Tiina Paunio

  • PL 22 (Välskärinkatu 12)

    00014

    Finland

  • PL 22 (Välskärinkatu 12)

    HELSINGIN YLIOPISTO

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1992 …2025
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Personal profile

Curriculum vitae

Curriculum vitae

I performed my PhD work at the laboratory of Professor Leena Peltonen-Palotie  during 1990-1995. This work led to DNA diagnostics of gelsolin-related amyloidosis and revelation of pathogenic processing of mutant gelsolin in neuronal cells. During a 2-year post doc period (1996-1998) at LGN-CNRS, Paris, I developed novel recombinant adenoviral vectors for gene therapy on an experimental model of Parkinson’s disease. Then, my focus shifted towards research on psychiatric traits and I started working as a project leader for large international collaboration on schizophrenia. This work led to understanding the truly heterogeneous background of psychosis as well as connections between genes, cognitive disturbances, and schizophrenia.

From year 2003, my main research focus has been on understanding the molecular mechanisms for disturbed mood and sleep and their relationship. We have revealed association of two genes, DISC1 and DAOA, to intermediate traits for BPD and we were able to replicate some of the findings from earlier genome-wide association studies. We found in a large nation-wide cohort of twins that poor sleep predicted depressed mood in a consistent pattern, while depressed mood did not predict poor sleep, evidencing for the central role of disturbed sleep in mood disorders. We have also found inter-individual variability in sleep quality-related responses to stressful life events and relation of childhood traumatic events to insomnia in adulthood. We found in a systematic association study in a population-based sample that some susceptibility genes associate to depression only in the presence of disturbed sleep. We also found a link between a bipolar susceptibility gene and visual performance, evidencing further for the direct neurobiological link between visual perception, circadian rhythm, and regulation of mood.

Fields of Science

  • 311 Basic medicine
  • Molekyyligenetiikka
  • 312 Clinical medicine
  • Psykiatria
  • Mielialahäiriöt, uni, psykoosisairaudet

International and National Collaboration Publications and projects within past five years.

Publications 1992 2020

Trajectories of mothers’ and fathers’ depressive symptoms from pregnancy to 24 months postpartum

Kiviruusu, O. H., Pietikäinen, J. T., Kylliäinen, A., Pölkki, P., Saarenpää-Heikkilä, O., Marttunen, M., Paunio, T. & Paavonen, E. J., 1 Jan 2020, In : Journal of Affective Disorders. 260, p. 629-637 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

A distinctive DNA methylation pattern in insufficient sleep

Lahtinen, A., Puttonen, S., Vanttola, P., Viitasalo, K., Sulkava, S., Pervjakova, N., Joensuu, A., Salo, P., Toivola, A., Härmä, M., Milani, L., Perola, M. & Paunio, T., 4 Feb 2019, In : Scientific Reports. 9, 9 p., 1193.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Comparison of face-to-face and online mindfulness interventions among healthcare professional students in Finland: A randomized controlled trial

Repo, S., Paunio, T., Pyörälä, E., Holopainen, M. I., Räsänen, P. & Elovainio, M., 27 Aug 2019.

Research output: Conference materialsPaperResearchpeer-review

Development of sleep–wake rhythms during the first year of age

Paavonen, E. J., Morales-Munoz, I., Pölkki, P., Paunio, T., Porkka-Heiskanen, T., Kylliainen, A., Partonen, T. & Saarenpaa-Heikkila, O., 8 Sep 2019, In : Journal of Sleep Research.

Research output: Contribution to journalArticleScientificpeer-review

Epigenetic dysregulation of genes related to synaptic long-term depression among adolescents with depressive disorder and sleep symptoms

Ämmälä, A-J., Urrila, A-S., Lahtinen, A., Santangeli, O., Hakkarainen, A., Kantojärvi, K., Castaneda, A. E., Lundbom, N., Marttunen, M. & Paunio, T., Sep 2019, In : Sleep Medicine. 61, p. 95-103 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Projects 2010 2025

Tietoisuustaitoja opiskelijoille

Repo, S., Paunio, T., Elovainio, M., Pyörälä, E., Saarinen, J., Peltola, K., Härkönen, T. & Holopainen, M.

01/01/201831/12/2025

Project: Research project

Studies and wellbeing - Opiskelu ja hyvinvointi -tutkimus

Paunio, T., Pyörälä, E., Saarinen, J., Peltola, K., Härkönen, T., Vartia, J. & Elovainio, M.

09/12/2016 → …

Project: Research project

Lapsen uni ja terveys

Paavonen, J., Paunio, T., Saarenpää-Heikkilä, O., Pölkki, P., Kylliainen, A., Rusanen, E. & Pietiläinen, K.

01/01/2010 → …

Project: Research project

Prizes

Vuoden artikkeli Lääkärilehdessä

Juulia Paavonen (Recipient), Tiina Maria Paunio (Recipient) & Tytti Solantaus (Recipient), 2009

Prize: Prizes and awards

Activities 2005 2019

AMEE 2019

Taina Hintsa (Speaker: Presenter), Anne Helena Monni (Attendee), Eeva Pyörälä (Attendee), Marko Elovainio (Attendee), Saara Repo (Attendee), Tiina Paunio (Attendee)
24 Aug 201928 Aug 2019

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

AMEE 2019

Saara Repo (Speaker: Presenter), Tiina Paunio (Attendee), Eeva Pyörälä (Attendee), Marianne Holopainen (Attendee), panajiota Räsänen (Attendee), Marko Elovainio (Attendee)
24 Aug 201928 Aug 2019

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

AMEE 2017

Tiina Maria Paunio (Poster Presentation), Eeva Pyörälä (Poster Presentation), Jussi Jukka Saarinen (Poster Presentation), Kari Risto Johannes Peltola (Attendee), Jonne Juntura (Poster Presentation), Marko Juhani Elovainio (Poster Presentation)
26 Aug 201730 Aug 2017

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

The 2nd Finnish Symposium of Biological Psychiatry, Finland

Zuzanna Misiewicz (Member of organizing committee), Iiris Maaria Hovatta (Member of organizing committee), Tiina Maria Paunio (Member of organizing committee)
19 Dec 2016

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Hosting a Seminar at Evidence-Based Psychotherapy

Tiina Paunio (Chair)
11 Jan 2016

Activity: Participating in or organising an event typesOrganisation and participation in conferences, workshops, courses, seminars

Press / Media

Interview for Anna: Is it something serious?

Tiina Paunio & Kari Tikkinen

24/11/2018

1 item of media coverage

Press/Media: Press / Media

Interview on Iltalehti

Tiina Paunio

02/01/2017

1 media contribution

Press/Media: Press / Media

Interview on Reuters

Tiina Paunio

10/11/2016

1 media contribution

Press/Media: Press / Media

Interview on Helsingin Sanomat

Tiina Paunio

28/10/2016

1 media contribution

Press/Media: Press / Media

Interview on Yleisradio

Tiina Paunio

27/10/2016

1 media contribution

Press/Media: Press / Media