Research output per year
Research output per year
Personal profile
Education/Academic qualification
PhD, Neuroscience Center
1 Sep 2003 → 2 Apr 2008
Award Date: 2 Apr 2008
MSc, University of Eastern Finland (UEF)
9 Sep 1996 → 13 Aug 2003
Award Date: 13 Aug 2003
Fields of Science
- 3111 Biomedicine
- 318 Medical biotechnology
- 1182 Biochemistry, cell and molecular biology
- 3122 Cancers
International and National Collaboration
Publications and projects within past five years.
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Hepsin regulates TGF beta signaling via fibronectin proteolysis
Belitskin, D., Pant, S. M., Munne, P., Suleymanova, I., Belitskina, K., Ala-Hongisto, H., Englund, J., Raatikainen, T., Klezovitch, O., Vasioukhin, V., Li, S., Wu, Q., Monni, O., Kuure, S., Laakkonen, P., Pouwels, J., Tervonen, T. A. & Klefström, J., 4 Nov 2021, In: EMBO Reports. 22, 11, 16 p., 52532.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Oncogenic Ras Disrupts Epithelial Integrity by Activating the Transmembrane Serine Protease Hepsin
Tervonen, T. A., Pant, S. M., Belitskin, D., Englund, J. I., Närhi, K., Haglund, C., Kovanen, P. E., Verschuren, E. W. & Klefström, J., 15 Mar 2021, In: Cancer Research. 81, 6, p. 1513-1527 15 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Analyzing the Type II Transmembrane Serine Protease Hepsin-Dependent Basement Membrane Remodeling in 3D Cell Culture
Pant, S. M., Belitskin, D., Ala-Hongisto, H., Klefström, J. & Tervonen, T. A., 2018, PROTEASES AND CANCER: METHODS AND PROTOCOLS . Cal, S. & Obaya, A. J. (eds.). TOTOWA, NJ : Humana press, p. 169-178 10 p. (Methods in Molecular Biology ; vol. 1731).Research output: Chapter in Book/Report/Conference proceeding › Chapter › Scientific › peer-review
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Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform
Pant, S. M., Mukonoweshuro, A., Desai, B., Ramjee, M. K., Selway, C. N., Tarver, G. J., Wright, A. G., Birchall, K., Chapman, T. M., Tervonen, T. A. & Klefström, J., 24 May 2018, In: Journal of Medicinal Chemistry. 61, 10, p. 4335-4347 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
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Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion
Tervonen, T. A., Belitskin, D., Pant, S. M., Englund, J. I., Marques, E., Ala-Hongisto, H., Nevalaita, L., Sihto, H., Heikkila, P., Leidenius, M., Hewitson, K., Ramachandra, M., Moilanen, A., Joensuu, H., Kovanen, P. E., Poso, A. & Klefstrom, J., 7 Apr 2016, In: Oncogene. 35, 14, p. 1832-1846 15 p.Research output: Contribution to journal › Article › Scientific › peer-review
Prizes
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Travel grant of the Chancellor of University of Helsinki 2012: 1200 € (Mechanism & Models of Cancer 2012, Cold Spring Harbor Lab, NY, USA)
Tervonen, Topi (Recipient), 2012
Prize: Prizes and awards
Activities
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Small molecular inhibitors of hepsin in breast cancer
Topi Tervonen (Co-supervisor)
2015 → …Activity: Examination types › Supervisor or co-supervisor of doctoral thesis
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Advanced molecular biology techniques 51070
Topi Tervonen (Speaker: Presenter)
Jan 2015Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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EMEA CRISPR Core Directors Meeting 2015
Topi Tervonen (Attendee)
May 2015Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
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Viral Gene Transfer and Cell Therapy Technology Platform (VGTCT), Biocenter Finland (External organisation)
Topi Tervonen (Member)
Nov 2015 → …Activity: Membership types › Membership or other role in research network
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Advanced molecular biology techniques 51070
Topi Tervonen (Speaker: Presenter)
Jan 2015Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars