Research Output per year
Personal profile
Curriculum vitae
Tobias Freitag, MD, is a medical researcher and experimental immunologist, trained in gastroenterology and rheumatology. His scientific research is focused on (mucosal) immunology and translational medicine, autoimmune diseases, particularly celiac disease, mechanisms of tolerance to intestinal antigens (food, microbial and self-proteins), regulatory T cell function and rodent disease models. He has been a principal investigator of the Finnish-Swedish NARPANord consortium, investigating pathogenesis of type 1 narcolepsy, and is currently a member of the Academy of Finland Personalized Health-DIGIN Health research consortium, searching for microbial triggers of celiac disease. Starting from 2019, he will contribute as Junior Researcher to the Translational Immunology Research Program at the University of Helsinki, studying therapeutic immune tolerance induction.
Keywords
- 311 Basic medicine
- Immunology
- Mucosal Immunology
- Autoimmunity
- Oral Tolerance
- HLA class II
- Regulatory T cells
- 312 Clinical medicine
- Gastroenterology
- Rheumatology
- Celiac disease
- Inflammatory bowel diseases
- Narcolepsy/cataplexy
International and National Collaboration
Publications and projects within past five years.
Publications 2001 2017
Deep sequencing of blood and gut T-cell receptor beta-chains reveals gluten-induced immune signatures in celiac disease
Yohannes, D. A., Freitag, T. L., de Kauwe, A., Kaukinen, K., Kurppa, K., Wacklin, P., Mäki, M., Arstila, T. P., Anderson, R. P., Greco, D. & Saavalainen, P., 21 Dec 2017, In : Scientific Reports. 7, 12 p., 17977.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
Antigenic Differences between AS03 Adjuvanted Influenza A (H1N1) Pandemic Vaccines: Implications for Pandemrix-Associated Narcolepsy Risk
Vaarala, O., Vuorela, A., Partinen, M., Baumann, M., Freitag, T. L., Meri, S., Saavalainen, P., Jauhiainen, M., Soliymani, R., Kirjavainen, T., Olsen, P., Saarenpaa-Heikkila, O., Rouvinen, J., Roivainen, M., Nohynek, H., Jokinen, J., Julkunen, I. & Kilpi, T., 15 Dec 2014, In : PLoS One. 9, 12, 23 p., 114361.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4
Junker, Y., Zeissig, S., Kim, S-J., Barisani, D., Wieser, H., Leffler, D. A., Zevallos, V., Libermann, T. A., Dillon, S., Freitag, T. L., Kelly, C. P. & Schuppan, D., 17 Dec 2012, In : Journal of Experimental Medicine. 209, 13, p. 2395-2408 14 p.Research output: Contribution to journal › Article › Scientific › peer-review
Human Risk Allele HLA-DRB1*0405 Predisposes Class II Transgenic Ab0 NOD Mice to Autoimmune Pancreatitis
Freitag, T. L., Cham, C., Sung, H-H., Beilhack, G. F., Durinovic-Bello, I., Patel, S. D., Bronson, R. T., Schuppan, D. & Sonderstrup, G., 2010, In : Gastroenterology. 139, 1, p. 281-291 11 p.Research output: Contribution to journal › Article › Scientific › peer-review
Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent small intestinal damage after adoptive transfer into lymphopenic mice
Freitag, T. L., Rietdijk, S., Junker, Y., Popov, Y., Bhan, A. K., Kelly, C. P., Terhorst, C. & Schuppan, D., 2009, In : Gut. 58, p. 1597-1605 9 p.Research output: Contribution to journal › Article › Scientific › peer-review
Projects 2009 2015
NARPANord Research Consortium - Subproject "Studying immunopathogenesis of human narcolepsy/cataplexy in mice"
01/09/2012 → 31/08/2015
Project: Research project
Finnish Ministry of Social Affairs and Health - Research Grant "Immunopathogenesis of Narcolepsy/Cataplexy"
01/07/2011 → 30/06/2013
Project: Research project
Marie Curie IRG grant "Mechanisms that underlie loss of antigen tolerance in HLA-associated autoimmune diseases"
01/11/2009 → 31/10/2013
Project: Research project
Biocentrum Helsinki Start-up Grant - Loss of antigen tolerance in HLA-associated autoimmune diseases
01/01/2009 → 31/12/2010
Project: Research project
Prizes
Oral Presentation Award at International Celiac Disease Symposium 2009
Tobias Freitag (Recipient), Apr 2009
Prize: Prizes and awards
Activities 2002 2015
American Journal of Physiology: Gastrointestinal and Liver Physiology (Journal)
Tobias Freitag (Member of editorial board)2015 → …
Activity: Publication peer-review and editorial work types › Editor of research journal
Invited lecture, Spring meeting of the German Society of Digestive and Metabolic Diseases (DGVS)
Tobias Freitag (Speaker: Presenter)Jun 2012
Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
Student teaching - Immunology Lectures - Translational Medicine Master Degree Programme
Tobias Freitag (Speaker: Presenter)May 2011 → …
Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
Haartman Institute Seminar Series
Tobias Freitag (Member of organizing committee)2009 → 2012
Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
2nd Nordic Meeting on Genetics and Pathogenesis of Immunological Diseases
Tobias Freitag (Member of organizing committee)9 Sep 2009 → 11 Sep 2009
Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars