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Publications 1994 2019

2019

Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson's disease

Albert, K., Voutilainen, M. H., Domanskyi, A., Piepponen, T. P., Ahola, S., Tuominen, R. K., Richie, C., Harvey, B. K. & Airavaara, M., Mar 2019, In : Journal of Neuroscience Research. 97, 3, p. 346-361 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Lääketieteellinen farmakologia ja toksikologia

Ruskoaho, H. (ed.), Hakkola, J. (ed.), Huupponen, R. (ed.), Kantele, A. (ed.), Korpi, E. (ed.), Moilanen, E. (ed.), Piepponen, P. (ed.), Savontaus, E., Tenhunen, O. (ed.), Vähäkangas, K. & Anttila, V-J., 2019, 5. uud. p. ed. Helsinki: Duodecim. 1288 p.

Research output: Book/ReportBookProfessional

2018

Amphetamine primes enhanced motivation toward uncertain choices in rats with genetic alcohol preference

Oinio, V., Sundström, M., Bäckström, P., Uhari-Väänänen, J., Kiianmaa, K., Raasmaja, A. & Piepponen, P., May 2018, In : Psychopharmacology. 235, 5, p. 1361-1370 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Combination of CDNF and Deep Brain Stimulation Decreases Neurological Deficits in Late-stage Model Parkinson's Disease

Huotarinen, A., Penttinen, A-M., Bäck, S., Voutilainen, M. H., Julku, U., Piepponen, T. P., Männistö, P. T., Saarma, M., Tuominen, R., Laakso, A. & Airavaara, M., 15 Mar 2018, In : Neuroscience. 374, p. 250-263 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Constitutive Ret signaling leads to long-lasting expression of amphetamine-induced place conditioning via elevation of mesolimbic dopamine

Kopra, J., Villarta-Aguilera, M., Savolainen, M., Weingerl, S., Myohänen, T. T., Rannanpää, S., Salvatore, M. E., Andressoo, J-O. & Piepponen, T. P., Jan 2018, In : Neuropharmacology. 128, p. 221-230 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Prolyl Oligopeptidase Regulates Dopamine Transporter Phosphorylation in the Nigrostriatal Pathway of Mouse

Julku, U. H., Panhelainen, A. E., Tiilikainen, S. E., Svarcbahs, R., Tammimäki, A. E., Piepponen, T. P., Savolainen, M. H. & Myöhänen, T. T., Jan 2018, In : Molecular Neurobiology. 55, 1, p. 470-482 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The effect of lipopolysaccharide (LPS) on inflammatory markers in blood and brain and on behavior in individually-housed pigs

Nordgreen, J., Munsterhjelm, C., Aae, F., Popova, A., Boysen, P., Ranheim, B., Heinonen, M., Raszplewicz, J., Piepponen, P., Lervik, A., Valros, A. & Janczak, A. M., 2 Aug 2018, In : Physiology & Behavior. 195, p. 98-111 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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The κ-opioid receptor antagonist JDTic decreases ethanol intake in alcohol-preferring AA rats

Uhari-Väänänen, J., Raasmaja, A., Bäckström, P., Oinio, V., Carroll, F. I., Airavaara, M., Kiianmaa, K. & Piepponen, P., May 2018, In : Psychopharmacology. 235, 5, p. 1581-1591 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Towards developing a model to study alcohol drinking and craving in female mice housed in automated cages

Koskela, M., Piepponen, T. P., Andressoo, J-O., Võikar, V. & Airavaara, M., 15 Oct 2018, In : Behavioural Brain Research. 352, p. 116-124 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2017

A Simple Method for Improving the Spatial Resolution in Infrared Laser Ablation Mass Spectrometry Imaging

Hieta, J-P., Vaikkinen, A., Auno, S., Räikkönen, H., Haapala, M., Scotti, G., Kopra, J., Piepponen, T. & Kauppila, T. J., Jun 2017, In : Journal of the American Society for Mass Spectrometry. 28, 6, p. 1060-1065 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Dampened Amphetamine-Stimulated Behavior and Altered Dopamine Transporter Function in the Absence of Brain GDNF

Kopra, J. J., Panhelainen, A., af Bjerken, S., Porokuokka, L. L., Varendi, K., Olfat, S., Montonen, H., Piepponen, T. P., Saarma, M. & Andressoo, J-O., 8 Feb 2017, In : Journal of Neuroscience. 37, 6, p. 1581-1590 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Dicer and microRNAs protect adult dopamine neurons

Chmielarz, P., Konovalova, J., Najam, S. S., Alter, H., Piepponen, T. P., Erfle, H., Sonntag, K. C., Schutz, G., Vinnikov, I. A. & Domanskyi, A., 25 May 2017, In : Cell Death and Disease. 8, 5, 9 p., 2813.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Dopaminergic modulation of reward-guided decision making in alcohol-preferring AA rats

Oinio, V., Bäckström, P., Uhari-Väänänen, J., Raasmaja, A., Piepponen, T. & Kiianmaa, K., 30 May 2017, In : Behavioural Brain Research. 326, p. 87-95 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Accumbal µ-opioid receptors modulate ethanol intake in alcohol-preferring Alko Alcohol rats

Uhari-Väänänen, J. K., Raasmaja, A. I., Bäckström, P., Oinio, V., Airavaara, M. T., Piepponen, P. & Kiianmaa, K., Oct 2016, In : Alcoholism: Clinical and Experimental Research. 40, 10, p. 2114-2123 10 p.

Research output: Contribution to journalArticleScientificpeer-review

AMIGO-Kv2.1 Potassium Channel Complex is Associated With Schizophrenia-Related Phenotypes

Peltola, M. A., Kuja-Panula, J., Liuhanen, J., Voikar, V., Piepponen, P., Hiekkalinna, T., Taira, T., Lauri, S. E., Suvisaari, J., Kulesskaya, N., Paunio, T. & Rauvala, H., 2016, In : Schizophrenia bulletin. 42, 1, p. 191-201 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Histamine H3 receptor antagonist decreases cue-induced alcohol reinstatement in mice

Nuutinen, S., Mäki, T., Rozov, S., Bäckström, P., Hyytiä, P., Piepponen, P. & Panula, P., Jul 2016, In : Neuropharmacology. 106, p. 156-163 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Evidence for a link between tail biting and central monoamine metabolism in pigs (Sus scrofa domestica)

Valros, A., Palander, P., Heinonen, M., Munsterhjelm, C., Brunberg, E., Keeling, L. & Piepponen, P., 1 May 2015, In : Physiology & Behavior. 143, p. 151-157 7 p.

Research output: Contribution to journalArticleScientificpeer-review

GDNF is not required for catecholaminergic neuron survival in vivo

Kopra, J., Vilenius, C., Grealish, S., Härma, M-A., Varendi, K., Lindholm, J., Castrén, E., Voikar, V., Björklund, A., Piepponen, T. P., Saarma, M. & Andressoo, J-O., Mar 2015, In : Nature Neuroscience. 18, 3, p. 319-322 4 p.

Research output: Contribution to journalArticleScientificpeer-review

GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function

Kumar, A., Kopra, J. J., Varendi, K., Porokuokka, L. L., Panhelainen, A. E., Kuure, S. H., Marshall, P. O. L., Karalija, N., Härma, M-A., Vilenius, C. L., Lilleväli, K., Tekko, T., Mijatovic, J., Pulkkinen, N., Jakobson, M., Jakobson, M., Ola, R., Palm, E., Lindahl, M. S., Strömberg, I. & 4 othersVõikar, V., Piepponen, T. P., Saarma, M. & Andressoo, J-O., 2015, In : PLoS Genetics. 11, 12, 24 p., e1005710.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Mutaatio kaliumkanavageenissä skitsofrenian alttiustekijänä

Peltola, M. A., Kuja-Panula, J., Liuhanen, J., Voikar, V., Piepponen, P., Hiekkalinna, T., Taira, T., Lauri, S. E., Suvisaari, J., Kulesskaya, N., Paunio, T. & Rauvala, H., 2015, In : Duodecim. 131, 19, p. 1819 1 p.

Research output: Contribution to journalArticleScientific

Permeation of Dopamine Sulfate through the Blood-Brain Barrier

Suominen, T., Piepponen, T. P. & Kostiainen, R., 24 Jul 2015, In : PLoS One. 10, 7, 13 p., 0133904.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2014

Mice deficient in transmembrane prostatic acid phosphatase display increased GABAergic transmission and neurological alterations.

Nousiainen, H., Quintero, IB., Myöhänen, T. T., Voikar, V., Mijatovic, J., Segerstråle, M., Herrala, A. M., Kulesskaya, N., Pulkka, A., Kivinummi, T., Abo Ramadan, U., Taira, T., Piepponen, T. P., Rauvala, H. & Vihko, P., 2014, In : PLoS One. 9, 5, 15 p., e97851.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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OPIOIDERGIC MODULATION OF ETHANOL INTAKE IN THE NUCLEUS ACCUMBENS OF ALCOHOL-PREFERRING AA RATS

Kiianmaa, K., Uhari-Vaananen, J., Airavaara, M., Backstrom, P., Oinio, V., Raasmaja, A. & Piepponen, P., Sep 2014, In : Alcohol & Alcoholism. 49, p. 28 1 p.

Research output: Contribution to journalConference articleScientific

2013
Open Access
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Pharmacological Characterisation of a Structurally Novel alpha(2C)-Adrenoceptor Antagonist ORM-10921 and its Effects in Neuropsychiatric Models

Sallinen, J., Holappa, J., Koivisto, A., Kuokkanen, K., Chapman, H., Lehtimaki, J., Piepponen, P., Mijatovic, J., Tanila, H., Virtanen, R., Sirviö, J. & Haapalinna, A., Oct 2013, In : Basic & Clinical Pharmacology & Toxicology. 113, 4, p. 239-249 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Cell-autonomous FGF signaling regulates anteroposterior patterning and neuronal differentiation in the mesodiencephalic dopaminergic progenitor domain

Lahti, L. S., Peltopuro, P. P., Piepponen, T. P. & Partanen, J., 2012, In : Development. 139, 5, p. 894-905 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Mesolimbic dopamine release is linked to symptom severity in pathological gambling

Joutsa, J., Johansson, J., Niemela, S., Ollikainen, A., Hirvonen, M. M., Piepponen, T. P., Arponen, E., Alho, H., Voon, V., Rinne, J. O., Hietala, J. & Kaasinen, V., 2012, In : NeuroImage. 60, 4, p. 1992-1999 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Peliriippuvuuden taustalla ei aivojen palkkiojärjestelmän vajaatoimintaa

Joutsa, J., Johansson, J., Niemelä, S., Ollikainen, A., Hirvonen, M. M., Piepponen, T. P., Arponen, E., Alho, H., Voon, V., Rinne, J. O., Hietala, J. & Kaasinen, V., 2012, In : Duodecim. 128, 8, p. 831

Research output: Contribution to journalArticleScientific

The effect of prolyl oligopeptidase inhibition on extracellular acetylcholine and dopamine levels in the rat striatum

Jalkanen, A. J., Piepponen, T. P., Hakkarainen, J. J., De Meester, I., Lambeir, A-M. & Forsberg, M. M., 1 Feb 2012, In : Neurochemistry International. 60, 3, p. 301-309 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Transgenic expression and activation of PGC-1 alpha protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease

Mudo, G., Mäkelä, J., Di Liberto, V., Tselykh, T. V., Olivieri, M., Piepponen, T. P., Eriksson-Rosenberg, O., Malkia, A., Bonomo, A., Kairisalo, M., Aguirre, J. A., Korhonen, L., Belluardo, N. & Lindholm, D., 2012, In : Cellular and Molecular Life Sciences. 69, 7, p. 1153-1165 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Constitutive Ret signaling is protective for dopaminergic cell bodies but not for axonal terminals

Mijatovic, J., Piltonen, M., Alberton, P., Männistö, P. T., Saarma, M. & Piepponen, T. P., 2011, In : Neurobiology of Aging. 32, 8, p. 1486-1494 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Nicotine-opioid interactions: in vitro and in vivo studies

Tuominen, R. K., Talka, R., Kivinummi, T., Pakkanen, J. S., Nuutinen, S., Ahtee, L., Piepponen, T. P., Männistö, P. T. & Salminen, O., 2011, In : European Neuropsychopharmacology. 21, Supplement 2, p. S105-S106 2 p.

Research output: Contribution to journalConference articleScientificpeer-review

2010

Determination of Steroids and Their Intact Glucuronide Conjugates in Mouse Brain by Capillary Liquid Chromatography-Tandem Mass Spectrometry

Jantti, S. E., Tammimaki, A., Raattamaa, H., Piepponen, P., Kostiainen, R. & Ketola, R. A., 2010, In : Analytical Chemistry. 82, p. 3168-3175 8 p.

Research output: Contribution to journalArticleScientificpeer-review

High Firing Rate of Neonatal Hippocampal Interneurons Is Caused by Attenuation of Afterhyperpolarizing Potassium Currents by Tonically Active Kainate Receptors

Segerstråle, M., Juuri, J., Lanore, F., Piepponen, T. P., Lauri, S. E., Mulle, C. & Taira, T., 12 May 2010, In : Journal of Neuroscience. 30, 19, p. 6507-6514 8 p.

Research output: Contribution to journalArticleScientificpeer-review

New Mouse Models for Studying Postnatal Role of GDNF In Vivo

Andressoo, J. -O., Mijatovic, J., Kuman, A., Amberg, C., Grealish, S., Lindahl, M., Bjorklund, A., Lindholm, J., Casten, E., Kulesskaya, N., Rauvala, H., Piepponen, P. & Saarma, M., 2010, In : Cell Transplantation. 19, p. 331-331 1 p.

Research output: Contribution to journalConference articleScientific

2009

Analysis of intact glucuronides and sulfates of serotonin, dopamine, and their phase I metabolites in rat brain microdialysates by liquid chromatography - tandem mass spectrometry

Uutela, P., Reinilä, R., Harju, K., Piepponen, P., Ketola, R. A. & Kostiainen, R., 2009, In : Analytical Chemistry. 81, 20, p. 8417-8425 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Comparison of different amino acid derivatives and analysis of rat brain microdialysates by liquid chromatography tandem mass spectrometry

Uutela, P., Ketola, R. A., Piepponen, P. & Kostiainen, R., 2009, In : Analytica Chimica Acta. 633, 2, p. 223-231 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Differences in basal and morphine-induced FosB/Delta FosB and pCREB immunoreactivities in dopaminergic brain regions of alcohol-preferring AA and alcohol-avoiding ANA rats

Kaste, K., Kivinummi, T., Piepponen, T. P., Kiianmaa, K. & Ahtee, L., 2009, In : Pharmacology, Biochemistry and Behavior. 92, p. 655-662 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Discovery of dopamine glucuronide in rat and mouse brain microdialysis samples using liquid chromatography tandem mass spectrometry

Uutela, P. S., Karhu, L., Piepponen, T. P., Käenmäki, M., Ketola, R. & Kostiainen, R., 2009, In : Analytical Chemistry. 2009, 81, p. 427-434

Research output: Contribution to journalArticleScientificpeer-review

Discovery of neurosteroid glucuronides in mouse brain

Kallonen, S., Tammimäki, A., Piepponen, P., Raattamaa, H., Ketola, R. A. & Kostiainen, R., 2009, In : Analytica Chimica Acta. 651, 1, p. 69-74 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons

Palgi, M., Lindström, R., Peränen, J., Piepponen, P., Saarma, M. & Heino, T. I., 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 7, p. 2429-2434 6 p.

Research output: Contribution to journalArticleScientificpeer-review

2008

Characterization of the striatal dopaminergic neurotransmission in MEN2B mice with elevated cerebral tissue dopamine

Mijatovic, J., Patrikainen, O., Yavich, L., Airavaara, M., Ahtee, L., Saarma, M. & Piepponen, P., 2008, In : Journal of Neurochemistry. 105, 5, p. 1716-1725 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Chronic nicotine modifies the effects of morphine on extracellular striatal dopamine and ventral tegmental GABA

Vihavainen, T., Relander, T., Leiviskä, R., Airavaara, M., Tuominen, R. K., Ahtee, L. & Piepponen, T. P., 2008, In : Journal of Neurochemistry. 107, 3, p. 844-854 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2007

Accumbal FosB/DeltaFosB immunoreactivity and conditioned place preference in alcohol-preferring AA rats and alcohol-avoiding ANA rats treated repeatedly with cocaine

Marttila, K., Piepponen, P., Kiianmaa, K. & Ahtee, L., 2007, In : Brain Research . 1160, p. 82-90 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Discovery of Dopamine Glucuronide in Brain, Using Liquid Chromatography-Tandem Mass Spectrometry

Uutela, P. S., Karhu, L., Piepponen, T. P., Ketola, R. & Kostiainen, R., 2007, the 55th ASMS Conference on Mass Spectrometry and Allied Topics,.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Effects of repeated morphine on locomotion, place preference and dopamine in heterozygous glial cell line-derived neurotrophic factor knockout mice

Airavaara, M., Tuomainen, H., Piepponen, P., Saarma, M. & Ahtee, L., 2007, In : Genes, Brain and Behavior. 6, 3, p. 287-298 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-C signaling pathways in mouse brain

Rantamäki, T., Hendolin, P., Kankaanpää, A., Mijatovic, J., Piepponen, P., Domenici, E., Chao, M. V., Männistö, P. T. & Castren, E., 2007, In : Neuropsychopharmacology. 32, p. 2152-2162 11 p.

Research output: Contribution to journalArticleScientificpeer-review

2006

Drosophila gene encoding a homolog of the novel human neurotrophic factor MANF

Palgi, M., Lindstrom, R., Peranen, J., Piepponen, P., Saarma, M. & Heino, T. I., 2006, In : Journal of Neurogenetics. 20, p. 196-197 2 p.

Research output: Contribution to journalConference articleScientific