Research output per year
Research output per year
Personal profile
Education information
M.Sc.
Education/Academic qualification
Master of Science, University of Helsinki
Fields of Science
- 1182 Biochemistry, cell and molecular biology
- 1183 Plant biology, microbiology, virology
- 1184 Genetics, developmental biology, physiology
- 3122 Cancers
- Translational research
- Personalized Medicine
- 318 Medical biotechnology
- 116 Chemical sciences
- drug screening
International and National Collaboration
Publications and projects within past five years.
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BCL-2/BCL-XL Inhibition Induces Apoptosis and Circumvents Venetoclax Resistance in TP53-mutated Acute Myeloid Leukemia
Vänttinen, I. M., Kytölä, S. J., Dufva, O., Hellesøy, M., Gullaksen, S-E., Ruokoranta, T., Bruck, O., Siitonen, S., Ettala, P., Pyörälä, M., Rimpilainen, J., Siitonen, T., Gjertsen, B. T., Heckman, C., Kuusanmäki, H. & Kontro, M., 8 Aug 2023, In: Hemasphere.Research output: Contribution to journal › Meeting Abstract › peer-review
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Erythroid/megakaryocytic differentiation confers BCL-XL dependency and venetoclax resistance in acute myeloid leukemia
Kuusanmäki, H., Dufva, O., Vähä-Koskela, M., Leppä, A-M., Huuhtanen, J., Vänttinen, I., Nygren, P., Klievink, J., Bouhlal, J., Pölönen, P., Zhang, Q., Adnan-Awad, S., Mancebo-Pérez, C., Saad, J., Miettinen, J., Javarappa, K. K., Aakko, S., Ruokoranta, T., Eldfors, S., Heinäniemi, M., & 9 others, 30 Mar 2023, In: Blood. 141, 13, p. 1610-1625 16 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia
Kuusanmaki, H., Kytölä, S., Vänttinen, I., Ruokoranta, T., Ranta, A., Huuhtanen, J., Suvela, M., Parsons, A., Holopainen, A., Partanen, A., Kuusisto, M. E. L., Koskela, S., Räty, R., Itälä-Remes, M., Västrik, I., Dufva, O., Siitonen, S., Porkka, K., Wennerberg, K., Heckman, C. A., & 5 others, Jul 2023, In: Haematologica. 108, 7, p. 1768-1781 14 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Ex Vivo Venetoclax Sensitivity Testing Predicts Response and Overall Survival in De Novo and s/R/R AML Patients Treated with Azacitidine and Venetoclax
Kytölä, S., Vänttinen, I., Ruokoranta, T., Holopainen, A., Partanen, A., Kuusisto, M. E. L., Koskela, S., Räty, R., Itälä-Remes, M., Ranta, A., Suvela, M., Parsons, A., Västrik, I., Siitonen, S. M., Porkka, K., Wennerberg, K., Heckman, C. A., Ettala, P., Rimpiläinen, J., Siitonen, T., & 3 others, 15 Nov 2022, In: Blood. 140, Suppl. 1, p. 2020-2022 3 p.Research output: Contribution to journal › Meeting Abstract › peer-review
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The Novel Peptide Drug Conjugate OPDC3 Is Highly Active in Different Hematological Malignancies
Miettinen, J., Ruokoranta, T., Ikonen, V. K., Huppunen, M-E. A., Acs, K., Lehmann, F. & Heckman, C., Nov 2022, In: Blood. 140, Supplement 1, p. 10697–10698 2 p.Research output: Contribution to journal › Meeting Abstract › peer-review
Open Access
Projects
- 1 Active
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Caroline Heckman NIH subaward ISB
Kallio, S. J., Ruokoranta, T., Sergeev, P., Srivastava, A. & Heckman, C.
National Institutes of Health (NIH) OFM
01/01/2023 → 31/12/2023
Project: Other funder