1991 …2020

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2020

DSP p.(Thr2104Glnfs*12) variant presents variably with early onset severe arrhythmias and left ventricular cardiomyopathy

Heliö, K., Kangas-Kontio, T., Weckström, S., Vanninen, S. U. M., Aalto-Setälä, K., Alastalo, T-P., Myllykangas, S., Heliö, T. M. & Koskenvuo, J. W., 31 Jan 2020, In : BMC Medical Genetics. 21, 1, 10 p., 19.

Research output: Contribution to journalArticleScientificpeer-review

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ESC EORP Cardiomyopathy Registry: real-life practice of genetic counselling and testing in adult cardiomyopathy patients

EORP Cardiomyopathy Registry Inves, Heliö, T., Elliott, P., Koskenvuo, J. W. & Charron, P., 7 Aug 2020, In : ESC Heart Failure. 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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2019

CMR derived left ventricular septal convexity in carriers of the hypertrophic cardiomyopathy-causing MYBPC3-Q1061X mutation

Tarkiainen, M., Sipola, P., Jalanko, M., Heliö, T., Jääskeläinen, P., Kivelä, K., Laine, M., Lauerma, K. & Kuusisto, J., 11 Apr 2019, In : Scientific Reports. 9, 7 p., 5960.

Research output: Contribution to journalArticleScientificpeer-review

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Genetic basis and outcome in a nationwide study of Finnish patients with hypertrophic cardiomyopathy

FinHCM Study Grp, Jääskeläinen, P., Vangipurapu, J., Raivo, J., Kuulasmaa, T., Helio, T., Aalto-Setala, K., Kaartinen, M., Ilveskoski, E., Vanninen, S., Hämäläinen, L., Melin, J., Kokkonen, J., Nieminen, M. S., Laakso, M., Kuusisto, J., Kervinen, H., Mustonen, J., Juvonen, J., Niemi, M. & 7 others, Uusimaa, P., Junttila, J., Kotila, M., Pietila, M., Jyrkila, H., Mahonen, I. & Vartia, P., Apr 2019, In : ESC Heart Failure. 6, 2, p. 436-445 10 p.

Research output: Contribution to journalArticleScientificpeer-review

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Modeling of LMNA-Related Dilated Cardiomyopathy Using Human Induced Pluripotent Stem Cells

Shah, D., Virtanen, L., Prajapati, C., Kiamehr, M., Gullmets, J., West, G., Kreutzer, J., Pekkanen-Mattila, M., Heliö, T., Kallio, P., Taimen, P. & Aalto-Setälä, K., Jun 2019, In : Cells. 8, 6, 21 p., 594.

Research output: Contribution to journalArticleScientificpeer-review

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Oikean kammion arytmogeeninen kardiomyopatia

Heliö, T. & Parikka, H., 2019, In : Sydänääni : Suomen kardiologisen seuran lehti. 30, 1A, p. 147-154 8 p.

Research output: Contribution to journalArticleProfessional

Relevance of Titin Missense and Non-Frameshifting Insertions/Deletions Variants in Dilated Cardiomyopathy

Akinrinade, O., Heliö, T., Deprez, R. H. L., Jongbloed, J. D. H., Boven, L. G., van den Berg, M. P., Pinto, Y. M., Alastalo, T-P., Myllykangas, S., van Spaendonck-Zwarts, K., van Tintelen, J. P., van der Zwaag, P. A. & Koskenvuo, J., 11 Mar 2019, In : Scientific Reports. 9, 9 p., 4093.

Research output: Contribution to journalArticleScientificpeer-review

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2018

Fibrosis and wall thickness affect ventricular repolarization dynamics in hypertrophic cardiomyopathy

Jalanko, M., Väänänen, H., Tarkiainen, M., Sipola, P., Jääskeläinen, P., Lauerma, K., Laitinen, T., Laitinen, T., Laine, M., Heliö, T., Kuusisto, J. & Viitasalo, M., Nov 2018, In : Annals of Noninvasive Electrocardiology. 23, 6, 10 p., 12582.

Research output: Contribution to journalArticleScientificpeer-review

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Genetiikka

Heliö, T. & Kuusisto, J., 2018, In : Sydänääni : Suomen kardiologisen seuran lehti. 29, 1A, p. 199-202 4 p.

Research output: Contribution to journalArticleProfessional

Heterozygous junctophilin-2 (JPH2) p. (Thr161Lys) is a monogenic cause for HCM with heart failure

Vanninen, S. U. M., Leivo, K., Seppälä, E. H., Aalto-Setälä, K., Pitkänen, O., Suursalmi, P., Annala, A-P., Anttila, I., Alastalo, T-P., Myllykangas, S., Heliö, T. M. & Koskenvuo, J. W., 20 Sep 2018, In : PLoS One. 13, 9, 14 p., 0203422.

Research output: Contribution to journalArticleScientificpeer-review

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Kardiomyopatiapotilaiden geenitutkimukset HYKS:in perinnöllisten sydänlihassairauksien poliklinikalla

Leivo, K., Koskenvuo, J. & Heliö, T., 2018, In : Sydänääni : Suomen kardiologisen seuran lehti. 29, 1, p. 43-51 9 p.

Research output: Contribution to journalArticleProfessional

Mitä kardiologin tulee tietää Turnerin oireyhtymästä?

Leskinen, M., Hiippala, A., Laine, T., Söderström-Anttila, V. & Heliö, T., 2018, In : Sydänääni : Suomen kardiologisen seuran lehti. 29, 2, p. 269-271 3 p.

Research output: Contribution to journalArticleProfessional

Novel electrocardiographic features in carriers of hypertrophic cardiomyopathy causing sarcomeric mutations

Jalanko, M., Heliö, T., Mustonen, P., Kokkonen, J., Huhtala, H., Laine, M., Jääskeläinen, P., Tarkiainen, M., Lauerma, K., Sipola, P., Laakso, M., Kuusisto, J. & Nikus, K., 2018, In : Journal of Electrocardiology. 51, 6, p. 983-989 7 p.

Research output: Contribution to journalArticleScientificpeer-review

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The Cardiomyopathy Registry of the EURObservational Research Programme of the European Society of Cardiology: baseline data and contemporarymanagement of adult patients with cardiomyopathies

EORP Cardiomyopathy Registry Inves, 21 May 2018, In : European Heart Journal. 39, 20, p. 1784-1793 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2017

Case reports of two pedigrees with recessive arrhythmogenic right ventricular cardiomyopathy associated with homozygous Thr335Ala variant in DSG2

Qadri, S., Anttonen, O., Viikila, J., Seppälä, E. H., Myllykangas, S., Alastalo, T-P., Holmström, M., Helio, T. & Koskenvuo, J. W., 17 Aug 2017, In : BMC Medical Genetics. 18, 9 p., 86.

Research output: Contribution to journalArticleScientificpeer-review

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Clinical disease presentation and ECG characteristics of LMNA mutation carriers

Ollila, L., Nikus, K., Holmström, M., Jalanko, M., Jurkko, R., Kaartinen, M., Koskenvuo, J., Kuusisto, J., Kärkkäinen, S., Palojoki, E., Reissell, E., Piirilä, P. & Heliö, T., 2017, In : Open Heart. 4, 1, 9 p., e000474.

Research output: Contribution to journalArticleScientificpeer-review

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Increased ventilatory response to exercise in symptomatic and asymptomatic LMNA mutation carriers: a follow-up study

Ollila, L., Heliö, T., Sovijärvi, A., Jalanko, M., Kaartinen, M., Kuusisto, J., Kärkkäinen, S., Jurkko, R., Reissell, E., Palojoki, E. & Piirilä, P., Jan 2017, In : Clinical Physiology and Functional Imaging. 37, 1, p. 8-16 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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2016

Cardiovascular magnetic resonance of mitral valve length in hypertrophic cardiomyopathy

Tarkiainen, M., Sipola, P., Jalanko, M., Helio, T., Laine, M., Jarvinen, V., Hayrinen, K., Lauerma, K. & Kuusisto, J., 4 Jun 2016, In : Journal of Cardiovascular Magnetic Resonance. 18, 10 p., 33.

Research output: Contribution to journalArticleScientificpeer-review

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Deleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy

West, G., Gullmets, J., Virtanen, L., Li, S-P., Keinanen, A., Shimi, T., Mauermann, M., Helio, T., Kaartinen, M., Ollila, L., Kuusisto, J., Eriksson, J. E., Goldman, R. D., Herrmann, H. & Taimen, P., 15 Jul 2016, In : Journal of Cell Science. 129, 14, p. 2732-2743 12 p.

Research output: Contribution to journalArticleScientificpeer-review

FGF21 is a biomarker for mitochondrial translation and mtDNA maintenance disorders

Lehtonen, J. M., Forsstrom, S., Bottani, E., Viscomi, C., Baris, O. R., Isoniemi, H., Hockerstedt, K., Osterlund, P., Hurme, M., Jylhava, J., Leppa, S., Markkula, R., Helio, T., Mombelli, G., Uusimaa, J., Laaksonen, R., Laaksovirta, H., Auranen, M., Zeviani, M., Smeitink, J. & 4 others, Wiesner, R. J., Nakada, K., Isohanni, P. & Suomalainen, A., 29 Nov 2016, In : Neurology. 87, 22, p. 2290-2299 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Left ventricular mechanical dispersion is associated with nonsustained ventricular tachycardia in hypertrophic cardiomyopathy

Jalanko, M., Tarkiainen, M., Sipola, P., Jaaskelainen, P., Lauerma, K., Laine, M., Nieminen, M. S., Laakso, M., Helio, T. & Kuusisto, J., 2016, In : Annals of Medicine. 48, 6, p. 417-427 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Cardiovascular magnetic resonance findings in patients with PRKAG2 gene mutations

Pöyhönen, P., Hiippala, A., Ollila, L., Kaasalainen, T., Hänninen, H., Helio, T., Tallila, J., Vasilescu, C., Kivistö, S. M., Ojala, T. & Holmstrom, M., 24 Oct 2015, In : Journal of Cardiovascular Magnetic Resonance. 17, 12 p., 89.

Research output: Contribution to journalArticleScientificpeer-review

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Familiaalinen hyperkolesterolemia : Suomessakin alidiagnosoitu

Laurila, P-P., Matikainen, N., Heliö, T., Kahri, J. & Nieminen, M. S., 2015, In : Sydänääni : Suomen kardiologisen seuran lehti. 26, 3A, p. 290-293 4 p.

Research output: Contribution to journalArticleProfessional

Genetics and genotype-phenotype correlations in Finnish patients with dilated cardiomyopathy

Akinrinade, O., Ollila, L., Vattulainen, S., Tallila, J., Gentile, M., Salmenpera, P., Koillinen, H., Kaartinen, M., Nieminen, M. S., Myllykangas, S., Alastalo, T-P., Koskenvuo, J. W. & Helio, T., 7 Sep 2015, In : European Heart Journal. 36, 34, p. 2327-2337 11 p.

Research output: Contribution to journalArticleScientificpeer-review

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The Metabolome in Finnish Carriers of the MYBPC3-Q1061X Mutation for Hypertrophic Cardiomyopathy

Jorgenrud, B., Jalanko, M., Helio, T., Jaaskelainen, P., Laine, M., Hilvo, M., Nieminen, M. S., Laakso, M., Hyotylainen, T., Oresic, M. & Kuusisto, J., 12 Aug 2015, In : PLoS One. 10, 8, 15 p., 0134184.

Research output: Contribution to journalArticleScientificpeer-review

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2014

A new common mutation in the cardiac beta-myosin heavy chain gene in Finnish patients with hypertrophic cardiomyopathy

Jaaskelainen, P., Helio, T., Aalto-Setala, K., Kaartinen, M. A., Ilveskoski, E., Hamalainen, L., Melin, J., Karkkainen, S., Peuhkurinen, K., Nieminen, M. S., Laakso, M., Kuusisto, J. & FinHCM Study Grp, Sep 2014, In : Annals of Medicine. 46, 6, p. 424-429 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Kenelle hypertrofista kardiomyopatiaa sairastavalle asennetaan rytmihäiriötahdistin ehkäisevästi?

Translated title of the contribution: Kenelle hypertrofista kardiomyopatiaa sairastavalle asennetaan rytmihäiriötahdistin ehkäisevästi?Heliö, T., 2014, In : Suomen lääkärilehti. 69, 40, p. 2514-2515 2 p.

Research output: Contribution to journalArticleProfessional

Triage strategy for urgent management of cardiac tamponade: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases

Ristic, A. D., Imazio, M., Adler, Y., Anastasakis, A., Badano, L. P., Brucato, A., Caforio, A. L. P., Dubourg, O., Elliott, P., Gimeno, J., Helio, T., Klingel, K., Linhart, A., Maisch, B., Mayosi, B., Mogensen, J., Pinto, Y., Seggewiss, H., Seferovic, P. M., Tavazzi, L. & 2 others, Tomkowski, W. & Charron, P., 7 Sep 2014, In : European Heart Journal. 35, 34, p. 2279-2284 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Use of Home Telemonitoring to Support Multidisciplinary Care of Heart Failure Patients in Finland: Randomized Controlled Trial

Vuorinen, A-L., Leppanen, J., Kaijanranta, H., Kulju, M., Helio, T., van Gils, M. & Lahteenmaki, J., Dec 2014, In : Journal of Medical Internet Research. 16, 12, p. 178-189 12 p.

Research output: Contribution to journalArticleScientificpeer-review

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2013

Atrial fibrillation is poorly tolerated by patients with hypertrophic concentric cardiomyopathy caused by mitochondrial tRNALeu (UUR) mutations

Heliö, T. M., Götz, A., Rapola, J., Kiuru-Enari, S., Kivistö, S., Heikinheimo, T. & Suomalainen, A., 2013, In : Cardiogenetics. 3, 1, p. 31-37 8 p.

Research output: Contribution to journalArticleScientificpeer-review

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Characteristics of Atrial Fibrillation and Comorbidities in Familial Atrial Fibrillation

Jurkko, R., Palojoki, E., Huttunen, H., Holm, C., Lehto, M., Heliö, T. M., Swan, H. & Toivonen, L., Jul 2013, In : Journal of Cardiovascular Electrophysiology. 24, 7, p. 768-774 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Current state of knowledge on aetiology, diagnosis, management, and therapy of myocarditis: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases

Caforio, A. L. P., Pankuweit, S., Arbustini, E., Basso, C., Gimeno-Blanes, J., Felix, S. B., Fu, M., Heliö, T. M., Heymans, S., Jahns, R., Klingel, K., Linhart, A., Maisch, B., McKenna, W., Mogensen, J., Pinto, Y. M., Ristic, A., Schultheiss, H-P., Seggewiss, H., Tavazzi, L. & 4 others, Thiene, G., Yilmaz, A., Charron, P. & Elliott, P. M., Sep 2013, In : European Heart Journal. 34, 33, p. 2636-+ 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Lamin A/C mutation affecting primarily the right side of the heart

Ollila, L., Kuusisto, J., Peuhkurinen, K., Kärkkäinen, S., Tuomainen, P., Kaartinen, M., Raheem, O., Udd, B., Magga, J., Rapola, J., Lahtinen, A., Lehtonen, E., Holmström, M., Kivistö, S. M., Widén, E., Saksa, M. & Heliö, T., 2013, In : Cardiogenetics. 3, 1, p. 1 1 p.

Research output: Contribution to journalArticleScientificpeer-review

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Two founder mutations in the alpha-tropomyosin and the cardiac myosin-binding protein C genes are common causes of hypertrophic cardiomyopathy in the Finnish population

Jaaskelainen, P., Heliö, T. M., Aalto-Setala, K., Kaartinen, M., Ilveskoski, E., Hamalainen, L., Melin, J., Nieminen, M. S., Laakso, M., Kuusisto, J., Kervinen, H., Mustonen, J., Juvonen, J., Niemi, M., Uusimaa, P., Huttunen, M., Kotila, M., Pietila, M. & FinHCM Study Grp, Feb 2013, In : Annals of Medicine. 45, 1, p. 85-90 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Funding: Finnish Foundation for Cardiovascular Research Scholarships 2012

Taylor, J., Huikuri, H. V. & Helio, T. M., 20 Nov 2012, In : Circulation . 126, 21, p. F125-F126 2 p.

Research output: Contribution to journalArticleScientific

2011

Arytmogeeninen oikean kammion kardiomyopatia/dysplasia

Kaartinen, M. A. & Heliö, T. M., 2011, In : Sydänääni : Suomen kardiologisen seuran lehti. 22, 5, p. 16-21

Research output: Contribution to journalArticleProfessional

Late gadolinium enhanced cardiovascular magnetic resonance of lamin A/C gene mutation related dilated cardiomyopathy

Holmstrom, M., Kivisto, S., Helio, T., Jurkko, R., Kaartinen, M., Antila, M., Reissell, E., Kuusisto, J., Karkkainen, S., Peuhkurinen, K., Koikkalainen, J., Lotjonen, J. & Lauerma, K-M. S., 2011, In : Journal of Cardiovascular Magnetic Resonance. 13, p. - 9 p.

Research output: Contribution to journalArticleScientificpeer-review

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Population-prevalent desmosomal mutations predisposing to arrhythmogenic right ventricular cardiomyopathy

Lahtinen, A. M., Lehtonen, E., Marjamaa, A., Kaartinen, M., Heliö, T. M., Porthan, K., Oikarinen, L., Toivonen, L., Swan, H., Jula, A., Palotie, L., Palotie, A., Salomaa, V. & Kontula, K., 2011, In : Heart rhythm.. 8, 8, p. 1214-1221 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Serum Lipidomics Meets Cardiac Magnetic Resonance Imaging: Profiling of Subjects at Risk of Dilated Cardiomyopathy

Sysi-Aho, M., Koikkalainen, J., Seppanen-Laakso, T., Kaartinen, M., Kuusisto, J., Peuhkurinen, K., Karkkainen, S., Antila, M., Lauerma, K-M. S., Reissell, E., Jurkko, R., Lotjonen, J., Heliö, T. & Oresic, M., 2011, In : PLoS One. 6, 1, p. - 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2010

Genetic counselling and testing in cardiomyopathies: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases

Charron, P., Arad, M., Arbustini, E., Basso, C., Bilinska, Z., Elliott, P., Heliö, T. M., Keren, A., McKenna, W. J., Monserrat, L., Pankuweit, S., Perrot, A., Rapezzi, C., Ristic, A., Seggewiss, H., van Langen, I. & Tavazzi, L., 2010, In : European Heart Journal. 31, p. 2715-2728B 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Pregnancy and childbirth in carriers of the lamin A/C-gene mutation

Palojoki, E., Kaartinen, M., Kaaja, R., Reissell, E., Kärkkäinen, S., Kuusisto, J. & Heliö, T. M., 2010, In : European Journal of Heart Failure. 12, 6, p. 630-633 4 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

The Need for Comprehensive Cardiac and Neurologic Assessment of Lamin A/C Mutation Carriers Response

Koikkalainen, J. R., Helio, T., Lotjonen, J. M. P., Sipola, P., Kaartinen, M. A., Kuusisto, J. & Peuhkurinen, K. J., Apr 2009, In : Radiology. 251, 1, p. 306 1 p.

Research output: Contribution to journalArticleScientific

2008

Early familial dilated cardiomyopathy: identification with determination of disease state parameter from cine MR image data

Koikkalainen, J., Antila, M., Lötjönen, J., Heliö, T., Lauerma, K., Kivistö, S., Sipola, P., Kaartinen, M., Kärkkäinen, S., Reissell, E., Kuusisto, J., Laakso, M., Oresic, M., Nieminen, M. S., Peuhkurinen, K. & Kaartinen, M. A., 2008, In : Radiology. 249, 1, p. 88-96 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Electrocardiographic ventricular repolarization during cardiovascular autonomic function testing in patients with arrhythmogenic right ventricular cardiomyopathy

Haapalahti, P., Viitasalo, M., Kaartinen, M., Väänänen, H., Oikarinen, L., Heliö, T. & Toivonen, L., 2008, In : Scandinavian Cardiovascular Journal. 42, 6, p. 375-382 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Suvuittain trabekuloiva kardiomyopatia

Heliö, T., Kaartinen, M., Luoma, J. & Pihkala, J., 2008, In : Duodecim. 124, p. 1842-1846 5 p.

Research output: Contribution to journalArticleScientific

2007

Characterization of familial and sporadic arrhythmogenic right ventricular cardiomyopathy in Finland

Kaartinen, M., Heliö, T., Lehtonen, A., Lahtinen, A. M., Kärkkäinen, S., Keto, P., Kontula, K. & Toivonen, L., 2007, In : Annals of Medicine. 39, 4, p. 312-318 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Prevalence of CARD15/NOD2 mutations in Caucasian healthy people

Hugot, J-P., Zaccaria, I., Cavanaugh, J., Yang, H., Vermeire, S., Lappalainen, M., Schreiber, S., Annese, V., Jewell, D. P., Fowler, E. V., Brant, S. R., Silverberg, M. S., Cho, J., Rioux, J. D., Satsangi, J., Parkes, M., Heliö, T., Kontula, K. & Paavola-Sakki, P., 2007, In : American Journal of Gastroenterology. 102, p. 1259-1267 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Novel mutations in the lamin A/C gene in heart transplant recipients with end stage dilated cardiomyopathy

Kärkkäinen, S., Reissell, E., Heliö, T., Kaartinen, M., Tuomainen, P., Toivonen, L., Kuusisto, J., Kupari, M., Nieminen, M. S., Laakso, M. & Peuhkurinen, K., 2006, In : Heart. 92, p. 524-526 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Prevalence and impact of worsening renal function in patients hospitalized with decompensated heart failure: results of the prospective outcomes study in heart failure (POSH)

Cowie, M. R., Komajda, M., Murray-Thomas, T., Underwood, J., Ticho, B., Nieminen, M. S., Heliö, T. & POSH investigators, 2006, In : European Heart Journal. 27, p. 1216-1222 7 p.

Research output: Contribution to journalArticleScientificpeer-review