Photo of Tuomas Mirtti
  • PL 20 (Tukholmankatu 8)

    00014

    Finland

20012019
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Publications 2001 2019

2019
Open Access
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Fibroblast as a critical stromal cell type determining prognosis in prostate cancer

Blom, S., Erickson, A., Östman, A., Rannikko, A., Mirtti, T., Kallioniemi, O. & Pellinen, T., Sep 2019, In : Prostate. 79, 13, p. 1505-1513 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Lähtökohdaltaan tuntematon syöpä

Suonpää, P., Nevala, R., Beule, A., Schildt, J., Bova, S. & Mirtti, T., 2019, In : Duodecim. 135, 9, p. 838-846 9 p.

Research output: Contribution to journalReview ArticleScientificpeer-review

Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity

Polianskyte-Prause, Z., Tolvanen, T. A., Lindfors, S., Dumont, V., Van, M., Wang, H., Dash, S. N., Berg, M., Naams, J-B., Hautala, L. C., Nisen, H., Mirtti, T., Groop, P-H., Wähälä, K., Tienari, J. & Lehtonen, S., Feb 2019, In : FASEB Journal. 33, 2, p. 2858-2869 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Validation of IMPROD biparametric MRI in men with clinically suspected prostate cancer: A prospective multi-institutional trial

Jambor, I., Verho, J., Ettala, O., Knaapila, J., Taimen, P., Syvänen, K. T., Kiviniemi, A., Kähkönen, E., Perez, I. M., Seppänen, M., Rannikko, A., Oksanen, O., Riikonen, J., Vimpeli, S. M., Kauko, T., Merisaari, H., Kallajoki, M., Mirtti, T., Lamminen, T., Saunavaara, J. & 2 othersAronen, H. J. & Boström, P. J., 3 Jun 2019, In : PLoS Medicine. 16, 6, p. e1002813

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2018

Cumulative Cancer Locations is a Novel Metric for Predicting Active Surveillance Outcomes: A Multicenter Study

Erickson, A. M., Luzzago, S., Semjonow, A., Vasarainen, H., Laajala, T. D., Musi, G., de Cobelli, O., Mirtti, T. & Rannikko, A., Sep 2018, In : European urology oncology. 1, 4, p. 268-275 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Feasibility of Prostate PAXgene Fixation for Molecular Research and Diagnostic Surgical Pathology Comparison of Matched Fresh Frozen, FFPE, and PFPE Tissues

Högnäs, G., Kivinummi, K., Kallio, H. M. L., Hieta, R., Ruusuvuori, P., Koskenalho, A., Kesseli, J., Tammela, T. L. J., Riikonen, J., Ilvesaro, J., Kares, S., Hirvikoski, P. P., Laurila, M., Mirtti, T., Nykter, M., Kujala, P. M., Visakorpi, T., Tolonen, T. & Bova, G. S., Jan 2018, In : American Journal of Surgical Pathology. 42, 1, p. 103-115 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Increased HSF1 expression predicts shorter disease-specific survival of prostate cancer patients following radical prostatectomy

Björk, J. K., Ahonen, I., Mirtti, T., Erickson, A., Rannikko, A., Butzow, A., Nordling, S., Lundin, J., Lundin, M., Sistonen, L., Nees, M. & Akerfelt, M., 2018, In : Oncotarget. 9, 58, p. 31200-31213 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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ITGB1-dependent upregulation of Caveolin-1 switches TGF beta signalling from tumour-suppressive to oncogenic in prostate cancer

Pellinen, T., Blom, S., Sanchez, S., Välimäki, K., Mpindi, J-P., Azegrouz, H., Strippoli, R., Nieto, R., Viton, M., Palacios, I., Turkki, R., Wang, Y., Sanchez-Alvarez, M., Nordling, S., Bützow, A., Mirtti, T., Rannikko, A., Montoya, M. C., Kallioniemi, O. & del Pozo, M. A., 5 Feb 2018, In : Scientific Reports. 8, 1, 14 p., 2338.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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New prostate cancer grade grouping system predicts survival after radical prostatectomy

Erickson, A., Sandeman, K., Lahdensuo, K., Nordling, S., Kallajoki, M., Seikkula, H., Bützow, A., Vasarainen, H., Boström, P. J., Taimen, P., Rannikko, A. & Mirtti, T., May 2018, In : Human Pathology. 75, p. 159-166 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Patient Experience of Systematic Versus Fusion Prostate Biopsies

Eineluoto, J. T., Järvinen, P., Kilpeläinen, T., Lahdensuo, K., Kalalahti, I., Sandeman, K., Mirtti, T. & Rannikko, A., Aug 2018, In : European urology oncology. 1, 3, p. 202-207 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Proteaasit eturauhassyövän merkkiaineina

Koistinen, H., Rantala, J. & Mirtti, T. K., 2018, In : Kliin lab : kliinisen laboratorioalan julkaisu : SKKY:n jäsenlehti.. 35, 3, p. 62-65 4 p.

Research output: Contribution to journalArticleProfessional

Open Access
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Open Access
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Uusi eturauhassyövän seulontatutkimus pyrkii parantamaan hyötyjen ja haittojen suhdetta

ProScreen-tutkimusryhmä , 2018, In : Duodecim. 134, 15, p. 1429-1432 4 p.

Research output: Contribution to journalEditorialProfessional

Open Access
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2017

A randomized trial of early detection of clinically significant prostate cancer (ProScreen): study design and rationale

Auvinen, A., Rannikko, A., Taari, K., Kujala, P., Mirtti, T., Kenttämies, A., Rinta-Kiikka, I., Lehtimäki, T., Oksala, N., Pettersson, K. & Tammela, T. L., Jun 2017, In : European Journal of Epidemiology. 32, 6, p. 521-527 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Immunological tumor status may predict response to neoadjuvant chemotherapy and outcome after radical cystectomy in bladder cancer

Tervahartiala, M., Taimen, P., Mirtti, T., Koskinen, I., Ecke, T., Jalkanen, S. & Bostrom, P. J., 4 Oct 2017, In : Scientific Reports. 7, 9 p., 12682.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Open Access
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Precision systems medicine in urological Tumors – Molecular profiling and functional testing

Saeed, K., Ojamies, P., Pellinen, T., Rahkama, V., Eldfors, S., Paavolainen, L., Turkki, R., Horvath, P., Lundin, J., Nisén, H., af Hällström, T. M., Rannikko, A., Mirtti, T., Kallioniemi, O. & Östling, P., 17 Oct 2017, In : Annals of Oncology. 28, Suppl 7, 1 p.

Research output: Contribution to journalConference articleScientific

Open Access
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Prediction of overall survival for patients with metastatic castration-resistant prostate cancer: development of a prognostic model through a crowdsourced challenge with open clinical trial data

Guinney, J., Wang, T., Laajala, T. D., Winner, K. K., Bare, J. C., Neto, E. C., Khan, S. A., Peddinti, G., Airola, A., Pahikkala, T., Mirtti, T., Yu, T., Bot, B. M., Shen, L., Abdallah, K., Norman, T., Friend, S., Stolovitzky, G., Soule, H., Sweeney, C. J. & 8 othersRyan, C. J., Scher, H. I., Sartor, O., Xie, Y., Aittokallio, T., Zhou, F. L., Costello, J. C. & Prostate Canc Challenge DREAM Comm, Jan 2017, In : Lancet Oncology. 18, 1, p. 132-142 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Repeat multiparametric MRI in prostate cancer patients on active surveillance

Eineluoto, J. T., Jarvinen, P., Kenttämies, A., Kilpeläinen, T. P., Vasarainen, H., Sandeman, K., Erickson, A., Mirtti, T. & Rannikko, A., 27 Dec 2017, In : PLoS One. 12, 12, 11 p., 0189272.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2016

Association of Angiopoietin-2 and Ki-67 Expression with Vascular Density and Sunitinib Response in Metastatic Renal Cell Carcinoma

Rautiola, J., Lampinen, A., Mirtti, T., Ristimaki, A., Joensuu, H., Bono, P. & Saharinen, P., 21 Apr 2016, In : PLoS One. 11, 4, 15 p., 0153745.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Eturauhassyövän diagnostiikka murroksessa

Sandeman, K., Rannikko, A., Kenttämies, A. & Mirtti, T., 2016, In : Duodecim. 132, 24, p. 2351-2358 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Increased expression of fibroblast growth factor 13 in prostate cancer is associated with shortened time to biochemical recurrence after radical prostatectomy

Yu, L., Toriseva, M., Tuomala, M., Seikkula, H., Elo, T., Tuomela, J., Kallajoki, M., Mirtti, T., Taimen, P., Bostrom, P. J., Alanen, K., Nurmi, M., Nees, M. & Harkonen, P., 1 Jul 2016, In : International Journal of Cancer. 139, 1, p. 140-152 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access

Longitudinal modeling of ultrasensitive and traditional prostate-specific antigen and prediction of biochemical recurrence after radical prostatectomy

Laajala, T. D., Seikkula, H., Sadat, F. S., Mirtti, T., Bostrom, P. J. & Elo, L. L., 2 Nov 2016, In : Scientific Reports. 6, 10 p., 36161.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Loss of PTEN expression in ERG-negative prostate cancer predicts secondary therapies and leads to shorter disease-specific survival time after radical prostatectomy

Lahdensuo, K., Erickson, A., Saarinen, I., Seikkula, H., Lundin, J., Lundin, M., Nordling, S., Butzow, A., Vasarainen, H., Bostrom, P. J., Taimen, P., Rannikko, A. & Mirtti, T., Dec 2016, In : Modern Pathology. 29, 12, p. 1565-1574 10 p.

Research output: Contribution to journalArticleScientificpeer-review

Outcome of surgery for patients with renal cell carcinoma and tumour thrombus in the era of modern targeted therapy

Tornberg, S., Nisén, H., Visapää, H., Kilpeläinen, T. P., Järvinen, R., Mirtti, T., Kantonen, I., Simpanen, J., Bono, P., Taari, K. & Järvinen, P., 7 Sep 2016, In : Scandinavian Journal of Urology. 50, 5, p. 380-386 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

Androgen receptor-interacting protein HSPBAP1 facilitates growth of prostate cancer cells in androgen-deficient conditions

Saeed, K., Östling, P. K., Björkman, M., Mirtti, T., Alanen, K., Vesterinen, T., Sankila, A., Lundin, J., Lundin, M., Rannikko, A., Nordling, S., Mpindi, J-P., Kohonen, P., Iljin, K., Kallioniemi, O. & Rantala, J. K., 2015, In : International Journal of Cancer. 136, 11, p. 2535-2545 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Differential Predictive Roles of A- and B-Type Nuclear Lamins in Prostate Cancer Progression

Saarinen, I., Mirtti, T., Seikkula, H., Bostrom, P. J. & Taimen, P., 15 Oct 2015, In : PLoS One. 10, 10, 16 p., 0140671.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer

Hoang, D. T., Gu, L., Liao, Z., Shen, F., Talati, P. G., Koptyra, M., Tan, S-H., Ellsworth, E., Gupta, S., Montie, H., Dagvadorj, A., Savolainen, S., Leiby, B., Mirtti, T., Merry, D. E. & Nevalainen, M. T., Mar 2015, In : Molecular Cancer Therapeutics. 14, 3, p. 713-726 14 p.

Research output: Contribution to journalArticleScientificpeer-review

Performance of transrectal prostate biopsies in detecting tumours and implications for focal therapy

Lahdensuo, K., Mirtti, T., Petas, A. & Rannikko, A., Apr 2015, In : Scandinavian Journal of Urology. 49, 2, p. 90-96 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Rac1 Nucleocytoplasmic Shuttling Drives Nuclear Shape Changes and Tumor Invasion

Navarro-Lerida, I., Pellinen, T., Sanchez, S. A., Guadamillas, M. C., Wang, Y., Mirtti, T., Calvo, E. & Del Pozo, M. A., 9 Feb 2015, In : Developmental Cell. 32, 3, p. 318-334 17 p.

Research output: Contribution to journalArticleScientificpeer-review

Tumor-Associated Macrophages Provide Significant Prognostic Information in Urothelial Bladder Cancer

Bostrom, M. M., Irjala, H., Mirtti, T., Taimen, P., Kauko, T., Algars, A., Jalkanen, S. & Bostrom, P. J., 21 Jul 2015, In : PLoS One. 10, 7, 16 p., 0133552.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2014

Pharmacologic Suppression of JAK1/2 by JAK1/2 Inhibitor AZD1480 Potently Inhibits IL-6-Induced Experimental Prostate Cancer Metastases Formation

Gu, L., Talati, P., Vogiatzi, P., Romero-Weaver, A. L., Abdulghani, J., Liao, Z., Leiby, B., Hoang, D. T., Mirtti, T., Alanen, K., Zinda, M., Huszar, D. & Nevalainen, M. T., May 2014, In : Molecular Cancer Therapeutics. 13, 5, p. 1246-1258 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

Nuclear Stat5a/b predicts early recurrence and prostate cancer-specific death in patients treated by radical prostatectomy

Mirtti, T., Leiby, B. E., Abdulghani, J., Aaltonen, E., Pavela, M., Mamtani, A., Alanen, K., Egevad, L., Granfors, T., Josefsson, A., Stattin, P., Bergh, A. & Nevalainen, M. T., Mar 2013, In : Human Pathology. 44, 3, p. 310-319 10 p.

Research output: Contribution to journalArticleScientificpeer-review

STAT5A/B Gene Locus Undergoes Amplification during Human Prostate Cancer Progression

Haddad, B. R., Gu, L., Mirtti, T., Dagvadorj, A., Vogiatzi, P., Hoang, D. T., Bajaj, R., Leiby, B., Ellsworth, E., Blackmon, S., Ruiz, C., Curtis, M., Fortina, P., Ertel, A., Liu, C., Rui, H., Visakorpi, T., Bubendorf, L., Lallas, C. D., Trabulsi, E. J. & 3 othersMcCue, P., Gomella, L. & Nevalainen, M. T., Jun 2013, In : The American Journal of Pathology. 182, 6, p. 2264-2275 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Upper urinary tract and urethral recurrences following radical cystectomy: review of risk factors and outcomes between centres with different follow-up protocols

Perlis, N., Turker, P., Bostrom, P. J., Kuk, C., Mirtti, T., Kulkarni, G., Fleshner, N. E., Jewett, M. A. S., Finelli, A. & Zlotta, A. R., Feb 2013, In : World Journal of Urology. 31, 1, p. 161-167 7 p.

Research output: Contribution to journalArticleScientificpeer-review

2012

Does patient age affect survival after radical cystectomy?

Horovitz, D., Turker, P., Bostrom, P. J., Mirtti, T., Nurmi, M., Kuk, C., Kulkarni, G., Fleshner, N. E., Finelli, A., Jewett, M. A. & Zlotta, A. R., Dec 2012, In : BJU International. 110, 11B, p. E486-E493 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Eturauhassyövän yksilöllinen hoitovalinta : apuna molekyylipatologiset merkkiaineet ja biopankki

Mirtti, T. & Rannikko, A., 2012, In : Duodecim. 128, 24, p. 2497-2499 3 p.

Research output: Contribution to journalArticleScientific

High-Throughput Transcriptomic and RNAi Analysis Identifies AIM1, ERGIC1, TMED3 and TPX2 as Potential Drug Targets in Prostate Cancer

Vainio, P., Mpindi, J. P., Kohonen, P., Fey, V., Mirtti, T., Alanen, K. A., Perala, M., Kallioniemi, O. & Iljin, K., 2012, In : PLoS One. 7, 6, p. Article Number: e398013 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models

Härmä, V., Knuuttila, M., Virtanen, J., Mirtti, T., Kohonen, P., Kovanen, P. E., Happonen, A., Kaewphan, S., Ahonen, I., Kallioniemi, O., Nees, M., Grafström, R. & Lötjönen, J., 2012, In : Oncogene. 31, 16, p. 2075-2089 16 p.

Research output: Contribution to journalArticleScientificpeer-review

Sex differences in bladder cancer outcomes among smokers with advanced bladder cancer

Bostroem, P. J., Alkhateeb, S., Trottier, G., Athanasopoulos, P. Z., Mirtti, T., Kortekangas, H., Laato, M., van Rhijn, B., van der Kwast, T., Fleshner, N. E., Jewett, M. A., Finelli, A. & Zlotta, A. R., 2012, In : BJU International. 109, 1, p. 70-76 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion.

Björkman, M., Östling, P. K., Härmä, V., Virtanen, J., Mpindi, JP., Rantala, J., Mirtti, T., Vesterinen, T., Lundin, M. E., Sankila, A. M., Rannikko, A. S., Kaivanto, E., Kohonen, P., Kallioniemi, O-P. & Nees, M., 2012, In : Oncogene. 31, 29, p. 3444-3456 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Transcription Factors Stat5a/b and Stat3 in Prostate Cancer Growth and Metastases

Mirtti, T., Talati, P. & Nevalainen, M. T., 2012, Signaling Pathways and Molecular Mediators in Metastasis : Transcription Factors Stat5a/b and Stat3 in Prostate Cancer Growth and Metastases. Fatatis, A. (ed.). Netherlands: Springer, p. 245-260 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Upstaging of urothelial cancer at the time of radical cystectomy: factors associated with upstaging and its effect on outcome

Turker, P., Bostrom, P. J., Wroclawski, M. L., van Rhijn, B., Kortekangas, H., Kuk, C., Mirtti, T., Fleshner, N. E., Jewett, M. A., Finelli, A., Kwast, T. V., Evans, A., Sweet, J., Laato, M. & Zlotta, A. R., 1 Sep 2012, In : BJU International. 110, 6, p. 804-811 8 p.

Research output: Contribution to journalArticleScientificpeer-review

2011

Detection of melanoma-derived cancer-testis antigen CT16 in patient sera by a novel immunoassay

Rappu, P., Nylund, C., Ristiniemi, N., Kulpakko, J., Vihinen, P., Hernberg, M., Mirtti, T., Alanen, K., Kallajoki, M., Vuoristo, M-S., Pyrhonen, S. & Heino, J., 2011, In : International Journal of Cancer. 128, 10, p. 2382-2392 11 p.

Research output: Contribution to journalArticleScientificpeer-review

Dual role of FoxA1 in androgen receptor binding to chromatin, androgen signalling and prostate cancer

Sahu, B., Laakso, M., Ovaska, K., Mirtti, T., Lundin, J., Rannikko, A., Sankila, A., Turunen, J-P., Lundin, M., Konsti, J., Vesterinen, T., Nordling, S., Kallioniemi, O., Hautaniemi, S. & Janne, O. A., 2011, In : EMBO Journal. 30, 19, p. 3962-3976 15 p.

Research output: Contribution to journalArticleScientificpeer-review

Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins

Vainio, P., Lehtinen, L., Mirtti, T., Hilvo, M., Seppänen-Laakso, T., Virtanen, J., Sankila, A., Nordling, F. S. A., Lundin, J., Rannikko, A., Orešič, M., Kallioniemi, O. & Iljin, K., 2011, In : Oncotarget. 2, 12, p. 1176-1190 15 p.

Research output: Contribution to journalArticleScientificpeer-review