Photo of Tanja Talvikki Holopainen

Tanja Talvikki Holopainen

20052018
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Publications 2005 2018

2018

Treating cachexia using soluble ACVR2B improves survival, alters mTOR localization, and attenuates liver and spleen responses

Nissinen, T. A., Hentilä, J., Penna, F., Lampinen, A., Lautaoja, J. H., Fachada, V., Holopainen, T., Ritvos, O., Kivelä, R. & Hulmi, J. J., Jun 2018, In : Journal of cachexia, sarcopenia and muscle. 9, 3, p. 514-529 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

TIE

Saharinen, P. & Holopainen, T., 2017, Cancer Therapeutic Targets. Marshall, J. L. (ed.). New York: Springer, Vol. 2-2. p. 611-624

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

2016

Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors

Honkanen, H-K., Izzi, V., Petaisto, T., Holopainen, T., Harjunen, V., Pihlajaniemi, T., Alitalo, K. & Heljasvaara, R., Jul 2016, In : NeoPlasia. 18, 7, p. 436-446 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Targeting endothelial tyrosine kinase pathways in tumor growth and metastasis

Holopainen, T., 2016, Helsinki: University of Helsinki. 94 p.

Research output: ThesisDoctoral ThesisCollection of Articles

2015

Assessment of tumour viability in human lung cancer xenografts with texture-based image analysis

Turkki, R., Linder, N., Holopainen, T., Wang, Y., Grote, A., Lundin, M., Alitalo, K. & Lundin, J., Aug 2015, In : Journal of Clinical Pathology. 68, 8, p. 614-621 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling

Holopainen, T., Rasanen, M., Anisimov, A., Tuomainen, T., Zheng, W., Tvorogov, D., Hulmi, J. J., Andersson, L. C., Cenni, B., Tavi, P., Mervaala, E., Kivela, R. & Alitalo, K., 20 Oct 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. 13063-13068 6 p.

Research output: Contribution to journalArticleScientificpeer-review

MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma

Tatti, O., Gucciardo, E., Pekkonen, P., Holopainen, T., Louhimo, R., Repo, P., Maliniemi, P., Lohi, J., Rantanen, V., Hautaniemi, S., Alitalo, K., Ranki, A., Ojala, P. M., Keski-Oja, J. & Lehti, K., 15 May 2015, In : Cancer Research. 75, 10, p. 2083-2094 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions

Zheng, W., Nurmi, H., Appak, S., Sabine, A., Bovay, E., Korhonen, E. A., Orsenigo, F., Lohela, M., D'Amico, G., Holopainen, T., Leow, C. C., Dejana, E., Petrova, T. V., Augustin, H. G. & Alitalo, K., 15 Jul 2014, In : Genes & Development. 28, 14, p. 1592-1603 12 p.

Research output: Contribution to journalArticleScientificpeer-review

CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3-Mediated Vascular Endothelial Growth Factor-C Activation

Jeltsch, M., Jha, S. K., Tvorogov, D., Anisimov, A., Leppanen, V-M., Holopainen, T., Kivela, R., Ortega, S., Karpanen, T. & Alitalo, K., 13 May 2014, In : Circulation . 129, 19, p. 1962-1971 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Prox1 Promotes Expansion of the Colorectal Cancer Stem Cell Population to Fuel Tumor Growth and Ischemia Resistance

Wiener, Z., Hogstrom, J., Hyvonen, V., Band, A. M., Kallio, P., Holopainen, T., Dufva, O., Haglund, C., Kruuna, O., Oliver, G., Ben-Neriah, Y. & Alitalo, K., 25 Sep 2014, In : Cell Reports. 8, 6, p. 1943-1956 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy

D'Amico, G., Korhonen, E. A., Anisimov, A., Zarkada, G., Holopainen, T., Haegerling, R., Kiefer, F., Eklund, L., Sormunen, R., Elamaa, H., Brekken, R. A., Adams, R. H., Koh, G. Y., Saharinen, P. & Alitalo, K., Feb 2014, In : Journal of Clinical Investigation. 124, 2, p. 824-834 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

The Basis for the Distinct Biological Activities of Vascular Endothelial Growth Factor Receptor-1 Ligands

Anisimov, A., Leppanen, V-M., Tvorogov, D., Zarkada, G., Jeltsch, M., Holopainen, T., Kaijalainen, S. & Alitalo, K., 2 Jul 2013, In : Science signaling. 6, 282, p. ra52 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis

Anisimov, A., Tvorogov, D., Alitalo, A., Leppänen, V-M., An, Y., Han, E. C., Orsenigo, F., Gaal, E. I., Holopainen, T., Koh, Y. J., Tammela, T., Korpisalo, P., Keskitalo, S., Jeltsch, M., Yla-Herttuala, S., Dejana, E., Koh, G. Y., Choi, C., Saharinen, P. & Alitalo, K., 2013, In : Circulation . 127, 4, p. 424-434 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth.

Holopainen, T. T., López Alpuche, V., Zheng, W., Heljasvaara, R., Jones, D., He, Y., Tvorogov, D., D Amico Lago, G. V., Wiener, Z., Andersson, L. C., Pihlajaniemi, T., Min, W. & Alitalo, K., 15 Jul 2012, In : Cancer Research. 72, 14, p. 3512-3521 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis

Holopainen, T. T., Saharinen, P. I., D Amico Lago, G. V., Lampinen, A., Eklund, L., Sormunen, R., Anisimov, A., Zarkada, G., Lohela, M. K., Heloterä, H., Tammela, T., Benjamin, L., Ylä-Herttuala, S., Leow, C. C., Koh, G. Y. & Alitalo, K., 21 Mar 2012, In : Journal of the National Cancer Institute. 104, 6, p. 461-475 15 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor

Zheng, W., Tammela, T., Yamamoto, M., Anisimov, A., Holopainen, T., Kaijalainen, S., Kärpänen, T. H., Lehti, K., Yla-Herttuala, S. & Alitalo, K., 2011, In : Blood. 118, 4, p. 1154-1162 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Perspectives on Lymphangiogenesis and Angiogenesis in Cancer

Holopainen, T., Bry, M., Alitalo, K. & Saaristo, A., 2011, In : Journal of Surgical Oncology. 103, 6, p. 484-488 5 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis

Tammela, T., Saaristo, A., Holopainen, T. T., Ylä-Herttuala, S., Andersson, L. C., Virolainen, M. S., Immonen, I. & Alitalo, K., 2011, In : Science translational medicine. 3, 69ra11, p. - 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization

Tvorogov, D., Anisimov, A., Zheng, W., Leppänen, V-M., Tammela, T., Laurinavicius, S., Holnthoner, W., Heloterä, H., Holopainen, T., Jeltsch, M., Kalkkinen, N., Lankinen, H., Ojala, P. M. & Alitalo, K., 2010, In : Cancer Cell. 18, 6, p. 630-640 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation

Bry, M., Kivelä, R., Holopainen, T., Anisimov, A., Tammela, T., Soronen, J., Silvola, J., Saraste, A., Jeltsch, M., Korpisalo, P., Carmeliet, P., Lemström, K. B., Shibuya, M., Yla-Herttuala, S., Alhonen, L., Mervaala, E., Andersson, L. C., Knuuti, J. & Alitalo, K., 2010, In : Circulation . 122, 17, p. 1725-1733 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment

Holopainen, T., Huang, H., Chen, C., Kim, K. E., Zhang, L., Zhou, F., Han, W., Li, C., Yu, J., Wu, J., Koh, G. Y., Alitalo, K. & He, Y., 1 Jun 2009, In : Cancer Research. 69, 11, p. 4656-4664 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Molecular Targeting of Lymphangiogenesis and Tumor Metastasis

Heckman, C. A., Holopainen, T. T. & Alitalo, K., 2009, From Local Invasion to Metastatic Cancer . Stanley, L. (ed.). Humana Press, p. 283-295

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

2008

Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy

Mitchell-Jordan, S. A., Holopainen, T., Ren, S., Wang, S., Warburton, S., Zhang, M. J., Alitalo, K., Wang, Y. & Vondriska, T. M., 2008, In : Circulation Research. 103, 12, p. 1359-1362 4 p.

Research output: Contribution to journalArticleScientificpeer-review

The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis

Heckman, C. A., Holopainen, T., Wirzenius, M., Keskitalo, S., Jeltsch, M., Ylä-Herttuala, S., Wedge, S. R., Jurgensmeier, J. M. & Alitalo, K., 2008, In : Cancer Research. 68, 12, p. 4754-4762 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation

Tammela, T., Saaristo, A., Holopainen, T., Lyytikkä, J., Kotronen, A., Pitkonen, M., Abo-Ramadan, U., Ylä-Herttuala, S., Petrova, T. V. & Alitalo, K., 2007, In : Nature Medicine. 13, 12, p. 1458-1466 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth

Laakkonen, P., Waltari, M., Holopainen, T., Takahashi, T., Pytowski, B., Steiner, P., Hicklin, D., Persaud, K., Tonra, J. R., Witte, L. & Alitalo, K., 2007, In : Cancer Research. 67, 2, p. 593-599 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels

He, Y., Rajantie, I., Pajusola, K., Jeltsch, M., Holopainen, T. T., Ylä-Herttuala, S., Harding, T., Jooss, K., Takahashi, T. & Alitalo, K., 2005, In : Cancer Research. 65, 11, p. 4739-4746 8 p.

Research output: Contribution to journalArticleScientificpeer-review