• Viikinkaari 5

    HELSINKI

    Finland

  • PL 56 (Viikinkaari 5)

    00014

    Finland

20072022
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Publications 2007 2019

2019

Ang II (Angiotensin II) Conversion to Angiotensin-(1-7) in the Circulation Is POP (Prolyloligopeptidase)-Dependent and ACE2 (Angiotensin-Converting Enzyme 2)-Independent

Serfozo, P., Wysocki, J., Gulua, G., Schulze, A., Ye, M., Liu, P., Jin, J., Bader, M., Myöhänen, T., Garcia Horsman, J. A. & Batlle, D., 2 Dec 2019, In : Hypertension. Hypertension. ;0:HYPERTENSIONAHA.119.14071.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
Open Access
File

Entsyymien merkitys hermorappeumataudeissa

Kursula, P. & Myöhänen, T., 2019, In : Duodecim. 135, 8, p. 745-752

Research output: Contribution to journalArticleScientificpeer-review

New tricks of prolyl oligopeptidase inhibitors - A common drug therapy for several neurodegenerative diseases

Svarcbahs, R., Julku, U., Kilpelainen, T., Kyyrö, M., Jäntti, M. & Myohänen, T. T., Mar 2019, In : Biochemical Pharmacology. 161, p. 113-120 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Prolyl oligopeptidase inhibition activates autophagy via protein phosphatase 2A

Svarcbahs, R., Jäntti, M., Kilpeläinen, T., Julku, U., Urvas, L., Kivioja, S. E., Norrbacka, S. M. & Myöhänen, T., 2019, In : Pharmacological Research.

Research output: Contribution to journalArticleScientificpeer-review

Prolyl oligopeptidase inhibition reduces PolyQ aggregation and improves cell viability in cellular model of Huntington’s disease

Norrbacka, S., Lindholm, D. & Myöhänen, T. T., 29 Sep 2019, In : Journal of Cellular and Molecular Medicine. 23, 12, p. 8511-8515 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Tetrazole as a Replacement of the Electrophilic Group in Characteristic Prolyl Oligopeptidase Inhibitors

Kilpeläinen, T., Tyni, J., Lahtela-Kakkonen, M., Eteläinen, T., Myöhänen, T. & Wallén, E. A. A., 2019, In : ACS Medicinal Chemistry Letters.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
2018

Constitutive Ret signaling leads to long-lasting expression of amphetamine-induced place conditioning via elevation of mesolimbic dopamine

Kopra, J., Villarta-Aguilera, M., Savolainen, M., Weingerl, S., Myohänen, T. T., Rannanpää, S., Salvatore, M. E., Andressoo, J-O. & Piepponen, T. P., Jan 2018, In : Neuropharmacology. 128, p. 221-230 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Prolyl Oligopeptidase Regulates Dopamine Transporter Phosphorylation in the Nigrostriatal Pathway of Mouse

Julku, U. H., Panhelainen, A. E., Tiilikainen, S. E., Svarcbahs, R., Tammimäki, A. E., Piepponen, T. P., Savolainen, M. H. & Myöhänen, T. T., Jan 2018, In : Molecular Neurobiology. 55, 1, p. 470-482 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo

Svarcbahs, R., Julku, U. H., Norrbacka, S. & Myöhänen, T. T., 2018, In : Scientific Reports. 8, 1, 18 p., 1552.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2017
Open Access
File

Prolyl oligopeptidase inhibition attenuates the toxicity of a proteasomal inhibitor, lactacystin, in the alpha-synuclein overexpressing cell culture

Myöhänen, T. T., Norrbacka, S. & Savolainen, M. H., 1 Jan 2017, In : Neuroscience Letters. 636, p. 83-89 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Prolyylioligopeptidaasin estäjällä Parkinsonin tautia vastaan?

Svarcbahs, R., Julku, U. & Myöhänen, T. T., Jan 2017, In : Duodecim. 133, 1, p. 89 1 p.

Research output: Contribution to journalArticleProfessional

2015

Prolyl Oligopeptidase Enhances α-synuclein Dimerization via Direct Protein-Protein Interaction

Savolainen, M. H., Yan, X., Myöhänen, T. T. & Huttunen, H. J., 2015, In : Journal of Biological Chemistry. 290, 8, p. 5117-5126 11 p.

Research output: Contribution to journalArticleScientificpeer-review

File
2014

Analysis of oxysterols and vitamin D metabolites in mouse brain and cell line samples by ultra-high-performance liquid chromatography-atmospheric pressure photoionization-mass spectrometry

Ahonen, L., Maire, F. B. R., Savolainen, M., Kopra, J., Vreeken, R. J., Hankemeier, T., Myöhänen, T., Kylli, P. & Kostiainen, R., 17 Oct 2014, In : Journal of Chromatography. A. 1364, p. 214-222 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice

Kim, J. D., Toda, C., D'Agostino, G., Zeiss, C. J., DiLeone, R. J., Elsworth, J. D., Kibbey, R. G., Chan, O., Harvey, B. K., Richie, C. T., Savolainen, M., Myöhänen, T., Jeong, J. K. & Diano, S., 12 Aug 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 32, p. 11876-11881 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Mice deficient in transmembrane prostatic acid phosphatase display increased GABAergic transmission and neurological alterations.

Nousiainen, H., Quintero, IB., Myöhänen, T. T., Voikar, V., Mijatovic, J., Segerstråle, M., Herrala, A. M., Kulesskaya, N., Pulkka, A., Kivinummi, T., Abo Ramadan, U., Taira, T., Piepponen, T. P., Rauvala, H. & Vihko, P., 2014, In : PLoS One. 9, 5, 15 p., e97851.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse

Savolainen, M. H., Richie, C. T., Harvey, B. K., Männistö, P. T., Maguire-Zeiss, K. A. & Myöhänen, T. T., Aug 2014, In : Neurobiology of Disease. 68, p. 1-15 15 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Catechol-O-methyltransferase (COMT) protein expression and activity after dopaminergic and noradrenergic lesions of the rat brain

Schendzielorz, N., Oinas, J-P., Myöhänen, T. T., Reenilä, I., Raasmaja, A. & Männistö, P. T., Apr 2013, In : PLoS One. 8, 4, 12 p., e61392.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Comparison of motor performance, brain biochemistry and histology of two A30P α-synuclein transgenic mouse strains.

Piltonen, M., Savolainen, M., Patrikainen, S., Baekelandt, V., Myöhänen, T. T. & Männistö, P. T., 2013, In : Neuroscience. 231, p. 157-168 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Thymosin β4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis

Zuo, Y., Chun, B., Potthoff, S., Kazi, N., Brolin, T., Orhan, D., Yang, H-C., Ma, L-J., Kon, V., Myöhänen, T. T., Rhaleb, N-E., Carretero, O. & Fogo, A., 2013, In : Kidney International. 84, p. 1166–1175

Research output: Contribution to journalArticleScientificpeer-review

2012

A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease

Myöhänen, T. T., Hannula, M. J., Van Elzen, R., Gerard, M., Van der Veken, P., Garcia Horsman, J. A., Baekelandt, V., Männistö, P. T. & Lambeir, A. M., 10 Jan 2012, In : British Journal of Pharmacology. 166, 3, p. 1097-1113 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Different interactions of prolyl oligopeptidase and neurotensin in dopaminergic function of the rat nigrostriatal and mesolimbic pathways.

Peltonen, I., Myöhänen, T. T. & Männistö, P. T., 2012, In : Neurochemical Research. 37, 9, p. 2033-2041 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Distribution of Prolyl Oligopeptidase in Human Peripheral Tissues and in Ovarian and Colorectal Tumors.

Myöhänen, T. T., Pyykko, E., Männistö, P. T. & Carpen, O., 2012, In : Journal of Histochemistry and Cytochemistry. 60, 9, p. 706-715 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Association of prolyl oligopeptidase and conventional neurotransmitters in the brain

Peltonen, I., Myöhänen, T. T. & Männistö, P., May 2011, In : CNS & Neurological Disorders - Drug Targets. 10, 3, p. 311-318 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Association of Prolyl Oligopeptidase with Conventional Neurotransmitters in the Brain

Peltonen, I., Myohänen, T. T. & Männistö, P. T., May 2011, In : C N S & Neurological Disorders. 10, 3, p. 311-318 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner

Myöhänen, T. T., Tenorio-Laranga, J., Jokinen, B., Vázquez-Sanchez, R., Moreno-Baylach, M. J., Garcia Horsman, J. A. & Männistö, P. T., 2011, In : British Journal of Pharmacology. 163, 8, p. 1666-1678 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Vascular endothelial growth factor C acts as a neurotrophic factor for dopamine neurons in vitro and in vivo

Piltonen, M. H., Planken, A., Leskelä, O., Myöhänen, T. T., Hänninen, A-L., Auvinen, P., Alitalo, K., Anderssoo, J-O., Saarma, M. & Männistö, P., 14 Jul 2011, In : Neuroscience. 192, p. 550-563 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Distribution and functions of catechol-O-methyltransferase proteins: do recent findings change the picture?

Myöhänen, T. T. & Männistö, P., 2010, In : International Review of Neurobiology. 95, p. 29-47 18 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Distribution of catechol-O-methyltransferase (COMT) proteins and enzymatic activities in wild-type and soluble COMT deficient mice

Myöhänen, T. T., Schendzielorz, N. & Männistö, P., 2010, In : Journal of Neurochemistry. 113, 6, p. 1632-1643 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice

Käenmäki, M., Tammimäki, A. E., Myöhänen, T. T., Pakarinen, K., Amberg, C. L., Karayiorgou, M., Gogos, J. & Männistö, P., 2010, In : Journal of Neurochemistry. 114, 6, p. 1745-1755 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2009

Importance of membrane-bound catechol-O-methyltransferase in L-DOPA metabolism: a pharmacokinetic study in two types of Comt gene modified mice

Käenmäki, M., Tammimäki, A., García-Horsman, JA., Myöhänen, T., Schendzielorz, N., Karayiorgou, M., Gogos, J. & Männistö, P. T., 2009, In : British Journal of Pharmacology. 158, 8, p. 1884-1894 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Localization of prolyl oligopeptidase in the thalamic and cortical projection neurons: a retrograde neurotracing study in the rat brain

Myöhänen, T. T., Kääriäinen, T., Jalkanen, A., Piltonen, M. H. & Männistö, P. T., 2009, In : Neuroscience Letters. 450, 2, p. 201-205 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Cellular and subcellular distribution of rat brain prolyl oligopeptidase and its association with specific neuronal neurotransmitters

Myöhänen, T., Venäläinen, J., García-Horsman, JA., Piltonen, M. & Männistö, P. T., 2008, In : Journal of Comparative Neurology. 507, 5, p. 1694-1708 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Distribution of prolyl oligopeptidase in the mouse whole-body sections and peripheral tissues

Myöhänen, T. T., Venäläinen, J., Garcia Horsman, J. A., Piltonen, M. H. & Männistö, P., 2008, In : Histochemistry and Cell Biology. 130, 5, p. 993-1003 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Distribution of immunoreactive prolyl oligopeptidase in human and rat brain

Myöhänen, T. T., Venäläinen, J., Tupala, E., Garcia Horsman, J. A., Miettinen, R. & Männistö, P., 2007, In : Neurochemical Research. 32, 8, p. 1365-1374 10 p.

Research output: Contribution to journalArticleScientificpeer-review