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Tomi Rantamäki

Academy Research Fellow

  • PL 56 (Viikinkaari 5E)

    00014

    Finland

20052019
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Publications 2005 2019

2019

Brain metabolome during anesthesia - similarities and differences between post-ictal state

Kohtala, S., Kärkkäinen, O. & Rantamäki, T., 2019, In : European Neuropsychopharmacology. 29, p. S645-S646 2 p.

Research output: Contribution to journalMeeting AbstractResearch

Cortical Excitability and Activation of TrkB Signaling During Rebound Slow Oscillations Are Critical for Rapid Antidepressant Responses

Kohtala, H. S., Theilmann, W., Rosenholm, M., Penna, L., Karabulut, G., Uusitalo, S., Järventausta, K., Yli-Hankala, A., Yalcin, I., Matsui, N., Wigren, H-K. & Rantamäki, T., Jun 2019, In : Molecular Neurobiology. 56, 6, p. 4163-4174 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Depression and antidepressant actionfrom molecules to networks

Rantamäki, T. & Yalcin, I., Jul 2019, In : Cell and Tissue Research. 377, 1, p. 1-4 4 p.

Research output: Contribution to journalEditorialScientific

Dose-dependent effects of isoflurane on TrkB and GSK3β signaling: Importance of burst suppression pattern

Theilmann, W., Alitalo, O. A., Yorke, I. & Rantamäki, T. P. J., 16 Feb 2019, In : Neuroscience Letters. 694, p. 29-33 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Dual mechanism of TRKB activation by anandamide through CB1 and TRPV1 receptors

Diniz, C. R. A. F., Biojone, C., Joca, S. R. L., Rantamäki, T., Castren, E., Guimaraes, F. S. & Casarotto, P. C., 21 Feb 2019, In : PeerJ. 7, 21 p., 6493.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Improving Group Work Practices in Teaching Life Sciences: Trialogical Learning

Tammeorg, P., Mykkänen, A., Rantamäki, T., Lakkala, M. & Muukkonen, H., Jun 2019, In : Research in Science Education. 49, 3, p. 809-828 20 p.

Research output: Contribution to journalArticleScientificpeer-review

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Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine metabolites

Kohtala, H. S., Theilmann, W., Rosenholm, M. P., Müller, H. K., Kiuru, P. S., Wegener, G., Yli-Kauhaluoma, J. T. & Rantamäki, T. P. J., 25 Jun 2019, In : Neuropharmacology. 157, 9 p., 107684.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Searching for ketamine's antidepressant mechanisms: From synaptic plasticity to dentate gyrus cell proliferation

Rantamaki, T., Apr 2019, In : Acta Physiologica. 225, 4, 3 p., 13252.

Research output: Contribution to journalEditorialScientific

TrkB neurotrophin receptor at the core of antidepressant effects, but how?

Rantamaki, T., Jul 2019, In : Cell and Tissue Research. 377, 1, p. 115-124 10 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Open Access
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2018
Open Access
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Neurobiologiset ilmiöt nopean masennuslääkevasteen taustalla

Kohtala, S., Järventausta, K. & Rantamäki, T., 2018, In : Duodecim. 134, 19, p. 1905-1912 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

P11 promoter methylation predicts the antidepressant effect of electroconvulsive therapy

Neyazi, A., Theilmann, W., Brandt, C., Rantamäki, T. P. J., Matsui, N., Rhein, M., Kornhuber, J., Bajbouj, M., Sperling, W., Bleich, S., Frieling, H. & Löscher, W., 22 Jan 2018, In : Translational Psychiatry. 8, 25, 25.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2017

BDNF receptor TRKB as a target of antidepressants

Rantamäki, T., 2017, Major Depressive Disorder: Risk Factors, Characteristics and Treatment Options. Kim, Y-K. (ed.). New York, NY: Nova Science Publishers, p. 277-294 28 p. (Psychiatry – Theory, Applications and Treatments).

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Brief isoflurane anesthesia regulates striatal AKT-GSK3 beta signaling and ameliorates motor deficits in a rat model of early-stage Parkinson's disease

Leikas, J. V., Kohtala, S., Theilmann, W., Jalkanen, A. J., Forsberg, M. M. & Rantamaki, T., Aug 2017, In : Journal of Neurochemistry. 142, 3, p. 456-463 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Combined Ipsilateral Limb Use Score as an Index of Motor Deficits and Neurorestoration in Parkinsonian Rats

Leikas, J. V., Kaariainen, T. M., Jalkanen, A. J., Lehtonen, M., Rantamaki, T. & Forsberg, M. M., Sep 2017, In : Journal of Neuroscience Research. 95, 9, p. 1858-1870 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

Antila, H., Ryazantseva, M., Popova, D., Sipilä, P., Guirado, R., Kohtala, S., Yalcin, I., Lindholm, J., Vesa, L., Sato, V., Cordeira, J., Autio, H., Kislin, M., Rios, M., Joca, S., Casarotto, P., Khiroug, L., Lauri, S., Taira, T., Castren, E. & 1 othersRantamäki, T., 10 Aug 2017, In : Scientific Reports. 7, 12 p., 7811.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Modulation of BDNF cleavage by plasminogen-activator inhibitor-1 contributes to Alzheimer's neuropathology and cognitive deficits

Gerenu, G., Martisova, E., Ferrero, H., Carracedo, M., Rantamäki, T., Javier Ramirez, M. & Javier Gil-Bea, F., Apr 2017, In : Biochimica et Biophysica Acta. Molecular Basis of Disease. 1863, 4, p. 991-1001 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Repeated brief isoflurane anesthesia during early postnatal development produces negligible changes on adult behavior in male mice

Rosenholm, M., Paro, E., Antila, H., Voikar, V. & Rantamäki, T., 5 Apr 2017, In : PLoS One. 12, 4, 16 p., 0175258.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Aivosairauksien lääkehoito tälle vuosituhannelle

Rantamäki, T., 2016, In : Dosis. 32, 2, p. 91-96 6 p.

Research output: Contribution to journalArticleProfessional

Aivosairauksien lääkehoito tälle vuosituhannelle

Rantamäki, T. P. J., 2016, In : Dosis. 32, 2, p. 91-95 5 p.

Research output: Contribution to journalArticleScientific

Antidepressant drug action – from rapid changes on network function to network rewiring

Rantamäki, T. P. J. & Yalcin, I., 2016, In : Progress in Neuro-Psychopharmacology & Biological Psychiatry. 64, p. 285-292

Research output: Contribution to journalArticleScientificpeer-review

Brief Isoflurane Anesthesia Produces Prominent Phosphoproteomic Changes in the Adult Mouse Hippocampus

Kohtala, S., Theilmann, W., Suomi, T., Wigren, H-K., Porkka-Heiskanen, T., Elo, L. L., Rokka, A. & Rantamaki, T., Jun 2016, In : ACS chemical neuroscience. 7, 6, p. 749-756 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2015

NCAM-deficient mice show prominent abnormalities in serotonergic and BDNF systems in brain - Restoration by chronic amitriptyline

Aonurm-Helm, A., Anier, K., Zharkovsky, T., Castren, E., Rantamäki, T., Stepanov, V., Jaerv, J. & Zharkovsky, A., Dec 2015, In : European Neuropsychopharmacology. 25, 12, p. 2394-2403 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2014

Distinctive behavioral and cellular responses to fluoxetine in the mouse model for Fragile X syndrome

Uutela, M., Lindholm, J., Rantamaki, T., Umemori, J., Hunter, K., Voikar, V. & Castren, M. L., 28 May 2014, In : Frontiers in Cellular Neuroscience. 8, 9 p., 150.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells

Antila, H., Autio, H., Turunen, L., Harju, K., Tammela, P., Wennerberg, K., Yli-Kauhaluoma, J., Huttunen, H. J., Castren, E. & Rantamaki, T., 30 Jan 2014, In : Journal of Neuroscience Methods. 222, p. 142-146 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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VGF (TLQP-62)-induced neurogenesis targets early phase neural progenitor cells in the adult hippocampus and requires glutamate and BDNF signaling

Thakker-Varia, S., Behnke, J., Doobin, D., Dalal, V., Thakkar, K., Khadim, F., Wilson, E., Palmieri, A., Antila, H., Rantamaki, T. & Alder, J., 2014, In : Stem Cell Research. 12, 3, p. 762-777 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2013

Lääke antaa masentuneelle mahdollisuuden

Rantamäki, T., 2013, In : Tiede. 33, p. 52-55

Research output: Contribution to journalArticleGeneral public

Lukijalta: Änkytys on kommunikaation häiriö.

Rantamäki, T., 15 Mar 2013, In : Aamulehti.

Research output: Contribution to journalArticleGeneral public

Masennuslääkkeet edistävät hermoverkkojen muovautuvuutta – mitä hyötyä siitä on aivoille?

Rantamäki, T., 2013, In : Suomen lääkärilehti. 68, 42, p. 2675-2680 6 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

The Impact of Bdnf Gene Deficiency to the Memory Impairment and Brain Pathology of APPswe/PS1dE9 Mouse Model of Alzheimer's Disease

Rantamäki, T., Kemppainen, S., Autio, H., Staven, S., Koivisto, H., Kojima, M., Antila, H., Miettinen, P. O., Kärkkäinen, E., Karpova, N., Vesa, L., Lindemann, L., Hoener, M. C., Tanila, H. & Castren, E., 3 Jul 2013, In : PLoS One. 8, 7, 14 p., e68722.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2012

Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice

Kemppainen, S., Rantamäki, T., Jeronimo-Santos, A., Lavasseur, G., Autio, H., Karpova, N., Kärkkäinen, E., Staven, S., Miranda, H. V., Outeiro, T. F., Diogenes, M. J., Laroche, S., Davis, S., Sebastiao, A. M., Castrén, E. & Tanila, H., Jun 2012, In : Neurobiology of Aging. 33, 6, p. 1122.e23–1122.e39 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Masennuslääkkeet - Kannattaako niitä syödä, onko niillä tehoa ja miten ne oikein vaikuttavat?

Rantamäki, T., 2012, In : Suomen apteekkarilehti. 101, 7-8, p. 38-39 2 p.

Research output: Contribution to journalArticleGeneral public

Mielipide: Parantuuko masennus vain lääkehoidolla?

Rantamäki, T. & Castrén, E., 15 Apr 2012, In : Helsingin Sanomat.

Research output: Contribution to journalArticleGeneral public

Sleep homeostasis and depression: Studies with the rat clomipramine model of depression

Savelyev, S. A., Rantamäki, T., Rytkönen, K-M., Castren, E. & Porkka-Heiskanen, T., 2012, In : Neuroscience. 212, p. 149-158 10 p.

Research output: Contribution to journalArticleScientificpeer-review

The antidepressant-like effects of glutamatergic drugs ketamine and AMPA receptor potentiator LY 451646 are preserved in bdnf(+/-) heterozygous null mice.

Lindholm, J., Autio, H., Vesa, L. K., Antila, H., Lindemann, L., Hoener, M., Skolnick, P., Rantamäki, T. & Castrén, E., 2012, In : Neuropharmacology. 62, 1, p. 391-397 7 p.

Research output: Contribution to journalArticleScientificpeer-review

The Responsiveness of TrkB to BDNF and Antidepressant Drugs Is Differentially Regulated during Mouse Development

Di Lieto, A., Rantamaki, T., Vesa, L., Yanpallewar, S., Antila, H., Lindholm, J., Rios, M., Tessarollo, L. & Castren, E., 2012, In : PLoS One. 7, 3, p. e32869 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Tutkija ahersi koulussa

Rantamäki, T., 2012, In : Yliopisto : Helsingin yliopiston tiedelehti. 60, 4, p. 52 1 p.

Research output: Contribution to journalArticleGeneral public

Vastine: Aivolääkkeet toiminnallisen terapian tueksi

Rantamäki, T., 3 Oct 2012, In : Aamulehti.

Research output: Contribution to journalArticleGeneral public

2011

Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus

Autio, H., Mätlik, K., Rantamäki, T., Lindemann, L., Hoener, M. C., Chao, M., Arumäe, U. & Castrén, E., Dec 2011, In : Neuropharmacology. 61, 8, p. 1291-1296 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Alterations in BDNF and phospho-CREB levels following chronic oral nicotine treatment and its withdrawal in dopaminergic brain areas of mice

Kivinummi, T., Kaste, K., Rantamäki, T., Castrén, E. & Ahtee, L., 2011, In : Neuroscience Letters. 491, 2, p. 108-112 5 p.

Research output: Contribution to journalArticleScientificpeer-review

Änkytys – Haaste aivotutkimukselle

Rantamäki, T., 2011, In : Puheenvuoro. 2, p. 8-10 3 p.

Research output: Contribution to journalArticleGeneral public

Antidepressant Drugs Transactivate TrkB Neurotrophin Receptors in the Adult Rodent Brain Independently of BDNF and Monoamine Transporter Blockade.

Rantamäki, T., Vesa, L. K., Antila, H., Di Lieto, A., Tammela, P., Schmitt, A., Lesch, K-P., Rios, M. & Castrén, E., Jun 2011, In : PLoS One. 6, 6, p. e20567 8 p.

Research output: Contribution to journalArticleScientificpeer-review

A role for BDNF/TrkB signaling in behavioral and physiological consequences of social defeat stress

Razzoli, M., Domenici, E., Carboni, L., Rantamaki, T., Lindholm, J., Castren, E. & Arban, R., 2011, In : Genes, Brain and Behavior. 10, 4, p. 424-433 10 p.

Research output: Contribution to journalArticleScientificpeer-review

BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouse

Louhivuori, V., Vicario, A., Uutela, M., Rantamaki, T., Louhivuori, L. M., Castren, E., Tongiorgi, E., Akerman, K. E. & Castren, M. L., 2011, In : Neurobiology of Disease. 41, p. 469-480 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2010

Aivoyhdyshenkilö apteekkiin

Rantamäki, T., 2010, In : Suomen apteekkarilehti. 99, 7-8, p. 31 1 p.

Research output: Contribution to journalArticleProfessional

Änkytys lähtee aivoista, mutta miten?

Rantamäki, T., 2010, In : Puheenvuoro. 2010, 4, p. 17-18 32 p.

Research output: Contribution to journalArticleGeneral public

Darkness Reduces BDNF Expression in the Visual Cortex and Induces Repressive Chromatin Remodeling at the BDNF Gene in Both Hippocampus and Visual Cortex

Karpova, N. N., Rantamaki, T., Di Lieto, A., Lindemann, L., Hoener, M. C. & Castren, E., 2010, In : Cellular and Molecular Neurobiology. 30, p. 1117-1123 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Effects of maternal smoking and exposure to methylmercury on Brain-Derived Neurotrophic Factor (BDNF) concentrations umbilical cord serum

Spulber, S., Rantamäki, T., Nikkilä, O., Castrén, E., Weihe, P., Grandjean, P. & Ceccatelli, S., 2010, In : Toxicological Sciences. 117, 2, p. 263-269 7 p.

Research output: Contribution to journalArticleScientificpeer-review