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Publications 2011 2019

2019

Combined prognostic value of CD274 (PD-L1)/PDCDI (PD-1) expression and immune cell infiltration in colorectal cancer as per mismatch repair status.

Ahtiainen, M., Wirta, E-V., Kuopio, T., Seppälä, T., Rantala, J., Mecklin, J-P. & Böhm, J., 5 Feb 2019, In : Modern Pathology.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Epidemiological, clinical and molecular characterization of Lynch-like syndrome: A population-based study

Porkka, N., Lahtinen, L., Ahtiainen, M., Böhm, J. P., Kuopio, T., Eldfors, S., Mecklin, J-P., Seppälä, T. T. & Peltomäki, P., 1 Jul 2019, In : International Journal of Cancer. 145, 1, p. 87-98 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers

Hanninen, U. A., Wirta, E-V., Katainen, R., Tanskanen, T., Hamberg, J., Taipale, M., Böhm, J., Renkonen-Sinisalo, L., Lepistö, A., Forsström, L. M., Pitkänen, E., Palin, K., Seppälä, T. T., Mäkinen, N., Mecklin, J-P. & Aaltonen, L. A., 30 Apr 2019, In : British Journal of Cancer. 120, 9, p. 922-930 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Lack of association between screening interval and cancer stage in Lynch syndrome may be accounted for by over-diagnosis; a prospective Lynch syndrome database report

Seppala, T. T., Ahadova, A., Dominguez-Valentin, M., Macrae, F., Evans, D. G., Therkildsen, C., Sampson, J., Scott, R., Burn, J., Möslein, G., Bernstein, I., Holinski-Feder, E., Pylvänäinen, K., Renkonen-Sinisalo, L., Lepistö, A., Lautrup, C. K., Lindblom, A., Plazzer, J-P., Winship, I., Tjandra, D. & 37 othersKatz, L. H., Aretz, S., Hueneburg, R., Holzapfel, S., Heinimann, K., Della Valle, A., Neffa, F., Gluck, N., Cappel, W. H. D. V. T. N., Vasen, H., Morak, M., Steinke-Lange, V., Engel, C., Rahner, N., Schmiegel, W., Vangala, D., Thomas, H., Green, K., Lalloo, F., Crosbie, E. J., Hill, J., Capella, G., Pineda, M., Navarro, M., Blanco, I., ten Broeke, S., Nielsen, M., Ljungmann, K., Nakken, S., Lindor, N., Frayling, I., Hovig, E., Sunde, L., Kloor, M., Mecklin, J-P., Kalager, M. & Moller, P., 28 Feb 2019, In : Hereditary Cancer in Clinical Practice. 17, 8 p., 8.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Lynchin oireyhtymä ei lisää rintasyövän riskiä

Seppälä, T., Renkonen-Sinisalo, L. & Lepistö, A., 2019, In : Suomen lääkärilehti. 74, 17, p. 1026 1 p.

Research output: Contribution to journalLetterProfessional

2018

Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database

Moller, P., Seppala, T. T., Bernstein, I., Holinski-Feder, E., Sala, P., Evans, D. G., Lindblom, A., Macrae, F., Blanco, I., Sijmons, R. H., Jeffries, J., Vasen, H. F. A., Burn, J., Nakken, S., Hovig, E., Rodland, E. A., Tharmaratnam, K., Cappel, W. H. D. V. T. N., Hill, J., Wijnen, J. T. & 19 othersJenkins, M. A., Green, K., Lalloo, F., Sunde, L., Mints, M., Bertario, L., Pineda, M., Navarro, M., Morak, M., Renkonen-Sinisalo, L., Valentin, M. D., Frayling, I. M., Plazzer, J-P., Pylvanainen, K., Genuardi, M., Mecklin, J-P., Moeslein, G., Sampson, J. R. & Capella, G., Jul 2018, In : Gut. 67, 7, p. 1306-1316 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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No Difference in Colorectal Cancer Incidence or Stage at Detection by Colonoscopy Among 3 Countries With Different Lynch Syndrome Surveillance Policies

German HNPCC Consortium, Dutch Lynch Syndrome & Finnish Lynch Syndrome Registry, Nov 2018, In : Gastroenterology. 155, 5, p. 1400-+ 12 p.

Research output: Contribution to journalArticleScientificpeer-review

2017

Cancer incidence and survival in Lynch syndrome patients receiving colonoscopic and gynaecological surveillance: first report from the prospective Lynch syndrome database

Moller, P., Seppälä, T., Bernstein, I., Holinski-Feder, E., Sala, P., Evans, D. G., Lindblom, A., Macrae, F., Blanco, I., Sijmons, R., Jeffries, J., Vasen, H., Burn, J., Nakken, S., Hovig, E., Rodland, E. A., Tharmaratnam, K., Cappel, W. H. D. V. T. N., Hill, J., Wijnen, J. & 17 othersGreen, K., Lalloo, F., Sunde, L., Mints, M., Bertario, L., Pineda, M., Navarro, M., Morak, M., Renkonen-Sinisalo, L., Frayling, I. M., Plazzer, J-P., Pylvanainen, K., Sampson, J. R., Capella, G., Mecklin, J-P., Moslein, G. & Mallorca Grp, Mar 2017, In : Gut. 66, 3, p. 464-472 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Colorectal cancer incidence in path_MLH1 carriers subjected to different follow-up protocols: a Prospective Lynch Syndrome Database report

Seppala, T., Pylvanainen, K., Evans, D. G., Jarvinen, H., Renkonen-Sinisalo, L., Bernstein, I., Holinski-Feder, E., Sala, P., Lindblom, A., Macrae, F., Blanco, I., Sijmons, R., Jeffries, J., Vasen, H., Burn, J., Nakken, S., Hovig, E., Rodland, E. A., Tharmaratnam, K., Cappel, W. H. D. V. T. N. & 20 othersHill, J., Wijnen, J., Jenkins, M., Genuardi, M., Green, K., Lalloo, F., Sunde, L., Mints, M., Bertario, L., Pineda, M., Navarro, M., Morak, M., Frayling, I. M., Plazzer, J-P., Sampson, J. R., Capella, G., Moslein, G., Mecklin, J-P., Moller, P. & Collaboration Mallorca Grp, 10 Oct 2017, In : Hereditary Cancer in Clinical Practice. 15, 10 p., 18.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Immunoscore in mismatch repair-proficient and -deficient colon cancer

Wirta, E-V., Seppälä, T., Friman, M., Väyrynen, J., Ahtiainen, M., Kautiainen, H., Kuopio, T., Kellokumpu, I., Mecklin, J-P. & Böhm, J., 2017, In : The Journal of Pathology: Clinical Research. 3, 3, p. 203-213 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Incidence of and survival after subsequent cancers in carriers of pathogenic MMR variants with previous cancer: a report from the prospective Lynch syndrome database

Moller, P., Seppälä, T., Bernstein, I., Holinski-Feder, E., Sala, P., Evans, D. G., Lindblom, A., Macrae, F., Blanco, I., Sijmons, R., Jeffries, J., Vasen, H., Burn, J., Nakken, S., Hovig, E., Rodland, E. A., Tharmaratnam, K., Cappel, W. H. D. V. T. N., Hill, J., Wijnen, J. & 19 othersJenkins, M., Green, K., Lalloo, F., Sunde, L., Mints, M., Bertario, L., Pineda, M., Navarro, M., Morak, M., Renkonen-Sinisalo, L., Frayling, I. M., Plazzer, J-P., Pylvanainen, K., Genuardi, M., Mecklin, J-P., Moslein, G., Sampson, J. R., Capella, G. & Mallorca Grp, Sep 2017, In : Gut. 66, 9, p. 1657-1664 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Subtotal Colectomy for Colon Cancer Reduces the Need for Subsequent Surgery in Lynch Syndrome

Renkonen-Sinisalo, L., Seppälä, T. T., Järvinen, H. J. & Mecklin, J-P., Aug 2017, In : Diseases of the Colon & Rectum. 60, 8, p. 792-799 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Uptake of genetic testing by the children of Lynch syndrome variant carriers across three generations

Seppala, T. T., Pylvanainen, K. & Mecklin, J-P., Nov 2017, In : European Journal of Human Genetics. 25, 11, p. 1237-1245 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Lynchin oireyhtymän diagnostiikka ja hoito

Seppälä, T., Pylvänäinen, K., Renkonen-Sinisalo, L., Böhm, J., Kuopio, T., Järvinen, H. & Mecklin, J-P., 2016, In : Duodecim. 132, 3, p. 233-240 8 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

2014
2011

Riittääkö Suomessa lääkäritutkijoita?

Renkonen, R., Björkroth, J., Helve, O., Louhimo, J., Rautava, P., Remes, A., Seppälä, T., Turunen, J-P., Virjo, I., Visakorpi, T. & Heikinheimo, M., 2011, In : Duodecim. 127, 10, p. 1003-1009 7 p.

Research output: Contribution to journalArticleScientificpeer-review