Photo of Tero Ahola
  • PL 56 (Viikinkaari 9)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

19952019
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Publications 1995 2019

2019

New Phylogenetic Grouping of Positive-Sense RNA Viruses Is Concordant with Replication Complex Morphology

Ahola, T., 2019, In : mBio. 10, 4, 2 p., ARTN e01402-19.

Research output: Contribution to journalLetterScientific

Open Access
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Separate domains of G3BP promote efficient clustering of alphavirus replication complexes and recruitment of the translation initiation machinery

Götte, B., Panas, M. D., Hellström, K., Liu, L., Samreen, B., Larsson, O., Ahola, T. & McInerney, G. M., 14 Jun 2019, In : PLoS Pathogens. 15, 6, 24 p., 1007842.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Purification of Highly Active Alphavirus Replication Complexes Demonstrates Altered Fractionation of Multiple Cellular Membranes

Pietila, M. K., van Hemert, M. J. & Ahola, T., Apr 2018, In : Journal of Virology. 92, 8, 19 p., ARTN e01852-17.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The RNA Capping Enzyme Domain in Protein A is Essential for Flock House Virus Replication

Quirin, T., Chen, Y., Pietilä, M. K., Guo, D. & Ahola, T., 9 Sep 2018, In : Viruses. 10, 9, 18 p., 483.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

Alphavirus polymerase and RNA replication

Pietilä, M., Hellström, K. & Ahola, T., 15 Apr 2017, In : Virus Research. 234, p. 44-57 14 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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Blockade of the LRP16-PKR-NF-κB signaling axis sensitizes colorectal carcinoma cells to DNA-damaging cytotoxic therapy.

Li, X., Wu, Z., An, X., Mei, Q., Bai, M., Hanski, L., Li, X., Ahola, T. & Han, W., 2017, In : eLife. 6, 34 p., e27301.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Obatoclax Inhibits Alphavirus Membrane Fusion by Neutralizing the Acidic Environment of Endocytic Compartments

Varghese, F. S., Rausalu, K., Hakanen, M., Saul, S., Kuemmerer, B. M., Susi, P., Merits, A. & Ahola, T., Mar 2017, In : Antimicrobial Agents and Chemotherapy. 61, 3, 17 p., e02227-16.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Partially Uncleaved Alphavirus Replicase Forms Spherule Structures in the Presence and Absence of RNA Template

Hellström, K., Kallio, K., Utt, A., Quirin, T., Jokitalo, E., Merits, A. & Ahola, T., Sep 2017, In : Journal of Virology. 91, 18, 13 p., e00787-17.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Polyprotein processing as a determinant for in vitro activity of Semliki Forest virus replicase

Pietilä, M. K., Albulescu, I. C., van Hemert, M. J. & Ahola, T. T., 2017, In : Viruses. 9, 10, 18 p., 292.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Ability of minus strands and modified plus strands to act as templates in Semliki Forest virus RNA replication.

Hellström, K. J., Kallio, K. A., Meriläinen, H-M., Jokitalo, E. S. & Ahola, T. T., 2016, In : Journal of General Virology. 87, 6, p. 1395-1407 13 p.

Research output: Contribution to journalArticleScientificpeer-review

An siRNA screen for ATG protein depletion reveals the extent of the unconventional functions of the autophagy proteome in virus replication

Mauthe, M., Langereis, M., Jung, J., Zhou, X., Jones, A., Omta, W., Tooze, S. A., Stork, B., Riis Paludan, S., Ahola, T., Egan, D., Behrends, C., Mokry, M., de Haan, C., van Kuppeveld, F. & Reggiori, F., 2016, In : Journal of Cell Biology. 214, 5, p. 619-635 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Chikungunya virus infectivity, RNA replication and non-structural polyprotein processing depend on the nsP2 protease's active site cysteine residue

Rausalu, K., Utt, A., Quirin, T., Varghese, F. S., Zusinaite, E., Das, P. K., Ahola, T. & Merits, A., 15 Nov 2016, In : Scientific Reports. 6, 17 p., 37124.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Design and Validation of Novel Chikungunya Virus Protease Inhibitors

Das, P. K., Puusepp, L., Varghese, F. S., Utt, A., Ahola, T., Kananovich, D. G., Lopp, M., Merits, A. & Karelson, M., Dec 2016, In : Antimicrobial Agents and Chemotherapy. 60, 12, p. 7382-7395 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses

Varghese, F. S., Kaukinen, P., Glasker, S., Bespalov, M., Hanski, L., Wennerberg, K., Kummerer, B. M. & Ahola, T., Feb 2016, In : Antiviral Research. 126, p. 117-124 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Functions of chikungunya virus nonstructural proteins

Ahola, T. T. & Merits, A., 2016, Chikungunya virus: Advances in biology, pathogenesis, and treatment. Okeoma, C. (ed.). Cham: Springer International Publishing AG, p. 75-98 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

Identification and characterization of a ribose 2′-O-methyltransferase encoded by the ronivirus branch of Nidovirales.

Zeng, C., Wu, A., Wang, Y., Xu, S., Tang, Y., Jin, X., Wang, S., Qin, L., Sun, Y., Fan, C., Snijder, E., Neuman, B., Chen, Y., Ahola, T. T. & Guo, D., 2016, In : Journal of Virology. 90, 15, p. 6675-6685 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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RNA Replication and Membrane Modification Require the Same Functions of Alphavirus Nonstructural Proteins

Kallio, K., Hellström, K., Jokitalo, E. & Ahola, T., Feb 2016, In : Journal of Virology. 90, 3, p. 1687-1692 6 p.

Research output: Contribution to journalArticleScientificpeer-review

The Antiviral Alkaloid Berberine Reduces Chikungunya Virus-Induced Mitogen-Activated Protein Kinase Signaling

Varghese, F. S., Thaa, B., Amrun, S. N., Simarmata, D., Rausalu, K., Nyman, T. A., Merits, A., McInerney, G. M., Ng, L. F. P. & Ahola, T., Nov 2016, In : Journal of Virology. 90, 21, p. 9743-9757 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Versatile Trans-Replication Systems for Chikungunya Virus Allow Functional Analysis and Tagging of Every Replicase Protein

Utt, A., Quirin, T., Saul, S., Hellstrom, K., Ahola, T. & Merits, A., 10 Mar 2016, In : PLoS One. 11, 3, 27 p., 0151616.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2015

Coronavirus nsp10/nsp16 Methyltransferase Can Be Targeted by nsp10-Derived Peptide In Vitro and In Vivo To Reduce Replication and Pathogenesis

Wang, Y., Sun, Y., Wu, A., Xu, S., Pan, R., Zeng, C., Jin, X., Ge, X., Shi, Z., Ahola, T., Chen, Y. & Guo, D., Aug 2015, In : Journal of Virology. 89, 16, p. 8416-8427 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Correlative light and electron microscopy enables viral replication studies at the ultrastructural level

Hellstrom, K., Vihinen, H., Kallio, K., Jokitalo, E. & Ahola, T., 15 Nov 2015, In : Methods. 90, p. 49-56 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Differential Phosphatidylinositol-3-Kinase-Akt-mTOR Activation by Semliki Forest and Chikungunya Viruses Is Dependent on nsP3 and Connected to Replication Complex Internalization

Thaa, B., Biasiotto, R., Eng, K., Neuvonen, M., Gotte, B., Rheinemann, L., Mutso, M., Utt, A., Varghese, F., Balistreri, G., Merits, A., Ahola, T. & McInerney, G. M., Nov 2015, In : Journal of Virology. 89, 22, p. 11420-11437 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Sequence analysis reveals a conserved extension in the capping enzyme of the alphavirus supergroup, and a homologous domain in nodaviruses

Ahola, T. & Karlin, D. G., 11 Apr 2015, In : Biology Direct. 10, 21 p., 16.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Therapeutics and Vaccines Against Chikungunya Virus

Ahola, T., Courderc, T., Ng, L. F. P., Hallengard, D., Powers, A., Lecuit, M., Esteban, M., Merits, A., Roques, P. & Liljestrom, P., 1 Apr 2015, In : Vector Borne and Zoonotic Diseases. 15, 4, p. 250-257 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2014

The C-Terminal Repeat Domains of nsP3 from the Old World Alphaviruses Bind Directly to G3BP

Panas, M. D., Ahola, T. & McInerney, G. M., 2014, In : Journal of Virology. 88, 10, p. 5888-5893 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Early secretory pathway localization and lack of processing for hepatitis E virus replication protein pORF1.

Perttilä, J., Spuul, P. & Ahola, T., 2013, In : Journal of General Virology. 94, 4, p. 807-816 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Structure-Function Analysis of Severe Acute Respiratory Syndrome Coronavirus RNA Cap Guanine-N7-Methyltransferase

Chen, Y., Tao, J., Sun, Y., Wu, A., Su, C., Gao, G., Cai, H., Qiu, S., Wu, Y., Ahola, T. & Guo, D., 2013, In : Journal of Virology. 87, 11, p. 6296-6305 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Template RNA Length Determines the Size of Replication Complex Spherules for Semliki Forest Virus

Kallio, K., Hellström, K., Balistreri, G., Spuul, P., Jokitalo, E. & Ahola, T., Aug 2013, In : Journal of Virology. 87, 16, p. 9125-9134 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Hepatiitti C infektion lääkehoito: kohti viruksen hävittämistä elimistöstä.

Ahola, T. & Kaukinen, P., 2012, In : Duodecim. 128, p. 1911-1917 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Obatoclax, Saliphenylhalamide, and Gemcitabine Inhibit Influenza A Virus Infection

Denisova, O. V., Kakkola, L., Feng, L., Stenman, J., Nagaraj, A., Lampe, J., Yadav, B., Aittokallio, T., Kaukinen, P., Ahola, T., Kuivanen, S., Vapalahti, O., Kantele, A., Tynell, J., Julkunen, I., Kallio-Kokko, H., Paavilainen, H., Hukkanen, V., Elliott, R. M., De Brabander, J. K. & 2 othersSaelens, X. & Kainov, D. E., 12 Oct 2012, In : Journal of Biological Chemistry. 287, 42, p. 35324-35332 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Assembly of Alphavirus Replication Complexes from RNA and Protein Components in a Novel trans-Replication System in Mammalian Cells

Spuul, P., Balistreri, G., Hellström, K., Golubtsov, A. V., Jokitalo, E. & Ahola, T., 2011, In : Journal of Virology. 85, 10, p. 4739-4751 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Biochemical and structural insights into the mechanisms of SARS coronavirus RNA ribose 2'-O-methylation by nsp16/nsp10 protein complex

Chen, Y., Su, C., Ke, M., Jin, X., Xu, L., Zhang, Z., Wu, A., Sun, Y., Yang, Z., Tein, P., Ahola, T., Liang, Y., Liu, X. & Guo, D., 2011, In : PLoS Pathogens. 7, 10, p. e1002294 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Inhibitors of Alphavirus Entry and Replication Identified with a Stable Chikungunya Replicon Cell Line and Virus-Based Assays

Pohjala, L., Utt, A., Varjak, M., Lulla, A., Merits, A., Ahola, T. & Tammela, P., 19 Dec 2011, In : PLoS One. 6, 12, p. e28923 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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SH3 Domain-Mediated Recruitment of Host Cell Amphiphysins by Alphavirus nsP3 Promotes Viral RNA Replication

Neuvonen, M., Kazlauskas, A., Martikainen, M., Hinkkanen, A., Ahola, T. & Saksela, K., 2011, In : PLoS Pathogens. 7, 11, p. e1002383 15 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Phosphatidylinositol 3-Kinase-, Actin-, and Microtubule-Dependent Transport of Semliki Forest Virus Replication Complexes from the Plasma Membrane to Modified Lysosomes

Spuul, P., Balistreri, G., Kääriäinen, L. J. & Ahola, T., 2010, In : Journal of Virology. 84, 15, p. 7543-7557 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Virusten lisääntyminen

Hyypiä, T., Ahola, T. & Söderlund-Venermo, A. M., 2010, Mikrobiologia : mikrobiologia, immunologia ja infektiosairaudet, kirja 1. Hedman, K., Heikkinen, T., Huovinen, P., Järvinen, A., Meri, S. & Vaara, M. (eds.). Helsinki: Duodecim, Vol. 2010. p. 460-469 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

2009

Betulin-derived compounds as inhibitors of alphavirus replication

Pohjala, L., Alakurtti, S., Ahola, T., Yli-Kauhaluoma, J. & Tammela, P., 2009, In : Journal of Natural Products. 72, 11, p. 1917-1926 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Differential activities of cellular and viral macro domain proteins in binding of ADP-ribose metabolites

Neuvonen, K. M. & Ahola, T., 2009, In : Journal of Molecular Biology. 385, 1, p. 212-225 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase

Chen, Y., Cai, H., Pan, J. A., Xiang, N., Tien, P., Ahola, T. & Guo, D., 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 9, p. 3484-3489 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Lentiviral vector-derived shRNAs confer enhanced suppression of Semliki forest virus replication in BHK-21 cells compared to shRNAs expressed from plasmids

Zhang, K., Chen, Y., Pan, J., Ahola, T. & Guo, D., Apr 2009, In : Biotechnology Letters. 31, 4, p. 501-508 8 p.

Research output: Contribution to journalArticleScientificpeer-review

The crystal structures of chikungunya and venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket

Malet, H., Coutard, B., Jamal, S., Dutartre, H., Papageorgiou, N., Neuvonen, K. M., Ahola, T., Forrester, N., Gould, E. A., Lafitte, D., Ferron, F., Lescar, J., Gorbalenya, A. E., de Lamballerie, X. & Canard, B., 2009, In : Journal of Virology. 83, 13, p. 6534-6545 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

A luciferase-based screening method for inhibitors of alphavirus replication applied to nucleoside analogues

Pohjala, L., Barai, V., Azhayev, A., Lapinjoki, S. & Ahola, T., 2008, In : Antiviral Research. 78, 3, p. 215-222 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Molecular defects caused by temperature-sensitive mutations in Semliki Forest virus nsP1

Lulla, V., Sawicki, D. L., Sawicki, S. G., Lulla, A., Merits, A. & Ahola, T., 2008, In : Journal of Virology. 82, 18, p. 9236-9244 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Enzymatic defects of the nsP2 proteins of Semliki Forest virus temperature-sensitive mutants

Balistreri, G., Caldentey, J., Kääriäinen, L. & Ahola, T., 2007, In : Journal of Virology. 81, 6, p. 2849-2860 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Molekyylitiedon avulla influenssaa vastaan

Kääriäinen, L. & Ahola, T., 2007, In : Duodecim. 123, p. 899-907 9 p.

Research output: Contribution to journalArticleScientific

Role of the amphipathic peptide of Semliki Forest virus replicase protein nsP1 in membrane association and virus replication

Spuul, P., Salonen, A., Merits, A., Jokitalo, E., Kääriäinen, L. & Ahola, T., 2007, In : Journal of Virology. 81, 2, p. 872-883 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Identification of mutations causing temperature-sensitive defects in Semliki forest virus RNA synthesis

Lulla, V., Merits, A., Sarin, P., Kääriäinen, L., Keränen, S. & Ahola, T., 2006, In : Journal of Virology. 80, 6, p. 3108-3111 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Molecular determinants of substrate specificity for Semliki forest virus nonstructural protease

Lulla, A., Lulla, V., Tints, K., Ahola, T. & Merits, A., 2006, In : Journal of Virology. 80, 11, p. 5413-5422 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Structural and functional basis for ADP-ribose and poly(ADP-Ribose) binding by viral macro domains

Egloff, M-P., Malet, H., Putics, A., Heinonen, M., Dutartre, H., Frangeul, A., Gruez, A., Campanacci, V., Cambillau, C., Ziebuhr, J., Ahola, T. & Canard, B., 2006, In : Journal of Virology. 80, 17, p. 8493-8502 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Inhibitors of virus replication: recent developments and prospects

Magden, J., Kääriäinen, L. & Ahola, T., 2005, In : Applied Microbiology and Biotechnology. 66, p. 612-621 10 p.

Research output: Contribution to journalReview ArticleScientificpeer-review