Research output per year
Research output per year
- 23 results
Search results
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2018
Treating cachexia using soluble ACVR2B improves survival, alters mTOR localization, and attenuates liver and spleen responses
Nissinen, T. A., Hentilä, J., Penna, F., Lampinen, A., Lautaoja, J. H., Fachada, V., Holopainen, T., Ritvos, O., Kivelä, R. & Hulmi, J. J., Jun 2018, In: Journal of cachexia, sarcopenia and muscle. 9, 3, p. 514-529 16 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
2016
Elevated VEGF-D Modulates Tumor Inflammation and Reduces the Growth of Carcinogen-Induced Skin Tumors
Honkanen, H.-K., Izzi, V., Petaisto, T., Holopainen, T., Harjunen, V., Pihlajaniemi, T., Alitalo, K. & Heljasvaara, R., Jul 2016, In: NeoPlasia. 18, 7, p. 436-446 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
2015
Assessment of tumour viability in human lung cancer xenografts with texture-based image analysis
Turkki, R., Linder, N., Holopainen, T., Wang, Y., Grote, A., Lundin, M., Alitalo, K. & Lundin, J., Aug 2015, In: Journal of Clinical Pathology. 68, 8, p. 614-621 8 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Endothelial Bmx tyrosine kinase activity is essential for myocardial hypertrophy and remodeling
Holopainen, T., Rasanen, M., Anisimov, A., Tuomainen, T., Zheng, W., Tvorogov, D., Hulmi, J. J., Andersson, L. C., Cenni, B., Tavi, P., Mervaala, E., Kivela, R. & Alitalo, K., 20 Oct 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 42, p. 13063-13068 6 p.Research output: Contribution to journal › Article › Scientific › peer-review
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MMP16 Mediates a Proteolytic Switch to Promote Cell-Cell Adhesion, Collagen Alignment, and Lymphatic Invasion in Melanoma
Tatti, O., Gucciardo, E., Pekkonen, P., Holopainen, T., Louhimo, R., Repo, P., Maliniemi, P., Lohi, J., Rantanen, V., Hautaniemi, S., Alitalo, K., Ranki, A., Ojala, P. M., Keski-Oja, J. & Lehti, K., 15 May 2015, In: Cancer Research. 75, 10, p. 2083-2094 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
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2014
Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions
Zheng, W., Nurmi, H., Appak, S., Sabine, A., Bovay, E., Korhonen, E. A., Orsenigo, F., Lohela, M., D'Amico, G., Holopainen, T., Leow, C. C., Dejana, E., Petrova, T. V., Augustin, H. G. & Alitalo, K., 15 Jul 2014, In: Genes & Development. 28, 14, p. 1592-1603 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
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CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3-Mediated Vascular Endothelial Growth Factor-C Activation
Jeltsch, M., Jha, S. K., Tvorogov, D., Anisimov, A., Leppanen, V.-M., Holopainen, T., Kivela, R., Ortega, S., Karpanen, T. & Alitalo, K., 13 May 2014, In: Circulation . 129, 19, p. 1962-1971 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Prox1 Promotes Expansion of the Colorectal Cancer Stem Cell Population to Fuel Tumor Growth and Ischemia Resistance
Wiener, Z., Hogstrom, J., Hyvonen, V., Band, A. M., Kallio, P., Holopainen, T., Dufva, O., Haglund, C., Kruuna, O., Oliver, G., Ben-Neriah, Y. & Alitalo, K., 25 Sept 2014, In: Cell Reports. 8, 6, p. 1943-1956 14 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy
D'Amico, G., Korhonen, E. A., Anisimov, A., Zarkada, G., Holopainen, T., Haegerling, R., Kiefer, F., Eklund, L., Sormunen, R., Elamaa, H., Brekken, R. A., Adams, R. H., Koh, G. Y., Saharinen, P. & Alitalo, K., Feb 2014, In: Journal of Clinical Investigation. 124, 2, p. 824-834 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
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2013
The Basis for the Distinct Biological Activities of Vascular Endothelial Growth Factor Receptor-1 Ligands
Anisimov, A., Leppanen, V.-M., Tvorogov, D., Zarkada, G., Jeltsch, M., Holopainen, T., Kaijalainen, S. & Alitalo, K., 2 Jul 2013, In: Science signaling. 6, 282, p. ra52 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis
Anisimov, A., Tvorogov, D., Alitalo, A., Leppänen, V.-M., An, Y., Han, E. C., Orsenigo, F., Gaal, E. I., Holopainen, T., Koh, Y. J., Tammela, T., Korpisalo, P., Keskitalo, S., Jeltsch, M., Yla-Herttuala, S., Dejana, E., Koh, G. Y., Choi, C., Saharinen, P. & Alitalo, K., 2013, In: Circulation . 127, 4, p. 424-434 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
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2012
Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth.
Holopainen, T. T., López Alpuche, V., Zheng, W., Heljasvaara, R., Jones, D., He, Y., Tvorogov, D., D Amico Lago, G. V., Wiener, Z., Andersson, L. C., Pihlajaniemi, T., Min, W. & Alitalo, K., 15 Jul 2012, In: Cancer Research. 72, 14, p. 3512-3521 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Effects of angiopoietin-2-blocking antibody on endothelial cell-cell junctions and lung metastasis
Holopainen, T. T., Saharinen, P. I., D Amico Lago, G. V., Lampinen, A., Eklund, L., Sormunen, R., Anisimov, A., Zarkada, G., Lohela, M. K., Heloterä, H., Tammela, T., Benjamin, L., Ylä-Herttuala, S., Leow, C. C., Koh, G. Y. & Alitalo, K., 21 Mar 2012, In: Journal of the National Cancer Institute. 104, 6, p. 461-475 15 p.Research output: Contribution to journal › Article › Scientific › peer-review
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2011
Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor
Zheng, W., Tammela, T., Yamamoto, M., Anisimov, A., Holopainen, T., Kaijalainen, S., Kärpänen, T. H., Lehti, K., Yla-Herttuala, S. & Alitalo, K., 2011, In: Blood. 118, 4, p. 1154-1162 9 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Photodynamic ablation of lymphatic vessels and intralymphatic cancer cells prevents metastasis
Tammela, T., Saaristo, A., Holopainen, T. T., Ylä-Herttuala, S., Andersson, L. C., Virolainen, M. S., Immonen, I. & Alitalo, K., 2011, In: Science translational medicine. 3, 69ra11, p. - 8 p.Research output: Contribution to journal › Article › Scientific › peer-review
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2010
Effective suppression of vascular network formation by combination of antibodies blocking VEGFR ligand binding and receptor dimerization
Tvorogov, D., Anisimov, A., Zheng, W., Leppänen, V.-M., Tammela, T., Laurinavicius, S., Holnthoner, W., Heloterä, H., Holopainen, T., Jeltsch, M., Kalkkinen, N., Lankinen, H., Ojala, P. M. & Alitalo, K., 2010, In: Cancer Cell. 18, 6, p. 630-640 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Vascular Endothelial Growth Factor-B Acts as a Coronary Growth Factor in Transgenic Rats Without Inducing Angiogenesis, Vascular Leak, or Inflammation
Bry, M., Kivelä, R., Holopainen, T., Anisimov, A., Tammela, T., Soronen, J., Silvola, J., Saraste, A., Jeltsch, M., Korpisalo, P., Carmeliet, P., Lemström, K. B., Shibuya, M., Yla-Herttuala, S., Alhonen, L., Mervaala, E., Andersson, L. C., Knuuti, J. & Alitalo, K., 2010, In: Circulation . 122, 17, p. 1725-1733 9 p.Research output: Contribution to journal › Article › Scientific › peer-review
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2009
Angiopoietin-1 Overexpression Modulates Vascular Endothelium to Facilitate Tumor Cell Dissemination and Metastasis Establishment
Holopainen, T., Huang, H., Chen, C., Kim, K. E., Zhang, L., Zhou, F., Han, W., Li, C., Yu, J., Wu, J., Koh, G. Y., Alitalo, K. & He, Y., 1 Jun 2009, In: Cancer Research. 69, 11, p. 4656-4664 9 p.Research output: Contribution to journal › Article › Scientific › peer-review
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2008
Loss of Bmx nonreceptor tyrosine kinase prevents pressure overload-induced cardiac hypertrophy
Mitchell-Jordan, S. A., Holopainen, T., Ren, S., Wang, S., Warburton, S., Zhang, M. J., Alitalo, K., Wang, Y. & Vondriska, T. M., 2008, In: Circulation Research. 103, 12, p. 1359-1362 4 p.Research output: Contribution to journal › Article › Scientific › peer-review
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The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis
Heckman, C. A., Holopainen, T., Wirzenius, M., Keskitalo, S., Jeltsch, M., Ylä-Herttuala, S., Wedge, S. R., Jurgensmeier, J. M. & Alitalo, K., 2008, In: Cancer Research. 68, 12, p. 4754-4762 9 p.Research output: Contribution to journal › Article › Scientific › peer-review
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2007
Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation
Tammela, T., Saaristo, A., Holopainen, T., Lyytikkä, J., Kotronen, A., Pitkonen, M., Abo-Ramadan, U., Ylä-Herttuala, S., Petrova, T. V. & Alitalo, K., 2007, In: Nature Medicine. 13, 12, p. 1458-1466 9 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth
Laakkonen, P., Waltari, M., Holopainen, T., Takahashi, T., Pytowski, B., Steiner, P., Hicklin, D., Persaud, K., Tonra, J. R., Witte, L. & Alitalo, K., 2007, In: Cancer Research. 67, 2, p. 593-599 7 p.Research output: Contribution to journal › Article › Scientific › peer-review
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2005
Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels
He, Y., Rajantie, I., Pajusola, K., Jeltsch, M., Holopainen, T. T., Ylä-Herttuala, S., Harding, T., Jooss, K., Takahashi, T. & Alitalo, K., 2005, In: Cancer Research. 65, 11, p. 4739-4746 8 p.Research output: Contribution to journal › Article › Scientific › peer-review