Tommi Kilpeläinen — University of Helsinki

Emailtommi.kilpelainenhelsinkifi

Research activity per year

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Fields of Science

317 Pharmacy

9 Article
1 Review Article
1 Doctoral Thesis

A prolyl oligopeptidase inhibitor reduces tau pathology in cellular models and in mice with tauopathy
Eteläinen, T., Silva, M. C., Uhari-Väänänen, J., De Lorenzo, F., Jäntti, M., Cui, H., Chavero-Pieres, M., Kilpeläinen, T., Mechtler, C., Svarcbahs, R., Seppälä, E., Savinainen, J., Puris, E., Fricker, G., Gynther, M., Julku, U., Huttunen, H., Haggarty, S. & Myöhänen, T., 12 Apr 2023, In: Science translational medicine. 15, 691, 10.1126/scitranslmed.abq2915.
Research output: Contribution to journal › Article › Scientific › peer-review
Nonpeptidic Oxazole-Based Prolyl Oligopeptidase Ligands with Disease-Modifying Effects on alpha-Synuclein Mouse Models of Parkinson's Disease
Kilpelainen, T. P., Patsi, H. T., Svarcbahs, R., Julku, U. H., Eteläinen, T. S., Cui, H., Auno, S., Sipari, N., Norrbacka, S., Leino, T. O., Jäntti, M., Myöhänen, T. T. & Wallen, E. A. A., 29 May 2023, In: Journal of Medicinal Chemistry. 66, 11, p. 7475-7496 22 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
Removal of proteinase K resistant alpha Syn species does not correlate with cell survival in a virus vector-based Parkinson's disease mouse model
Eteläinen, T. S., Kilpeläinen, T. P., Ignatius, A., Auno, S., De Lorenzo, F., Uhari-Väänänen, J. K., Julku, U. H. & Myöhänen, T. T., 1 Nov 2022, In: Neuropharmacology. 218, 15 p., 109213.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
2-Imidazole as a Substitute for the Electrophilic Group Gives Highly Potent Prolyl Oligopeptidase Inhibitors
Pätsi, H. T., Kilpeläinen, T. P., Auno, S., Dillemuth, P. M. J., Arja, K., Lahtela-Kakkonen, M. K., Myöhänen, T. T. & Wallen, E. A. A., 14 Oct 2021, In: ACS Medicinal Chemistry Letters. 12, 10, p. 1578-1584 7 p.
Research output: Contribution to journal › Article › Scientific › peer-review

Open Access
File
Development and biological characterization of novel ligands for protein-protein interaction-based effects of prolyl oligopeptidase
Kilpeläinen, T., 2021, Helsinki: Helsingin yliopisto.
Research output: Thesis › Doctoral Thesis › Collection of Articles

Open Access

1 Finished

Prolyylioligopeptidaasi (PREP) - mahdollinen biomarkkeri ja yhteinen lääkekehityskohde useaan hermostoa rappeuttavaan sairauteen?
Myöhänen, T. & Kilpeläinen, T.
Sigrid Jusélius Stiftelse
01/09/2018 → 31/08/2022
Project: Research project