Research output per year
Research output per year
Personal profile
Curriculum vitae
Principal Investigator, Senior Scientist (Insititute of Biotechnolgoy) 2011-
Academy Research Fellow (Insititute of Biotechnolgoy) 2011-2016
Head of Crystallization Core facility (Instruct-HiLIFE) 2013-
Qualifications:
Ph.D. (2003 University of Helsinki, Biochemistry), Title of Docent in Protein chemistry (Uinv. Helsinki) (2009).
Addtional training:
University pedagogics I + III + IV (2009-2016) (20 ECTS).
Leadership Programme for Academic Staff (2013) (5 ECTS).
Previous appointments:
Post doctoral fellow at Yale University 2003-2006
Resaercher, Dept. of Virology, Univ. Helsinki, 2001-2003.
Description of research and teaching
Research interests: Structural biology, crystallization, protein-protein interactions, protein engineering and molecular mechanisms, synaptic adhesion, integral membrane proteins.
Teaching: Introduciton to structural biology and biophysics (5 ECTS)
Fields of Science
- 1182 Biochemistry, cell and molecular biology
- biochemistry
- structural biology
- biophysics
- protein engineering
- protein chemistry
International and National Collaboration
Publications and projects within past five years.
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MDGA1 negatively regulates amyloid precursor protein-mediated synapse inhibition in the hippocampus
Kim, J., Kim, S., Kim, H., Hwang, I-W., Bae, S., Karki, S., Kim, D., Ogelman, R., Bang, G., Kim, J. Y., Kajander, T., Um, J. W., Oh, W. C. & Ko, J., 25 Jan 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 4, 11 p., 2115326119.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Crystallization and low-resolution structure solution of the SALM3–PTPσ synaptic adhesion complex
Karki, S. & Kajander, T., 2021, In: Acta crystallographica section f-Structural biology communications. F78, p. 39-44Research output: Contribution to journal › Article › Scientific › peer-review
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Structural basis of SALM3 dimerization and synaptic adhesion complex formation with PTPσ
Karki, S., Shkumatov, A. V., Bae, S., Kim, H., Ko, J. & Kajander, T., 14 Jul 2020, In: Scientific Reports. 10 , 1, 13 p., 11557.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Inhibitor screening assay for neurexin-LRRTM adhesion protein interaction involved in synaptic maintenance and neurological disorders.
Karki, S., Maksimainen, M. M., Lehtiö, L. & Kajander, T., 15 Dec 2019, In: Analytical Biochemistry. 587, 113463.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Structure-based virtual screening of LsrK kinase inhibitors to target quorum sensing
Medarametla, P., Gatta, V., Kajander, T. A., Laitinen, T., Tammela, P. S. M. & Poso, A., 20 Nov 2018, In: ChemMedChem : chemistry enabling drug discovery.. 13, 22, p. 2400-2407 8 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Integrated Structural Biology Infrastructure-European Research Infrastructure Consortium (Instruct-ERIC) / Consortium FINStruct and Instruct-ERIC
Butcher, S., Poranen, M., Varjosalo, M., Kajander, T., Oksanen, H. M., Eskelin , K., Lehtiö, L., Salminen, T. A. & Papageorgiou, A. C.
01/01/2022 → 31/12/2026
Project: Academy of Finland: Research infrastructure
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Structural Biology Finland (FINStruct) & Instruct-ERIC Centre FI / Research Infrastructure Roadmap 2021-2024
Butcher, S., Poranen, M., Kajander, T., Iwai, H., Varjosalo, M., Lehtiö, L., Rouvinen, J., Salminen, T. A., Papageorgiou, A. C., Oksanen, H. M. & Eskelin , K.
01/01/2021 → 31/12/2024
Project: Academy of Finland: Research infrastructure
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Integrated Structural Biology Infrastructure / Consortium: Instruct-Suomi
Butcher, S., Kajander, T., Lehtiö, L., Määttä, J. A. E., Papageorgiou, A., Rouvinen, J., Salminen, T., Iwai, H., Poranen, M., Eskelin , K. & Oksanen, H. M.
01/01/2020 → 31/12/2022
Project: Other project
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Hermoston leusiinirikkaiden toistoproteiinien rakennebiologia
01/09/2011 → 31/08/2016
Project: Research project
Activities
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Instruct-ERIC Centre Finland Opening and Structural Biology Finland Conference 2021
Tommi Kajander (Member of organizing committee)
17 Dec 2021Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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Frontiers in Molecular Biosciences (Journal)
Tommi Kajander (Member of editorial board)
1 Jun 2021 → …Activity: Publication peer-review and editorial work types › Peer review of manuscripts
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Calsyntenin-3 Laminin G-Like Domain Forms Dimers in a Solution
Tommi Kajander (Supervisor)
27 Jan 2021Activity: Examination types › Supervision of other thesis (Master's, Licentiate)
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The Finnish Annual Structural Biology meeting FINNBOX 2019
Tommi Kajander (Chair of organizing committee)
3 Sep 2019Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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Expression and characterization of neuronal membrane receptor proteins
Tommi Kajander (Supervisor)
16 Dec 2016Activity: Examination types › Supervisor or co-supervisor of doctoral thesis
Equipment
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Instruct-HILIFE protein crystallography platform
Tommi Kajander (Manager)
Institute of BiotechnologyFacility/equipment: Core Facility
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Structural Biology Finland (FINStruct)
Sarah Butcher (Manager), Hanna M Oksanen (Other), Minna Poranen (Other), Katri Eskelin (Other), Tommi Kajander (Other), Perttu Permi (Other), Lari Lehtiö (Other), Juha Rouvinen (Other), Tiina A Salminen (Other) & Anastassios Papageorgiou (Other)
Faculty of Biological and Environmental SciencesFacility/equipment: Core Facility