No photo of Timo Hiltunen
  • PL 22 (Haartmaninkatu 4)

    00014

    Finland

19942019
If you made any changes in Pure these will be visible here soon.

Publications 1994 2019

  • 43 Article
  • 3 Review Article
  • 1 Conference contribution
  • 1 Doctoral Thesis
Filter
Article
2019

Genome-wide association study of white-coat effect in hypertensive patients

Rimpelä, J., Niiranen, T., Jula, A., Pörsti, I., Tikkakoski, A. J., Havulinna, A., Lehtimäki, T., Salomaa, V., Kontula, K. & Hiltunen, T., 2019, In : Blood Pressure. 2019 / 28, 4, p. 239-249 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2018

Effect of hydrochlorothiazide on serum uric acid concentration: a genome-wide association study

Ala-Mutka, E. M., Rimpelä, J. M., Fyhrquist, F., Kontula, K. K. & Hiltunen, T. P., Apr 2018, In : Pharmacogenomics. 19, 6, p. 517-527 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome-wide association study of nocturnal blood pressure dipping in hypertensive patients

Rimpelä, J. M., Pörsti, I. H., Jula, A., Lehtimäki, T., Niiranen, T. J., Oikarinen, L., Porthan, K., Tikkakoski, A., Virolainen, J., Kontula, K. K. & Hiltunen, T. P., 4 Jul 2018, In : BMC Medical Genetics. 19, 11 p., 110.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2017

Effects of four different antihypertensive drugs on plasma metabolomic profiles in patients with essential hypertension

Hiltunen, T. P., Rimpela, J. M., Mohney, R. P., Stirdivant, S. M. & Kontula, K. K., 9 Nov 2017, In : PLoS One. 12, 11, 16 p., 0187729.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide

Salvi, E., Wang, Z., Rizzi, F., Gong, Y., McDonough, C. W., Padmanabhan, S., Hiltunen, T. P., Lanzani, C., Zaninello, R., Chittani, M., Bailey, K. R., Sarin, A-P., Barcella, M., Melander, O., Chapman, A. B., Manunta, P., Kontula, K. K., Glorioso, N., Cusi, D., Dominiczak, A. F. & 5 othersJohnson, J. A., Barlassina, C., Boerwinkle, E., Cooper-DeHoff, R. M. & Turner, S. T., Jan 2017, In : Hypertension. 69, 1, p. 51-59 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Replicated evidence for aminoacylase 3 and nephrin gene variations to predict antihypertensive drug responses

Rimpelä, J. M., Kontula, K. K., Fyhrquist, F., Donner, K. M., Tuiskula, A. M., Sarin, A-P., Mohney, R., Stirdivant, S. & Hiltunen, T. P., 28 Mar 2017, In : Pharmacogenomics. 18, 5, p. 445-458 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2015

Pharmacogenomics of Hypertension: A Genome-Wide, Placebo-Controlled Cross-Over Study, Using Four Classes of Antihypertensive Drugs

Hiltunen, T. P., Donner, K. M., Sarin, A-P., Saarela, J., Ripatti, S., Chapman, A. B., Gums, J. G., Gong, Y., Cooper-DeHoff, R. M., Frau, F., Glorioso, V., Zaninello, R., Salvi, E., Glorioso, N., Boerwinkle, E., Turner, S. T., Johnson, J. A. & Kontula, K. K., Jan 2015, In : Journal of the American Heart Association. 4, 1, 26 p., 001521.

Research output: Contribution to journalArticleScientificpeer-review

PTPRD gene associated with blood pressure response to atenolol and resistant hypertension

Gong, Y., McDonough, C. W., Beitelshees, A. L., El Rouby, N., Hiltunen, T. P., O'Connell, J. R., Padmanabhan, S., Langaee, T. Y., Hall, K., Schmidt, S. O. F., Curry, R. W., Gums, J. G., Donner, K. M., Kontula, K. K., Bailey, K. R., Boerwinkle, E., Takahashi, A., Tanaka, T., Kubo, M., Chapman, A. B. & 4 othersTurner, S. T., Pepine, C. J., Cooper-DeHoff, R. M. & Johnson, J. A., Nov 2015, In : Journal of Hypertension. 33, 11, p. 2278-2285 8 p.

Research output: Contribution to journalArticleScientificpeer-review

TET2 and CSMD1 genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives

Chittani, M., Zaninello, R., Lanzani, C., Frau, F., Ortu, M. F., Salvi, E., Fresu, G., Citterio, L., Braga, D., Piras, D. A., Carpini, S. D., Velayutham, D., Simonini, M., Argiolas, G., Pozzoli, S., Troffa, C., Glorioso, V., Kontula, K. K., Hiltunen, T. P., Donner, K. M. & 16 othersTurner, S. T., Boerwinkle, E., Chapman, A. B., Padmanabhan, S., Dominiczak, A. F., Melander, O., Johnson, J. A., Cooper-Dehoff, R. M., Gong, Y., Rivera, N. V., Condorelli, G., Trimarco, B., Manunta, P., Cusi, D., Glorioso, N. & Barlassina, C., 1 Jun 2015, In : Journal of Hypertension. 33, 6, p. 1301-1309 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Elevated serum squalene and cholesterol synthesis markers in pregnant obese women with gestational diabetes mellitus

Miettinen, H. E., Rönö, K., Koivusalo, S., Stach-Lempinen, B., Pöyhönen-Alho, M., Eriksson, J. G., Hiltunen, T. P. & Gylling, H., Dec 2014, In : Journal of Lipid Research. 55, 12, p. 2644-2654 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Genome-wide association study identifies CAMKID variants involved in blood pressure response to losartan: the SOPHIA study

Frau, F., Zaninello, R., Salvi, E., Ortu, M. F., Braga, D., Velayutham, D., Argiolas, G., Fresu, G., Troffa, C., Bulla, E., Bulla, P., Pitzoi, S., Piras, D. A., Glorioso, V., Chittani, M., Bernini, G., Bardini, M., Fallo, F., Malatino, L., Stancanelli, B. & 22 othersRegolisti, G., Ferri, C., Desideri, G., Scioli, G. A., Galletti, F., Sciacqua, A., Perticone, F., Esposti, E. D., Sturani, A., Semplicini, A., Veglio, F., Mulatero, P., Williams, T. A., Lanzani, C., Hiltunen, T. P., Kontula, K., Boerwinkle, E., Turner, S. T., Manunta, P., Barlassina, C., Cusi, D. & Glorioso, N., 2014, In : Pharmacogenomics. 15, 13, p. 1643-1652 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Genomic Association Analysis of Common Variants Influencing Antihypertensive Response to Hydrochlorothiazide

Turner, S. T., Boerwinkle, E., O'Connell, J. R., Bailey, K. R., Gong, Y., Chapman, A. B., McDonough, C. W., Beitelshees, A. L., Schwartz, G. L., Gums, J. G., Padmanabhan, S., Hiltunen, T. P., Citterio, L., Donner, K. M., Hedner, T., Lanzani, C., Melander, O., Saarela, J., Ripatti, S., Wahlstrand, B. & 5 othersManunta, P., Kontula, K., Dominiczak, A. F., Cooper-DeHoff, R. M. & Johnson, J. A., Aug 2013, In : Hypertension. 62, 2, p. 391-397 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Effects of long-term intake of lactotripeptides on cardiovascular risk factors in hypertensive subjects

Jauhiainen, T., Niittynen, L., Oresic, M., Jarvenpaa, S., Hiltunen, T. P., Rönnback, M., Vapaatalo, H. & Korpela, R., 2012, In : European Journal of Clinical Nutrition. 66, 7, p. 843-849 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Preface to the proceedings of the XVII Paavo Nurmi Symposium

Hiltunen, T. P. & Porsti, I., 2012, In : Annals of Medicine. 44, Suppl. 1, p. S1-S1 1 p.

Research output: Contribution to journalArticleScientific

STK39 variation predicts the ambulatory blood pressure response to losartan in hypertensive men

Donner, K. M., Hiltunen, T. P., Hannila-Handelberg, T., Suonsyrja, T. & Kontula, K., 2012, In : Hypertension Research. 35, 1, p. 107-114 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Common genetic variation of beta 1-and beta 2-adrenergic receptor and response to four classes of antihypertensive treatment

Suonsyrja, T., Donner, K., Hannila-Handelberg, T., Fodstad, H. M., Kontula, K. & Hiltunen, T. P., 2010, In : Pharmacogenetics and Genomics. 20, 5, p. 342-345 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Licorice-induced hypertension and common variants of genes regulating renal sodium reabsorption

Miettinen, H. E., Piippo, K., Hannila-Handelberg, T., Paukku, K. R. S., Hiltunen, T. P., Gautschi, I., Schild, L. & Kontula, K., 2010, In : Annals of Medicine. 42, 6, p. 465-474 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

CYP2C9 genotype modifies activity of the renin-angiotensin-aldosterone system in hypertensive men

Donner, K., Hiltunen, T. P., Suonsyrjä, T., Hannila-Handelberg, T., Tikkanen, I., Antikainen, M., Hirvonen, A. & Kontula, K., 2009, In : Journal of Hypertension. 27, p. 2001-2009 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Renin-angiotensin system and [alpha]-adducin gene polymorphisms and their relation to responses to antihypertensive drugs: results from the GENRES study

Suonsyrjä, T., Hannila-Handelberg, T., Fodstad, H., Donner, K., Kontula, K. & Hiltunen, T. P., 2009, In : American Journal of Hypertension. 22, 2, p. 169-175 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Short-term electrophysiological effects of losartan, bisoprolol, amlodipine, and hydrochlorothiazide in hypertensive men

Porthan, K., Viitasalo, M., Hiltunen, T. P., Väänänen, H., Dabek, J., Suonsyrjä, T., Hannila-Handelberg, T., Virolainen, J., Nieminen, M. S., Toivonen, L., Kontula, K. & Oikarinen, L., 2009, In : Annals of Medicine. 41, p. 29-37 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Laboratory tests as predictors of the antihypertensive effects of amlodipine, bisoprolol, hydrochlorothiazide and losartan in men: results from the randomized, double-blind, crossover GENRES study

Suonsyrjä, T., Hannila-Handelberg, T., Paavonen, K. J., Miettinen, H. E., Donner, K., Strandberg, T., Tikkanen, I., Tilvis, R., Pentikäinen, P. J., Kontula, K. & Hiltunen, T. P., 2008, In : Journal of Hypertension. 26, p. 1250-1256 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Geenit ja verenpaine.

Hiltunen, T., 2007, In : Nutrifocus : ajankohtaisia ravitsemustutkimuksia. 2007, 1, p. 6-7 2 p.

Research output: Contribution to journalArticleProfessional

Predictors of antihypertensive drug responses: initial data from a placebo-controlled, randomized, cross-over study with four antihypertensive drugs (The GENRES Study)

Hiltunen, T. P., Suonsyrjä, T., Hannila-Handelberg, T., Paavonen, K. J., Miettinen, H. E., Strandberg, T., Tikkanen, I., Tilvis, R., Pentikäinen, P. J., Virolainen, J. & Kontula, K., 2007, In : American Journal of Hypertension. 20, p. 311-318 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Relationship of electrocardiographic repolarization measures to echocardiographic left ventricular mass in men with hypertension

Porthan, K., Virolainen, J., Hiltunen, T. P., Viitasalo, M., Väänänen, H., Dabek, J., Hannila-Handelberg, T., Toivonen, L., Nieminen, M. S., Kontula, K. & Oikarinen, L., 2007, In : Journal of Hypertension. 25, p. 1951-1957 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2005

Akuutti sydäninfarkti rankan lumisateen jälkeen

Sipilä, R., Hiltunen, T. & Näveri, H., 2005, In : Duodecim. 121, 2, p. 181-183 3 p.

Research output: Contribution to journalArticleScientific

Common variants of the beta and gamma subunits of the epithelial sodium channel and their relation to plasma renin and aldosterone levels in essential hypertension

Hannila-Handelberg, T., Kontula, K., Tikkanen, I., Tikkanen, T., Fyhrquist, F., Helin, K., Fodstad, H., Piippo, K., Miettinen, H. E., Virtamo, J., Krusius, T., Sarna, S., Gautschi, I., Schild, L., Hiltunen, T. P. & Hannila-Handerberg, T., 2005, In : BMC Medical Genetics. 6

Research output: Contribution to journalArticleScientificpeer-review

2002

Liddle's syndrome associated with a point mutation in the extracellular domain of the epithelial sodium channel gamma subunit

Hiltunen, T., Hannila-Handelberg, T., Petäjäniemi, N., Kantola, I., Tikkanen, I., Virtamo, J., Gautschi, I., Schild, L. & Kontula, K., 2002, In : Journal of Hypertension. 20, 12, p. 2383-2390 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2001

Rabbit atherosclerotic lesions express scavenger receptor AIII mRNA, a naturally occurring splice variant that encodes a non-functional, dominant negative form of the macrophage scavenger receptor.

Hiltunen, T. P., Gough, PJ., Greaves, DR., Gordon, S. & Ylä-Herttuala, S., 2001, In : Atherosclerosis. 2001 / 154, p. 415-419 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2000

677 C -> T polymorphism of the methylenetetrahydrofolate reductase gene and preeclampsia

Laivuori, H. M., Kaaja, R., Ylikorkala, O., Hiltunen, T. & Kontula, K., 2000, In : Obstetrics and Gynecology. 96, p. 277-280 4 p.

Research output: Contribution to journalArticleScientificpeer-review

Rapid detection of angiotensinogen M/T235 polymorphism by fluorescence probe melting curves

Malin, R., Wirta, V., Hiltunen, T. & Lehtimäki, T., 2000, In : Clinical Chemistry (Washington, DC). 46, 6 Part 1, p. 880-881 2 p.

Research output: Contribution to journalArticleScientific

1999

Relationship of angiotensin-converting enzyme gene polymorphism to carotid wall thickness in middle-aged men.

Huang, XH., Loimaala, A., Nenonen, A., Mercuri, M., Vuori, I., Pasanen, M., Oja, P., Bond, G., Koivula, T., Hiltunen, T., Nikkari, T. & Lehtimäki, T., 1999, In : Journal of Molecular Medicine. 1999 / 77, p. 853-858 6 p.

Research output: Contribution to journalArticleScientificpeer-review

1998

Angiotensin-converting enzyme gene polymorphism is associated with coronary heart disease in non-insulin-dependent diabetic patients evaluated for 9 years.

Huang, XH., Rantalaiho, V., Wirta, O., Pasternack, A., Koivula, T., Hiltunen, T., Nikkari, T. & Lehtimäki, T., 1998, In : Metabolism, clinical and experimental. 1998 / 47, p. 1258-1262 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Angiotensin-converting enzyme insertion/deletion polymorphism and diabetic albuminuria in patients with NIDDM followed up for 9 years.

Huang, XH., Rantalaiho, V., Wirta, O., Pasternack, A., Koivula, T., Hiltunen, T., Malminiemi, K., Nikkari, T. & Lehtimäki, T., 1998, In : Nephron. 1998 / 80, p. 17-24 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Expression of extracellular SOD and iNOS in macrophages and smooth muscle cells in human and rabbit atherosclerotic lesions: colocalization with epitopes characteristic of oxidized LDL and peroxynitrite-modified proteins.

Luoma, JS., Strålin, P., Marklund, SL., Hiltunen, T., Särkioja, T. & Ylä-Herttuala, S., 1998, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 1998 / 18, p. 157-167 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Expression of LDL receptor, VLDL receptor, LDL receptor-related protein, and scavenger receptor in rabbit atherosclerotic lesions: marked induction of scavenger receptor and VLDL receptor expression during lesion development.

Hiltunen, T., Luoma, JS., Nikkari, T. & Ylä-Herttuala, S., 1998, In : Circulation . 1998 / 97, p. 1079-1086 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Relationship of the angiotensin-converting enzyme gene polymorphism to glucose intolerance, insulin resistance, and hypertension in NIDDM.

Huang, XH., Rantalaiho, V., Wirta, O., Pasternack, A., Koivula, T., Hiltunen, T., Nikkari, T. & Lehtimäki, T., 1998, In : Human Genetics. 1998 / 102, p. 372-378 7 p.

Research output: Contribution to journalArticleScientificpeer-review

1995

Induction of 15-lipoxygenase mRNA and protein in early atherosclerotic lesions.

Hiltunen, T., Luoma, J., Nikkari, T. & Ylä-Herttuala, S., 1995, In : Circulation . 1995 / 92, p. 3297-3303 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Monitoring of lipoprotein oxidation by gas chromatographic analysis of hydroxy fatty acids.

Nikkari, T., Malo-Ranta, U., Hiltunen, T., Jaakkola, O. & Ylä-Herttuala, S., 1995, In : Journal of Lipid Research. 1995 / 36, p. 200-207 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Transfer of 15-lipoxygenase gene into rabbit iliac arteries results in the appearance of oxidation-specific lipid-protein adducts characteristic of oxidized low density lipoprotein.

Ylä-Herttuala, S., Luoma, J., Viita, H., Hiltunen, T., Sisto, T. & Nikkari, T., 1995, In : Journal of Clinical Investigation. 1995 / 95, p. 2692-2698 7 p.

Research output: Contribution to journalArticleScientificpeer-review

1994

A PCR artifact under low-stringency conditions due to amplification by only one primer.

Hiltunen, T., Raja-Honkala, M., Nikkari, T. & Ylä-Herttuala, S., 1994, In : BioTechniques. 1994 / 17, p. 240-242 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Expression of alpha2-macroglobulin receptor/low density lipoprotein receptor-related protein and scavenger receptor in human atherosclerotic lesions.

Luoma, J., Hiltunen, T., Särkioja, T., Moestrup, S., Gliemann, J., Nikkari, T. & Ylä-Herttuala, S., 1994, In : Journal of Clinical Investigation. 1994 / 93, p. 2014-2021 8 p.

Research output: Contribution to journalArticleScientificpeer-review