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  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

19962020

Research output per year

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Publications

2020

Androgen deprivation and SARS-CoV-2 in men with prostate cancer

Koskinen, M., Carpen, O., Honkanen, V., Seppänen, M. R. J., Miettinen, P. J., Tuominen, J. A. & Raivio, T., Oct 2020, In : Annals of Oncology. 31, 10, p. 1417-1418 2 p.

Research output: Contribution to journalLetterScientific

Anti-Müllerian hormone and letrozole levels in boys with constitutional delay of growth and puberty treated with letrozole or testosterone

Kohva, E., Varimo, T., Huopio, H., Tenhola, S., Voutilainen, R., Toppari, J., Miettinen, P. J., Vaaralahti, K., Viinamäki, J., Backman, J. T., Hero, M. & Raivio, T., Feb 2020, In : Human Reproduction. 35, 2, p. 257-264 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Characterization of the human GnRH neuron developmental transcriptome using a GNRH1-TdTomato reporter line in human pluripotent stem cells

Lund, C., Yellapragada, V., Vuoristo, S., Balboa, D., Trova, S., Allet, C., Eskici, N., Pulli, K., Giacobini, P., Tuuri, T. & Raivio, T., 1 Mar 2020, In : Disease Models & Mechanisms. 13, 3, 13 p., 040105.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Effect of Pediatric Testicular Torsion on Testicular Function in the Short Term

Taskinen, S., Mäkelä, E. & Raivio, T., Aug 2020, In : Journal of Pediatric Surgery. 55, 8, p. 1613-1615 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Loss-of-Function Variants in TBC1D32 Underlie Syndromic Hypopituitarism

Hietamäki, J., Gregory, L. C., Ayoub, S., Iivonen, A-P., Vaaralahti, K., Liu, X., Brandstack, N., Buckton, A. J., Laine, T., Känsäkoski, J., Hero, M., Miettinen, P. J., Varjosalo, M., Wakeling, E., Dattani, M. T. & Raivio, T., 1 Jun 2020, In : Journal of Clinical Endocrinology and Metabolism. 105, 6, p. 1748-1758 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism

Messina, A., Pulli, K., Santini, S., Acierno, J., Kansakoski, J., Cassatella, D., Xu, C., Casoni, F., Malone, S. A., Ternier, G., Conte, D., Sidis, Y., Tommiska, J., Vaaralahti, K., Dwyer, A., Gothilf, Y., Merlo, G. R., Santoni, F., Niederlander, N. J., Giacobini, P. & 2 others, Raivio, T. & Pitteloud, N., 2 Jan 2020, In : American Journal of Human Genetics. 106, 1, p. 58-70 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2019

Clinical Management of Congenital Hypogonadotropic Hypogonadism

Young, J., Xu, C., Papadakis, G. E., Acierno, J. S., Maione, L., Hietamäki, J., Raivio, T. & Pitteloud, N., Apr 2019, In : Endocrine Reviews. 40, 2, p. 669-710 42 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Open Access
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Haittaako tietosuojalainsäädäntö tutkimusta?

Seppänen, M., Kahri, P., Kere, J., Raivio, T. & Pitkäranta, A., 2019, In : Suomen lääkärilehti. 74, 12, p. 719-719a 2 p.

Research output: Contribution to journalEditorialProfessional

Open Access
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Letrozole Monotherapy in Pre- and Early-Pubertal Boys Does Not Increase Adult Height

Varimo, T., Toiviainen-Salo, S., Raivio, T., Kerttula, L., Dunkel, L. & Hero, M., 5 Apr 2019, In : Frontiers in Endocrinology. 10, 6 p., 201.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Letrozole versus testosterone for promotion of endogenous puberty in boys with constitutional delay of growth and puberty: a randomised controlled phase 3 trial

Varimo, T., Huopio, H., Kariola, L., Tenhola, S., Voutilainen, R., Toppari, J., Toiviainen-Salo, S., Hämäläinen, E., Pulkkinen, M-A., Lääperi, M., Tarkkanen, A., Vaaralahti, K., Miettinen, P. J., Hero, M. & Raivio, T., Feb 2019, In : Lancet child & adolescent health. 3, 2, p. 109-120 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Screening for mutations in selected miRNA genes in hypogonadotropic hypogonadism patients

Iivonen, A-P., Känsäkoski, J., Vaaralahti, K. & Raivio, T., May 2019, In : Endocrine Connections. 8, 5, p. 506-509 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Treatment of gonadotropin deficiency during the first year of life: long-term observation and outcome in five boys

Kohva, E., Huopio, H., Hietamäki, J., Hero, M., Miettinen, P. J. & Raivio, T., May 2019, In : Human Reproduction. 34, 5, p. 863-871 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Disorders of sex development: timing of diagnosis and management in a single large tertiary center

Kohva, E., Miettinen, P. J., Taskinen, S., Hero, M., Tarkkanen, A. & Raivio, T., 1 Apr 2018, In : Endocrine Connections. 7, 4, p. 595-603 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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New intronic Fibroblast Growth Factor Receptor 1 (FGFR1) mutation leading to disrupted splicing and Kallmann syndrome

Känsäkoski, J., Vaaralahti, K. & Raivio, T., Feb 2018, In : Human Reproduction. 33, 2, p. 328-330 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Recombinant Human FSH Treatment Outcomes in Five Boys With Severe Congenital Hypogonadotropic Hypogonadism

Kohva, E., Huopio, H., Hero, M., Miettinen, P. J., Vaaralahti, K., Sidoroff, V., Toppari, J. & Raivio, T., 15 Oct 2018, In : Journal of the Endocrine Society. 2, 12, p. 1345-1356 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Screening for germline KCNQ1 and KCNE2 mutations in a set of somatotropinoma patients

Iivonen, A-P., Känsäkoski, J., Karppinen, A., Kivipelto, L., Schalin-Jäntti, C., Karhu, A. & Raivio, T., 1 May 2018, In : Endocrine Connections. 7, 5, p. 645-652 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

The Role of KCNQ1 Mutations and Maternal Beta Blocker Use During Pregnancy in the Growth of Children With Long QT Syndrome

Huttunen, H., Hero, M., Lääperi, M., Känsäkoski, J., Swan, H., Hirsch, J. A., Miettinen, P. J. & Raivio, T., 24 Apr 2018, In : Frontiers in Endocrinology. 9, 7 p., 194.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome

Kim, Y-J., Osborn, D. P. S., Lee, J-Y., Araki, M., Araki, K., Mohun, T., Känsäkoski, J., Brandstack, N., Kim, H-T., Miralles, F., Kim, C-H., Brow, N. A., Kim, H-G., Martinez-Barbera, J. P., Ataliotis, P., Raivio, T., Layman, L. C. & Kim, S-H., Feb 2018, In : EMBO Reports. 19, 2, p. 269-289 21 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Open Access
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Precocious Puberty or Premature Thelarche: analysis of a large Patient series in a single Tertiary center with special emphasis on 6-to 8-Year-Old girls

Varimo, T., Huttunen, H., Miettinen, P. J., Kariola, L., Hietamaki, J., Tarkkanen, A., Hero, M. & Raivio, T., 23 Aug 2017, In : Frontiers in Endocrinology. 8, 7 p., 213.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Puberteettikehitys ja sen häiriöt

Raivio, T., 2017, Lääkärin käsikirja. Jousimaa, J., Alenius, H., Atula, S., Berghem, N., Kattainen, A., Kunnamo, I., Pelttari, H. & Teikari, M. (eds.). 12. uud. p. ed. Helsinki: Duodecim, p. 1271-1273 3 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

The Role of Sequential BMP Signaling in Directing Human Embryonic Stem Cells to Bipotential Gonadal Cells

Sepponen, K., Lundin, K., Knuus, K., Vayrynen, P., Raivio, T., Tapanainen, J. S. & Tuuri, T., 1 Nov 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 11, p. 4303-4314 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Two missense mutations in KCNQ1 cause pituitary hormone deficiency and maternally inherited gingival fibromatosis

Tommiska, J., Känsäkoski, J., Skibsbye, L., Vaaralahti, K., Liu, X., Lodge, E. J., Tang, C., Yuan, L., Fagerholm, R., Kanters, J. K., Lahermo, P., Kaunisto, M., Keski-Filppula, R., Vuoristo, S., Pulli, K., Ebeling, T., Valanne, L., Sankila, E-M., Kivirikko, S., Lääperi, M. & 15 others, Casoni, F., Giacobini, P., Phan-Hug, F., Buki, T., Tena-Sempere, M., Pitteloud, N., Veijola, R., Lipsanen-Nyman, M., Kaunisto, K., Mollard, P., Andoniadou, C. L., Hirsch, J. A., Varjosalo, M., Jespersen, T. & Raivio, T., 3 Nov 2017, In : Nature Communications. 8, 11 p., 1289.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Childhood growth in boys with congenital hypogonadotropic hypogonadism

Varimo, T., Hero, M., Laitinen, E-M., Miettinen, P., Tommiska, J., Känsäkoski, J., Juul, A. & Raivio, T., May 2016, In : Pediatric Research. 79, 5, p. 705-709 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Circulating makorin ring finger protein 3 levels decline in boys before the clinical onset of puberty

Varimo, T., Dunkel, L., Vaaralahti, K., Miettinen, P., Hero, M. & Raivio, T., Jun 2016, In : European Journal of Endocrinology. 174, 6, p. 785-790 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Complete androgen insensitivity syndrome caused by a deep intronic pseudoexon-activating mutation in the androgen receptor gene

Känsäkoski, J., Jaaskelainen, J., Jaaskelainen, T., Tommiska, J., Saarinen, L., Lehtonen, R., Hautaniemi, S., Frilander, M. J., Palvimo, J. J., Toppari, J. & Raivio, T., 9 Sep 2016, In : Scientific Reports. 6, 7 p., 32819.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Development of Gonadotropin-Releasing Hormone-Secreting Neurons from Human Pluripotent Stem Cells

Lund, C., Pulli, A. K., Yellapragada, V., Giacobini, P., Lundin (Stenroos), K., Vuoristo, S., Tuuri, T., Noisa, P. & Raivio, T., 9 Aug 2016, In : Stem cell reports. 7, 2, p. 149-157 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Gonadotropin-releasing hormone receptor mutations in ageing men

Tommiska, J., Kansakoski, J., Pitteloud, N., Wu, F. & Raivio, T., Jan 2016, In : Clinical Endocrinology. 84, 1, p. 150-151 3 p.

Research output: Contribution to journalArticleScientific

Reversible hypogonadotropic hypogonadism

Dwyer, A. A., Raivio, T. & Pitteloud, N., Jun 2016, In : European Journal of Endocrinology. 174, 6, p. R267-R274 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2015

A missense mutation in MKRN3 in a Danish girl with central precocious puberty and her brother with early puberty

Kansakoski, J., Raivio, T., Juul, A. & Tommiska, J., Dec 2015, In : Pediatric Research. 78, 6, p. 709-711 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Childhood growth of females with Kallmann syndrome and FGFR1 mutations

Hero, M., Laitinen, E-M., Varimo, T., Vaaralahti, K., Tommiska, J. & Raivio, T., Jan 2015, In : Clinical Endocrinology. 82, 1, p. 122-126 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Combined negative effect of donor age and time in culture on the reprogramming efficiency into induced pluripotent stem cells

Trokovic, R., Weltner, J., Noisa, P., Raivio, T. & Otonkoski, T., Jul 2015, In : Stem Cell Research. 15, 1, p. 254-262 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Comment on reversal of hypogonadotropic hypogonadism in a Chinese cohort

Dwyer, A. & Raivio, P. T., May 2015, In : Asian journal of andrology. 17, 3, p. 580-580 1 p.

Research output: Contribution to journalArticleScientific

Congenital hypogonadotropic hypogonadism with split hand/foot malformation: a clinical entity with a high frequency of FGFR1 mutations

Villanueva, C., Jacobson-Dickman, E., Xu, C., Manouvrier, S., Dwyer, A. A., Sykiotis, G. P., Beenken, A., Liu, Y., Tommiska, J., Hu, Y., Tiosano, D., Gerard, M., Leger, J., Drouin-Garraud, V., Lefebvre, H., Polak, M., Carel, J-C., Phan-Hug, F., Hauschild, M., Plummer, L. & 7 others, Rey, J-P., Raivio, T., Bouloux, P., Sidis, Y., Mohammadi, M., de Roux, N. & Pitteloud, N., Aug 2015, In : Genetics In medicine. 17, 8, p. 651-659 9 p.

Research output: Contribution to journalArticleScientificpeer-review

EXPERT CONSENSUS DOCUMENT European Consensus Statement on congenital hypogonadotropic hypogonadism-pathogenesis, diagnosis and treatment

Boehm, U., Bouloux, P-M., Dattani, M. T., de Roux, N., Dode, C., Dunkel, L., Dwyer, A. A., Giacobini, P., Hardelin, J-P., Juul, A., Maghnie, M., Pitteloud, N., Prevot, V., Raivio, T., Tena-Sempere, M., Quinton, R. & Young, J., Sep 2015, In : Nature reviews. Endocrinology. 11, 9, p. 547-564 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Gonadotrophin replacement for induction of fertility in hypogonadal men

Dwyer, A. A., Raivio, T. & Pitteloud, N., Jan 2015, In : Best Practice & Research. Clinical Endocrinology & Metabolism. 29, 1, p. 91-103 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Health-related quality of life in male patients with congenital hypogonadotropic hypogonadism

Varimo, T., Hero, M., Laitinen, E-M., Sintonen, H. & Raivio, T., Jul 2015, In : Clinical Endocrinology. 83, 1, p. 141-143 3 p.

Research output: Contribution to journalArticleScientific

Neural Progenitor Cells Derived from Human Embryonic Stem Cells as an Origin of Dopaminergic Neurons

Noisa, P., Raivio, T. & Cui, W., 2015, In : Stem Cells International. 2015, 10 p., 647437.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Poikien viivästynyt murrosiän kehitys

Varimo, T., Hero, M. & Raivio, T., 2015, In : Suomen lääkärilehti. 70, 26-32, p. 1903-1907 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

De novo SOX10 nonsense mutation in a patient with Kallmann syndrome and hearing loss

Vaaralahti, K., Tommiska, J., Tillmann, V., Liivak, N., Kansakoski, J., Laitinen, E-M. & Raivio, T., Jul 2014, In : Pediatric Research. 76, 1, p. 115-116 2 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetics of congenital hypogonadotropic hypogonadism in Denmark

Tommiska, J., Kansakoski, J., Christiansen, P., Jorgensen, N., Lawaetz, J. G., Juul, A. & Raivio, T., Jul 2014, In : European Journal of Medical Genetics. 57, 7, p. 345-348 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Hereditary myopathy with early respiratory failure: occurrence in various populations

Palmio, J., Evila, A., Chapon, F., Tasca, G., Xiang, F., Bradvik, B., Eymard, B., Echaniz-Laguna, A., Laporte, J., Karppa, M., Mahjneh, I., Quinlivan, R., Laforet, P., Damian, M., Berardo, A., Taratuto, A. L., Bueri, J. A., Tommiska, J., Raivio, T., Tuerk, M. & 10 others, Goelitz, P., Chevessier, F., Sewry, C., Norwood, F., Hedberg, C., Schroeder, R., Edstrom, L., Oldfors, A., Hackman, P. & Udd, B., Mar 2014, In : Journal of Neurology, Neurosurgery and Psychiatry. 85, 3, p. 345-353 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Mutation screening of SEMA3A and SEMA7A in patients with congenital hypogonadotropic hypogonadism

Kansakoski, J., Fagerholm, R., Laitinen, E-M., Vaaralahti, K., Hackman, P., Pitteloud, N., Raivio, T. & Tommiska, J., May 2014, In : Pediatric Research. 75, 5, p. 641-644 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Neural Crest Cells: From Developmental Biology to Clinical Interventions

Noisa, P. & Raivio, T., Sep 2014, In : Birth defects research. Part C, Embryo today: Reviews. 102, 3, p. 263-274 12 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Notch signaling regulates the differentiation of neural crest from human pluripotent stem cells

Noisa, P., Lund, C., Kanduri, K., Lund, R., Lahdesmaki, H., Lahesmaa, R., Lundin, K., Chokechuwattanalert, H., Otonkoski, T., Tuuri, T. & Raivio, T., 1 May 2014, In : Journal of Cell Science. 127, 9, p. 2083-2094 12 p.

Research output: Contribution to journalArticleScientificpeer-review