Toni T. Seppälä, adjunct professor, surgery

20102022

Research output per year

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Personal profile

Curriculum vitae

EDUCATION

Adjunct professor in surgery                                                                                    
2019

Specialist (board certification) in gastrointestinal surgery                                          
2018

Doctor of Medical Sciences (PhD), University of Eastern Finland
2012

Licentiate of Medicine (MD), University of Eastern Finland
2010

 

CURRENT POSITIONS

GI surgeon - Department of Gastrointestinal Surgery, Helsinki University Hospital  
2018 

Principal investigator - University of Helsinki, Faculty of Medicine
2017

Research fellow - Johns Hopkins University, Dept. of Surgical Oncology
2019

 

PREVIOUS PROFESSIONAL APPOINTMENTS

Postdoc - Helsinki University Hospital and University of Helsinki                 
2017–2018

Resident - Department of Gastrointestinal Surgery, HUS                            
2016–2018

Resident - Central Finland Central Hospital, Jyväskylä                                
2012–2015                                                            

 

RESEARCH AWARDS AND HONOURS

Young Scientist of the Year                                                                                       
2016, Gastropäivät, Finnish Digestive Surgeons

 

REFEREE TASKS AND EDITORIAL BOARD MEMBERSHIPS

In scientific journals: 34 reviews listed @ publons.com                                              
2012–2020

Reviewer for the Dutch Cancer Society (KWF)                                                          
2018–2020

Assistant Editor, Journal of Alzheimer’s disease                                                        
2012–2013

 

PEER-REVIEWED SCIENTIFIC PUBLICATIONS

Total number of peer-reviewed publications: 34                                                    
Number of citations: 1053 (Google Scholar 3/31/2020
H-index: 13

 

PROFESSIONAL MEMBERSHIPS

European Hereditary Tumour Group (EHTG)                                                            
2018–
Member of the board of directors, Secretary                                                
2019–

Prospective Lynch Syndrome Database (PLSD)
Member of the Scientific Steering committee                                              
2017–

The International Society for Gastrointestinal Hereditary Tumours                            
2017–

European Society of Coloproctology (ESCP)                                                            
2017–

Finnish Digestive Surgeons                                                                                    
2014–

Finnish Society of Surgeons                                                                                  
2014–

The Finnish Medical Society Duodecim
Member 2006–
Board of directors 2009–2011

 

MEDICAL COMMUNITY SERVICE

Finnish Junior Doctors’ Association
Board of directors, treasurer 2011–2014
Chairman of the Council 2015–2018

Finnish Medical Association
Member of the Council 2010–2012
5 other committees 2006–2014

National Institute for Health and Welfare 
Member of the Expert Working Group on developing nursing and multiprofessional documentation practices 2011–2012 

Finnish Medical Students’ Association
Vice president, board of directors 2006–2007

Medical Students’ Association of Kuopio
Chairman of the board of directors 2006–2007

 

GRANTS AND RESEARCH SUPERVISION

Fellowship Grant, Sigrid Juselius Foundation (140,000 €)
2019–2021 Research Fellowship at Johns Hopkins Hospital

Fellowship Grant, Instrumentarium Science Foundation (40,000 €) 
2019–2021 Research Fellowship at Johns Hopkins Hospital

Research Grant, Emil Aaltonen’s Foundation (210,000 €)                                          
2019–2021

Research Grant, Finnish Medical Foundation (150,000 €) 
2019–2021

Postdoctoral 12 months funded position (50% during 2 years)
Helsinki University Hospital and University of Helsinki, about 100,000 € 
2017–2018

Research Grant, Finnish Medical Foundation (9,000 €, 4 months) 
2015 

Research Grant, Research Fund in Gastrointestinal Diseases      
Grant for advanced researcher (10,000 €, 4 months) 2014                             

Six minor grants (several foundations, less than 10,000 €)    
2008–2012

Supervisor of PhD and bachelor theses                           
2018–

Pedagogical training: 10 credits /University of Helsinki                       
2018

 

PRESENTATIONS 2018-2019

Invited oral presentation: Highlights 2019, CGA 2019, Salt Lake City, UT   
2019

Invited oral presentation: Missing the target: over and underdiagnosis in LS
EHTG 2019, Barcelona, Spain

Invited oral presentation: Clinical Guidance in LS, EHTG 2019, Barcelona, Spain
2019

Invited oral presentation: Incident cancers during colonoscopy surveillance for LS are usually not preceded by compromised quality of colonoscopy
EHTG 2019, Barcelona, Spain

Invited oral presentation: Finnish LS-research meeting
2019

Invited oral presentation: Insight 2019, Auckland, New Zealand 
2019

Invited oral presentation: Clinical Aspects: from phenotype to genotype and back
ESCP 2018, Nice, France

Invited oral presentation: EHTG 2018, Nice, France                
2018

Invited oral presentation: EHTG 2018, Nice, France
2018

Invited oral presentation: Finnish LS-research meeting 
2018

Invited oral presentation: Finnish Medical Genetics Annual Meeting  
2018

External positions

Research fellow, Johns Hopkins Medicine

5 Aug 2019 → …

Fields of Science

  • 3126 Surgery, anesthesiology, intensive care, radiology

International and National Collaboration Publications and projects within past five years.

Publications

Associations of Pathogenic Variants in MLH1, MSH2, and MSH6 With Risk of Colorectal Adenomas and Tumors and With Somatic Mutations in Patients With Lynch Syndrome

German HNPCC Consortium, Dutch Lynch Syndrome Collaborative, Finnish Lynch Syndrome Registry, Engel, C., Ahadova, A., Seppälä, T. T., Lepistö, A., Renkonen-Sinisalo, L. & Vasen, H. F., Apr 2020, In : Gastroenterology. 158, 5, p. 1326-1333 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database

Dominguez-Valentin, M., Sampson, J. R., Seppälä, T. T., Ten Broeke, S. W., Plazzer, J-P., Nakken, S., Engel, C., Aretz, S., Jenkins, M. A., Sunde, L., Bernstein, I., Capella, G., Balaguer, F., Thomas, H., Evans, D. G., Burn, J., Greenblatt, M., Hovig, E., de Vos Tot Nederveen Cappel, W. H., Sijmons, R. H. & 68 others, Bertario, L., Tibiletti, M. G., Cavestro, G. M., Lindblom, A., Della Valle, A., Lopez-Köstner, F., Gluck, N., Katz, L. H., Heinimann, K., Vaccaro, C. A., Büttner, R., Görgens, H., Holinski-Feder, E., Morak, M., Holzapfel, S., Hüneburg, R., Knebel Doeberitz, M. V., Loeffler, M., Rahner, N., Schackert, H. K., Steinke-Lange, V., Schmiegel, W., Vangala, D., Pylvänäinen, K., Renkonen-Sinisalo, L., Hopper, J. L., Win, A. K., Haile, R. W., Lindor, N. M., Gallinger, S., Le Marchand, L., Newcomb, P. A., Figueiredo, J. C., Thibodeau, S. N., Wadt, K., Therkildsen, C., Okkels, H., Ketabi, Z., Moreira, L., Sánchez, A., Serra-Burriel, M., Pineda, M., Navarro, M., Blanco, I., Green, K., Lalloo, F., Crosbie, E. J., Hill, J., Denton, O. G., Frayling, I. M., Rødland, E. A., Vasen, H., Mints, M., Neffa, F., Esperon, P., Alvarez, K., Kariv, R., Rosner, G., Pinero, T. A., Gonzalez, M. L., Kalfayan, P., Tjandra, D., Winship, I. M., Macrae, F., Möslein, G., Mecklin, J-P., Nielsen, M. & Møller, P., Jan 2020, In : Genetics In medicine. 22, 1, p. 15-25 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
File

Factors associated with decision-making on prophylactic hysterectomy and attitudes towards gynecological surveillance among women with Lynch syndrome (LS): a descriptive study

Kalamo, M. H., Mäenpää, J. U., Seppälä, T. T., Mecklin, J. P., Huhtala, H., Sorvettula, K., Pylvänäinen, K. & Staff, S., 29 Jan 2020, In : Familial Cancer. 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Combined prognostic value of CD274 (PD-L1)/PDCDI (PD-1) expression and immune cell infiltration in colorectal cancer as per mismatch repair status

Ahtiainen, M., Wirta, E-V., Kuopio, T., Seppälä, T., Rantala, J., Mecklin, J-P. & Böhm, J., Jun 2019, In : Modern Pathology. 32, 6, p. 866-883 18 p.

Research output: Contribution to journalArticleScientificpeer-review

Projects

Press / Media

Lynch Syndrome Mutation Study Suggests Changes to Clinical Management

Toni T. Seppälä

25/07/2019

1 item of Media coverage

Press/Media: Press / Media

Geenivirheen ja syövän yhteys

Toni T. Seppälä

02/11/2018

1 item of Media coverage

Press/Media: Press / Media

Geenivirheen ja syövän yhteys

Toni T. Seppälä

02/11/2018

1 item of Media coverage

Press/Media: Press / Media

Harvempi tähystystahti riittää Lynchin oireyhtymässä

Toni T. Seppälä

08/08/2018

1 item of Media coverage

Press/Media: Press / Media

Selkäydinneste tuo viestiä aivoista

Toni T. Seppälä

10/09/2012

1 item of Media coverage

Press/Media: Press / Media