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Publications 1988 2019

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Factor H interferes with the adhesion of sickle red cells to vascular endothelium: a novel disease-modulating molecule

Lombardi, E., Matte, A., Risitano, A. M., Ricklin, D., Lambris, J. D., De Zanet, D., Jokiranta, S. T., Martinelli, N., Scambi, C., Salvagno, G., Bisoffi, Z., Colato, C., Siciliano, A., Bortolami, O., Mazzuccato, M., Zorzi, F., De Marco, L. & De Franceschi, L., 30 Apr 2019, In : Haematologica. 104, 5, p. 919-928 10 p.

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Pool-seq driven proteogenomic database for Group G Streptococcus

Weldatsadik, R. G., Datta, N., Kolmeder, C., Vuopio, J., Kere, J., Wilkman, S. V., Flatt, J. W., Vuento, R., Haapasalo, K. J., Keskitalo, S., Varjosalo, M. & Jokiranta, T. S., 15 Jun 2019, In : Journal of Proteomics. 201, p. 84-92 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Role of Pneumococcal NanA Neuraminidase Activity in Peripheral Blood

Syed, S., Hakala, P., Singh, A. K., Lapatto, H. A. K., King, S. J., Meri, S., Jokiranta, T. S. & Haapasalo, K., 26 Jun 2019, In : Frontiers in Cellular and Infection Microbiology. 9, 11 p., 218.

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2018

Complement Factor H and Apolipoprotein E Participate in Regulation of Inflammation in THP-1 Macrophages

Nissilä, E., Hakala, P., Leskinen, K., Roig, A., Syed, S., Van Kessel, K. P. M., Metso, J., De Haas, C. J. C., Saavalainen, P., Meri, S., Chroni, A., Van Strijp, J. A. G., Öörni, K., Jauhiainen, M., Jokiranta, T. S. & Haapasalo, K., 21 Nov 2018, In : Frontiers in Immunology. 9, 14 p., 2701.

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Distribution of exogenous complement factor H in mice invivo

Koskinen, A. R., Cheng, Z-Z., Pickering, M. C., Kairemo, K., Meri, T., Cook, H. T., Meri, S. & Jokiranta, T. S., Jul 2018, In : Scandinavian Journal of Immunology. 88, 1, 10 p., 12671.

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The Psoriasis Risk Allele HLA-C*06: 02 Shows Evidence of Association with Chronic or Recurrent Streptococcal Tonsillitis

Haapasalo, K., Koskinen, L. L. E., Suvilehto, J., Jousilahti, P., Wolin, A., Suomela, S., Trembath, R., Barker, J., Vuopio, J., Kere, J., Jokiranta, T. S. & Saavalainen, P., Oct 2018, In : Infection and Immunity. 86, 10, 9 p., ARTN e00304-18.

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2017

Analysis of Linear Antibody Epitopes on Factor H and CFHR1 Using Sera of Patients with Autoimmune Atypical Hemolytic Uremic Syndrome

Trojnar, E., Jozsi, M., Uray, K., Csuka, D., Szilagyi, A., Milosevic, D., Stojanovic, V. D., Spasojevic, B., Rusai, K., Mueller, T., Arbeiter, K., Kelen, K., Szabo, A. J., Reusz, G. S., Hyvarinen, S., Jokiranta, T. S. & Prohaszka, Z., 30 Mar 2017, In : Frontiers in Immunology. 8, 9 p., 302.

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Crystal structure of a tripartite complex between C3dg, C-terminal domains of factor H and OspE of Borrelia burgdorferi

Kolodziejczyk, R., Mikula, K. M., Kotila, T., Postis, V. L. G., Jokiranta, T. S., Goldman, A. & Meri, T., 30 Nov 2017, In : PLoS One. 12, 11, 17 p., e0188127.

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Differential diagnosis of thrombotic microangiopathy in nephrology

Jokiranta, T. S., Viklicky, O., Al Shorafa, S., Coppo, R., Gasteyger, C., Macia, M., Pankratenko, T., Shenoy, M., Soylemezoglu, O., Tsimaratos, M., Wetzels, J. & Haller, H., 28 Oct 2017, In : BMC Nephrology. 18, 8 p., 324.

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Dirofilaria repens transmission in southeastern Finland

Pietikainen, R., Nordling, S., Jokiranta, S., Saari, S., Heikkinen, P., Gardiner, C., Kerttula, A-M., Kantanen, T., Nikanorova, A., Laaksonen, S., Lavikainen, A. & Oksanen, A., 10 Nov 2017, In : Parasites & vectors. 10, 6 p., 561.

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FHR-1 Binds to C-Reactive Protein and Enhances Rather than Inhibits Complement Activation

Csincsi, A. I., Szabo, Z., Banlaki, Z., Uzonyi, B., Cserhalmi, M., Karpati, E., Tortajada, A., Caesar, J. J. E., Prohaszka, Z., Jokiranta, T. S., Lea, S. M., de Cordoba, S. R. & Jozsi, M., 1 Jul 2017, In : Journal of Immunology. 199, 1, p. 292-303 12 p.

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Genomilääketieteen sovelluksia sairauksien hoidossa

Porkka, K., Niemi, M., Leppä, E., Västrik, I., Partanen, J., Ihalainen, J., Jokiranta, S. & Pöllänen, P., 2017, In : Duodecim. 133, 8, p. 782-790 9 p.

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Klamydian ja tippurin Internet-pohjaisen kotinäytteenottopalvelun tulokset Vantaalla

Jokiranta, S., Valtonen, K., Kutvonen, H., Ihalainen, J., Halttunen, T., Lappalainen, M. & Hiltunen-Back, E., 2017, In : Suomen lääkärilehti. 72, 7, p. 419-424 6 p.

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Sequence analysis of pooled bacterial samples enables identification of strain variation in group A streptococcus

Weldatsadik, R. G., Wang, J., Puhakainen, K., Jiao, H., Jalava, J., Raisanen, K., Datta, N., Skoog, T., Vuopio, J., Jokiranta, T. S. & Kere, J., 31 Mar 2017, In : Scientific Reports. 7, 10 p., 45771.

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Staphylococcal protein Ecb impairs complement receptor-1 mediated recognition of opsonized bacteria

Amdahl, H., Haapasalo, K., Tan, L., Meri, T., Kuusela, P. I., van Strijp, J. A., Rooijakkers, S. & Jokiranta, T. S., 8 Mar 2017, In : PLoS One. 12, 3, 18 p., 0172675.

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2016

Cost-effectiveness of routine measuring of serum drug concentrations and anti-drug antibodies in treatment of rheumatoid arthritis patients with TNF-alpha blockers

Laine, J., Jokiranta, S., Eklund, K., Väkeväinen, M. & Puolakka, K., 1 Apr 2016, In : Biologics : targets & therapy. 2016, 10, p. 67-73 7 p.

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Disturbed sialic acid recognition on endothelial cells and platelets in complement attack causes atypical hemolytic uremic syndrome

Hyvarinen, S., Meri, S. & Jokiranta, T. S., 2 Jun 2016, In : Blood. 127, 22, p. 2701-2710 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Esimerkkitapauksia biologisen hoidon yksilöllistämisestä

Sipponen, T., Isomäki, P., Leinonen, S., Mälkönen, T. & Jokiranta, S., 2016, In : Duodecim. 132, 4, p. 387-390 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Heterogeneity but individual constancy of epitopes, isotypes and avidity of factor H autoantibodies in atypical hemolytic uremic syndrome

Nozal, P., Bernabeu-Herrero, M. E., Uzonyi, B., Szilagyi, A., Hyvarinen, S., Prohaszka, Z., Jokiranta, T. S., Sanchez-Corral, P., Lopez-Trascasa, M. & Jozsi, M., Feb 2016, In : Molecular Immunology. 70, p. 47-55 9 p.

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Mutations in Complement Factor H Impair Alternative Pathway Regulation on Mouse Glomerular Endothelial Cells in Vitro

Loeven, M. A., Rops, A. L., Lehtinen, M. J., van Kuppevelt, T. H., Daha, M. R., Smith, R. J., Bakker, M., Berden, J. H., Rabelink, T. J., Jokiranta, T. S. & van der Vlag, J., 4 Mar 2016, In : Journal of Biological Chemistry. 291, 10, p. 4974-4981 8 p.

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Suolistoparasiitteja voi saada sekä ulkomailta että kotimaasta

Jokiranta, S., Siikamäki, H. & Kantele, A., 2016, In : Sic! Lääketietoa Fimeasta. 6, 3, p. 26-29 4 p.

Research output: Contribution to journalArticleProfessional

T cell receptor diversity in the human thymus

Vanhanen, R., Heikkila, N., Aggarwal, K., Hamm, D., Tarkkila, H., Pätilä, T., Jokiranta, T. S., Saramaki, J. & Arstila, T. P., Aug 2016, In : Molecular Immunology. 76, p. 116-122 7 p.

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2015

Anti-Factor H Autoantibodies in C3 Glomerulopathies and in Atypical Hemolytic Uremic Syndrome: One Target, Two Diseases

Blanc, C., Togarsimalemath, S. K., Chauvet, S., Le Quintrec, M., Moulin, B., Buchler, M., Jokiranta, T. S., Roumenina, L. T., Fremeaux-Bacchi, V. & Dragon-Durey, M-A., 1 Jun 2015, In : Journal of Immunology. 194, 11, p. 5129-5138 10 p.

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Biologisen reumalääkityksen monitorointi laboratoriotutkimuksin

Jokiranta, S., 2015, In : Moodi.. 39, 2, p. 76-78 3 p.

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Complement Factor H Binds to Human Serum Apolipoprotein E and Mediates Complement Regulation on High Density Lipoprotein Particles

Haapasalo, K., van Kessel, K., Nissilä, E., Metso, J., Johansson, T., Miettinen, S., Varjosalo, M., Kirveskari, J., Kuusela, P., Chroni, A., Jauhiainen, M., van Strijp, J. & Jokiranta, T. S., 27 Nov 2015, In : Journal of Biological Chemistry. 290, 48, p. 28977-28987 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Egenskaper hos biologiska läkemedel och terapeutiska antikroppar

Jokiranta, S., 2015, In : Finska Läkaresällskapets Handlingar. 175, 2, p. 87-92 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Mapping interactions between complement C3 and regulators using mutations in atypical hemolytic uremic syndrome

Schramm, E. C., Roumenina, L. T., Rybkine, T., Chauvet, S., Vieira-Martins, P., Hue, C., Maga, T., Valoti, E., Wilson, V., Jokiranta, S., Smith, R. J. H., Noris, M., Goodship, T., Atkinson, J. P. & Fremeaux-Bacchi, V., 9 Apr 2015, In : Blood. 125, 15, p. 2359-2369 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Minor Role of Plasminogen in Complement Activation on Cell Surfaces

Hyvarinen, S. & Jokiranta, T. S., 4 Dec 2015, In : PLoS One. 10, 12, 19 p., 0143707.

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The Local Complement Activation on Vascular Bed of Patients with Systemic Sclerosis: A Hypothesis-Generating Study

Scambi, C., Ugolini, S., Jokiranta, T. S., De Franceschi, L., Bortolami, O., La Verde, V., Guarini, P., Caramaschi, P., Ravagnani, V., Martignoni, G., Colato, C., Pedron, S., Benedetti, F., Sorio, M., Poli, F. & Biasi, D., 6 Feb 2015, In : PLoS One. 10, 2, 15 p., 0114856.

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The Major Autoantibody Epitope on Factor H in Atypical Hemolytic Uremic Syndrome Is Structurally Different from Its Homologous Site in Factor H-related Protein 1, Supporting a Novel Model for Induction of Autoimmunity in This Disease

Bhattacharjee, A., Reuter, S., Trojnar, E., Kolodziejczyk, R., Seeberger, H., Hyvarinen, S., Uzonyi, B., Szilagyi, A., Prohaszka, Z., Goldman, A., Jozsi, M. & Jokiranta, T. S., 10 Apr 2015, In : Journal of Biological Chemistry. 290, 15, p. 9500-9510 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status

Rayes, J., Roumenina, L. T., Dimitrov, J. D., Repesse, Y., Ing, M., Christophe, O., Jokiranta, T. S., Halbwachs-Mecarelli, L., Borel-Derlon, A., Kaveri, S. V., Fremeaux-Bacchi, V. & Lacroix-Desmazes, S., 2 Jan 2014, In : Blood. 123, 1, p. 121-125 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

An Engineered Construct Combining Complement Regulatory and Surface-Recognition Domains Represents a Minimal-Size Functional Factor H

Hebecker, M., Alba-Dominguez, M., Roumenina, L. T., Reuter, S., Hyvarinen, S., Dragon-Durey, M-A., Jokiranta, T. S., Sanchez-Corral, P. & Jozsi, M., 15 Jul 2013, In : Journal of Immunology. 191, 2, p. 912-921 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Microbes Bind Complement Inhibitor Factor H via a Common Site

Meri, T., Amdahl, H., Lehtinen, M. J., Hyvärinen, S., McDowell, J. V., Bhattacharjee, A., Meri, S., Marconi, R., Goldman, A. & Jokiranta, T. S., Apr 2013, In : PLoS Pathogens. 9, 4, p. Article Number: e1003308 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Staphylococcal Ecb Protein and Host Complement Regulator Factor H Enhance Functions of Each Other in Bacterial Immune Evasion

Amdahl, H., Jongerius, I., Meri, T., Pasanen, T., Hyvärinen, S., Haapasalo, K., van Strijp, J. A., Rooijakkers, S. H. & Jokiranta, T. S., 15 Aug 2013, In : Journal of Immunology. 191, 4, p. 1775-1784 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Structural Basis for Complement Evasion by Lyme Disease Pathogen Borrelia burgdorferi

Bhattacharjee, A., Oeemig, J. S., Kolodziejczyk, R., Meri, T., Kajander, T., Lehtinen, M. J., Iwai, H., Jokiranta, T. S. & Goldman, A., 28 Jun 2013, In : Journal of Biological Chemistry. 288, 26, p. 18685-18695 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Acquisition of Complement Factor H Is Important for Pathogenesis of Streptococcus pyogenes Infections: Evidence from Bacterial In Vitro Survival and Human Genetic Association

Haapasalo, K., Vuopio, J., Syrjänen, J., Suvilehto, J., Massinen, S., Karppelin, M., Järvelä, I., Meri, S., Kere, J. & Jokiranta, T. S., 2 Dec 2012, In : Journal of Immunology. 188, 1, p. 426-435 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Enzyme Immunoassay Tests for Detection of Hantavirus Infection and Immunity

Kelo, E., Parviainen, M., Sirola, H., Vaheri, A., Vapalahti, O. P., Avsic-Zupanc, T., Flinck, H., Jokiranta, T. S. & Mononen, I., 2012, In : European Infectious Disease. 6, 1, p. 9-13 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Overall Neutralization of Complement Factor H by Autoantibodies in the Acute Phase of the Autoimmune Form of Atypical Hemolytic Uremic Syndrome

Blanc, C., Roumenina, L. T., Ashraf, Y., Hyvärinen, S., Sethi, S. K., Ranchin, B., Niaudet, P., Loirat, C., Gulati, A., Bagga, A., Fridman, W. H., Sautes-Fridman, C., Jokiranta, T. S., Fremeaux-Bacchi, V. & Dragon-Durey, M-A., 1 Oct 2012, In : Journal of Immunology. 189, 7, p. 3528-3537 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Apolipoprotein A-I Exerts Bactericidal Activity against Yersinia enterocolitica Serotype O:3

Biedzka-Sarek, M., Metso, J., Kateifides, A., Meri, T., Jokiranta, T. S., Muszynski, A., Radziejewska-Lebrecht, J., Zannis, V., Skurnik, M. & Jauhiainen, M., 2011, In : Journal of Biological Chemistry. 286, 44, p. 38211-38219 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Complement Activation During Liver Transplantation-Special Emphasis on Patients With Atypical Hemolytic Uremic Syndrome

Koskinen, A. R., Tukiainen, E. J., Arola, J., Nordin, A., Höckerstedt, K., Nilsson, B., Isoniemi, H. & Jokiranta, T. S., 2011, In : American Journal of Transplantation. 11, 9, p. 1885-1895 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Dual interaction of factor H with C3d and glycosaminoglycans in host-nonhost discrimination by complement

Kajander, T., Lehtinen, M. J., Hyvärinen, S., Bhattacharjee, A., Leung, E., Isenman, D. E., Meri, S., Goldman, A. & Jokiranta, T. S., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 7, p. 2897-2902 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Giardia and Cryptosporidium infection in Finland: a registry-based study of their demographic determinants

Rimhanen-Finne, R., Jokiranta, T. S., Virtanen, M. J. & Kuusi, M., 2011, In : APMIS. 119, 11, p. 735-740 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Identification of the five human Plasmodium species including P. knowlesi by real-time polymerase chain reaction

Oddoux, O., Debourgogne, A., Kantele, A., Kocken, C. H., Jokiranta, T. S., Vedy, S., Puyhardy, J. M. & Machouart, M., 2011, In : European Journal of Clinical Microbiology & Infectious Diseases. 30, 4, p. 597-601 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Interactions between Bordetella pertussis and the complement inhibitor factor H

Amdahl, H., Jarva, H., Haanperä, M., Mertsola, J., He, Q., Jokiranta, T. S. & Meri, S., 2011, In : Molecular Immunology. 48, 4, p. 697-705 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Molecular Characterization of the Interaction between Sialylated Neisseria gonorrhoeae and Factor H

Shaughnessy, J., Ram, S., Bhattacharjee, A., Pedrosa, J., Tran, C., Horvath, G., Monks, B., Visintin, A., Jokiranta, T. S. & Rice, P. A., 2011, In : Journal of Biological Chemistry. 286, 25, p. 22235-22242 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Reply to Antinori et al [Correspondence]

Kantele, A. & Jokiranta, T. S., 2011, In : Clinical Infectious Diseases. 53, 8, p. 849-850 2 p.

Research output: Contribution to journalArticleScientific

2010

Both domain 19 and domain 20 of factor H are involved in binding to complement C3b and C3d

Bhattacharjee, A., Lehtinen, M. J., Kajander, T., Goldman, A. & Jokiranta, T. S., 2010, In : Molecular Immunology. 47, 9, p. 1686-1691 6 p.

Research output: Contribution to journalArticleScientificpeer-review