A., 2006, In : EMBO Journal. 25, 8, p. 1784-1794 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Activities 2003 2014

ECN board (External organisation)

T. Sakari Jokiranta (Board member)
25 Aug 2009 → …

Activity: Membership typesMembership or other role in national/international committee, council, board

European autoimmunity standardization initiative (External organisation)

T. Sakari Jokiranta (Board member)
14 Sep 2009 → …

Activity: Membership typesMembership or other role in national/international committee, council, board

Laatutoimikunta (External organisation)

T. Sakari Jokiranta (Board member)
2010 → …

Activity: Membership typesMembership or other role in national/international committee, council, board

YVV-toimikunta (External organisation)

T. Sakari Jokiranta (Board member)
2010 → …

Activity: Membership typesMembership or other role in national/international committee, council, board

International Complement Standardization Committee (External organisation)

T. Sakari Jokiranta (Board member)
15 Oct 2008 → …

Activity: Membership typesMembership or other role in national/international committee, council, board

Press / Media

Päätäit

T. Sakari Jokiranta

04/08/2011

1 media contribution

Press/Media: Press / Media

Teema-artikkeli: Vierasta vastaan

T. Sakari Jokiranta

07/02/2011

1 media contribution

Press/Media: Press / Media