1992 …2025
If you made any changes in Pure these will be visible here soon.

Personal profile

Curriculum vitae

Curriculum vitae

I performed my PhD work at the laboratory of Professor Leena Peltonen-Palotie  during 1990-1995. This work led to DNA diagnostics of gelsolin-related amyloidosis and revelation of pathogenic processing of mutant gelsolin in neuronal cells. During a 2-year post doc period (1996-1998) at LGN-CNRS, Paris, I developed novel recombinant adenoviral vectors for gene therapy on an experimental model of Parkinson’s disease. Then, my focus shifted towards research on psychiatric traits and I started working as a project leader for large international collaboration on schizophrenia. This work led to understanding the truly heterogeneous background of psychosis as well as connections between genes, cognitive disturbances, and schizophrenia.

From year 2003, my main research focus has been on understanding the molecular mechanisms for disturbed mood and sleep and their relationship. We have revealed association of two genes, DISC1 and DAOA, to intermediate traits for BPD and we were able to replicate some of the findings from earlier genome-wide association studies. We found in a large nation-wide cohort of twins that poor sleep predicted depressed mood in a consistent pattern, while depressed mood did not predict poor sleep, evidencing for the central role of disturbed sleep in mood disorders. We have also found inter-individual variability in sleep quality-related responses to stressful life events and relation of childhood traumatic events to insomnia in adulthood. We found in a systematic association study in a population-based sample that some susceptibility genes associate to depression only in the presence of disturbed sleep. We also found a link between a bipolar susceptibility gene and visual performance, evidencing further for the direct neurobiological link between visual perception, circadian rhythm, and regulation of mood.

Keywords

  • 311 Basic medicine
  • Molekyyligenetiikka
  • 312 Clinical medicine
  • Psykiatria
  • Mielialahäiriöt, uni, psykoosisairaudet

International and National Collaboration Publications and projects within past five years.

Publications 1992 2019

A distinctive DNA methylation pattern in insufficient sleep

Lahtinen, A., Puttonen, S., Vanttola, P., Viitasalo, K., Sulkava, S., Pervjakova, N., Joensuu, A., Salo, P., Toivola, A., Härmä, M., Milani, L., Perola, M. & Paunio, T., 4 Feb 2019, In : Scientific Reports. 9, 9 p., 1193.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
Open Access

Gene expression changes related to immune processes associate with cognitive endophenotypes of schizophrenia

Ukkola-Vuoti, L., Torniainen-Holm, M., Ortega-Alonso, A., Sinha, V., Tuulio-Henriksson, A., Paunio, T., Lönnqvist, J., Suvisaari, J. & Hennah, W., 10 Jan 2019, In : Progress in Neuro-Psychopharmacology & Biological Psychiatry. 88, p. 159-167 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Gene expression imputation across multiple brain regions provides insights into schizophrenia risk

CommonMind Consortium, Psychiat Genomics Consortium, iPSYCH-GEMS Schizophrenia Working, Huckins, L. M., Dobbyn, A., Ruderfer, D. M., Eriksson, J., Karjalainen, J., Lönnqvist, J., Paunio, T., Pietiläinen, O., Suvisaari, J., Palotie, A., Daly, M. J. & Salomaa, V., Apr 2019, In : Nature Genetics. 51, 4, p. 659-+ 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Genetic Basis of Human Sleep

Paunio, T. M., 2019, Dreams: Understanding Biology, Psychology, and Culture . Valli, K. & Hoss, RJ. (eds.). Santa Barbara, CA: ABC-CLIO, Vol. 2019. p. 42-54 4

Research output: Chapter in Book/Report/Conference proceedingChapterScientific

Projects 2010 2025

Tietoisuustaitoja opiskelijoille

Repo, S., Paunio, T., Elovainio, M., Pyörälä, E., Saarinen, J., Peltola, K., Härkönen, T. & Holopainen, M.

01/01/201831/12/2025

Project: Research project

Studies and wellbeing - Opiskelu ja hyvinvointi -tutkimus

Paunio, T., Pyörälä, E., Saarinen, J., Peltola, K., Härkönen, T., Vartia, J. & Elovainio, M.

09/12/2016 → …

Project: Research project

Lapsen uni ja terveys

Paavonen, J., Paunio, T., Saarenpää-Heikkilä, O., Pölkki, P., Kylliainen, A., Rusanen, E. & Pietiläinen, K.

01/01/2010 → …

Project: Research project

Prizes

Vuoden artikkeli Lääkärilehdessä

Juulia Paavonen (Recipient), Tiina Paunio (Recipient) & Tytti Solantaus (Recipient), 2009

Prize: Prizes and awards

Activities 2005 2017

AMEE 2017

Tiina Maria Paunio (Poster Presentation), Eeva Pyörälä (Poster Presentation), Jussi Jukka Saarinen (Poster Presentation), Kari Risto Johannes Peltola (Attendee), Jonne Juntura (Poster Presentation), Marko Juhani Elovainio (Poster Presentation)
26 Aug 201730 Aug 2017

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Hosting a Seminar at Evidence-Based Psychotherapy

Tiina Paunio (Chair)
11 Jan 2016

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

The 2nd Finnish Symposium of Biological Psychiatry, Finland

Zuzanna Misiewicz (Member of organizing committee), Iiris Maaria Hovatta (Member of organizing committee), Tiina Maria Paunio (Member of organizing committee)
19 Dec 2016

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Organizing and opening of the national seminar on Psychotherapies at Special Health Care

Tiina Paunio (Attendee)
24 Aug 2015

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Presentation at Kansanterveyspäivät (Public Health Day)

Tiina Paunio (Speaker: Presenter)
7 Dec 2015

Activity: Participating in or organising an event typesPublic Talks

Press / Media

Interview on Iltalehti

Tiina Paunio

02/01/2017

1 media contribution

Press/Media: Press / Media

Interview on Reuters

Tiina Paunio

10/11/2016

1 media contribution

Press/Media: Press / Media

Interview on Helsingin Sanomat

Tiina Paunio

28/10/2016

1 media contribution

Press/Media: Press / Media

Interview on Yleisradio

Tiina Paunio

27/10/2016

1 media contribution

Press/Media: Press / Media

Interview on a Biomedicum Webpage

Tiina Paunio

23/08/2016

1 media contribution

Press/Media: Press / Media