Research output per year
Research output per year
Publications
- 16 Article
- 16 results
Search results
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2023
An oncolytic adenovirus coding for a variant interleukin 2 cytokine improves response to chemotherapy through enhancement of effector lymphocyte cytotoxicity, fibroblast compartment modulation and mitotic slippage
Pakola, S., Quixabeira, D. C. A., Kudling, T. V., Clubb, J. H. A., Grönberg-Vähä-Koskela, S., Basnet, S., Jirovec, E., Arias, V., Haybout, L., Heiniö, C., Santos, J. M., Cervera-Carrascon, V., Havunen, R., Anttila, M. & Hemminki, A., 5 Jul 2023, In: Frontiers in Immunology. 14, 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access -
Boosting cytotoxicity of adoptive allogeneic NK cell therapy with an oncolytic adenovirus encoding a human vIL-2 cytokine for the treatment of human ovarian cancer
Quixabeira, D. C. A., Pakola, S., Jirovec, E., Havunen, R., Basnet, S., Santos, J. M., Kudling, T. V., Clubb, J. H. A., Haybout, L., Arias, V., Grönberg-Vähä-Koskela, S., Cervera-Carrascon, V., Kerkelä, E., Pasanen, A., Anttila, M., Tapper, J., Kanerva, A. & Hemminki, A., 10 Nov 2023, In: Cancer Gene Therapy. 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting
Clubb, J. H. A., Kudling, T. V., Girych, M., Haybout, L., Pakola, S., Hamdan, F., Cervera-Carrascon, V., Hemmes, A., Grönberg-Vähä-Koskela, S., Santos, J. M., Quixabeira, D. C. A., Basnet, S., Heiniö, C., Arias, V., Jirovec, E., Kaptan, S., Havunen, R., Sorsa, S., Erikat, A., Schwartz, J., & 7 others, 3 Feb 2023, In: Frontiers in Immunology. 14, 20 p., 1060540.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Effective intravenous delivery of adenovirus armed with TNFα and IL-2 improves anti-PD-1 checkpoint blockade in non-small cell lung cancer
Kudling, T. V., Clubb, J. H. A., Pakola, S., Quixabeira, D. C. A., Lähdeniemi, I. A. K., Heiniö, C., Arias, V., Havunen, R., Cervera-Carrascon, V., Santos, J. M., Sutinen, E., Räsänen, J., Borenius, K., Mäyränpää, M. I., Aaltonen, E., Sorsa, S., Hemminki, O., Kanerva, A., Verschuren, E. W., Ilonen, I., & 1 others, 2023, In: OncoImmunology. 12, 1, 14 p., 2241710.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Improving the cytotoxic response of tumor-infiltrating lymphocytes towards advanced stage ovarian cancer with an oncolytic adenovirus expressing a human vIL-2 cytokine
Quixabeira, D. C. A., Jirovec, E., Pakola, S., Havunen, R., Basnet, S., Santos, J. M., Kudling, T. V., Clubb, J. H. A., Haybout, L., Arias, V., Grönberg-Vähä-Koskela, S., Cervera-Carrascon, V., Pasanen, A., Anttila, M., Tapper, J., Kanerva, A. & Hemminki, A., Nov 2023, In: Cancer Gene Therapy. 30, 11, p. 1543-1553 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Oncolytic adenovirus coding for bispecific T cell engager against human MUC-1 potentiates T cell response against solid tumors
Basnet, S., Santos, J. M., Quixabeira, D. C. A., Clubb, J. H. A., Grönberg-Vähä-Koskela, S. A. M., Arias, V., Pakola, S., Kudling, T. V., Heiniö, C., Havunen, R., Cervera-Carrascon, V., Sorsa, S., Anttila, M., Kanerva, A. & Hemminki, A., 16 Mar 2023, In: Molecular Therapy - Oncolytics. 28, p. 59-73 15 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
2022
Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer
Clubb, J. H. A., Kudling, T. V., Heinioe, C., Basnet, S., Pakola, S., Cervera Carrascon, V., Santos, J. M., Quixabeira, D. C. A., Havunen, R., Sorsa, S., Zheng, V., Salo, T., Bäck, L., Aro, K., Tulokas, S., Loimu, V. & Hemminki, A., 7 Mar 2022, In: Frontiers in Immunology. 13, 17 p., 794251.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Effective Combination Immunotherapy with Oncolytic Adenovirus and Anti-PD-1 for Treatment of Human and Murine Ovarian Cancers
Heiniö, C., Clubb, J., Kudling, T., Quixabeira, D., Cervera-Carrascon, V., Havunen, R., Grönberg-Vähä-Koskela, S., Santos, J. M., Tapper, J., Kanerva, A. & Hemminki, A., Sep 2022, In: Viruses (Basel). 10, 3, 16 p., 52.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Local delivery of interleukin 7 with an oncolytic adenovirus activates tumor-infiltrating lymphocytes and causes tumor regression
Kudling, T. V., Clubb, J. H. A., Quixabeira, D. C. A., Santos, J. M., Havunen, R., Kononov, A., Heiniö, C., Cervera-Carrascon, V., Pakola, S., Basnet, S., Grönberg-Vähä-Koskela, S., Arias, V., Gladwyn-Ng, I., Aro, K., Bäck, L., Räsänen, J., Ilonen, I., Borenius, K., Räsänen, M., Hemminki, O., & 4 others, 31 Dec 2022, In: OncoImmunology. 11, 1, 16 p., 2096572.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Local therapy with an engineered oncolytic adenovirus enables antitumor response in non- injected melanoma tumors in mice treated with aPD-1
Quixabeira, D. C. A., Cervera-Carrascon, V., Santos, J. M., Clubb, J. H. A., Kudling, T. V., Basnet, S., Heiniö, C., Grönberg-Vähä-Koskela, S., Anttila, M., Havunen, R., Kanerva, A. & Hemminki, A., 22 Jan 2022, In: OncoImmunology. 11, 1, 14 p., 2028960.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
2021
Ad5/3 is able to avoid neutralization by binding to erythrocytes and lymphocytes
Zafar, S., Quixabeira, D. C. A., Kudling, T. V., Cervera-Carrascon, V., Santos, J. M., Grönberg-Vähä-Koskela, S., Zhao, F., Aronen, P., Heiniö, C., Havunen, R., Sorsa, S., Kanerva, A. & Hemminki, A., May 2021, In: Cancer Gene Therapy. 28, 5, p. 442-454 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Clean and folded: Production of active, high quality recombinant human interferon-lambda 1
Shaldzhyan, A., Zabrodskaya, Y., Yolshin, N., Kudling, T., Lozhkov, A., Plotnikova, M., Ramsay, E., Taraskin, A., Nekrasov, P., Grudinin, M. & Vasin, A., Dec 2021, In: Process Biochemistry. 111, p. 32-39 8 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Microenvironment and Confers Enhanced Tumor Control
Quixabeira, D. C. A., Zafar, S., Santos, J. M., Cervera-Carrascon, V., Havunen, R., Kudling, T. V., Basnet, S., Anttila, M., Kanerva, A. & Hemminki, A., 18 May 2021, In: Frontiers in Immunology. 12, 13 p., 674400.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
2019
Crystal structures of CDC21-1 inteins from hyperthermophilic archaea reveal the selection mechanism for the highly conserved homing endonuclease insertion site
Beyer, H. M., Mikula, K. M., Kudling, T. V. & Iwaï, H., Nov 2019, In: Extremophiles. 23, 6, p. 669-679 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
2017
Comparison of E. Coli strains producing human interleukin-36 receptor antagonist (IL-36RA) with coexpression of E. coli methionine aminopeptidase
Kolobov, A. A., Kondratyeva, E. V., Kudling, T. V., Karasev, M. M., Kalinin, R. S., Khizhina, A. A., Protasov, E. A., Nimiritsky, P. P., Stefanov, V. E. & Petrov, A. V., 2017, In: Russian Journal of Biopharmaceuticals. 9, 4, p. 20-26 7 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Human IL-36RA production in Escherichia coli with coexpression of E. coli methionine aminopeptidase. I. Comparison of IL-36RA production in different strains
Kolobov, A. A., Kondratyeva, E. V., Kudling, T. V., Karasev, M. M., Kalinin, R. S., Khizhina, A. A., Nimiritsky, P. P., Stefanov, V. E. & Petrov, A. V., 2017, In: Cell and tissue biology. 11, 6, p. 447-452 6 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile