Photo of Taru Tukiainen
20082020

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  • Article

    A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk

    Manning, A., Highland, H. M., Gasser, J., Sim, X., Tukiainen, T., Fontanillas, P., Grarup, N., Rivas, M. A., Mahajan, A., Locke, A. E., Cingolani, P., Pers, T. H., Vinuela, A., Brown, A. A., Wu, Y., Flannick, J., Fuchsberger, C., Gamazon, E. R., Gaulton, K. J., Im, H. K. & 243 others, Teslovich, T. M., Blackwell, T. W., Bork-Jensen, J., Burtt, N. P., Chen, Y., Green, T., Hartl, C., Kang, H. M., Kumar, A., Ladenvall, C., Ma, C., Moutsianas, L., Pearson, R. D., Perry, J. R. B., Rayner, N. W., Robertson, N. R., Scott, L. J., van de Bunt, M., Eriksson, J. G., Jula, A., Koskinen, S., Lehtimaki, T., Palotie, A., Raitakari, O. T., Jacobs, S. B. R., Wessel, J., Chu, A. Y., Scott, R. A., Goodarzi, M. O., Blancher, C., Buck, G., Buck, D., Chines, P. S., Gabriel, S., Gjesing, A. P., Groves, C. J., Hollensted, M., Huyghe, J. R., Jackson, A. U., Jun, G., Justesen, J. M., Mangino, M., Murphy, J., Neville, M., Onofrio, R., Small, K. S., Stringham, H. M., Trakalo, J., Banks, E., Carey, J., Carneiro, M. O., DePristo, M., Farjoun, Y., Fennell, T., Goldstein, J. I., Grant, G., de Angelis, M. H., Maguire, J., Neale, B. M., Poplin, R., Purcell, S., Schwarzmayr, T., Shakir, K., Smith, J. D., Strom, T. M., Wieland, T., Lindstrom, J., Brandslund, I., Christensen, C., Surdulescu, G. L., Lakka, T. A., Doney, A. S. F., Nilsson, P., Wareham, N. J., Langenberg, C., Varga, T. V., Franks, P. W., Rolandsson, O., Rosengren, A. H., Farook, V. S., Thameem, F., Puppala, S., Kumar, S., Lehman, D. M., Jenkinson, C. P., Curran, J. E., Hale, D. E., Fowler, S. P., Arya, R., DeFronzo, R. A., Abboud, H. E., Syvanen, A-C., Hicks, P. J., Palmer, N. D., Ng, M. C. Y., Bowden, D. W., Freedman, B. I., Esko, T., Magi, R., Milani, L., Mihailov, E., Metspalu, A., Narisu, N., Kinnunen, L., Bonnycastle, L. L., Swift, A., Pasko, D., Wood, A. R., Fadista, J., Pollin, T. I., Barzilai, N., Atzmon, G., Glaser, B., Thorand, B., Strauch, K., Peters, A., Roden, M., Mueller-Nurasyid, M., Liang, L., Kriebel, J., Illig, T., Grallert, H., Gieger, C., Meisinger, C., Lannfelt, L., Musani, S. K., Griswold, M., Taylor, H. A., Wilson, G., Correa, A., Oksa, H., Scott, W. R., Afzal, U., Tan, S-T., Loh, M., Chambers, J. C., Sehmi, J., Kooner, J. S., Lehne, B., Cho, Y. S., Lee, J-Y., Han, B-G., Karajamaki, A., Qi, Q., Qi, L., Huang, J., Hu, F. B., Melander, O., Orho-Melander, M., Below, J. E., Aguilar, D., Wong, T. Y., Liu, J., Khor, C-C., Chia, K. S., Lim, W. Y., Cheng, C-Y., Chan, E., Tai, E. S., Aung, T., Linneberg, A., Isomaa, B., Meitinger, T., Tuomi, T., Hakaste, L., Kravic, J., Jorgensen, M. E., Lauritzen, T., Deloukas, P., Stirrups, K. E., Owen, K. R., Farmer, A. J., Frayling, T. M., O'Rahilly, S. P., Walker, M., Levy, J. C., Hodgkiss, D., Hattersley, A. T., Kuulasmaa, T., Stancakova, A., Barroso, I., Bharadwaj, D., Chan, J., Chandak, G. R., Daly, M. J., Donnelly, P. J., Ebrahim, S. B., Elliott, P., Fingerlin, T., Froguel, P., Hu, C., Jia, W., Ma, R. C. W., McVean, G., Park, T., Prabhakaran, D., Sandhu, M., Scott, J., Sladek, R., Tandon, N., Teo, Y. Y., Zeggini, E., Watanabe, R. M., Koistinen, H. A., Kesaniemi, Y. A., Uusitupa, M., Spector, T. D., Salomaa, V., Rauramaa, R., Palmer, C. N. A., Prokopenko, I., Morris, A. D., Bergman, R. N., Collins, F. S., Lind, L., Ingelsson, E., Tuomilehto, J., Karpe, F., Groop, L., Jorgensen, T., Hansen, T., Pedersen, O., Kuusisto, J., Abecasis, G., Bell, G. I., Blangero, J., Cox, N. J., Duggirala, R., Seielstad, M., Wilson, J. G., Dupuis, J., Ripatti, S., Hanis, C. L., Florez, J. C., Mohlke, K. L., Meigs, J. B., Laakso, M., Morris, A. P., Boehnke, M., Altshuler, D., McCarthy, M. I., Gloyn, A. L. & Lindgren, C. M., 1 Jul 2017, In : Diabetes. 66, 7, p. 2019-2032 14 p.

    Research output: Contribution to journalArticleScientificpeer-review

  • A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension

    Huan, T., Esko, T., Peters, M. J., Pilling, L. C., Schramm, K., Schurmann, C., Chen, B. H., Liu, C., Joehanes, R., Johnson, A. D., Yao, C., Ying, S-X., Courchesne, P., Milani, L., Raghavachari, N., Wang, R., Liu, P., Reinmaa, E., Dehghan, A., Hofman, A. & 377 others, Uitterlinden, A. G., Hernandez, D. G., Bandinelli, S., Singleton, A., Melzer, D., Metspalu, A., Carstensen, M., Grallert, H., Herder, C., Meitinger, T., Peters, A., Roden, M., Waldenberger, M., Dörr, M., Felix, S. B., Zeller, T., (ICBP), I. C. F. B. P. GWAS., Vasan, R., O'Donnell, C. J., Munson, P. J., Yang, X., Prokisch, H., Völker, U., van Meurs, J. B. J., Ferrucci, L., Levy, D., Ehret, G. B., Munroe, P. B., Rice, K. M., Bochud, M., Johnson, A. D., Chasman, D. I., Smith, A. V., Tobin, M. D., Verwoert, G. C., Hwang, S-J., Pihur, V., Vollenweider, P., O’Reilly, P. F., Amin, N., Bragg-Gresham, J. L., Teumer, A., Glazer, N. L., Launer, L., Zhao, J. H., Aulchenko, Y., Heath, S., Sõber, S., Parsa, A., Luan, J., Arora, P., Zhang, F., Lucas, G., Hicks, A. A., Jackson, A. U., Peden, J. F., Tanaka, T., Wild, S. H., Rudan, I., Igl, W., Milaneschi, Y., Parker, A. N., Fava, C., Chambers, J. C., Fox, E. R., Kumari, M., Go, M. J., van der Harst, P., Kao, W. H. L., Sjögren, M., Vinay, D. G., Alexander, M., Tabara, Y., Shaw-Hawkins, S., Whincup, P. H., Liu, Y., Shi, G., Kuusisto, J., Tayo, B., Seielstad, M., Sim, X., Hoang Nguyen, K-D., Lehtimäki, T., Matullo, G., Wu, Y., Gaunt, T. R., Onland-Moret, N. C., Cooper, M. N., Platou, C. G. P., Org, E., Hardy, R., Dahgam, S., Palmen, J., Vitart, V., Braund, P. S., Kuznetsova, T., Uiterwaal, C. S. P. M., Adeyemo, A., Palmas, W., Campbell, H., Ludwig, B., Tomaszewski, M., Tzoulaki, I., Palmer, N. D., consortium, CARDIRAM., Consortium, CKDG., Consortium, K., consortium, E., consortium, CHARGE-HF., Aspelund, T., Garcia, M., Chang, Y-PC., O’Connell, J. R., Steinle, N. I., Grobbee, D. E., Arking, D. E., Kardia, S. L., Morrison, A. C., Hernandez, D., Najjar, S., McArdle, W. L., Hadley, D., Brown, M. J., Connell, J. M., Hingorani, A. D., Day, I. N. M., Lawlor, D. A., Beilby, J. P., Lawrence, R. W., Clarke, R., Collins, R., Hopewell, J. C., Ongen, H., Dreisbach, A. W., Li, Y., Young, J. H., Bis, J. C., Kähönen, M., Viikari, J., Adair, L. S., Lee, N. R., Chen, M-H., Olden, M., Pattaro, C., Hoffman Bolton, J. A., Köttgen, A., Bergmann, S., Mooser, V., Chaturvedi, N., Frayling, T. M., Islam, M., Jafar, T. H., Erdmann, J., Kulkarni, S. R., Bornstein, S. R., Grässler, J., Groop, L., Voight, B. F., Kettunen, J., Howard, P., Taylor, A., Guarrera, S., Ricceri, F., Emilsson, V., Plump, A., Barroso, I., Khaw, K-T., Weder, A. B., Hunt, S. C., Sun, Y. V., Bergman, R. N., Collins, F. S., Bonnycastle, L. L., Scott, L. J., Stringham, H. M., Peltonen, L., Perola, M., Vartiainen, E., Brand, S-M., Staessen, J. A., Wang, T. J., Burton, P. R., Soler Artigas, M., Dong, Y., Snieder, H., Wang, X., Zhu, H., Lohman, K. K., Rudock, M. E., Heckbert, S. R., Smith, N. L., Wiggins, K. L., Doumatey, A., Shriner, D., Veldre, G., Viigimaa, M., Kinra, S., Prabhakaran, D., Tripathy, V., Langefeld, C. D., Rosengren, A., Thelle, D. S., Maria, A. C., Singleton, A., Forrester, T., Hilton, G., McKenzie, C. A., Salako, T., Iwai, N., Kita, Y., Ogihara, T., Ohkubo, T., Okamura, T., Ueshima, H., Umemura, S., Eyheramendy, S., Meitinger, T., Wichmann, H-E., Shin Cho, Y., Kim, H-L., Lee, J-Y., Scott, J., Sehmi, J. S., Zhang, W., Hedblad, B., Nilsson, P., Davey Smith, G., Wong, A., Narisu, N., Stančáková, A., Raffel, L. J., Yao, J., Kathiresan, S., O’Donnell, C., Schwartz, S. M., Arfan Ikram, M., Longstreth W.T., J., Mosley, T. H., Seshadri, S., Shrine, N. R. G., Wain, L. V., Morken, M. A., Swift, A. J., Laitinen, J., Prokopenko, I., Zitting, P., Cooper, J. A., Humphries, S. E., Danesh, J., Rasheed, A., Goel, A., Hamsten, A., Watkins, H., Bakker, S. J. L., van Gilst, W. H., Janipalli, C. S., RadhaMani, K., Yajnik, C. S., Hofman, A., Mattace-Raso, F. U. S., Oostra, B. A., Demirkan, A., Isaacs, A., Rivadeneira, F., Lakatta, E. G., Orru, M., Scuteri, A., Ala-Korpela, M., Kangas, A. J., Lyytikäinen, L-P., Soininen, P., Tukiainen, T., Würtz, P., Ong, RT-H., Dörr, M., Kroemer, H. K., Völker, U., Völzke, H., Galan, P., Hercberg, S., Lathrop, M., Zelenika, D., Deloukas, P., Mangino, M., Spector, T. D., Zhai, G., Meschia, J. F., Nalls, M. A., Sharma, P., Terzic, J., Kranthi Kumar, M. J., Denniff, M., Zukowska-Szczechowska, E., Wagenknecht, L. E., Fowkes, F. G. R., Charchar, F. J., Schwarz, P. E. H., Hayward, C., Guo, X., Rotimi, C., Bots, M. L., Brand, E., Samani, N. J., Polasek, O., Talmud, P. J., Nyberg, F., Kuh, D., Laan, M., Hveem, K., Palmer, L. J., van der Schouw, Y. T., Casas, J. P., Mohlke, K. L., Vineis, P., Raitakari, O., Ganesh, S. K., Wong, T. Y., Tai, E. S., Cooper, R. S., Laakso, M., Rao, D. C., Harris, T. B., Morris, R. W., Dominiczak, A. F., Kivimaki, M., Marmot, M. G., Miki, T., Saleheen, D., Chandak, G. R., Coresh, J., Navis, G., Salomaa, V., Han, B-G., Zhu, X., Kooner, J. S., Melander, O., Ridker, P. M., Bandinelli, S., Gyllensten, U. B., Wright, A. F., Wilson, J. F., Ferrucci, L., Farrall, M., Tuomilehto, J., Pramstaller, P. P., Elosua, R., Soranzo, N., Sijbrands, E. J. G., Altshuler, D., Loos, R. J. F., Shuldiner, A. R., Gieger, C., Meneton, P., Uitterlinden, A. G., Wareham, N. J., Gudnason, V., Rotter, J. I., Rettig, R., Uda, M., Strachan, D. P., Witteman, J. C. M., Hartikainen, A-L., Witteman, J. C. M., Boerwinkle, E., Vasan, R. S., Larson, M. G., Larson, M. G., Järvelin, M-R., Psaty, B. M., Abecasis, G. R., Chakravarti, A., Elliott, P., van Duijn, C. M., Newton-Cheh, C., Levy, D., Caulfield, M. J. & Johnson, T., 2015, In : PLoS Genetics. 11, 3, 29 p.

    Research output: Contribution to journalArticleScientificpeer-review

  • Analysis of protein-coding genetic variation in 60,706 humans

    Lek, M., Karczewski, K. J., Minikel, E. V., Samocha, K. E., Banks, E., Fennell, T., O'Donnell-Luria, A. H., Ware, J. S., Hill, A. J., Cummings, B. B., Tukiainen, T., Birnbaum, D. P., Kosmicki, J. A., Duncan, L. E., Estrada, K., Zhao, F., Zou, J., Pierce-Hollman, E., Berghout, J., Cooper, D. N. & 31 others, Deflaux, N., DePristo, M., Do, R., Flannick, J., Fromer, M., Gauthier, L., Goldstein, J., Gupta, N., Howrigan, D., Kiezun, A., Kurki, M. I., Moonshine, A. L., Natarajan, P., Orozeo, L., Peloso, G. M., Poplin, R., Rivas, M. A., Ruano-Rubio, V., Rose, S. A., Ruderfer, D. M., Shakir, K., Stenson, P. D., Stevens, C., Thomas, B. P., Tiao, G., Tusie-Luna, M. T., Weisburd, B., Palotie, A., Tuomilehto, J., Daly, M. J. & Exome Aggregation Consortium, 18 Aug 2016, In : Nature. 536, 7616, p. 285-+ 13 p.

    Research output: Contribution to journalArticleScientificpeer-review

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  • A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis

    Rivas, M. A., Graham, D., Sulem, P., Stevens, C., Desch, A. N., Goyette, P., Gudbjartsson, D., Jonsdottir, I., Thorsteinsdottir, U., Degenhardt, F., Mucha, S., Kurki, M. I., Li, D., D'Amato, M., Annese, V., Vermeire, S., Weersma, R. K., Halfvarson, J., Paavola-Sakki, A. L. P., Lappalainen, A. M. & 28 others, Lek, M., Cummings, B., Tukiainen, T., Haritunians, T., Halme, L., Koskinen, L. L. E., Ananthakrishnan, A. N., Luo, Y., Heap, G. A., Visschedijk, M. C., MacArthur, D. G., Neale, B. M., Ahmad, T., Anderson, C. A., Brant, S. R., Duerr, R. H., Silverberg, M. S., Cho, J. H., Palotie, A., Saavalainen, P., Kontula, K., Farkkila, M., McGovern, D. P. B., Franke, A., Stefansson, K., Rioux, J. D., Xavier, R. J. & Daly, M. J., Aug 2016, In : Nature Communications. 7, 7 p., 12342.

    Research output: Contribution to journalArticleScientificpeer-review

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  • Chromosome X-Wide Association Study Identifies Loci for Fasting Insulin and Height and Evidence for Incomplete Dosage Compensation

    Tukiainen, T., Pirinen, M., Sarin, A-P., Ladenvall, C., Kettunen, J., Lehtimaeki, T., Lokki, M-L., Perola, M., Sinisalo, J., Vlachopoulou, E., Eriksson, J. G., Groop, L., Jula, A., Jaervelin, M-R., Raitakari, O. T., Salomaa, V. & Ripatti, S., Feb 2014, In : PLoS Genetics. 10, 2, 12 p.

    Research output: Contribution to journalArticleScientificpeer-review

    Open Access
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  • Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci

    Tukiainen, T., Kettunen, J., Kangas, A. J., Lyytikainen, L-P., Soininen, P., Sarin, A-P., Tikkanen, E., O'Reilly, P. F., Savolainen, M. J., Kaski, K., Pouta, A., Jula, A., Lehtimaki, T., Kahonen, M., Viikari, J., Taskinen, M-R., Jauhiainen, M., Eriksson, J. G., Raitakari, O., Salomaa, V. & 5 others, Jarvelin, M-R., Perola, M., Palotie, A., Ala-Korpela, M. & Ripatti, S., 2012, In : Human Molecular Genetics. 21, 6, p. 1444-1455 12 p.

    Research output: Contribution to journalArticleScientificpeer-review

  • Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population

    Sequencing Initiative Suomi, 1 Jul 2014, In : PLoS Genetics. 10, 7, 12 p., 1004494.

    Research output: Contribution to journalArticleScientificpeer-review

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  • Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study

    Nowak, C., Salihovic, S., Ganna, A., Brandmaier, S., Tukiainen, T., Broeckling, C. D., Magnusson, P. K., Prenni, J. E., Wang-Sattler, R., Peters, A., Strauch, K., Meitinger, T., Giedraitis, V., Arnlov, J., Berne, C., Gieger, C., Ripatti, S., Lind, L., Pedersen, N. L., Sundstrom, J. & 2 others, Ingelsson, E. & Fall, T., Oct 2016, In : PLoS Genetics. 12, 10, 19 p., 1006379.

    Research output: Contribution to journalArticleScientificpeer-review

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  • Effect of predicted protein-truncating genetic variants on the human transcriptome

    Rivas, M. A., Pirinen, M., Conrad, D. F., Lek, M., Tsang, E. K., Karczewski, K. J., Maller, J. B., Kukurba, K. R., DeLuca, D. S., Fromer, M., Ferreira, P. G., Smith, K. S., Zhang, R., Zhao, F., Banks, E., Poplin, R., Ruderfer, D. M., Purcell, S. M., Tukiainen, T., Minikel, E. V. & 19 others, Stenson, P. D., Cooper, D. N., Huang, K. H., Sullivan, T. J., Nedzel, J., Bustamante, C. D., Li, J. B., Daly, M. J., Guigo, R., Donnelly, P., Ardlie, K., Sammeth, M., Dermitzakis, E. T., McCarthy, M. I., Montgomery, S. B., Lappalainen, T., MacArthur, D. G., GTEx Consortium & Geuvadis Consortium, 8 May 2015, In : Science. 348, 6235, p. 666-669 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

    Ehret, G. B., Munroe, P. B., Rice, K. M., Bochud, M., Johnson, A. D., Chasman, D. I., Smith, A. V., Tobin, M. D., Verwoert, G. C., Hwang, S-J., Pihur, V., Vollenweider, P., O'Reilly, P. F., Amin, N., Bragg-Gresham, J. L., Teumer, A., Glazer, N. L., Launer, L., Zhao, J. H., Aulchenko, Y. & 31 others, Heath, S., Sober, S., Parsa, A., Luan, J., Arora, P., Dehghan, A., Zhang, F., Lucas, G., Hicks, A. A., Jackson, A. U., Peden, J. F., Tanaka, T., Wild, S. H., Rudan, I., Igl, W., Milaneschi, Y., Parker, A. N., Fava, C., Chambers, J. C., Fox, E. R., Kumari, M., Go, M. J., van der Harst, P., Kao, W. H. L., Sjogren, M., Kettunen, J., Palotie, L., Tukiainen, T. T., Wurtz, P., Tuomilehto, J. & CARDIoGRAM Consortium, KidneyGen Consortium, EchoGen Consortium, CKDGen Consortium, Int Consortium Blood Pressure Geno, CHARGE-HF Consortium, 2011, In : Nature. 478, 7367, p. 103-109 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  • Genome-wide association study identifies multiple loci influencing human serum metabolite levels

    Kettunen, J., Tukiainen, T., Sarin, A-P., Ortega-Alonso, A., Tikkanen, E., Lyytikainen, L-P., Kangas, A. J., Soininen, P., Wuertz, P., Silander, K., Dick, D. M., Rose, R. J., Savolainen, M. J., Viikari, J., Kahonen, M., Lehtimaki, T., Pietilainen, K. H., Inouye, M., McCarthy, M. I., Jula, A. & 11 others, Eriksson, J., Raitakari, O. T., Salomaa, V., Kaprio, J., Jarvelin, M-R., Peltonen, L., Perola, M., Freimer, N. B., Ala-Korpela, M., Palotie, A. & Ripatti, S., 2012, In : Nature Genetics. 44, 3, p. 269-276 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  • Genome-Wide Association Study Implicates Atrial Natriuretic Peptide Rather Than B-Type Natriuretic Peptide in the Regulation of Blood Pressure in the General Population

    Salo, P. P., Havulinna, A. S., Tukiainen, T., Raitakari, O., Lehtimäki, T., Kähönen, M., Kettunen, J., Männikkö, M., Eriksson, J. G., Jula, A., Blankenberg, S., Zeller, T., Salomaa, V., Kristiansson, K. & Perola, M., Dec 2017, In : Circulation. Cardiovascular genetics. 10, 6, 9 p., 001713.

    Research output: Contribution to journalArticleScientificpeer-review

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  • Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA

    Kettunen, J., Demirkan, A., Wurtz, P., Draisma, H. H. M., Haller, T., Rawal, R., Vaarhorst, A., Kangas, A. J., Lyytikäinen, L-P., Pirinen, M., Pool, R., Sarin, A-P., Soininen, P., Tukiainen, T., Wang, Q., Tiainen, M., Tynkkynen, T., Amin, N., Zeller, T., Beekman, M. & 30 others, Deelen, J., van Dijk, K. W., Esko, T., Hottenga, J-J., van Leeuwen, E. M., Lehtimaki, T., Mihailov, E., Rose, R. J., de Craen, A. J. M., Gieger, C., Kahonen, M., Perola, M., Blankenberg, S., Savolainen, M. J., Verhoeven, A., Viikari, J., Willemsen, G., Boomsma, D. I., van Duijn, C. M., Eriksson, J., Jula, A., Jarvelin, M-R., Kaprio, J., Metspalu, A., Raitakari, O., Salomaa, V., Slagboom, P. E., Waldenberger, M., Ripatti, S. & Ala-Korpela, M., Mar 2016, In : Nature Communications. 7, 9 p., 11122.

    Research output: Contribution to journalArticleScientificpeer-review

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  • Hydroxysteroid 17-beta dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease

    Luukkonen, P. K., Tukiainen, T., Juuti, A., Sammalkorpi, H., Haridas, P. A. N., Niemelä, O., Arola, J., Orho-Melander, M., Hakkarainen, A., Kovanen, P. T., Dwivedi, O., Groop, L., Hodson, L., Gastaldelli, A., Hyötyläinen, T., Oresic, M. & Yki-Järvinen, H., 12 Mar 2020, In : JCI INSIGHT. 5, 5, 12 p., 132158.

    Research output: Contribution to journalArticleScientificpeer-review

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  • Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD

    Luukkonen, P. K., Zhou, Y., Haridas, N. P. A., Dwivedi, O. P., Hyotylainen, T., Ali, A., Juuti, A., Leivonen, M., Tukiainen, T., Ahonen, L., Scott, E., Palmer, J. M., Arola, J., Orho-Melander, M., Vikman, P., Anstee, Q. M., Olkkonen, V. M., Oresic, M., Groop, L. & Yki-Jarvinen, H., Jul 2017, In : Journal of Hepatology. 67, 1, p. 128-136 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

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  • Mergeomics: multidimensional data integration to identify pathogenic perturbations to biological systems

    Shu, L., Zhao, Y., Kurt, Z., Byars, S. G., Tukiainen, T., Kettunen, J., Orozco, L. D., Pellegrini, M., Lusis, A. J., Ripatti, S., Zhang, B., Inouye, M., Makinen, V-P. & Yang, X., 4 Nov 2016, In : BMC Genomics. 17, 16 p., 874.

    Research output: Contribution to journalArticleScientificpeer-review

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  • Metabolic Signatures of Insulin Resistance in 7,098 Young Adults

    Wurtz, P., Makinen, V-P., Soininen, P., Kangas, A. J., Tukiainen, T., Kettunen, J., Savolainen, M. J., Tammelin, T., Viikari, J. S., Ronnemaa, T., Kahonen, M., Lehtimaki, T., Ripatti, S., Raitakari, O. T., Jarvelin, M-R. & Ala-Korpela, M., 2012, In : Diabetes. 61, 6, p. 1372-1380 9 p.

    Research output: Contribution to journalArticleScientificpeer-review

  • Navigated transcranial magnetic stimulation of the primary somatosensory cortex impairs perceptual processing of tactile temporal discrimination

    Hannula, H., Neuvonen, T., Savolainen, P., Tukiainen, T., Salonen, O., Carlson, S. & Pertovaara, A., 2008, In : Neuroscience Letters. 437, 2, p. 144-147 4 p.

    Research output: Contribution to journalArticleScientificpeer-review

  • No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis

    Loley, C., Alver, M., Assimes, T. L., Bjonnes, A., Goel, A., Gustafsson, S., Hernesniemi, J., Hopewell, J. C., Kanoni, S., Kleber, M. E., Lau, K. W., Lu, Y., Lyytikainen, L-P., Nelson, C. P., Nikpay, M., Qu, L., Salfati, E., Scholz, M., Tukiainen, T., Willenborg, C. & 58 others, Won, H-H., Zeng, L., Zhang, W., Anand, S. S., Beutner, F., Bottinger, E. P., Clarke, R., Dedoussis, G., Do, R., Esko, T., Eskola, M., Farrall, M., Gauguier, D., Giedraitis, V., Granger, C. B., Hall, A. S., Hamsten, A., Hazen, S. L., Huang, J., Kahonen, M., Kyriakou, T., Laaksonen, R., Lind, L., Lindgren, C., Magnusson, P. K. E., Marouli, E., Mihailov, E., Morris, A. P., Nikus, K., Pedersen, N., Rallidis, L., Salomaa, V., Shah, S. H., Stewart, A. F. R., Thompson, J. R., Zalloua, P. A., Chambers, J. C., Collins, R., Ingelsson, E., Iribarren, C., Karhunen, P. J., Kooner, J. S., Lehtimaki, T., Loos, R. J. F., Maerz, W., McPherson, R., Metspalu, A., Reilly, M. P., Ripatti, S., Sanghera, D. K., Thiery, J., Watkins, H., Deloukas, P., Kathiresan, S., Samani, N. J., Schunkert, H., Erdmann, J. & Koenig, I. R., 12 Oct 2016, In : Scientific Reports. 6, 9 p., 35278.

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  • Polygenic Hyperlipidemias and Coronary Artery Disease Risk

    FinnGen Project, Ripatti, P., Rämö, J. T., Mars, N. J., Fu, Y., Lin, J., Söderlund, S., Benner, C., Surakka, I., Kiiskinen, T., Havulinna, A. S., Palta, P., Freimer, N. B., Widén, E., Salomaa, V., Tukiainen, T., Pirinen, M., Palotie, A., Taskinen, M-R. & Ripatti, S., Apr 2020, In : Circulation-Genomic and precision medicine. 13, 2, p. 59-65 7 p.

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  • The landscape of genomic imprinting across diverse adult human tissues

    Baran, Y., Subramaniam, M., Biton, A., Tukiainen, T., Tsang, E. K., Rivas, M. A., Pirinen, M., Gutierrez-Arcelus, M., Smith, K. S., Kukurba, K. R., Zhang, R., Eng, C., Torgerson, D. G., Urbanek, C., Li, J. B., Rodriguez-Santana, J. R., Burchard, E. G., Seibold, M. A., MacArthur, D. G., Montgomery, S. B. & 3 others, Zaitlen, N. A., Lappalainen, T. & GTEx Consortium, Jul 2015, In : Genome Research. 25, 7, p. 927-936 10 p.

    Research output: Contribution to journalArticleScientificpeer-review

  • The transcriptional landscape of age in human peripheral blood

    Peters, M. J., Joehanes, R., Pilling, L. C., Schurmann, C., Conneely, K. N., Powell, J., Reinmaa, E., Sutphin, G. L., Zhernakova, A., Schramm, K., Wilson, Y. A., Kobes, S., Tukiainen, T., Ramos, Y. F., Goering, H. H. H., Fornage, M., Liu, Y., Gharib, S. A., Stranger, B. E., De Jager, P. L. & 31 others, Aviv, A., Levy, D., Murabito, J. M., Munson, P. J., Huan, T., Hofman, A., Uitterlinden, A. G., Rivadeneira, F., van Rooij, J., Stolk, L., Broer, L., Verbiest, M. M. P. J., Jhamai, M., Arp, P., Metspalu, A., Tserel, L., Milani, L., Samani, N. J., Peterson, P., Kasela, S., Codd, V., Peters, A., Ward-Caviness, C. K., Herder, C., Waldenberger, M., Roden, M., Hovatta, I., Perola, M., Ripatti, S., Kettunen, J. & NABEC UKBEC Consortium, Oct 2015, In : Nature Communications. 6, 14 p., 8570.

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  • Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

    Surendran, P., Drenos, F., Young, R., Warren, H., Cook, J. P., Manning, A. K., Grarup, N., Sim, X., Barnes, D. R., Witkowska, K., Staley, J. R., Tragante, V., Tukiainen, T., Yaghootkar, H., Masca, N., Freitag, D. F., Ferreira, T., Giannakopoulou, O., Tinker, A., Harakalova, M. & 44 others, Mihailov, E., Liu, C., Kraja, A. T., Nielsen, S. F., Rasheed, A., Samue, M., Zhao, W., Bonnycastle, L. L., Jackson, A. U., Narisu, N., Swift, A. J., Southam, L., Marten, J., Huyghe, J. R., Stancakova, A., Fava, C., Ohlsson, T., Matchan, A., Stirrups, K. E., Bork-Jensen, J., Gjesing, A. P., Kontto, J., Perola, M., Shaw-Hawkins, S., Havulinna, A. S., Kajantie, E., Tuomi, T., Groop, L., Palotie, A., Ripatti, S., CHARGE Heart Failure Consortiumm, EchoGen Consortiumm, Metastroke Consortiumm, Giant Consortiumm, EPIC-InterAct Consortium, Lifelines Cohort Study, Wellcome Trust Case Control Consor, Understanding Soc Sci Grp, EPIC-CVD Consortium, CHARGE Exome Chip Blood Pressure C, T2D-GENES Consortium, GoT2DGenes Consortium, ExomeBP Consortium & CHD Exome Consortium, Oct 2016, In : Nature Genetics. 48, 10, p. 1151-1161 11 p.

    Research output: Contribution to journalArticleScientificpeer-review

  • Transient modification of lin28b expression - Permanent effects on zebrafish growth

    Leinonen, J. T., Chen, Y-C., Tukiainen, T., Panula, P. & Widen, E., 5 Jan 2019, In : Molecular and Cellular Endocrinology. 479, p. 61-70 10 p.

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  • Letter

    Landscape of X chromosome inactivation across human tissues

    Tukiainen, T., Villani, A-C., Yen, A., Rivas, M. A., Marshall, J. L., Satija, R., Aguirre, M., Gauthier, L., Fleharty, M., Kirby, A., Ummings, B. B. . C., Astel, S. E. C., Karczewski, K. J., Aguet, F., Byrnes, A., Lappalainen, T., Regev, A., Ardlie, K. G., Hacohen, N., MacArthur, D. G. & 1 others, GTEx Consortium, 12 Oct 2017, In : Nature. 550, 7675, p. 244-+ 21 p.

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