Photo of Timo Otonkoski
  • PL 63 (Haartmaninkatu 8), C507b

    HELSINGIN YLIOPISTO

    Finland

  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

  • Finland

19962020

Research output per year

If you made any changes in Pure these will be visible here soon.

Publications

Clinical and Genetic Characterization of 153 Patients with Persistent or Transient Congenital Hyperinsulinism

Männistö, J. M. E., Maria, M., Raivo, J., Kuulasmaa, T., Otonkoski, T., Huopio, H. & Laakso, M., Apr 2020, In : Journal of Clinical Endocrinology and Metabolism. 105, 4, 9 p., 271.

Research output: Contribution to journalArticleScientificpeer-review

2019

Characterization of neural crest-derived stem cells isolated from human bone marrow for improvement of transplanted islet function

Brboric, A., Vasylovska, S., Saarimäki-Vire, J., Espes, D., Caballero-Corbalan, J., Larfors, G., Otonkoski, T. & Lau, J., Nov 2019, In : Upsala Journal of Medical Sciences. 124, 4, p. 228-237 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Concise Review: Human Pluripotent Stem Cells for the Modeling of Pancreatic beta-Cell Pathology

Balboa, D., Saarimaki-Vire, J. & Otonkoski, T., Jan 2019, In : Stem Cells. 37, 1, p. 33-41 9 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access

Early Detection of Peripheral Blood Cell Signature in Children Developing beta-Cell Autoimmunity at a Young Age

Kallionpää, H., Somani, J., Tuomela, S., Ullah, U., de Albuquerque, R., Lönnberg, T., Komsi, E., Siljander, H., Honkanen, J., Härkönen, T., Peet, A., Tillmann, V., Chandra, V., Anagandula, M. K., Frisk, G., Otonkoski, T., Rasool, O., Lund, R., Lähdesmäki, H., Knip, M. & 1 others, Lahesmaa, R., Oct 2019, In : Diabetes. 68, 10, p. 2024-2034 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Genome editing of human pancreatic beta cell models: problems, possibilities and outlook

Balboa, D., Prasad, R. B., Groop, L. & Otonkoski, T., Aug 2019, In : Diabetologia. 62, 8, p. 1329-1336 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
File

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Dwivedi, O. P., Lehtovirta, M., Hastoy, B., Chandra, V., Krentz, N. A. J., Kleiner, S., Jain, D., Richard, A-M., Abaitua, F., Beer, N. L., Grotz, A., Prasad, R. B., Hansson, O., Ahlqvist, E., Krus, U., Artner, I., Suoranta, A., Gomez, D., Baras, A., Champon, B. & 27 others, Payne, A. J., Moralli, D., Thomsen, S. K., Kramer, P., Spiliotis, I., Ramracheya, R., Chabosseau, P., Theodoulou, A., Cheung, R., van de Bunt, M., Flannick, J., Trombetta, M., Bonora, E., Wolheim, C. B., Sarelin, L., Bonadonna, R. C., Rorsman, P., Davies, B., Brosnan, J., McCarthy, M., Otonkoski, T., Lagerstedt, J. O., Rutter, G. A., Gromada, J., Gloyn, A. L., Tuomi, T. & Groop, L., Nov 2019, In : Nature Genetics. 51, 11, p. 1596-+ 22 p.

Research output: Contribution to journalArticleScientificpeer-review

MANF is Required for the Postnatal Expansion and Maintenance of the Pancreatic β-Cell Mass in Mice

Danilova, T., Belevich, I., Li, H., Palm, E., Jokitalo, E., Otonkoski, T. & Lindahl, M., Jan 2019, In : Diabetes. 68, 1, p. 66-80 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy

Haikala, H. M., Anttila, J. M., Marques, E., Raatikainen, T., Ilander, M., Hakanen, H., Ala-Hongisto, H., Savelius, M., Balboa, D., Von Eyss, B., Eskelinen, V., Munne, P., Nieminen, A. I., Otonkoski, T., Schüler, J., Laajala, T. D., Aittokallio, T., Sihto, H., Mattson, J., Heikkilä, P. & 7 others, Leidenius, M., Joensuu, H., Mustjoki, S., Kovanen, P., Eilers, M., Leverson, J. D. & Klefström, J., 6 Feb 2019, In : Nature Communications. 10, 17 p., 620.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2018

Human pluripotent reprogramming with CRISPR activators

Weltner, J., Balboa, D., Katayama, S., Bespalov, M., Krjutskov, K., Jouhilahti, E-M., Trokovic, R., Kere, J. & Otonkoski, T., 6 Jul 2018, In : Nature Communications. 9, 12 p., 2643.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

In memoriam : Ilkka Sipilä 23.6.1942-19.3.2018

Lenko, H. L., Lumio, J. & Otonkoski, T., 2018, In : Suomen lääkärilehti. 73, 19, p. 1238 1 p.

Research output: Contribution to journalArticleProfessional

Open Access
File

Insulin mutations impair beta-cell development in a patient-derived iPSC model of neonatal diabetes

Balboa, D., Saarimäki-Vire, J., Borshagovski, D., Survila, M., Lindholm, P., Galli, E., Eurola, S., Ustinov, J., Grym, H., Huopio, H., Partanen, J., Wartiovaara, K. & Otonkoski, T., 9 Nov 2018, In : eLife. 7, 35 p., 38519.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

MANF protects human pancreatic beta cells against stress-induced cell death

Hakonen, E., Chandra, V., Fogarty, C. L., Yu, N. Y-L., Ustinov, J., Katayama, S., Galli, E., Danilova, T., Lindholm, P., Vartiainen, A., Einarsdottir, E., Krjutskov, K., Kere, J., Saarma, M., Lindahl, M. & Otonkoski, T., Oct 2018, In : Diabetologia. 61, 10, p. 2202-2214 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Pancreatic beta-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Cosentino, C., Toivonen, S., Villamil, E. D., Atta, M., Ravanat, J-L., Demine, S., Schiavo, A. A., Pachera, N., Deglasse, J-P., Jonas, J-C., Balboa, D., Otonkoski, T., Pearson, E. R., Marchetti, P., Eizirik, D. L., Cnop, M. & Igoillo-Esteve, M., 2 Nov 2018, In : Nucleic Acids Research. 46, 19, p. 10302-10318 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2017

An Activating STAT3 Mutation Causes Neonatal Diabetes through Premature Induction of Pancreatic Differentiation

Saarimaki-Vire, J., Balboa, D., Russell, M. A., Saarikettu, J., Kinnunen, M., Keskitalo, S., Malhi, A., Valensisi, C., Andrus, C., Eurola, S., Grym, H., Ustinov, J., Wartiovaara, K., Hawkins, R. D., Silvennoinen, O., Varjosalo, M., Morgan, N. G. & Otonkoski, T., 11 Apr 2017, In : Cell Reports. 19, 2, p. 281-294 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

A Strong Contractile Actin Fence and Large Adhesions Direct Human Pluripotent Colony Morphology and Adhesion

Narva, E., Stubb, A., Guzman, C., Blomqvist, M., Balboa, D., Lerche, M., Saari, M., Otonkoski, T. & Ivaska, J., 11 Jul 2017, In : Stem cell reports. 9, 1, p. 67-76 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Generation of an OCT4 reporter human induced pluripotent stem cell line using CRISPR/SpCas9

Balboa, D., Weltner, J., Novik, Y., Eurola, S., Wartiovaara, K. & Otonkoski, T., Aug 2017, In : Stem Cell Research. 23, p. 105-108 4 p.

Research output: Contribution to journalArticleScientific

Open Access
File

Generation of a SOX2 reporter human induced pluripotent stem cell line using CRISPR/SaCas9

Balboa, D., Weltner, J., Novik, Y., Eurola, S., Wartiovaara, K. & Otonkoski, T., Jul 2017, In : Stem Cell Research. 22, p. 16-19 4 p.

Research output: Contribution to journalArticleScientific

Open Access
File

Mitä hyötyä kantasolututkimuksesta ja geenien räätälöinnistä on diabeetikoille?

Otonkoski, T., 2017, In : Diabetes ja lääkäri. 46, 4, p. 21-25 4 p.

Research output: Contribution to journalArticleProfessional

Open Access
File

p73 is required for appropriate BMP-induced mesenchymal-to-epithelial transition during somatic cell reprogramming

Martin-Lopez, M., Maeso-Alonso, L., Fuertes-Alvarez, S., Balboa, D., Rodriguez-Cortez, V., Weltner, J., Diez-Prieto, I., Davis, A., Wu, Y., Otonkoski, T., Flores, E. R., Menendez, P., Marques, M. M. & Marin, M. C., Sep 2017, In : Cell Death and Disease. 8, 13 p., 3034.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2016

Activating STAT3 mutation leads to pancreatic hypoplasia through premature differentiation

Saarimaki-Vire, J., Balboa, D., Russell, M., Morgan, N., Eurola, S., Grym, H., Ustinov, J., Valensisi, C., Andrus, C., Saarikettu, J., Silvennoinen, O., Hawkins, D., Varjosalo, M. & Otonkoski, T., Nov 2016, In : Human Gene Therapy. 27, 11, p. A142-A142 1 p.

Research output: Contribution to journalArticleScientificpeer-review

Clinical, Genetic, and Biochemical Characteristics of Early-Onset Diabetes in the Finnish Population

Huopio, H., Miettinen, P. J., Ilonen, J., Nykanen, P., Veijola, R., Keskinen, P., Nanto-Salonen, K., Vangipurapu, J., Raivo, J., Stancakova, A., Mannisto, J., Kuulasmaa, T., Knip, M., Otonkoski, T. & Laakso, M., Aug 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 8, p. 3018-3026 9 p.

Research output: Contribution to journalArticleScientificpeer-review

CRISPR/Cas9-mediated transcriptional activation for maturation of human stem cell derived beta cells

Balboa, D., Saarimaki-Vire, J., Eurola, S., Weltner, J., Grym, H., Ustinov, J. & Otonkoski, T., Nov 2016, In : Human Gene Therapy. 27, 11, p. A142-A142 1 p.

Research output: Contribution to journalArticleScientificpeer-review

Executive Summary of IPITA-TTS Opinion Leaders Report on the Future of beta-Cell Replacement

Markmann, J. F., Bartlett, S. T., Johnson, P., Korsgren, O., Hering, B. J., Scharp, D., Kay, T. W. H., Bromberg, J., Odorico, J. S., Weir, G. C., Bridges, N., Kandaswamy, R., Stock, P., Friend, P., Gotoh, M., Cooper, D. K. C., Park, C-G., O'Connell, P. J., Stabler, C., Matsumoto, S. & 14 others, Ludwig, B., Choudhary, P., Khovatchev, B., Rickels, M. R., Sykes, M., Wood, K., Kraemer, K., Hwa, A., Stanley, E., Ricordi, C., Zimmerman, M., Greenstein, J., Montanya, E. & Otonkoski, T., Jul 2016, In : Transplantation. 100, 7, p. E25-E31 7 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access

Genetic Variability Overrides the Impact of Parental Cell Type and Determines iPSC Differentiation Potential

Kyttala, A., Moraghebi, R., Valensisi, C., Kettunen, J., Andrus, C., Pasumarthy, K. K., Nakanishi, M., Nishimura, K., Ohtaka, M., Weltner, J., Van Handel, B., Parkkonen, O., Sinisalo, J., Jalanko, A., Hawkins, R. D., Woods, N-B., Otonkoski, T. & Trokovic, R., 9 Feb 2016, In : Stem cell reports. 6, 2, p. 200-212 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Hoidosta parantamiseen

Wartiovaara, K. & Otonkoski, T., 2016, In : Duodecim. 132, 23, p. 2221-2226 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Hypoglykemia

Huopio, H. & Otonkoski, T., 2016, Lastentautien päivystyskirja. Korppi, M., Kröger, L., Rantala, H. & Niinikoski, H. (eds.). 3. uud. p. ed. Helsinki: Duodecim, p. 203-206 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapterProfessional

New tools for experimental diabetes research: Cellular reprogramming and genome editing

Otonkoski, T., May 2016, In : Upsala Journal of Medical Sciences. 121, 2, p. 146-150 5 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Regulation of Human Pluripotent Stem Cell-Derived Hepatic Cell Phenotype by Three-Dimensional Hydrogel Models

Toivonen, S., Malinen, M. M., Kublbeck, J., Petsalo, A., Urtti, A., Honkakoski, P. & Otonkoski, T., Jul 2016, In : Tissue Engineering. Part A. Tissue Engineering. 22, 13-14, p. 971-984 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Report from IPITA-TTS Opinion Leaders Meeting on the Future of beta-Cell Replacement

Bartlett, S. T., Markmann, J. F., Johnson, P., Korsgren, O., Hering, B. J., Scharp, D., Kay, T. W. H., Bromberg, J., Odorico, J. S., Weir, G. C., Bridges, N., Kandaswamy, R., Stock, P., Friend, P., Gotoh, M., Cooper, D. K. C., Park, C-G., O'Connell, P., Stabler, C., Matsumoto, S. & 14 others, Ludwig, B., Choudhary, P., Kovatchev, B., Rickels, M. R., Sykes, M., Wood, K., Kraemer, K., Hwa, A., Stanley, E., Ricordi, C., Zimmerman, M., Greenstein, J., Montanya, E. & Otonkoski, T., Feb 2016, In : Transplantation. 100, p. S1-S44 44 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

sept7b is required for the differentiation of pancreatic endocrine progenitors

Dash, S., Hakonen, E., Ustinov, J., Otonkoski, T., Andersson, O. & Lehtonen, S., 26 Apr 2016, In : Scientific Reports. 6, 14 p., 24992.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2015

Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3

Haapaniemi, E. M., Kaustio, M., Rajala, H. L. M., van Adrichem, A. J., Kainulainen, L., Glumoff, V., Doffinger, R., Kuusanmaki, H., Heiskanen-Kosma, T., Trotta, L., Chiang, S., Kulmala, P., Eldfors, S., Katainen, R., Siitonen, S., Karjalainen-Lindsberg, M-L., Kovanen, P. E., Otonkoski, T., Porkka, K., Heiskanen, K. & 7 others, Hanninen, A., Bryceson, Y. T., Uusitalo-Seppala, R., Saarela, J., Seppanen, M., Mustjoki, S. & Kere, J., 22 Jan 2015, In : Blood. 125, 4, p. 639-648 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Combined negative effect of donor age and time in culture on the reprogramming efficiency into induced pluripotent stem cells

Trokovic, R., Weltner, J., Noisa, P., Raivio, T. & Otonkoski, T., Jul 2015, In : Stem Cell Research. 15, 1, p. 254-262 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation

Balboa, D., Weltner, J., Eurola, S., Trokovic, R., Wartiovaara, K. & Otonkoski, T., 8 Sep 2015, In : Stem cell reports. 5, 3, p. 448-459 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Congenital hyperinsulinism, neonatal diabetes and the risk of malignancies: an international collaborative study. Preliminary communication

Makov, M., Chodick, G., Mohnike, K., Otonkoski, T., Huopio, H., Banerjee, I., Cave, H., Polak, M., Christesen, H. T., Hussain, K., Deleon, D., Stanley, C., Cappa, M., Ramos, O., Zangen, D. & Laron, Z., May 2015, In : Diabetic Medicine. 32, 5, p. 701-703 3 p.

Research output: Contribution to journalArticleScientific

Early-Onset Diabetic E1-DN Mice Develop Albuminuria and Glomerular Injury Typical of Diabetic Nephropathy

Hyvonen, M. E., Dumont, V., Tienari, J., Lehtonen, E., Ustinov, J., Havana, M., Jalanko, H., Otonkoski, T., Miettinen, P. J. & Lehtonen, S., 2015, In : BioMed Research International. 11 p., 102969.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Generation of iPSC line HEL24.3 from human neonatal foreskin fibroblasts

Trokovic, R., Weltner, J. & Otonkoski, T., Jul 2015, In : Stem Cell Research. 15, 1, p. 266-268 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Generation of iPSC line HEL47.2 from healthy human adult fibroblasts

Trokovic, R., Weltner, J. & Otonkoski, T., Jul 2015, In : Stem Cell Research. 15, 1, p. 263-265 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Human pluripotent stem cell based islet models for diabetes research

Balboa, D. & Otonkoski, T. P. J., 2015, In : Best Practice & Research. Clinical Endocrinology & Metabolism. 29, 6, p. 899-909 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1

Tamminen, K., Balboa Alonso, D., Toivonen, S., Pakarinen, M. P., Wiener, Z., Alitalo, K. & Otonkoski, T., 31 Jul 2015, In : PLoS One. 10, 7, 19 p., 0134551.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

mtDNA Mutagenesis Disrupts Pluripotent Stem Cell Function by Altering Redox Signaling

Hamalainen, R. H., Ahlqvist, K. J., Ellonen, P., Lepisto, M., Logan, A., Otonkoski, T., Murphy, M. P. & Suomalainen, A., 16 Jun 2015, In : Cell Reports. 11, 10, p. 1614-1624 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Nuoruuden lähteillä : nuoren veren aivoja uudentavat vaikutukset paljastuvat

Lindsberg, P. J. & Otonkoski, T., 2015, In : Duodecim. 131, 5, p. 413-414 2 p.

Research output: Contribution to journalArticleScientific

Patient-Specific Induced Pluripotent Stem Cell-Derived RPE Cells: Understanding the Pathogenesis of Retinopathy in Long-Chain 3-Hydroxyacyl-CoA Dehydrogenase Deficiency

Polinati, P. P., Ilmarinen, T., Trokovic, R., Hyotylainen, T., Otonkoski, T., Suomalainen, A., Skottman, H. & Tyni, T., May 2015, In : Investigative Ophthalmology & Visual Science. 56, 5, p. 3371-3382 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI)

Andrews, P. W., Baker, D., Benvinisty, N., Miranda, B., Bruce, K., Bruestle, O., Choi, M., Choi, Y-M., Crook, J. M., de Sousa, P. A., Dvorak, P., Freund, C., Firpo, M., Furue, M. K., Gokhale, P., Ha, H-Y., Han, E., Haupt, S., Healy, L., Hei, D. J. & 45 others, Hovatta, O., Hunt, C., Hwang, S-M., Inamdar, M. S., Isasi, R. M., Jaconi, M., Jekerle, V., Kamthorn, P., Kibbey, M. C., Knezevic, I., Knowles, B. B., Koo, S-K., Laabi, Y., Leopoldo, L., Liu, P., Lomax, G. P., Loring, J. F., Ludwig, T. E., Montgomery, K., Mummery, C., Nagy, A., Nakamura, Y., Nakatsuji, N., Oh, S., Oh, S-K., Otonkoski, T., Pera, M., Peschanski, M., Pranke, P., Rajala, K. M., Rao, M., Ruttachuk, R., Reubinoff, B., Ricco, L., Rooke, H., Sipp, D., Stacey, G. N., Suemori, H., Takahashi, T. A., Takada, K., Talib, S., Tannenbaum, S., Yuan, B-Z., Zeng, F. & Zhou, Q., 2015, In : Regenerative Medicine. 10, 2, Suppl. 2, p. 1-44 44 p.

Research output: Contribution to journalArticleScientificpeer-review

Selective MicroRNA-Offset RNA Expression in Human Embryonic Stem Cells

Asikainen, S., Heikkinen, L., Juhila, J. J., Holm, F., Weltner, J., Trokovic, R., Mikkola, M., Toivonen, S., Balboa, D., Lampela, R., Icay, K., Tuuri, T., Otonkoski, T., Wong, G. & Hovatta, O., 30 Mar 2015, In : PLoS One. 10, 3, 25 p., 0116668.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File
2014

Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease

Flanagan, S. E., Haapaniemi, E., Russell, M. A., Caswell, R., Allen, H. L., De Francol, E., McDonald, T. J., Rajala, H., Ramelius, A., Barton, J., Heiskanen, K., Heiskanen-Kosmal, T., Kajosaari, M., Murphyli, N. P., Milenkovic, T., Seppanen, M., Lemmark, A., Mustjoki, S., Otonkoski, T., Kere, J. & 3 others, Morgan, N. G., Ellard, S. & Hattersley, A. T., 1 Aug 2014, In : Nature Genetics. 46, 8, p. 812-814 3 p.

Research output: Contribution to journalArticleScientificpeer-review

Advanced Feeder-Free Generation of Induced Pluripotent Stem Cells Directly From Blood Cells

Trokovic, R., Weltner, J., Nishimura, K., Ohtaka, M., Nakanishi, M., Salomaa, V., Jalanko, A., Otonkoski, T. & Kyttala, A., Dec 2014, In : Stem Cells Translational Medicine. 3, 12, p. 1402-1409 8 p.

Research output: Contribution to journalArticleScientificpeer-review

EGFR Signaling Promotes beta-Cell Proliferation and Survivin Expression during Pregnancy

Hakonen, E., Ustinov, J., Palgi, J., Miettinen, P. J. & Otonkoski, T., 2 Apr 2014, In : PLoS One. 9, 4, 11 p., 93651.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Ihmisen kantasolut haima- ja maksasairauksien hoidossa

Hakonen, E., Toivonen, S., Jalanko, H. & Otonkoski, T., 2014, In : Duodecim. 130, 19, p. 1973-1980 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Indusoidut pluripotentit kantasolut lääketieteellisessä tutkimuksessa

Weltner, J., Trokovic, R. & Otonkoski, T., 2014, In : Duodecim. 130, 8, p. 785-792 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review