Research output per year
Research output per year
PL 22 (Välskärinkatu 12)
00014
Finland
PL 22 (Välskärinkatu 12)
HELSINGIN YLIOPISTO
Finland
Viikinkaari 5, Biocenter 2
00790 Helsinki
Finland
Research activity per year
I performed my PhD work at the laboratory of Professor Leena Peltonen-Palotie during 1990-1995. This work led to DNA diagnostics of gelsolin-related amyloidosis and revelation of pathogenic processing of mutant gelsolin in neuronal cells. During a 2-year post doc period (1996-1998) at LGN-CNRS, Paris, I developed novel recombinant adenoviral vectors for gene therapy on an experimental model of Parkinson’s disease. Then, my focus shifted towards research on psychiatric traits and I started working as a project leader for large international collaboration on schizophrenia. This work led to understanding the truly heterogeneous background of psychosis as well as connections between genes, cognitive disturbances, and schizophrenia.
From year 2003, my main research focus has been on understanding the molecular mechanisms for disturbed mood and sleep and their relationship. We have revealed association of two genes, DISC1 and DAOA, to intermediate traits for BPD and we were able to replicate some of the findings from earlier genome-wide association studies. We found in a large nation-wide cohort of twins that poor sleep predicted depressed mood in a consistent pattern, while depressed mood did not predict poor sleep, evidencing for the central role of disturbed sleep in mood disorders. We have also found inter-individual variability in sleep quality-related responses to stressful life events and relation of childhood traumatic events to insomnia in adulthood. We found in a systematic association study in a population-based sample that some susceptibility genes associate to depression only in the presence of disturbed sleep. We also found a link between a bipolar susceptibility gene and visual performance, evidencing further for the direct neurobiological link between visual perception, circadian rhythm, and regulation of mood.
Research output: Contribution to journal › Article › Scientific › peer-review
Research output: Contribution to journal › Article › Scientific › peer-review
Research output: Contribution to journal › Article › Scientific › peer-review
Research output: Contribution to journal › Article › Scientific › peer-review
Research output: Contribution to journal › Article › Scientific › peer-review
Hazak, A., Nagatsu, M., Aydinonat, N. E., Vartiainen, H. & Paunio, T.
01/09/2020 → 31/08/2023
Project: Research project
Repo, S., Paunio, T., Elovainio, M., Pyörälä, E., Saarinen, J., Peltola, K., Härkönen, T. & Holopainen, M.
01/01/2018 → 31/12/2025
Project: Research project
Paunio, T., Pyörälä, E., Saarinen, J., Peltola, K., Härkönen, T., Vartia, J. & Elovainio, M.
09/12/2016 → …
Project: Research project
Paavonen, J., Paunio, T., Saarenpää-Heikkilä, O., Pölkki, P., Kylliainen, A., Rusanen, E. & Pietiläinen, K.
01/01/2010 → …
Project: Research project
Suvisaari, J. & Paunio, T.
Project: Other project
Paavonen, Juulia (Recipient), Paunio, Tiina (Recipient) & Solantaus, T. (Recipient), 2009
Prize: Prizes and awards
Saara Repo (Speaker: Presenter), Tiina Paunio (Attendee), Eeva Pyörälä (Attendee), Marianne Holopainen (Attendee), panajiota Räsänen (Attendee) & Marko Elovainio (Attendee)
Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
Taina Hintsa (Speaker: Presenter), Anne Helena Monni (Attendee), Eeva Pyörälä (Attendee), Marko Elovainio (Attendee), Saara Repo (Attendee) & Tiina Paunio (Attendee)
Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
Tiina Maria Paunio (Poster Presentation), Eeva Pyörälä (Poster Presentation), Jussi Jukka Saarinen (Poster Presentation), Kari Risto Johannes Peltola (Attendee), Jonne Juntura (Poster Presentation) & Marko Juhani Elovainio (Poster Presentation)
Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
Zuzanna Misiewicz (Member of organizing committee), Iiris Maaria Hovatta (Member of organizing committee) & Tiina Maria Paunio (Member of organizing committee)
Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
Tiina Paunio (Chair)
Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
24/11/2018
1 item of Media coverage
Press/Media: Press / Media