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Publications 2005 2019

2019

Dehydroabietylamine-Based Cellulose Nanofibril Films: A New Class of Sustainable Biomaterials for Highly Efficient, Broad-Spectrum Antimicrobial Effects

Hassan, G. A. M. S., Forsman, N., Wan, X., Keurulainen, L., Bimbo, L. M., Johansson, L-S., Sipari, N., Yli-Kauhaluoma, J. T., Zimmermann, R., Stehl, S., Werner, C., Saris, P. E. J., Österberg, M. & Moreira, V. M., 4 Mar 2019, In : ACS Sustainable Chemistry & Engineering. 7, 5, p. 5002-5009 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo

Mäki-Opas, I., Hämäläinen, M., Moilanen, L., Haavikko, R. H., Ahonen, T. J., Alakurtti, S., Moreira, V. M., Muraki, K., Yli-Kauhaluoma, J. T. & Moilanen, E., 19 Jun 2019, In : ACS chemical neuroscience. 10, 6, p. 2848-2857 10 p.

Research output: Contribution to journalArticleScientificpeer-review

2018

Catalytic, Tunable, One-Step Bismuth(III) Triflate Reaction with Alcohols: Dehydration Versus Dimerization

Kolsi, L. E., Yli-Kauhaluoma, J. & Moreira, V. M., 9 Aug 2018, In : ACS Omega. 3, 8, p. 8836–8842 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Dehydroabietic oximes halt pancreatic cancer cell growth in the G1 phase through induction of p27 and downregulation of cyclin D1

Kolsi, L. E., Leal, A. S., Yli-Kauhaluoma, J., Liby, K. T. & Moreira, V. M., 29 Oct 2018, In : Scientific Reports. 8, p. 1-13 13 p., 15923.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Discovery of 12-thiazole abietanes as selective inhibitors of the human metabolic serine hydrolase hABHD16A

Ahonen, T. J., Savinainen, J. R., Yli-Kauhaluoma, J. T., Kalso, E. A., Laitinen, J. T. & Moreira, V. M., 13 Dec 2018, In : ACS Medicinal Chemistry Letters. 9, 12, p. 1269-1273 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors

Ahonen, T. J., Rinne, M., Grutschreiber, P., Mätlik, K., Airavaara, M., Schaarschmidt, D., Lang, H., Reiss, D., Xhaard, H., Gaveriaux-Ruff, C., Yli-Kauhaluoma, J. & Moreira, V. M., 10 May 2018, In : European Journal of Medicinal Chemistry. 151, p. 495-507 13 p.

Research output: Contribution to journalArticleScientificpeer-review

Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents

Figueiredo, J., Serrano, J. L., Cavalheiro, E., Keurulainen, L., Yli-Kauhaluoma, J. T., Moreira, V. M., Ferreira, S., Domingues, F. C., Silvestre, S. & Almeida, P., 1 Jan 2018, In : European Journal of Medicinal Chemistry. 143, p. 829-842 14 p.

Research output: Contribution to journalArticleScientificpeer-review

2017

Antibacterial profiling of abietane-type diterpenoids

Helfenstein, A., Vahermo, M. M. A., Nawrot, D. A., Demirci, F., İşcan, G., Krogerus, S., Yli-Kauhaluoma, J. T., Moreira, V. M. & Tammela, P. S. M., Jan 2017, In : Bioorganic & Medicinal Chemistry. 25, 1, p. 132-137 6 p.

Research output: Contribution to journalArticleScientificpeer-review

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Pyrazine-fused triterpenoids block transient receptor potential ankyrin-1 (TRPA1) ion channel in vitro and inhibit TRPA1-mediated acute inflammation in vivo

Mäki-Opas, I., Hämäläinen, M., Moilanen, L. J., Ahonen, T., Haavikko, R., Moreira, V., Muraki, K., Yli-Kauhaluoma, J. T. & Moilainen, E., 18 Sep 2017, p. 424. 1 p.

Research output: Conference materialsAbstract

Regioselective Benzylic Oxidation of Aromatic Abietanes: Application to the Semisynthesis of the Naturally Occurring Picealactones A, B and C

Kolsi, L. E., Krogerus, S., Brito, V., Rüffer, T., Lang, H., Yli-Kauhaluoma, J. T., Silvestre, S. & Moreira, V. M., 22 Aug 2017, In : ChemistrySelect. 2, 24, p. 7008-7012 5 p.

Research output: Contribution to journalArticleScientificpeer-review

2016

Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi

Pirttimaa, M., Nasereddin, A., Kopelyanskiy, D., Kaiser, M., Yli-Kauhaluoma, J., Oksman-Caldentey, K-M., Brun, R., Jaffe, C. L., Moreira, V. M. & Alakurtti, S., Feb 2016, In : Journal of Natural Products. 79, 2, p. 362-368 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Abietane-type diterpenoids (WO 2016/051013 A1)

Moreira, V. M., Fallarero, A., Yli-Kauhaluoma, J., Vuorela, P. & Vahermo, M. M. A., 7 Apr 2016, Patent No. WO 2016/051013 A1, 7 Apr 2016

Research output: Patent

Open Access

Antiprotozoal activity of dehydroabietic acid derivatives against Leishmania donovani and Trypanosoma cruzi - SPECIAL ISSUE "NEW TALENT: EUROPE"

Vahermo, M., Krogerus, S., Nasereddin, A., Kaiser, M., Brun, R., Jaffe, C. L., Yli-Kauhaluoma, J. & Moreira, V. M., 2016, In : MedChemComm. 7, 3, p. 457-463 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo

Laavola, M., Haavikko, R., Hämäläinen, M., Leppänen, T., Nieminen, R., Alakurtti, S., Moreira, V. M., Yli-Kauhaluoma, J. & Moilanen, E., Feb 2016, In : Journal of Natural Products. 79, 2, p. 274-280 7 p.

Research output: Contribution to journalArticleScientificpeer-review

Contributors to ‘New Talent: Europe’

Moreira, V. M., 16 Mar 2016, (In preparation)

Research output: Other contribution

Synthesis and Anti-Proliferative Activity of Sulfanyltriazolylnaphthalenols and Sulfanyltriazolylnaphthalene-1,4-diones

Chaaban, I., El Khawass, E. S. M., Abd El Razik, H. A., El Salamouni, N. S., Redondo-Horcajo, M., Barasoain, I., Fernando Diaz, J., Yli-Kauhaluoma, J. & Moreira, V. M., Sep 2016, In : Archiv der Pharmazie : Chemistry in life sciences. 349, 9, p. 749-761 13 p.

Research output: Contribution to journalArticleScientificpeer-review

2015

New derivatives of dehydroabietic acid target planktonic and biofilm bacteria in Staphylococcus aureus and effectively disrupt bacterial membrane integrity

Manner, S., Vahermo, M., Skogman, M., Krogerus, S., Vuorela, P. M., Yli-Kauhaluoma, J., Fallarero, A. & Moreira, V. M., 21 Jul 2015, In : European Journal of Medicinal Chemistry. 102, p. 68-79 12 p.

Research output: Contribution to journalArticleScientificpeer-review

Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development

Härmä, V., Haavikko, R., Virtanen, J., Ahonen, I., Schukov, H-P., Alakurtti, S., Purev, E., Rischer, H., Yli-Kauhaluoma, J., Moreira, V. M., Nees, M. & Oksman-Caldentey, K-M., 12 May 2015, In : PLoS One. 10, 5, 22 p., 0126111.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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2014

Isolation and purification of ent-pimara-8(14),15-diene from engineered Aspergillus nidulans by accelerated solvent extraction combined with HPLC

Bromann, K., Viljanen, K., Moreira, V. M., Yli-Kauhaluoma, J., Ruohonen, L. & Nakari-Setälä, T., 2014, In : Analytical Methods. 6, 4, p. 1227-1234 8 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Synthesis and biological evaluation of new oxadiazoline-substituted naphthalenyl acetates as anticancer agents

Chaaban, I., El Khawass, E. S. M., El Razik, H. A. A., El Salamouni, N. S., Redondo-Horcajo, M., Barasoain, I., Díaz, J. F., Yli-Kauhaluoma, J. & Moreira, V. M., Oct 2014, In : European Journal of Medicinal Chemistry. 87, p. 805-813 9 p.

Research output: Contribution to journalArticleScientificpeer-review

2013

(+)-Dehydroabietic Acid, an Abietane-Type Diterpene, Inhibits Staphylococcus aureus Biofilms in Vitro

Fallarero, A., Skogman, M., Kujala, J., Rajaratnam, M., Moreira, V. M., Yli-Kauhaluoma, J. & Vuorela, P., Jun 2013, In : International Journal of Molecular Sciences. 14, 6, p. 12054-12072 19 p.

Research output: Contribution to journalArticleScientificpeer-review

Open Access
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Drug repositioning: a machine-learning approach through data integration

Napolitano, F., Zhao, Y., Moreira, V. M., Tagliaferri, R., Kere, J., D'Amato, M. & Greco, D., 22 Jun 2013, In : Journal of Cheminformatics. 5, Article Number: 30 , 9 p.

Research output: Contribution to journalArticleScientificpeer-review

Novel Oleanolic Vinyl Boronates: Synthesis and Antitumor Activity

Moreira, V. M., Salvador, J. A. R., Simões, S., Destro, F. & Gavioli, R., 31 Jan 2013, In : European Journal of Medicinal Chemistry. 63, p. 46-56

Research output: Contribution to journalArticleScientificpeer-review

Steroidal CYP17 Inhibitors for Prostate Cancer Treatment. From Concept to Clinic.

Salvador, J. A. R., Moreira, V. M. & Silvestre, S. M., 16 Jan 2013, Advances in Prostate Cancer. Hamilton, G. (ed.). Rijeka: INTECHopen, p. 275-304 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

2012

Efficient oxidation of oleanolic acid derivatives using magnesium bis(monoperoxyphthalate) hexahydrate (MMPP): A convenient 2-step procedure towards 12-oxo-28-carboxylic acid derivatives.

Salvador, J. A. R., Moreira, V. M., Pinto, R. M. A., Leal, A. S. & Paixão, J. A., 30 Jan 2012, In : Beilstein Journal of Organic Chemistry. 8, p. 164-169 6 p.

Research output: Contribution to journalArticleScientificpeer-review

Recent Developments in Oxidative Processes in Steroid Chemistry

Salvador, J. A. R., Silvestre, S. M. & Moreira, V. M., May 2012, In : Current Organic Chemistry. 16, p. 1243-1276

Research output: Contribution to journalReview ArticleScientificpeer-review

Ursane-type Pentacyclic Triterpenoids as Useful Platforms in Anticancer Drug Discovery

Salvador, J. A. R., Moreira, V. M., Goncalves, B. M. F., Leal, A. S. & Jing, Y., 9 Oct 2012, In : Natural Product Reports. 29, p. 1463-1479

Research output: Contribution to journalReview ArticleScientificpeer-review

2011

Bismuth(III) Triflate-Based Catalytic Direct Opening of Oleanolic Hydroxy-gamma-lactones to Afford 12-Oxo-28-carboxylic Acids

Salvador, J. A. R., Moreira, V. M., Pinto, R. M. A., Leal, A. S. & Le Roux, C., 10 Oct 2011, In : Advanced Synthesis & Catalysis. 353, p. 2637-2642

Research output: Contribution to journalArticleScientificpeer-review

C16 and C17-Heterocycle Bearing Androstanes. CYP17 Inhibition Studies and Multiple Effects on Prostate Cancer Cells

Moreira, V. M., Salvador, J. A. R., Matos Beja, A., Paixão, J. A., Vasaitis, T. S. & Njar, V. C. O., 24 Sep 2011, In : European Journal of Pharmaceutical Sciences. 44, p. 43 1 p.

Research output: Contribution to journalConference articleScientificpeer-review

Highlights of Natural Compounds in Prostate Cancer Drug Discovery

Salvador, J. & Moreira, V. M., 2011, Prostate Cancer - From Bench to Bedside. Spiess, P. E. (ed.). INTECHopen

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

The reaction of azoles with 17-chloro-16-formylandrosta-5,16-dien-3-yl-acetate: Synthesis and structural elucidation of novel 16-azolylmethylene-17-oxoandrostanes.

Moreira, V. M., Salvador, J. A. R., Matos Beja, A. & Paixão, J. A., 23 Feb 2011, In : Steroids. 76, p. 582-587

Research output: Contribution to journalArticleScientificpeer-review

2010

Semisynthetic Pentacyclic Triterpenoids in the Cancer Setting: Ursolic Acid and its Derivatives

Salvador, J. A. R. & Moreira, V. M., 2010, Pentacyclic Triterpenes as Promising Agents in Cancer. Salvador, J. A. R. (ed.). Nova Science Publishers

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

The multiple effects of CYP17 inhibitors on prostate cancer cells

Moreira, V. & Salvador, J., Sep 2010, In : Drugs of the Future. 35, Suppl. A

Research output: Contribution to journalConference articleScientificpeer-review

2009

3-Oxoandrosta-4,6-dien-17β-yl-2'-methyl-1H-imidazole-1-carboxylate and 3-oxo-5α-androst-17β-yl-2'-methyl-1H-imidazole-1-carboxylate: C—H..π and π•••π intermolecular interactions

Silva, M. R., Moreira, V. M., Cardoso, C., Matos Beja, A. & Salvador, J. A. R., 7 Feb 2009, In : Acta Crystallographica. Section C: Crystal Structure Communications. C65, p. o88-o91

Research output: Contribution to journalArticleScientificpeer-review

Natural Products Action on Prostate Cancer Cell Growth, Signaling and Survival

Salvador, J. A. R. & Moreira, V. M., 2009, Handbook of Prostate Cancer Cell Research: Growth, Signalling and Survival. Meredith, A. T. (ed.). Nova Science Publishers

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

2008

1H-and 2H-indazole derivatives of androsta-5,16-dien-3β-ol

Silva, M. R., Moreira, V., Cardoso, C., M. Beja, A. & Salvador, J. A. R., 15 Mar 2008, In : Acta Crystallographica. Section C: Crystal Structure Communications. C64, p. o217-o219

Research output: Contribution to journalArticleScientificpeer-review

Catalytic Epoxidation and syn-Dihydroxylation Reactions in Steroid Chemistry

Salvador, J. A. R., Silvestre, S. M. & Moreira, V. M., 2008, In : Current Organic Chemistry. 12, p. 492-522

Research output: Contribution to journalReview ArticleScientificpeer-review

Conformation of 17-Chloro-16-formylandrosta-5,16-dien-3β-yl acetate and 17-chloroandrosta-5,16-dien-3β-yl acetate

Silva, M. R., Moreira, V. M., Cardoso, C., Matos Beja, A. & Salvador, J. A. R., 2008, In : Acta Crystallographica. Section C: Crystal Structure Communications. C64, p. o529-o531

Research output: Contribution to journalArticleScientificpeer-review

CYP17 Inhibitors for Prostate Cancer Treatment – An Update

Moreira, V. M., Salvador, J. A. R., Vasaitis, T. S. & Njar, V. C. O., 26 Feb 2008, In : Current Medicinal Chemistry. 15, p. 868-899

Research output: Contribution to journalReview ArticleScientificpeer-review

Multiple targeted actions of CYP17 inhibitors on prostate cancer cells

Moreira, V. M. & Salvador, J. A. R., 2008, In : Revista Portuguesa de Farmácia. LII (3) Suppl., 46

Research output: Contribution to journalConference articleScientificpeer-review

Novos esteróides inibidores da biossíntese de androgénios

Translated title of the contribution: New steroidal inhibitors of androgen biosynthesisMoreira, V. M., 2008, Universidade de coimbra. 250 p.

Research output: ThesisDoctoral Thesis

Synthesis of novel C17 steroidal carbamates. Studies on CYP17 action, androgen receptor binding and function, and prostate cancer cell growth

Moreira, V. M., Vasaitis, T. S., Guo, Z., Njar, V. C. O. & Salvador, J. A. R., 6 Jun 2008, In : Steroids. 73, p. 1217-1227

Research output: Contribution to journalArticleScientificpeer-review

2007

3-Oxoandrost-4-en-17beta-yl 1H-imidazole-1-carboxylate

Silva, M. R., Matos Beja, A., Moreira, V., Santos, R. C. & Salvador, J. A. R., 9 Nov 2007, In : Acta Crystallographica. Section E: Structure Reports Online. E63, p. o4824-

Research output: Contribution to journalArticleScientificpeer-review

Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors

Moreira, V., Vasaitis, T. S., Njar, V. C. O. & Salvador, J. A. R., 15 Aug 2007, In : Steroids. 72, p. 939-948

Research output: Contribution to journalArticleScientificpeer-review

2006

Catalytic oxidative processes in steroid chemistry: allylic oxidation, β-selective epoxidation, alcohol oxidations and remote functionalization reactions

Salvador, J. A. R., Silvestre, S. M. & Moreira, V. M., 2006, In : Current Organic Chemistry. 10, p. 2227-2257

Research output: Contribution to journalReview ArticleScientificpeer-review

2005

New 5beta,6beta-epoxysteroids with cytotoxic activity

Moreira, V., Salvador, J., Sa e Melo, L., Hanson, J., Marques, A. & Simoes, S., Jun 2005, In : Scientia pharmaceutica. 73, S8

Research output: Contribution to journalConference articleScientificpeer-review

One-pot, high yield synthesis of α-ketols from delta5-steroids

Salvador, J. A. R., Moreira, V., Hanson, J. R. & Carvalho, R. A., 20 Dec 2005, In : Steroids. 71, p. 266-272 7 p.

Research output: Contribution to journalArticleScientificpeer-review