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Publications 1996 2019

2019

ORP2 interacts with phosphoinositides and controls the subcellular distribution of cholesterol

Koponen, A., Arora, A., Takahashi, K., Kentala, H., Kivela, A. M., Jaaskelainen, E., Peranen, J., Somerharju, P., Ikonen, E., Viitala, T. & Olkkonen, V. M., Mar 2019, In : Biochimie. 158, p. 90-101 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

3D label free bio-transfer standards

Järvinen, M., Vainikka, T., Viitala, T., Bermudez, C., Artigas, R., Nolvi, A., Martinez, P., Sandler, N., Hæggström, E. & Kassamakov, I., 7 Nov 2018, In : Proceedings of SPIE, the International Society for Optical Engineering. 10819, 8 p., 108190D.

Research output: Contribution to journalConference articleScientificpeer-review

AN ARTIFACT FOR DETERMINING RESOLUTION OF IMAGING BASED ON ELECTROMAGNETIC RADIATION AND/OR MECHANICAL WAVES

Haeggström, E. O., Kassamakov, I. V., Nolvi, A., Sandler, N., Viitala, T. J. S. & Nyman, J., 29 Jun 2018, IPC No. G01B11/06, G01B21/04, G01B9/02, University of Helsinki, Patent No. CA3022161 (A1), 16 Nov 2017, Priority No. FI20160005400 20160510; WO2017FI50353 20170508

Research output: PatentScientific

Biophysical Characterization of Supported Lipid Bilayers Using Parallel Dual-Wavelength Surface Plasmon Resonance and Quartz Crystal Microbalance Measurements

Parkkila, P., Elderdfi, M., Bunker, A. & Viitala, T., 10 Jul 2018, In : Langmuir. 34, 27, p. 8081-8091 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Characterization of membrane–foulant interactions with novel combination of Raman spectroscopy, surface plasmon resonance and molecular dynamics simulation

Virtanen, T., Parkkila, P., Koivuniemi, A., Lahti, J., Viitala, T., Kallioinen, M., Mänttäri, M. & Bunker, A., 23 May 2018, In : Separation and Purification Technology. 205, p. 263-272 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Comparison of time-gated surface-enhanced raman spectroscopy (TG-SERS) and classical SERS based monitoring of Escherichia coli cultivation samples

Kögler, M., Paul, A., Anane, E., Birkholz, M., Bunker, A., Viitala, T., Maiwald, M., Junne, S. & Neubauer, P., 2018, In : Biotechnology Progress. 34, 6, p. 1533-1542 10 p.

Research output: Contribution to journalArticleScientificpeer-review

High-Generation Amphiphilic Janus-Dendrimers as Stabilizing Agents for Drug Suspensions

Selin, M., Nummelin, S., Deleu, J., Ropponen, J., Viitala, T., Lahtinen, M., Koivisto, J., Hirvonen, J., Peltonen, L., Kostiainen, M. A. & Bimbo, L. M., Oct 2018, In : Biomacromolecules. 19, 10, p. 3983-3993 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Interaction of lecithin:cholesterol acyltransferase with lipid surfaces and apolipoprotein A-I-derived peptides

Casteleijn, M. G., Parkkila, P. K., Viitala, T. J. S. & Koivuniemi, A. S., Apr 2018, In : Journal of Lipid Research. 59, 4, p. 670-683 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Membrane bound COMT isoform is an interfacial enzyme: general mechanism and new drug design paradigm

Magarkar, A., Parkkila, P., Viitala, T., Lajunen, T., Mobarak, E., Licari, G., Cramariuc, O., Vauthey, E., Rog, T. & Bunker, A., 11 Apr 2018, In : Chemical Communications. 54, 28, p. 3440-3443 4 p.

Research output: Contribution to journalArticleScientificpeer-review

METHOD FOR CALIBRATING 3D IMAGING AND SYSTEM FOR 3D IMAGING

Haeggström, E. O., Kassamakov, I. V., Nolvi, A., Ylitalo, T. J., Sandler, N., Viitala, T. J. S. & Nyman, J., 17 Oct 2018, IPC No. G01B9/02, University of Helsinki, Patent No. CN107407550 (A), 28 Nov 2017, Priority No. FI20140006032 20141124; WO2015FI50744 20151029

Research output: PatentScientific

Personalized Cancer Vaccine Platform for Clinically Relevant Oncolytic Enveloped Viruses

Ylösmäki, E., Malorzo, C., Capasso, C., Honkasalo, O., Fusciello, M., Martins, B., Ylösmäki, L., Louna, A., Feola, S., Paavilainen, H., Peltonen, K., Hukkanen, V., Viitala, T. & Cerullo, V., 5 Sep 2018, In : Molecular therapy. 26, 9, p. 2315-2325 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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pH-Controlled Liposomes for Enhanced Cell Penetration in Tumor Environment

Barattin, M., Mattarei, A., Balasso, A., Paradisi, C., Cantu, L., Del Favero, E., Viitala, T., Mastrotto, F., Caliceti, P. & Salmaso, S., 30 May 2018, In : ACS Applied Materials & Interfaces. 10, 21, p. 17646-17661 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Spin coated chitin films for biosensors and its analysis are dependent on chitin-surface interactions

Casteleijn, M. G., Richardson, D., Parkkila, P. K., Granqvist, N. M., Urtti, A. O. & Viitala, T. J. S., 2018, In : Colloids and Surfaces A: Physicochemical and Engineering Aspects. 539, p. 261-272

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

16th International Conference on Organized Molecular Films (ICOMF16-LB16): Helsinki, Finland 25-29 July 2016

Viitala, T. J. S. (ed.), Feb 2017, Les Ulis Cedex A: EDP Sciences-Web of conferences. 40 p. (MATEC Web of Conferences; no. 98/2017)

Research output: Book/ReportAnthology or special issueScientificpeer-review

Interaction of LCAT enzyme with lipid surfaces and apolipoprotein A-I derived peptides

Casteleijn, M. G., Parkkila, P., Viitala, T. & Koivuniemi, A., Jul 2017, In : European Biophysics Journal. 46, p. S210-S210 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Multi-parametric surface plasmon resonance platform for studying liposome-serum interactions and protein corona formation

Kari, O. K., Rojalin, T., Salmaso, S., Barattin, M., Jarva, H., Meri, S., Yliperttula, M., Viitala, T. & Urtti, A., 2017, In : Drug Delivery and Translational Research. 7, 2, p. 1-13 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Oligomerization Alters Binding Affinity between Amyloid Beta and a Modulator of Peptide Aggregation

Hilt, S., Rojalin, T., Viitala, T., Koivuniemi, A., Bunker, A., Wachsmann-Hogiu, S., Kalai, T., Hideg, K., Yliperttula, M. & Voss, J. C., 2 Nov 2017, In : Journal of Physical Chemistry C. 121, 43, p. 23974-23987 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Real-time fouling monitoring with Raman spectroscopy

Virtanen, T., Reinikainen, S-P., Kögler, M., Mänttäri, M., Viitala, T. & Kallioinen, M., 1 Mar 2017, In : Journal of Membrane Science. 525, p. 312-319 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Round Robin test on bio-imaging transfer standard for 3D optical profilers

Nolvi, A. M., Viitala, T. J. S., Garcia Pérez, A., Sandler, N., Haeggström, E. O., Bermudez, C., Artigas, R. & Kassamakov, I. V., 20 Feb 2017, Photonic Instrumentation Engineering IV. Soskind, Y. S. & Olson, C. (eds.). Bellingham: SPIE, 9 p. (Proceedings ; vol. 10110).

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Stability optimization of microbial surface-enhanced Raman spectroscopy detection with immunomagnetic separation beads

Uusitalo, S., Kögler, M., Välimaa, A-L., Petäjä, J., Kontturi, V., Siitonen, S., Laitinen, R., Kinnunen, M., Viitala, T. & Hiltunen, J., Mar 2017, In : Optical Engineering. 56, 3, 7 p., 037102.

Research output: Contribution to journalArticleScientificpeer-review

Targeting Tumor-Associated Exosomes with Integrin-Binding Peptides

Carney, R. P., Hazari, S., Rojalin, T., Knudson, A., Gao, T., Tang, Y., Liu, R., Viitala, T., Yliperttula, M. & Lam, K. S., May 2017, In : Advanced Biosystems. 1, 5, 12 p., 1600038.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Time-resolved SERS for characterizing extracellular vesicles

Rojalin, T., Saari, H., Somersalo, P., Laitinen, S., Turunen, M., Viitala, T., Wachsmann-Hogiu, S., Smith, Z. J. & Yliperttula, M., 2017.

Research output: Conference materialsPosterResearch

2016

Detection of Listeria innocua on roll-to-roll produced SERS substrates with gold nanoparticles

Uusitalo, S., Kogler, M., Välimaa, A. -L., Popov, A., Ryabchikov, Y., Kontturi, V., Siitonen, S., Petäjä, J., Virtanen, T., Laitinen, R., Kinnunen, M., Meglinski, I., Kabashin, A., Bunker, A., Viitala, T. & Hiltunen, J., 2016, In : RSC Advances. 6, 67, p. 62981-62989 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Enhancement of Bioavailability and Pharmacodynamic Effects of Thymoquinone Via Nanostructured Lipid Carrier (NLC) Formulation

Elmowafy, M., Samy, A., Raslan, M. A., Salama, A., Said, R. A., Abdelaziz, A. E., El-Eraky, W., El Awdan, S. & Viitala, T., Jun 2016, In : AAPS PharmSciTech. 17, 3, p. 663-672 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Factorial design formulation optimization and in vitro characterization of curcumin-loaded PLGA nanoparticles for colon delivery

Akl, M. A., Kartal-Hodzic, A., Oksanen, T., Ismael, H. R., Afouna, M. M., Yliperttula, M., Samy, A. M. & Viitala, T., Apr 2016, In : Journal of Drug Delivery Science and Technology. 32, part A, p. 10-20 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier

Baghirov, H., Karaman, D., Viitala, T., Duchanoy, A., Lou, Y-R., Mamaeva, V., Pryazhnikov, E., Khiroug, L., Davies, C. D. L., Sahlgren, C. & Rosenholm, J. M., 22 Aug 2016, In : PLoS One. 11, 8, 22 p., 0160705.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Fluorescence-suppressed time-resolved Raman spectroscopy of pharmaceuticals using complementary metal-oxide semiconductor (CMOS) single-photon avalanche diode (SPAD) detector

Rojalin, T., Kurki, L., Laaksonen, T., Viitala, T., Kostamovaara, J., Gordon, K. C., Galvis, L., Wachsmann-Hogiu, S., Strachan, C. J. & Yliperttula, M., 2016, In : Analytical and Bioanalytical Chemistry. 408, 3, p. 761-774 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Indocyanine Green-Loaded Liposomes for Light-Triggered Drug Release

Lajunen, T., Kontturi, L-S., Viitala, L., Manna, M., Cramariuc, O., Rog, T., Bunker, A., Laaksonen, T., Viitala, T., Murtomäki, L. & Urtti, A., Jun 2016, In : Molecular Pharmaceutics. 13, 6, p. 2095-2107 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Novel cationic polyelectrolyte coatings for capillary electrophoresis

Dusa, F., Witos, J., Karjalainen, E., Viitala, T., Tenhu, H. & Wiedmer, S. K., Jan 2016, In : Electrophoresis. 37, 2, p. 363-371 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Oncolytic adenoviruses coated with MHC-I tumor epitopes increase the anti-tumor immunity and efficacy against melanoma

Capasso, C., Hirvinen, M., Garofalo, M., Romaniuk, D., Kuryk, L., Sarvela, T., Vitale, A., Antopolsky, M., Magarkar, A., Viitala, T., Suutari, T., Bunker, A., Yliperttula, M., Urtti, A. & Cerullo, V., 2016, In : OncoImmunology. 5, 4, 11 p., 1105429.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Photothermally Triggered Lipid Bilayer Phase Transition and Drug Release from Gold Nanorod and Indocyanine Green Encapsulated Liposomes

Viitala, L., Pajari, S., Lajunen, T., Kontturi, L-S., Laaksonen, T., Kuosmanen, P., Viitala, T., Urtti, A. & Murtomaki, L., 10 May 2016, In : Langmuir. 32, 18, p. 4554-4563 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Printed biotin-functionalised polythiophene films as biorecognition layers in the development of paper-based biosensors

Ihalainen, P., Pesonen, M., Sund, P., Viitala, T., Määttänen, A., Sarfraz, J., Wilen, C-E., Österbacka, R. & Peltonen, J., 28 Feb 2016, In : Applied Surface Science. 364, p. 477-483 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Raman spectroscopy of single extracellular vesicles reveals subpopulations with varying membrane content

Smith, Z. J., Lee, C., Rojalin, T., Carney, R. P., Hazari, S., Knudson, A., Lam, K. S., Saari, H., Ibanez, E. L., Viitala, T., Laaksonen, T., Yliperttula, M. & Wachsmann-Hogiu, S., 2016, In : Proceedings of SPIE, the International Society for Optical Engineering. 9704

Research output: Contribution to journalConference articleScientific

Real-Time Label-Free Monitoring of Nanoparticle Cell Uptake

Suutari, T., Silen, T., Sen Karaman, D., Saari, H., Desai, D., Kerkelä, E., Laitinen, S., Hanzlikova, M., Rosenholm, J. M., Yliperttula, M. & Viitala, T., 7 Dec 2016, In : Small. 12, 45, p. 6289-6300 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Real-time Raman based approach for identification of biofouling

Kögler, M., Zhang, B., Cui, L., Shi, Y., Yliperttula, M. L., Laaksonen, T. J., Viitala, T. J. S. & Zhang, K., Jul 2016, In : Sensors and Actuators B: Chemical. 230, p. 411-421 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Surface Plasmon Resonance Imaging Microscopy of Liposomes and Liposome-Encapsulated Gold Nanoparticles

Viitala, L., Maley, A. M., Fung, H. W. M., Corn, R. M., Viitala, T. & Murtomäki, L., 17 Nov 2016, In : Journal of Physical Chemistry C. 120, 45, p. 25958-25966 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Detection of Phase Transition in Photosensitive Liposomes by Advanced QCM

Viitala, L., Lajunen, T., Urtti, A., Viitala, T. & Murtomaki, L., 17 Sep 2015, In : Journal of Physical Chemistry C. 119, 37, p. 21395-21403 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Interaction Studies Between Indomethacin Nanocrystals and PEO/PPO Copolymer Stabilizers

Liu, P., Viitala, T., Kartal-Hodzic, A., Liang, H., Laaksonen, T., Hirvonen, J. & Peltonen, L., 2015, In : Pharmaceutical Research. 32, 2, p. 628-639 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Ionic liquids affect the adsorption of liposomes onto cationic polyelectrolyte coated silica evidenced by quartz crystal microbalance

Dusa, F., Ruokonen, S-K., Petrovaj, J., Viitala, T. J. S. & Wiedmer, S. K., 28 Sep 2015, In : Colloids and Surfaces B: Biointerfaces. 136, p. 496-505 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Light induced cytosolic drug delivery from liposomes with gold nanoparticles

Lajunen, T., Viitala, L., Kontturi, L-S., Laaksonen, T., Liang, H., Vuorimaa-Laukkanen, E., Viitala, T., Le Guevel, X., Yliperttula, M., Murtomäki, L. & Urtti, A., 10 Apr 2015, In : Journal of Controlled Release. 203, p. 85-98 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Microvesicle- and exosome- mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells

Saari, H., Lazaro Ibanez, E., Viitala, T., Vuorimaa-Laukkanen, E., Siljander, P. & Yliperttula, M., 24 Sep 2015, In : Journal of Controlled Release. 220, p. 727-737 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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New oncolytic vaccine platform enhance anti-tumor immunity in humanized mice with human melanomas

Capasso, C., Hirvinen, M., Garofalo, M., Romaniuk, D., Kuryk, L., Sarvela, T., Vitale, A., Antopolsky, M., Magarkar, A., Viitala, T., Suutari, T., Bunker, A., Yliperttula, M., Urtti, A. & Cerullo, V., 1 Oct 2015, In : Human Gene Therapy. 26, 10, p. A53-A53 1 p.

Research output: Contribution to journalMeeting AbstractResearchpeer-review

Optical 3D-imaging with nanometer vertical resolution

Nolvi, A. M., Ylitalo, T. J., Viitala, T. J. S., Nyman, J., Kassamakov, I. V., Sandler, N. & Haeggström, E. O., Mar 2015, PROCEEDINGS OF THE XLIX ANNUAL CONFERENCE OF THE FINNISH PHYSICAL SOCIETY.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientific

Single exosome study reveals subpopulations distributed among cell lines with variability related to membrane content

Smith, Z. J., Lee, C., Rojalin, T., Carney, R. P., Hazari, S., Knudson, A., Lam, K., Saari, H., Lazaro Ibanez, E., Viitala, T., Laaksonen, T., Yliperttula, M. & Wachsmann-Hogiu, S., 7 Dec 2015, In : Journal of Extracellular Vesicles. 4, 15 p., 28533.

Research output: Contribution to journalArticleScientificpeer-review

2014

An impedimetric study of DNA hybridization on paper-supported inkjet-printed gold electrodes

Ihalainen, P., Pettersson, F., Pesonen, M., Viitala, T., Määttänen, A., Österbacka, R. & Peltonen, J., 7 Mar 2014, In : Nanotechnology. 25, 9, 11 p., 094009.

Research output: Contribution to journalArticleScientificpeer-review

Cell Surface Models: Platform for Targeted Drug and Gene Delivery and Release Optimization

Viitala, T., Kartal-Hodzic, A. & Suutari, T., 2014, In : Dosis. 30, 3, p. 221 1 p.

Research output: Contribution to journalArticleScientific

Cholesterol level affects surface charge of lipid membranes in saline solution

Magarkar, A., Dhawan, V., Kallinteri, P., Viitala, T., Elmowafy, M., Rog, T. & Bunker, A., 21 May 2014, In : Scientific Reports. 4, 5 p., 5005.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Complement Activation Assay and In vivo Evaluation of Silymarin Loaded Liver Targeting Liposome

Samy, A., Elmowafy, M., Arafa, M., Kari, O., Viitala, T., Kassem, A., Abu-Elyazid, S., Ibrahim, H. & Yliperttula, M., 30 Jan 2014, In : Journal of Life Medicine. 2, 1, p. 15-24 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Control of the Morphology of Lipid Layers by Substrate Surface Chemistry

Granqvist, N., Yliperttula, M., Välimäki, S., Pulkkinen, P., Tenhu, H. & Viitala, T., 18 Mar 2014, In : Langmuir. 30, 10, p. 2799-2809 11 p.

Research output: Contribution to journalArticleScientificpeer-review