Photo of Tomi Mäkelä
  • Finland

  • PL 63 (Haartmaninkatu 8)

    00014

    Finland

  • Viikinkaari 5, Biocenter 2

    00790 Helsinki

    Finland

1986 …2018
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Personal profile

Curriculum vitae

Director, Helsinki Institute of Life Science HiLIFE

Vice Director, Academy of Finland Center of Excellence in Translational Genome-Scale Biology

Description of research and teaching

Kinase signaling linking metabolism and growth control

Major human diseases such as diabetes and cancer are due to deregulat- ed signaling stemming from genetic alterations and extrinsic factors. Signaling in pathways and in larger networks typically involves sequential activation of kinases phosphorylating substrates and thus relaying and amplifying signals ultimately mod- ulating transcriptional responses in target gene sets. Our longstanding interest is to characterize signaling pathways regulating mammalian cell growth and how these impinge on transcriptional responses in human disease.

tabolism are the transcriptional kinases Cdk7 and Cdk8 mediating signals to RNA polymerase II. We are investigating the molecular mechanisms and in vivo functions of Cdk7 and Cdlk8 combining mouse molecular genetics with Drosophila knockdown strategies and cell-based screening approaches. Recent discoveries include identify- ing that Cdk7 acts as a roadblock to adipogenesis and that this presumed ubiquitous basal transcription factor is not expressed in fat tissues. Our goal is to understand the basis for the specificity of transcriptional regulation by metazoan Cdk7 and Cdk8 and their contribution to growth control and differentiation.

One of the rare kinases acting normally to restrict tumor growth is the LKB1ser- ine/threonine kinase critical for activation of at least 14 related kinases involved in metabolism and polarity regulation. We are interested in how LKB1 mediates its tumor suppressing function, and recently identified that LKB1 signaling in mesen- chymal cells is required for suppression of epithelial hyperproliferation in a mouse polyposis model and likely also in the human Peutz-Jeghers syndrome. We are cur- rently extending investigations of tumor suppression mechanisms of the LKB1 tu- mor suppressor kinase from hereditary polyposis to sporadic cancer (lung, uterine cervix). For this a combination of tissue- and cell type specific targeting approaches in vivo (conditional mouse models) and in vitro (2D and 3D RNAi & conditional dele- tions) of LKB1 and LKB1 substrate mutations will be used with a specific interest in the Nuak2 and AMPK kinases and cytoskeletal regulation.

 

 

Fields of Science

  • 118 Biological sciences
  • 311 Basic medicine

International and National Collaboration Publications and projects within past five years.

Publications 1986 2018

  • 82 Article
  • 4 Review Article
  • 2 Conference article

The LKB1 tumor suppressor kinase in human disease

Katajisto, P., Vallenius, T., Vaahtomeri, K., Ekman, N., Udd, L., Tiainen, M. & Makela, T. P., 2007, In : Biochimica et Biophysica Acta. Reviews on Cancer. 1775, 1, p. 63-75 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Depletion of Mediator Kinase Module Subunits Represses Superenhancer-Associated Genes in Colon Cancer Cells

Kuuluvainen, E., Domenech-Moreno, E., Niemela, E. H. & Makela, T. P., Jun 2018, In : Molecular and Cellular Biology. 38, 12, 15 p., UNSP e00573-17.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Increased alpha-actinin-1 destabilizes E-cadherin-based adhesions and associates with poor prognosis in basal-like breast cancer

Kovac, B., Makela, T. P. & Vallenius, T., 9 May 2018, In : PLoS One. 13, 5, 20 p., 0196986.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK/STAT3 pathway

Ollila, S., Domenech-Moreno, E., Laajanen, K., Wong, I. P. L., Tripathi, S., Pentinmikko, N., Gao, Y., Yan, Y., Niemelä, E. H., Wang, T. C., Viollet, B., Leone, G., Katajisto, P., Vaahtomeri, K. & Mäkelä, T. P., 2 Jan 2018, In : Journal of Clinical Investigation. 128, 1, p. 402-414 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

AMPK negatively regulates tensin-dependent integrin activity

Georgiadou, M., Lilja, J., Jacquemet, G., Guzman, C., Rafaeva, M., Alibert, C., Yan, Y., Sahgal, P., Lerche, M., Manneville, J-B., Makela, T. P. & Ivaska, J., Apr 2017, In : Journal of Cell Biology. 216, 4, p. 1107-1121 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Prizes

Anders Jahre Young Investigator Award

Tomi Mäkelä (Recipient), 1 Jan 2005

Prize: Prizes and awards

Activities 1996 2010

Univ Helsinki, Faculty of Medicine (External organisation)

Tomi Mäkelä (Chair)
3 Jun 2010

Activity: Membership typesMembership or other role in national/international committee, council, board

Studia Medicina

Tomi Mäkelä (Attendee)
27 Jan 2010

Activity: Participating in or organising an event typesPublic Talks

Univ Helsinki (External organisation)

Tomi Mäkelä (Board member)
2010

Activity: Membership typesMembership or other role in national/international committee, council, board

Scientific Reports (Journal)

Tomi Mäkelä (Reviewer)
6 Dec 2010 → …

Activity: Publication peer-review and editorial work typesEditor of research journal

Press / Media

Radiaattori: telomeraasista Nobel / Sisko Loikkanen

Tomi Mäkelä

21/10/2010

1 media contribution

Press/Media: Press / Media

Tomi Mäkelä Helsingin biotekniikan instituutin johtoon

Tomi Mäkelä

16/01/2009

1 media contribution

Press/Media: Press / Media

Kiinnostus tutkijan työhön uhkaa hiipua

Tomi Mäkelä

01/01/2009

1 media contribution

Press/Media: Press / Media

Science Days Finland 2007: Opportunities from Cancer Biology

Tomi Mäkelä

10/01/2007

1 media contribution

Press/Media: Press / Media