Research output per year
Research output per year
Personal profile
Curriculum vitae
Tobias Freitag, MD, is an experimental immunologist, trained in clinical gastroenterology and rheumatology. He is a research group leader in the Translational Immunology Research Program at the Faculty of Medicine, University of Helsinki, studying and developing therapeutic immune tolerance induction. His scientific research is focused on (mucosal) immunology and translational medicine, autoimmune diseases – particularly celiac disease, mechanisms of tolerance to intestinal antigens (food, microbial and self-proteins), immune regulation and vaccinology. He has co-developed mouse models of celiac disease, tolerogenic gliadin nanoparticles for the treatment of celiac disease (now in clinical phase IIb), and an adenovirus-vectored, nasal vaccine against Sars-CoV-2.
Fields of Science
- 3111 Biomedicine
- 3121 General medicine, internal medicine and other clinical medicine
- 1182 Biochemistry, cell and molecular biology
- 3112 Neurosciences
- 416 Food Science
- 318 Medical biotechnology
International and National Collaboration
Publications and projects within past five years.
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TAK-101 Nanoparticles Induce Gluten-Specific Tolerance in Celiac Disease: A Randomized, Double-Blind, Placebo-Controlled Study
TAK-101 Study Group, Kelly, C. P., Murray, J. A., Leffler, D. A., Freitag, T. L. & Meri, S., Jul 2021, In: Gastroenterology. 161, 1, p. 66-+ 23 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1
Vuorela, A., Freitag, T. L., Leskinen, K., Pessa, H., Härkönen, T., Stracenski, I., Kirjavainen, T., Olsen, P., Saarenpää-Heikkilä, O., Ilonen, J., Knip, M., Vaheri, A., Partinen, M., Saavalainen, P., Meri, S. & Vaarala, O., 16 Apr 2021, In: Nature Communications. 12, 1, 17 p., 2283.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Gliadin Nanoparticles Induce Immune Tolerance to Gliadin in Mouse Models of Celiac Disease
Freitag, T. L., Podojil, J. R., Pearson, R. M., Fokta, F. J., Sahl, C., Messing, M., Andersson, L. C., Leskinen, K., Saavalainen, P., Hoover, L. I., Huang, K., Phippard, D., Maleki, S., King, N. J. C., Shea, L. D., Miller, S. D., Meri, S. K. & Getts, D. R., May 2020, In: Gastroenterology. 158, 6, p. 1667-+ 27 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Minor Effect of Antibiotic Pre-treatment on the Engraftment of Donor Microbiota in Fecal Transplantation in Mice
Freitag, T. L., Hartikainen, A., Jouhten, H., Sahl, C., Meri, S., Anttila, V.-J., Mattila, E., Arkkila, P., Jalanka, J. & Satokari, R., 21 Nov 2019, In: Frontiers in Microbiology. 10, 11 p., 2685.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Concerns about the histological assessment in a mouse model of human celiac disease
Freitag, T. L., Andersson, L. C. & Kipar, A., Mar 2024, In: Scandinavian Journal of Immunology. 99, 3, 3 p., e13351.Research output: Contribution to journal › Letter › Scientific
Open AccessFile
Projects
- 7 Finished
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Academy of Finland "DIG IN Health" Research Consortium - Subproject "Microbes as triggers of Celiac Disease"
Freitag, T. (Project manager) & Meri, S. (Principal Investigator)
01/09/2015 → 31/08/2019
Project: Research project
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Academy of Finland "NARPANord" Research Consortium - Subproject "Studying immunopathogenesis of human narcolepsy/cataplexy in mice"
Freitag, T. (Principal Investigator)
01/09/2012 → 31/08/2015
Project: Research project
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Finnish Ministry of Social Affairs and Health - Research Grant "Immunopathogenesis of Narcolepsy/Cataplexy"
Freitag, T. (Project manager) & Meri, S. (Principal Investigator)
01/07/2011 → 30/06/2013
Project: Research project
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Marie Curie IRG grant "Mechanisms that underlie loss of antigen tolerance in HLA-associated autoimmune diseases"
Freitag, T. (Principal Investigator)
01/11/2009 → 31/10/2013
Project: Research project
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Biocentrum Helsinki Start-up Grant - Loss of antigen tolerance in HLA-associated autoimmune diseases
Freitag, T. (Principal Investigator)
01/01/2009 → 31/12/2010
Project: Research project
Prizes
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Oral Presentation Award at International Celiac Disease Symposium 2009
Freitag, T. (Recipient), Apr 2009
Prize: Prizes and awards
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Activities
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American Journal of Physiology: Gastrointestinal and Liver Physiology (Journal)
Freitag, T. (Member of editorial board)
2015 → …Activity: Publication peer-review and editorial work types › Editor of research journal
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Invited lecture, Spring meeting of the German Society of Digestive and Metabolic Diseases (DGVS)
Freitag, T. (Speaker: Presenter)
Jun 2012Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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Student teaching - Immunology Lectures - Translational Medicine Master Degree Programme
Freitag, T. (Speaker: Presenter)
May 2011 → …Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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Haartman Institute Seminar Series
Freitag, T. (Member of organizing committee)
2009 → 2012Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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2nd Nordic Meeting on Genetics and Pathogenesis of Immunological Diseases
Freitag, T. (Member of organizing committee)
9 Sept 2009 → 11 Sept 2009Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars