Topi Tervonen — University of Helsinki

Personal profile

Education/Academic qualification

PhD, Neuroscience Center

1 Sep 2003 → 2 Apr 2008

MSc, University of Eastern Finland (UEF)

9 Sep 1996 → 13 Aug 2003

Keywords

3111 Biomedicine
318 Medical biotechnology
1182 Biochemistry, cell and molecular biology
3122 Cancers

International and National Collaboration Publications and projects within past five years.

Publications 2005 2018

10 Article
2 Review Article
1 Chapter
1 Digital or Visual Products
1 More
- 1 Doctoral Thesis

Analyzing the Type II Transmembrane Serine Protease Hepsin-Dependent Basement Membrane Remodeling in 3D Cell Culture

Pant, S. M., Belitskin, D., Ala-Hongisto, H., Klefström, J. & Tervonen, T. A., 2018, PROTEASES AND CANCER: METHODS AND PROTOCOLS . Cal, S. & Obaya, A. J. (eds.). TOTOWA, NJ : Humana Press Inc., p. 169-178 10 p. (Methods in Molecular Biology ; vol. 1731).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › Scientific › peer-review

Design, Synthesis, and Testing of Potent, Selective Hepsin Inhibitors via Application of an Automated Closed-Loop Optimization Platform

Pant, S. M., Mukonoweshuro, A., Desai, B., Ramjee, M. K., Selway, C. N., Tarver, G. J., Wright, A. G., Birchall, K., Chapman, T. M., Tervonen, T. A. & Klefström, J., 24 May 2018, In : Journal of Medicinal Chemistry. 61, 10, p. 4335-4347 13 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesion

Tervonen, T. A., Belitskin, D., Pant, S. M., Englund, J. I., Marques, E., Ala-Hongisto, H., Nevalaita, L., Sihto, H., Heikkila, P., Leidenius, M., Hewitson, K., Ramachandra, M., Moilanen, A., Joensuu, H., Kovanen, P. E., Poso, A. & Klefstrom, J., 7 Apr 2016, In : Oncogene. 35, 14, p. 1832-1846 15 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Par6G suppresses cell proliferation and is targeted by loss-of-function mutations in multiple cancers

Marques, E., Englund, J. I., Tervonen, T. A., Virkunen, E., Laakso, M., Myllynen, M., Mäkelä, A., Ahvenainen, M., Lepikhova, T., Monni, O., Hautaniemi, S. & Klefstrom, J., 17 Mar 2016, In : Oncogene. 35, 11, p. 1386-1398 13 p.

Research output: Contribution to journal › Article › Scientific › peer-review

Open Access