Research Output per year
Publications 2005 2019
2019
Dehydroabietylamine-Based Cellulose Nanofibril Films: A New Class of Sustainable Biomaterials for Highly Efficient, Broad-Spectrum Antimicrobial Effects
Hassan, G. A. M. S., Forsman, N., Wan, X., Keurulainen, L., Bimbo, L. M., Johansson, L-S., Sipari, N., Yli-Kauhaluoma, J. T., Zimmermann, R., Stehl, S., Werner, C., Saris, P. E. J., Österberg, M. & Moreira, V. M., 4 Mar 2019, In : ACS Sustainable Chemistry & Engineering. 7, 5, p. 5002-5009 8 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
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Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo
Mäki-Opas, I., Hämäläinen, M., Moilanen, L., Haavikko, R. H., Ahonen, T. J., Alakurtti, S., Moreira, V. M., Muraki, K., Yli-Kauhaluoma, J. T. & Moilanen, E., 19 Jun 2019, In : ACS chemical neuroscience. 10, 6, p. 2848-2857 10 p.Research output: Contribution to journal › Article › Scientific › peer-review
2018
Catalytic, Tunable, One-Step Bismuth(III) Triflate Reaction with Alcohols: Dehydration Versus Dimerization
Kolsi, L. E., Yli-Kauhaluoma, J. & Moreira, V. M., 9 Aug 2018, In : ACS Omega. 3, 8, p. 8836–8842 7 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
Dehydroabietic oximes halt pancreatic cancer cell growth in the G1 phase through induction of p27 and downregulation of cyclin D1
Kolsi, L. E., Leal, A. S., Yli-Kauhaluoma, J., Liby, K. T. & Moreira, V. M., 29 Oct 2018, In : Scientific Reports. 8, p. 1-13 13 p., 15923.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
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Discovery of 12-thiazole abietanes as selective inhibitors of the human metabolic serine hydrolase hABHD16A
Ahonen, T. J., Savinainen, J. R., Yli-Kauhaluoma, J. T., Kalso, E. A., Laitinen, J. T. & Moreira, V. M., 13 Dec 2018, In : ACS Medicinal Chemistry Letters. 9, 12, p. 1269-1273 9 p.Research output: Contribution to journal › Article › Scientific › peer-review
Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors
Ahonen, T. J., Rinne, M., Grutschreiber, P., Mätlik, K., Airavaara, M., Schaarschmidt, D., Lang, H., Reiss, D., Xhaard, H., Gaveriaux-Ruff, C., Yli-Kauhaluoma, J. & Moreira, V. M., 10 May 2018, In : European Journal of Medicinal Chemistry. 151, p. 495-507 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents
Figueiredo, J., Serrano, J. L., Cavalheiro, E., Keurulainen, L., Yli-Kauhaluoma, J. T., Moreira, V. M., Ferreira, S., Domingues, F. C., Silvestre, S. & Almeida, P., 1 Jan 2018, In : European Journal of Medicinal Chemistry. 143, p. 829-842 14 p.Research output: Contribution to journal › Article › Scientific › peer-review
2017
Antibacterial profiling of abietane-type diterpenoids
Helfenstein, A., Vahermo, M. M. A., Nawrot, D. A., Demirci, F., İşcan, G., Krogerus, S., Yli-Kauhaluoma, J. T., Moreira, V. M. & Tammela, P. S. M., Jan 2017, In : Bioorganic & Medicinal Chemistry. 25, 1, p. 132-137 6 p.Research output: Contribution to journal › Article › Scientific › peer-review
File
Pyrazine-fused triterpenoids block transient receptor potential ankyrin-1 (TRPA1) ion channel in vitro and inhibit TRPA1-mediated acute inflammation in vivo
Mäki-Opas, I., Hämäläinen, M., Moilanen, L. J., Ahonen, T., Haavikko, R., Moreira, V., Muraki, K., Yli-Kauhaluoma, J. T. & Moilainen, E., 18 Sep 2017, p. 424. 1 p.Research output: Conference materials › Abstract
Regioselective Benzylic Oxidation of Aromatic Abietanes: Application to the Semisynthesis of the Naturally Occurring Picealactones A, B and C
Kolsi, L. E., Krogerus, S., Brito, V., Rüffer, T., Lang, H., Yli-Kauhaluoma, J. T., Silvestre, S. & Moreira, V. M., 22 Aug 2017, In : ChemistrySelect. 2, 24, p. 7008-7012 5 p.Research output: Contribution to journal › Article › Scientific › peer-review
2016
Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi
Pirttimaa, M., Nasereddin, A., Kopelyanskiy, D., Kaiser, M., Yli-Kauhaluoma, J., Oksman-Caldentey, K-M., Brun, R., Jaffe, C. L., Moreira, V. M. & Alakurtti, S., Feb 2016, In : Journal of Natural Products. 79, 2, p. 362-368 7 p.Research output: Contribution to journal › Article › Scientific › peer-review
Abietane-type diterpenoids (WO 2016/051013 A1)
Moreira, V. M., Fallarero, A., Yli-Kauhaluoma, J., Vuorela, P. & Vahermo, M. M. A., 7 Apr 2016, Patent No. WO 2016/051013 A1, 7 Apr 2016Research output: Patent
Open Access
Antiprotozoal activity of dehydroabietic acid derivatives against Leishmania donovani and Trypanosoma cruzi - SPECIAL ISSUE "NEW TALENT: EUROPE"
Vahermo, M., Krogerus, S., Nasereddin, A., Kaiser, M., Brun, R., Jaffe, C. L., Yli-Kauhaluoma, J. & Moreira, V. M., 2016, In : MedChemComm. 7, 3, p. 457-463 7 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo
Laavola, M., Haavikko, R., Hämäläinen, M., Leppänen, T., Nieminen, R., Alakurtti, S., Moreira, V. M., Yli-Kauhaluoma, J. & Moilanen, E., Feb 2016, In : Journal of Natural Products. 79, 2, p. 274-280 7 p.Research output: Contribution to journal › Article › Scientific › peer-review
Contributors to ‘New Talent: Europe’
Moreira, V. M., 16 Mar 2016, (In preparation)Research output: Other contribution
Synthesis and Anti-Proliferative Activity of Sulfanyltriazolylnaphthalenols and Sulfanyltriazolylnaphthalene-1,4-diones
Chaaban, I., El Khawass, E. S. M., Abd El Razik, H. A., El Salamouni, N. S., Redondo-Horcajo, M., Barasoain, I., Fernando Diaz, J., Yli-Kauhaluoma, J. & Moreira, V. M., Sep 2016, In : Archiv der Pharmazie : Chemistry in life sciences. 349, 9, p. 749-761 13 p.Research output: Contribution to journal › Article › Scientific › peer-review
2015
New derivatives of dehydroabietic acid target planktonic and biofilm bacteria in Staphylococcus aureus and effectively disrupt bacterial membrane integrity
Manner, S., Vahermo, M., Skogman, M., Krogerus, S., Vuorela, P. M., Yli-Kauhaluoma, J., Fallarero, A. & Moreira, V. M., 21 Jul 2015, In : European Journal of Medicinal Chemistry. 102, p. 68-79 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development
Härmä, V., Haavikko, R., Virtanen, J., Ahonen, I., Schukov, H-P., Alakurtti, S., Purev, E., Rischer, H., Yli-Kauhaluoma, J., Moreira, V. M., Nees, M. & Oksman-Caldentey, K-M., 12 May 2015, In : PLoS One. 10, 5, 22 p., 0126111.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
2014
Isolation and purification of ent-pimara-8(14),15-diene from engineered Aspergillus nidulans by accelerated solvent extraction combined with HPLC
Bromann, K., Viljanen, K., Moreira, V. M., Yli-Kauhaluoma, J., Ruohonen, L. & Nakari-Setälä, T., 2014, In : Analytical Methods. 6, 4, p. 1227-1234 8 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
Synthesis and biological evaluation of new oxadiazoline-substituted naphthalenyl acetates as anticancer agents
Chaaban, I., El Khawass, E. S. M., El Razik, H. A. A., El Salamouni, N. S., Redondo-Horcajo, M., Barasoain, I., Díaz, J. F., Yli-Kauhaluoma, J. & Moreira, V. M., Oct 2014, In : European Journal of Medicinal Chemistry. 87, p. 805-813 9 p.Research output: Contribution to journal › Article › Scientific › peer-review
2013
(+)-Dehydroabietic Acid, an Abietane-Type Diterpene, Inhibits Staphylococcus aureus Biofilms in Vitro
Fallarero, A., Skogman, M., Kujala, J., Rajaratnam, M., Moreira, V. M., Yli-Kauhaluoma, J. & Vuorela, P., Jun 2013, In : International Journal of Molecular Sciences. 14, 6, p. 12054-12072 19 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open Access
File
Drug repositioning: a machine-learning approach through data integration
Napolitano, F., Zhao, Y., Moreira, V. M., Tagliaferri, R., Kere, J., D'Amato, M. & Greco, D., 22 Jun 2013, In : Journal of Cheminformatics. 5, Article Number: 30 , 9 p.Research output: Contribution to journal › Article › Scientific › peer-review
Novel Oleanolic Vinyl Boronates: Synthesis and Antitumor Activity
Moreira, V. M., Salvador, J. A. R., Simões, S., Destro, F. & Gavioli, R., 31 Jan 2013, In : European Journal of Medicinal Chemistry. 63, p. 46-56Research output: Contribution to journal › Article › Scientific › peer-review
Steroidal CYP17 Inhibitors for Prostate Cancer Treatment. From Concept to Clinic.
Salvador, J. A. R., Moreira, V. M. & Silvestre, S. M., 16 Jan 2013, Advances in Prostate Cancer. Hamilton, G. (ed.). Rijeka: INTECHopen, p. 275-304 30 p.Research output: Chapter in Book/Report/Conference proceeding › Chapter › Scientific › peer-review
2012
Efficient oxidation of oleanolic acid derivatives using magnesium bis(monoperoxyphthalate) hexahydrate (MMPP): A convenient 2-step procedure towards 12-oxo-28-carboxylic acid derivatives.
Salvador, J. A. R., Moreira, V. M., Pinto, R. M. A., Leal, A. S. & Paixão, J. A., 30 Jan 2012, In : Beilstein Journal of Organic Chemistry. 8, p. 164-169 6 p.Research output: Contribution to journal › Article › Scientific › peer-review
Recent Developments in Oxidative Processes in Steroid Chemistry
Salvador, J. A. R., Silvestre, S. M. & Moreira, V. M., May 2012, In : Current Organic Chemistry. 16, p. 1243-1276Research output: Contribution to journal › Review Article › Scientific › peer-review
Ursane-type Pentacyclic Triterpenoids as Useful Platforms in Anticancer Drug Discovery
Salvador, J. A. R., Moreira, V. M., Goncalves, B. M. F., Leal, A. S. & Jing, Y., 9 Oct 2012, In : Natural Product Reports. 29, p. 1463-1479Research output: Contribution to journal › Review Article › Scientific › peer-review
2011
Bismuth(III) Triflate-Based Catalytic Direct Opening of Oleanolic Hydroxy-gamma-lactones to Afford 12-Oxo-28-carboxylic Acids
Salvador, J. A. R., Moreira, V. M., Pinto, R. M. A., Leal, A. S. & Le Roux, C., 10 Oct 2011, In : Advanced Synthesis & Catalysis. 353, p. 2637-2642Research output: Contribution to journal › Article › Scientific › peer-review
C16 and C17-Heterocycle Bearing Androstanes. CYP17 Inhibition Studies and Multiple Effects on Prostate Cancer Cells
Moreira, V. M., Salvador, J. A. R., Matos Beja, A., Paixão, J. A., Vasaitis, T. S. & Njar, V. C. O., 24 Sep 2011, In : European Journal of Pharmaceutical Sciences. 44, p. 43 1 p.Research output: Contribution to journal › Conference article › Scientific › peer-review
Highlights of Natural Compounds in Prostate Cancer Drug Discovery
Salvador, J. & Moreira, V. M., 2011, Prostate Cancer - From Bench to Bedside. Spiess, P. E. (ed.). INTECHopenResearch output: Chapter in Book/Report/Conference proceeding › Chapter › Scientific › peer-review
The reaction of azoles with 17-chloro-16-formylandrosta-5,16-dien-3-yl-acetate: Synthesis and structural elucidation of novel 16-azolylmethylene-17-oxoandrostanes.
Moreira, V. M., Salvador, J. A. R., Matos Beja, A. & Paixão, J. A., 23 Feb 2011, In : Steroids. 76, p. 582-587Research output: Contribution to journal › Article › Scientific › peer-review
2010
Semisynthetic Pentacyclic Triterpenoids in the Cancer Setting: Ursolic Acid and its Derivatives
Salvador, J. A. R. & Moreira, V. M., 2010, Pentacyclic Triterpenes as Promising Agents in Cancer. Salvador, J. A. R. (ed.). Nova Science PublishersResearch output: Chapter in Book/Report/Conference proceeding › Chapter › Scientific › peer-review
The multiple effects of CYP17 inhibitors on prostate cancer cells
Moreira, V. & Salvador, J., Sep 2010, In : Drugs of the Future. 35, Suppl. AResearch output: Contribution to journal › Conference article › Scientific › peer-review
2009
3-Oxoandrosta-4,6-dien-17β-yl-2'-methyl-1H-imidazole-1-carboxylate and 3-oxo-5α-androst-17β-yl-2'-methyl-1H-imidazole-1-carboxylate: C—H..π and π•••π intermolecular interactions
Silva, M. R., Moreira, V. M., Cardoso, C., Matos Beja, A. & Salvador, J. A. R., 7 Feb 2009, In : Acta Crystallographica. Section C: Crystal Structure Communications. C65, p. o88-o91Research output: Contribution to journal › Article › Scientific › peer-review
Natural Products Action on Prostate Cancer Cell Growth, Signaling and Survival
Salvador, J. A. R. & Moreira, V. M., 2009, Handbook of Prostate Cancer Cell Research: Growth, Signalling and Survival. Meredith, A. T. (ed.). Nova Science PublishersResearch output: Chapter in Book/Report/Conference proceeding › Chapter › Scientific › peer-review
2008
1H-and 2H-indazole derivatives of androsta-5,16-dien-3β-ol
Silva, M. R., Moreira, V., Cardoso, C., M. Beja, A. & Salvador, J. A. R., 15 Mar 2008, In : Acta Crystallographica. Section C: Crystal Structure Communications. C64, p. o217-o219Research output: Contribution to journal › Article › Scientific › peer-review
Catalytic Epoxidation and syn-Dihydroxylation Reactions in Steroid Chemistry
Salvador, J. A. R., Silvestre, S. M. & Moreira, V. M., 2008, In : Current Organic Chemistry. 12, p. 492-522Research output: Contribution to journal › Review Article › Scientific › peer-review
Conformation of 17-Chloro-16-formylandrosta-5,16-dien-3β-yl acetate and 17-chloroandrosta-5,16-dien-3β-yl acetate
Silva, M. R., Moreira, V. M., Cardoso, C., Matos Beja, A. & Salvador, J. A. R., 2008, In : Acta Crystallographica. Section C: Crystal Structure Communications. C64, p. o529-o531Research output: Contribution to journal › Article › Scientific › peer-review
CYP17 Inhibitors for Prostate Cancer Treatment – An Update
Moreira, V. M., Salvador, J. A. R., Vasaitis, T. S. & Njar, V. C. O., 26 Feb 2008, In : Current Medicinal Chemistry. 15, p. 868-899Research output: Contribution to journal › Review Article › Scientific › peer-review
Multiple targeted actions of CYP17 inhibitors on prostate cancer cells
Moreira, V. M. & Salvador, J. A. R., 2008, In : Revista Portuguesa de Farmácia. LII (3) Suppl., 46Research output: Contribution to journal › Conference article › Scientific › peer-review
Novos esteróides inibidores da biossíntese de androgénios
Research output: Thesis › Doctoral Thesis
Synthesis of novel C17 steroidal carbamates. Studies on CYP17 action, androgen receptor binding and function, and prostate cancer cell growth
Moreira, V. M., Vasaitis, T. S., Guo, Z., Njar, V. C. O. & Salvador, J. A. R., 6 Jun 2008, In : Steroids. 73, p. 1217-1227Research output: Contribution to journal › Article › Scientific › peer-review
2007
3-Oxoandrost-4-en-17beta-yl 1H-imidazole-1-carboxylate
Silva, M. R., Matos Beja, A., Moreira, V., Santos, R. C. & Salvador, J. A. R., 9 Nov 2007, In : Acta Crystallographica. Section E: Structure Reports Online. E63, p. o4824-Research output: Contribution to journal › Article › Scientific › peer-review
Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
Moreira, V., Vasaitis, T. S., Njar, V. C. O. & Salvador, J. A. R., 15 Aug 2007, In : Steroids. 72, p. 939-948Research output: Contribution to journal › Article › Scientific › peer-review
2006
Catalytic oxidative processes in steroid chemistry: allylic oxidation, β-selective epoxidation, alcohol oxidations and remote functionalization reactions
Salvador, J. A. R., Silvestre, S. M. & Moreira, V. M., 2006, In : Current Organic Chemistry. 10, p. 2227-2257Research output: Contribution to journal › Review Article › Scientific › peer-review
2005
New 5beta,6beta-epoxysteroids with cytotoxic activity
Moreira, V., Salvador, J., Sa e Melo, L., Hanson, J., Marques, A. & Simoes, S., Jun 2005, In : Scientia pharmaceutica. 73, S8Research output: Contribution to journal › Conference article › Scientific › peer-review
One-pot, high yield synthesis of α-ketols from delta5-steroids
Salvador, J. A. R., Moreira, V., Hanson, J. R. & Carvalho, R. A., 20 Dec 2005, In : Steroids. 71, p. 266-272 7 p.Research output: Contribution to journal › Article › Scientific › peer-review