Tiina Sikanen

Publications

Research output per year 2004 2007 2016 2017 2018 2019 2020 2021 2023 2024 2024

• 79 Article
• 36 Conference contribution
• 29 Poster
• 10 Abstract
• 19 More
  • 5 Commissioned report
  • 5 Chapter
  • 1 Book
  • 1 Other conference material
  • 1 Paper
  • 1 Meeting Abstract
  • 1 Conference article
  • 1 Editorial
  • 1 Review Article
  • 1 Other contribution
  • 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2024

  A MICROFLUIDIC DEVICE FOR ISOLATION AND QUANTITATION OF HEPATOCYTE-SECRETED EXTRACELLULAR VESICLES AND MONITORING THEIR CYTOCHROME P450 ACTIVITY ON-CHIP

  Moradi, E., Järvinen, P., Haapala, M. & Sikanen, T., 10 May 2024.

  Research output: Conference materials › Poster › peer-review

• Big Question To Developing Solutions: A Decade of Progress in the Development of Aquatic New Approach Methodologies from 2012 to 2022

  Langan, L. M., Paparella, M., Burden, N., Constantine, L., Margiotta-Casaluci, L., Miller, T. H., Moe, S. J., Owen, S. F., Schaffert, A. & Sikanen, T., Mar 2024, In: Environmental Toxicology and Chemistry. 43, 3, p. 559-574 16 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Comparative in vitro hepatic clearances of commonly used antidepressants, antipsychotics, and anti-inflammatory agents in rainbow trout liver S9 fractions

  Pihlaja, T., Pätsi, J., Ollikainen, E. & Sikanen, T., Sept 2024, In: Aquatic Toxicology. 274, 12 p., 107048.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Current uncertainties and challenges of publicly available pharmaceutical environmental risk assessment data

  Pihlaja, T., Ahkola, H., Sikanen, T., Riikonen, S., Äystö, L. & Kauppi, S., 1 Jun 2024, In: European Journal of Pharmaceutical Sciences. 2024, 197, 106769.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Cytotoxicity of pharmaceuticals and their mixtures toward scaffold-free 3D spheroid cultures of rainbow trout (Oncorhynchus mykiss) hepatocytes

  Järvinen, P., Kakko, M. & Sikanen, T., Aug 2024, In: European Journal of Pharmaceutical Sciences. 199, 12 p., 106817.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Design of greener drugs: aligning parameters in pharmaceutical R&D and drivers for environmental impact

  Vidaurre, R., Bramke, I., Puhlmann, N., Owen, S., Angst, D., Moermond, C., Venhuis, B., Lombardo, A., Kümmerer, K., Sikanen, T., Ryan, J., Häner, A., Janer, G., Roggo, S. & Nimrod Perkins, A., 2024, In: Drug Discovery Today. 104022.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Environmental considerations along the life cycle of pharmaceuticals: Interview study on views regarding environmental challenges, concerns, strategies, and prospects within the pharmaceutical industry

  Riikonen, S., Timonen, J. & Sikanen, T., 13 Mar 2024, In: European Journal of Pharmaceutical Sciences. 2024, 196

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Establishment of microfluidic Staphylococcus aureus biofilms on thiol-ene polymer chips for antimicrobial screening

  Ferreira Amorim, J., Cruz, C., Haapala, M., Tammela, P. & Sikanen, T., 17 Sept 2024.

  Research output: Conference materials › Poster › peer-review

• Extending the shelf life of HLM chips through freeze-drying of human liver microsomes immobilized onto thiol–ene micropillar arrays

  Rautsola, I., Haapala, M., Huttunen, L. E., Korhonen, O. & Sikanen, T., 31 Jul 2024, In: Lab on a Chip. 24, 17, p. 4211-4220 10 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• HLM chip: a microfluidic in vitro model for mechanism-based enzyme inhibition studies using immobilized human liver microsomes

  Rautsola, I., Haapala, M., Häiväläinen, H. K., Huttunen, L. E. & Sikanen, T., 2024.

  Research output: Conference materials › Poster › peer-review

• HLM chip – A microfluidic approach to study the mechanistic basis of cytochrome P450 inhibition using immobilized human liver microsomes

  Pihlaja, T., Kiiski, I. & Sikanen, T., 1 Jun 2024, In: European Journal of Pharmaceutical Sciences. 197, 10 p., 106773.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Intrinsic Hepatic Clearances of Selected Pharmaceuticals by Rainbow Trout S9 Fractions and Their Use in Estimating Bioconcentration Factors

  Pihlaja, T., Järvinen, E., Oksanen, T. J., Vinkvist, N. E. & Sikanen, T., 6 May 2024.

  Research output: Conference materials › Poster › peer-review

• Lääkkeen keksiminen ja kehitys: Vihreä kemia lääkkeen kehityksessä

  Translated title of the contribution: Drug discovery and development: Green chemistry in drug developmentYli-Kauhaluoma, J., Sikanen, T., Repo, T. & Hanski, L., 2024, Lääkkeet ja ympäristö: Pharmaceuticals and the Environment. Hanski, L., Lapatto-Reiniluoto, O., Lehtisalo, M., Riikonen, S., Sikanen, T., Sivén, M. & Teräsalmi, E. (eds.). 1 ed. Helsinki: Generation Green Working Group, p. 58-62 5 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › Scientific › peer-review

  Open Access

• Lääkkeet ja ympäristö : kestävän lääkehuollon haasteita ja ratkaisuja

  Hanski, L., Lapatto-Reiniluoto, O., Lehtisalo, M., Riikonen, S., Sikanen, T., Siven, M. & Teräsalmi, E. K., 2024, Generation Green Working Group.

  Research output: Book/Report › Book › Professional

  Open Access

• Lääkkeiden ympäristöluokitus - mitä pitää tietää: Lääkityksellä on aina ympäristövaikutuksia, mutta niiden arviointi on erittäin haasteellista

  Lapatto-Reiniluoto, O., Riikonen, S., Sikanen, T. & Siven, M., 2024, In: Suomen lääkärilehti. 79, 1-2, p. 49-51 3 p.

  Research output: Contribution to journal › Article › Professional

  Open Access

  File

• Many human pharmaceuticals are weak inhibitors of the cytochrome P450 system in rainbow trout (Oncorhynchus mykiss) liver S9 fractions

  Pihlaja, T., Oksanen, T. J., Vinkvist, N. E. & Sikanen, T., 15 Jul 2024, In: Frontiers in Toxicology . 6, 13 p., 1406942.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File
• 2023

  A MICROFLUIDIC DEVICE FOR ISOLATION AND QUANTITATION OF HEPATOCYTE-SECRETED EXTRACELLULAR VESICLES AND MONITORING THEIR EXOSOMAL ENZYME ACTIVITIES ON-CHIP

  Moradi, E., Järvinen, P., Haapala, M. & Sikanen, T., 16 Oct 2023.

  Research output: Conference materials › Poster › peer-review

• A MICROFLUIDIC DEVICE FOR ISOLATION AND QUANTITATION OF HEPATOCYTE-SECRETED EXTRACELLULAR VESICLES AND MONITORING THEIR EXOSOMAL ENZYME ACTIVITIES ON-CHIP

  Moradi, E., Järvinen, P., Haapala, M. & Sikanen, T., 11 Dec 2023.

  Research output: Conference materials › Poster › peer-review

• Comparative Study on the Intrinsic Clearances of Pharmaceuticals in Rainbow Trout (Oncorhynchus mykiss) Subcellular S9 Fractions and 3D Primary Hepatocyte Cultures

  Pihlaja, T., Järvinen, P. & Sikanen, T., 2023.

  Research output: Conference materials › Poster › peer-review

• Establishing Normoxic and Hypoxic Conditions for Microfluidic Cell Cultures via Material-induced Oxygen Scavenging on Off-Stoichiometric Thiol-ene Microdevices

  Piironen, K., Järvinen, P., Haapala, M., Talman, V., Kiiski, I. & Sikanen, T., 11 Dec 2023.

  Research output: Conference materials › Poster › peer-review

• Establishment of microfluidic Staphylococcus aureus biofilm on thiol-ene polymers for antimicrobial efficacy screening

  Ferreira Amorim, J., Cruz, C., Haapala, M., Tammela, P. & Sikanen, T., Oct 2023.

  Research output: Conference materials › Poster › peer-review

• Freeze-drying of immobilized human liver microsomes inside microfluidic enzyme reactors

  Rautsola, I., Haapala, M., Huttunen, L. E., Korhonen, O. & Sikanen, T., 2023.

  Research output: Conference materials › Poster › peer-review

• Freeze-drying of immobilized human liver microsomes inside microfluidic enzyme reactors

  Rautsola, I., Haapala, M., Huttunen, L. E., Korhonen, O. & Sikanen, T., 2023.

  Research output: Conference materials › Poster › peer-review

• Harnessing T cell exhaustion and trogocytosis to isolate patient-derived tumor-specific TCR

  Manfredi, F., Stasi, L., Buonanno, S., Marzuttini, F., Noviello, M., Mastaglio, S., Abbati, D., Potenza, A., Balestrieri, C., Cianciotti, B. C., Tassi, E., Feola, S., Toffalori, C., Punta, M., Magnani, Z., Camisa, B., Tiziano, E., Lupo-Stanghellini, M. T., Branca, R. M. & Lehtiö, J. & 8 others, Sikanen, T. M., Haapala, M. J., Cerullo, V., Casucci, M., Vago, L., Ciceri, F., Bonini, C. & Ruggiero, E., 1 Dec 2023, In: Science Advances. 9, 48, 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

• MICROFLUIDIC 3D CULTURES OF SCAFFOLD-FREE CARDIOMYOCYTE SPHEROIDS DIFFERENTIATED FROM HUMAN-INDUCED PLURIPOTENT STEM CELLS

  Castro Guerrero, M., Järvinen, P., Talman, V., Haapala, M. & Sikanen, T., 11 Dec 2023.

  Research output: Conference materials › Poster › peer-review

• MICROFLUIDIC 3D CULTURES OF SCAFFOLD-FREE CARDIOMYOCYTE SPHEROIDS DIFFERENTIATED FROM HUMAN- INDUCED PLURIPOTENT STEM CELLS

  Castro Guerrero, M., Järvinen, P., Talman, V., Haapala, M. & Sikanen, T., Oct 2023, MicroTAS 2023 - 27th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

• 2022

  Cytochrome P450 Inhibition by Antimicrobials and Their Mixtures in Rainbow Trout Liver Microsomes In Vitro

  Pihlaja, T. L. M., Niemissalo, S. M. & Sikanen, T. M., Mar 2022, In: Environmental Toxicology and Chemistry. 41, 3, p. 663-676 14 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Microfluidic oxygen tolerability screening of nanocarriers for triplet fusion photon upconversion

  Isokuortti, J., Kiiski, I., Sikanen, T., Durandin, N. & Laaksonen, T., 24 Mar 2022, In: Journal of Materials Chemistry. C. 10, 12, p. 4871-4877 7 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Staphylococcus aureus biofilm metabolism and susceptibility to ciprofloxacin on thiol-ene polymer surfaces

  Ferreira Amorim, J., Cruz, C., Haapala, M., Tammela, P. & Sikanen, T., May 2022.

  Research output: Conference materials › Poster › peer-review

• The interactions of antipsychotics with the cytochrome P450 system of rainbow trout and its impact on hepatic clearance of pharmaceuticals in vitro

  Pihlaja, T., Ollikainen, E. & Sikanen, T., 2022.

  Research output: Conference materials › Other conference material › peer-review

• 2021

  Drug glucuronidation assays on human liver microsomes immobilized on microfluidic flow-through reactors

  Kiiski, I., Ollikainen, E., Artes, S., Järvinen, P., Jokinen, V. & Sikanen, T., 1 Mar 2021, In: European Journal of Pharmaceutical Sciences. 158, 9 p., 105677.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Fish-Liver-on-Chip: A Microfluidic Model to Assess Bioaccumulation of Environmental Drug Residues In Vitro

  Järvinen, P., Haapala, M., Tähkä, S., Lindstedt, H. & Sikanen, T., 2021, MicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Chemical and Biological Microsystems Society, p. 623-624

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

  Open Access

  File

• Human well-being and capabilities: Thematic Module B

  Oinas, E., Katsui, H., Jauhola, M., Korpelainen, N.-H. P., Kuusela, P., Lammi, T. J., Laisi, J. S. H., Lapatto-Reiniluoto, O., Lonka, K., Mariaselvam, G., Mkwesha, F., Rintala, H., Ristivojevic, D., Sikanen, T., Spännäri, J., Urpa, L., van der Wekken, R., Uusitalo, L., Varfolomeeva, A. & Vivitsou, M. & 1 others, Väyrynen, S., 2021, University of Helsinki.

  Research output: Other contribution

  Open Access

• Inkjet-printed flexible silver electrodes on thiol-enes

  Kuusisto, E., Heikkinen, J. J., Järvinen, P., Sikanen, T., Franssila, S. & Jokinen, V., 1 Jun 2021, In: Sensors and Actuators B: Chemical. 336, 8 p., 129727.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Lääkkeiden ympäristövaikutukset

  Karlsson, S., Sikanen, T., Vieno, N., Virtanen, V. & Äystö, L., 2021, Pharmaca Fennica 2021: Valmisteiden ja lääkeaineiden perustiedot terapiaryhmittäin. Kariaho, E. (ed.). Helsinki: Lääketietokeskus, p. 1410-1412 3 p. (Pharmaca Fennica; no. 2021).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › Professional

• Lääkkeiden ympäristövaikutukset

  Sikanen, T. & Lapatto-Reiniluoto, O., 2021, In: Finnanest. 54, 1, p. 27-31

  Research output: Contribution to journal › Article › Professional

  Open Access

• Oxygen Control in OSTE Organ-Chips

  Piironen, K., Kiiski, I., Järvinen, P. & Sikanen, T., 2021.

  Research output: Conference materials › Poster › peer-review

• PeptiCHIP: A Microfluidic Platform for Tumor Antigen Landscape Identification

  Feola, S., Haapala, M., Peltonen, K., Capasso, C., Martins, B., Antignani, G., Federico, A., Pietiäinen, V., Chiaro, J., Feodoroff, M., Russo, S., Rannikko, A., Fusciello, M., Koskela, S., Partanen, J., Hamdan, F., Tähkä, S. M., Ylösmäki, E., Greco, D. & Grönholm, M. & 8 others, Kekarainen, T., Eshaghi, M., Gurvich, O. L., Ylä-Herttuala, S., Branca, R. M. M., Lehtiö, J., Sikanen, T. M. & Cerullo, V., 26 Oct 2021, In: ACS Nano. 15, 10, p. 15992–16010 19 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• PeptiCHIP: A Novel Microfluidic-Based Chip Platform for Tumour Antigen Landscape Identification

  Feola, S., Haapala, M., Peltonen, K., Capasso, C., Martins, B., Antignani, G., Federico, A., Pietiainen, V., Chiaro, J., Feodoroff, M., Ranniko, A., Fusciello, M., Koskela, S., Partanen, J., Hamdan, F., Tahka, S., Ylosmaki, E., Greco, D., Gronholm, M. & Kekarainen, T. & 7 others, Eshaghi, M., Gurvich, O. L., Yla-Herttuala, S., Branca, R. M. M., Lehtio, J., Sikanen, T. & Cerullo, V., 27 Apr 2021, In: Molecular therapy. 29, 4, p. 330-330 1 p.

  Research output: Contribution to journal › Meeting Abstract › peer-review

• SUDDEN – tackling the environmental impacts of medicines across their life cycle

  Yli-Kauhaluoma, J., Sikanen, T., Karlsson, S. & Jalonen, K., 17 Dec 2021, In: Newsletter.

  Research output: Contribution to journal › Article › General public

  Open Access

• The material-enabled oxygen control in thiol-ene microfluidic channels and its feasibility for subcellular drug metabolism assays under hypoxia in vitro

  Kiiski, I., Järvinen, P., Ollikainen, E., Jokinen, V. & Sikanen, T., 7 May 2021, In: Lab on a Chip. 21, 9, p. 1820–1831 12 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• The role of cytochrome P450 metabolism in the clearance of antipsychotic drugs in rainbow trout in vitro

  Pihlaja, T., Sinisalo, J., Ollikainen, E. & Sikanen, T., 3 May 2021.

  Research output: Conference materials › Abstract › peer-review

• 2020

  A Digital-to-Channel Microfluidic Interface via Inkjet Printing of Silver and UV Curing of Thiol-Enes

  Sathyanarayanan, G., Haapala, M., Dixon, C., Wheeler, A. R. & Sikanen, T. M., Oct 2020, In: Advanced Materials Technologies. 5, 10, 9 p., 2000451.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Assessment of the risk for inhibition of hepatic clearance of pharmaceuticals in fish

  Pihlaja, T., Niemissalo, S. & Sikanen, T., 3 May 2020.

  Research output: Conference materials › Poster

• Cell adhesion and proliferation on common 3D printing materials used in stereolithography of microfluidic devices

  Piironen, K., Haapala, M., Talman, V., Järvinen, P. & Sikanen, T., 7 Jul 2020, In: Lab on a Chip. 20, 13, p. 2372-2382 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Digital Microfluidics-Enabled Analysis of Individual Variation in Liver Cytochrome P450 Activity

  Sathyanarayanan, G., Haapala, M. & Sikanen, T., 3 Nov 2020, In: Analytical Chemistry. 92, 21, p. 14693-14701 9 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Generation Green – A holistic approach to implementation of green principles and practices in educational programmes in pharmaceutical and medical sciences at the University of Helsinki

  Siven, M., Teppo, J., Lapatto-Reiniluoto, O., Teräsalmi, E., Salminen, O. & Sikanen, T., Jun 2020, In: Sustainable chemistry and pharmacy. 16, 9 p., 100262.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Generation Green – Ympäristönäkökulmat mukaan farmasian ja lääketieteen koulutukseen

  Translated title of the contribution: Generation Green – Incorporation of environmental aspects into the curricula of pharmaceutical and medical education Siven, M., Lapatto-Reiniluoto, O., Teppo, J., Teräsalmi, E., Sikanen, T. & Salminen, O., 2020, In: Dosis : farmaseuttinen aikakauskirja. 36, 3, p. 416-426 11 p.

  Research output: Contribution to journal › Article › Scientific › peer-review

  Open Access

  File

• Lääkeaineiden ympäristöluokituksen hyödyt ja haasteet

  Vieno, N., Sikanen, T., Äystö, L., Mehtonen, J., Karlsson, S. & Nystén, T., 7 Feb 2020, In: Vesitalous. vol 60, 1, p. 23-24 2 p.

  Research output: Contribution to journal › Article › Professional

  Open Access

  File

• Lääkejäämien vesistöriskien arviointi Suomessa

  Vieno, N., Äystö, L., Mehtonen, J., Sikanen, T., Karlsson, S., Fjäder, P. & Nystén, T., 7 Feb 2020, In: Vesitalous. vol 60, 1, p. 25-28 4 p.

  Research output: Contribution to journal › Article › Professional