Research output per year
Research output per year
Personal profile
Curriculum vitae
Personal details
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Last, first name |
Le Joncour, Vadim |
Nationality: |
French |
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Place of birth: |
Rouen, France |
Year of birth: |
1985 |
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ORCID: |
ResearcherID: |
Current affiliation: University of Helsinki, Helsinki Institute for Life Sciences (HiLIFE), Neuroscience Center and iCAN Flagship Digital Precision Cancer Medicine, Haartmaninkatu 8, 00290 Helsinki, Finland.
Degrees
2023 Title of Docent, Cancer Biology. Faculty of Medicine, University of Helsinki
2015 Doctor of Philosophy, Implication of the urotensinergic system in neo-angiogenesis and invasion mechanisms of high-grade glioma, Faculty of Science, University of Rouen, France
2010 Master of Science, Cellular and Molecular Neuroscience and Neuroendocrinology, Faculty of Science, University of Rouen, France
2008 Bachelor of Science, Life sciences – Animal Physiology, Neuroscience and Neuropsychology, Faculty of Science, University of Rouen, France
Current positions
2023 – 2028 University Researcher Neuroplasticity and Neurotrophic Factors lab (Research Director: Eero Castrén, M.D., Ph.D.).
Junior Team Leader Neo[plastic] Brain Team. HiLIFE, Neuroscience Center, University of Helsinki, Finland
2024 – 2026 Co-Principal Investigator iCAN-Plasticity: Neuroplasticity in clinical cancer. University of Helsinki, Finland.
Research output
2011 – 2024 Total number of peer reviewed publications: 27; conference proceedings: 11.
H-index: 16 (Web of Science) 16 (Google Scholar)
Number of times cited: 600 (Web of Science) 783 (Google Scholar)
2021 – 2024 Invention disclosure: UH ID No. 1121/2021 ‘Navigator: Peptide-based delivery of diagnostic tools and therapeutics to brain metastases’.
Research to Business (TUTL) 1051/31/2022. Navigator - novel tool for early brain metastases diagnostics. Helsingin Yliopisto.
Patent Pending on Navigator.
Previous work experience
2022 – 2023 iCAN Flagship Digital Precision Cancer Medicine, iCAN-Brain: Deciphering the Dialogue between Astrocytes and Brain Tumors. Faculty of Medicine, University of Helsinki, Finland
2019 – 2022 Academy of Finland Post-doctoral Fellow The Mechanistic and Transcriptomic Signature of Brain Tumor Invasion. CAN-PRO, University of Helsinki, Finland.
2015 – 2019 Post-doctoral researcher. Research of novel molecular and cellular targets for glioblastoma and brain metastasis treatment. Tumor Progression and Metastasis Lab (Lab. Head: Pirjo Laakkonen, Ph.D.), Research Programs Unit, Translational Cancer Biology, Faculty of Medicine, University of Helsinki, Finland
2013 – 2014 University lecturer & research assistant. Inserm U982/ANiVas lab. (Dir.: Hélène Castel, Ph.D.) University of Rouen, France
09.2010 – 06.14 Doctoral researcher, Inserm U982/ANiVas lab. (Dir.: Hélène Castel, Ph.D.) University of Rouen, France
Research funding and grants
Obtained as principal investigator
2025– 2028 Research Grant from the Finnish Cancer Society (EUR 181332) for Modulators of neuronal plasticity for brain tumor cells reprogramming
2024 Research Grant from the Finnish Cancer Society (EUR 50000) for Modulators of neuronal plasticity for brain tumor cells reprogramming
2023 Research Grant from the Magnus Ehrnrooth Foundation (EUR 5000) for Neurodevelopmental features of the Neoplastic brain
2022 Research Grant from the Magnus Ehrnrooth Foundation (EUR 5000) for Mapping invasive glioblastoma cells reprogramming into neuron-like cells
Maupertuis Programme (EUR 1200) collaborative grant for the scientific cooperation between the Seano (Institut Curie, FR) and Le Joncour (Helsinki University, FIN) Labs
2021 Research Grant from the Magnus Ehrnrooth Foundation (EUR 8000) for Revealing the invasive brain tumor cell identity
Personal grant from K. Albin Johansson stiftelse (EUR 5000) for Mapping brain tumor cells’ reprogramming and invasion
2020 Research Grant from the Magnus Ehrnrooth foundation (EUR 5000) for Cationic amphiphilic molecules to treat invasive brain tumors
2019 – 2022 Academy of Finland Postdoc fellowship Investigating the transcriptomic and mechanistic signature of invasive gliomas, University of Helsinki, Finland (EUR 290,000)
2019 Personal grant from K. Albin Johansson stiftelse (EUR 5000) for Investigating the transcriptomic and mechanistic signature of invasive gliomas
Awards and honors and academic merits
2022 Best presentation price at the Scandinavian Society of Neuro-Oncology (200+ participants). Helsinki, Finland https://bit.ly/3LYTm8i
Invited talks Université de Nantes, France (06.2021), Cardiff University, UK (03.2022), 10x Genomics, Helsinki (05.2022), Institut Curie, Paris (06.2022) https://bit.ly/3cy8j5r, Normandie Universités, France (06.2022), HiLIFE, Neuroscience Center (04.2023), Lundbeck Foundation (02.2024).
2020 & 2022 Organizer of the 1st & 3rd FiBTRA Virtual seminar (27.10.2022) https://bit.ly/3CFhtY2
2021 – 2022 Senior evaluator for the EuroTechPostdoc2 2021 & 2022 calls, Marie Skłodowska-Curie fellowship programme
2019 Award at the Finnish Brain Tumor Research Association (FiBTRA) (80+ participants). Helsinki, Finland.
2015 & 2019 Co-organizer of the FiBTRA annual meetings (Helsinki, Finland, 80+ participants)
2016 – Review of 30+ research and 3 review articles
2015 – Board, Finnish Brain Tumor Research Association http://fibtra.org/fibtra_board.html
Education information
Education and Degrees
2010 – 2015 Doctor of Philosophy, (Ph.D. University of Rouen), Dissertation title: Implication of the urotensinergic system in neo-angiogenesis and invasion mechanisms of high-grade glioma
Faculty of Science, University of Rouen, France
Supervisors: Professor Pierrick Gandolfo & Dr. Hélène Castel
2008 – 2010 Master of Science, Cellular and Molecular Neurosciences - Neuroendocrinology, Faculty of Science, University of Rouen, France
2004 – 2008 Bachelor of Science, Life sciences – Animal Physiology, Faculty of Science, University of Rouen, France
Description of research and teaching
Students Supervision
Currently Co-supervising Ph.D. student (P. Filppu, M.Sc.), at Translational Cancer Medicine Program, University of Helsinki, Finland
2017 – 2019 Local co-supervisor of the Ph.D. student A. Martins (M.Sc. from Exiris, Italy), as a part of her secondment in the Marie Curie program. Faculty of Medicine, Helsinki, Finland
2015 – 2019 Supervising PhD student (A. Ayo & J. Tanjore Ramanathan, M.Sc.), M.Sc. theses (M. Chevallot), and Undergraduate students (M. Hellén, K. Sarkkinen & A. Yilmazlar) at Tumor Progression and Metastasis Lab, Translational Cancer Medicine Program, University of Helsinki, Finland
2011 – 2014 Supervised M.Sc. theses (B. Poret & G. Lambert), Undergrad project students (A. Corla, D. Mussel) at the Inserm U982 DC2N, University of Rouen, France
Teaching Experience
Currently Lecturer and co-organizer of the TMED-103 Cancer from Biology to Research TRANSMED Master Program. University of Helsinki, Finland
2013 – 2014 University Lecturer at the Faculty of Sciences including lectures (53h), practical courses (68h) and workshops (80h) on animal physiology, cell biology, histology and neurosciences for undergraduates and biostatistics for Master students. Rouen, France
Organization of Scientific Meetings
2019 Co-organizer, 5th Finnish Brain Tumor Research Association symposium (Helsinki, Finland, 60 participants).
2016 Co-organizer, 2nd Finnish Brain Tumor Research Association symposium (Helsinki, Finland, 80 participants).
2012 Co-organizer, 15th Scientific Meeting of the Normandy Doctoral School (Rouen, France, 200 participants)
Communication
11/2019 5th meeting of the Finnish Brain Tumor Research association Helsinki, Finland Best talk award.
06/2019 EMBO Molecular Medicine selected cover Vol. 11 Issue 6. https://www.embopress.org/toc/17574684/2019/11/6
05/2019 Video methods published in JoVE. https://www.jove.com/video/59384/predicting-vivo-payloads-delivery-using-blood-brain-tumor-barrier
05/2012 IRIB scientific meeting, Rouen, France. Best talk award.
08/2012 Presentation at the 19th International Symposium on Regulatory Peptides, Copenhagen, Denmark. DOI:10.1016
Research interests
Selected collaborations
2019 – Cell Death and Lysosomes Group, Lund University (Sweden)
Dr. S. Aits. Collaboration for the high throughput screening and AI-driven meta-analysis of novel molecules targeting the tumor cell lysosome.
2017 – Helsinki University Hospital/Translational Cancer Medicine Research Program (Finland)
Dr. H. Seppänen. Preclinical therapeutic assessment of a lysosomal damaging agent for invasive pancreatic cancer treatment.
Dr. S. Karaman. Development of microfluidic devices, intravitaltools and in silico analytics solutions for the follow-up of diseases such as obesity-driven inflammation and tumor invasion. Published in: DOI 10.3791/59384
Dr. M. Barok. Preclinical evaluation of novel antibody-drug conjugates targeting HER2+ chemoresistant breast cancer. Published in: DOI 10.1158/1535-7163.MCT-19-0207
2018 – Turku Bioscience Centre (Finland)
Prof. J. Westermarck. Evaluation of the Blood-Brain-Barrier penetrance of novel PP2A activators for glioblastoma therapy. Published in: DOI 10.1093/braincomms/fcaa002
2015 – 2020 Helsinki University Hospital (HUS, Finland)
Prof. E. Hölttä & Dr. J. Eriksson. In vivo characterization of the role of CTRHC1 in melanoma tumorigenesis (Published in: DOI 10.18632/oncotarget.7604 ). In vivo characterization of P4HA1 implication in melanoma progression (Molecular Oncology, in press).
2013 Laboratory of Informatics, Information and Systems Treatment (Becquerel Centre, France)
Prof. P. Vera & Dr. P. Bohn (EA4108). Validation of a radiolabelled probe for tumor hypoxia. Published in: DOI 10.1016/j.bmcl.2013.05.015
2012 Cellular and Histological Cytopathology services (Rouen Hospital, France)
Prof. A. Laquerrière. Immunostaining techniques and analysis of paraffin-embedded patient tumor tissue. Published in: DOI 10.1038/onc.2014.433
Education/Academic qualification
Doctoral Studies, Doctor of Philosophy, Implication of the urotensinergic system in neo-angiogenesis and invasion mechanisms of high-grade glioma, INSERM
1 Sept 2010 → 1 Aug 2014
Award Date: 22 Jan 2015
Fields of Science
- 3111 Biomedicine
- 3122 Cancers
- 3112 Neurosciences
International and National Collaboration
Publications and projects within past five years.
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Disitamab vedotin in preclinical models of HER2-positive breast and gastric cancers resistant to trastuzumab emtansine and trastuzumab deruxtecan
Pourjamal, N., Le Joncour, V., Vereb, G., Honkamäki, C., Isola, J., Leyton, J. V., Laakkonen, P., Joensuu, H. & Barok, M., Mar 2025, In: Translational oncology. 53, 9 p., 102284.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Comparison of trastuzumab emtansine, trastuzumab deruxtecan, and disitamab vedotin in a multiresistant HER2-positive breast cancer lung metastasis model
Pourjamal, N., Yazdi, N., Halme, A., Le Joncour, V., Laakkonen, P., Saharinen, P., Joensuu, H. & Barok, M., 2024, In: Clinical and Experimental Metastasis. 41, p. 91–10 12 p.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Supersoft Sponge-like Cryogel As an Implant to Treat Glioblastoma
Wang, Y., Le Joncour, V., Laakkonen, P. & Newland, B., 15 Oct 2024, In: Neuro-Oncology. 26, Supplement 7 , p. vii16 1 p.Research output: Contribution to journal › Meeting Abstract › peer-review
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Bivalent EGFR-Targeting DARPin-MMAE Conjugates
Karsten, L., Janson, N., Le Joncour, V., Alam, S., Müller, B., Tanjore Ramanathan, J., Laakkonen, P., Sewald, N. & Mueller, K. M., Mar 2022, In: International Journal of Molecular Sciences. 23, 5, 26 p., 2468.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile -
Heparin-Derived Theranostic Nanoprobes Overcome the Blood-Brain Barrier and Target Glioma in Murine Model
Samanta, S., Le Joncour, V., Wegrzyniak, O., Rangasami, V. K., Ali-Loytty, H., Hong, T., Selvaraju, R. K., Aberg, O., Hilborn, J., Laakkonen, P., Varghese, O. P., Eriksson, O., Cabral, H. & Oommen, O. P., Jun 2022, In: Advanced Therapeutics. 5, 6, 17 p., 2200001.Research output: Contribution to journal › Article › Scientific › peer-review
Open AccessFile
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Lundbeck-Castrén
Castrén, E. (Project manager), Lauri, S. (Project manager), Vattulainen, I. T. (Project manager), Brunello, C. (Participant), Didio, G. (Participant), Kaptan, S. S. (Participant), Kaurinkoski, K. V. S. (Participant), Keskinen, R. (Participant), Kunnari, A.-J. A. (Participant), Le Joncour, V. (Participant), Ojanen, S. (Participant), Shteinikov, V. (Participant) & Srinivasan, R. (Participant)
Tuntematon rahoittaja, Lundbeckfonden Lundbeck Foundation
01/04/2023 → 31/03/2028
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
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iCAN - Digital precision cancer medicine for discoveries and improved treatments
Mäkelä, T. (Project manager), Adhikari, S. (Participant), Aldahdooh, J. M. F. (Participant), Ariotta, V. (Participant), Arjama, M. A. (Participant), Atarsaikhan, G. (Participant), Bao, J. (Participant), Barreiro, K. (Participant), Bhalke, M. S. (Participant), Bollepalli, S. (Participant), Brandt, J. A. J. (Participant), Chernenko, A. (Participant), Dashi, G. (Participant), Eloranta, K. (Participant), Eriksson, M. R. (Participant), Feodoroff, M. J. (Participant), Fey, E. (Participant), Gerber, L. J. (Participant), Grönholm, M. (Participant), Hannula, S. A. (Participant), Heistman, V. (Participant), Henriksson, M. E. J. (Participant), Hiitola, E. T. J. (Participant), Huttunen, A. T. (Participant), Hyyppä, S. P. P. (Participant), Högel-Starck, C. S. P. (Participant), Ianevski, A. (Participant), Ikonen, N. (Participant), Jansouz, S. (Participant), Jha, S. (Participant), Junquera Mencía, A. (Participant), Kalashnikov, I. (Participant), Kampanellou, E. (Participant), Karabayev, D. (Participant), Karhemo, P.-R. (Participant), Karling, T. S. (Participant), Kekkonen, J. (Participant), Kolikova, Y. (Participant), Krami Senhaji, O. (Participant), Kuisma-van der Linden, M. S. (Participant), Kumari, R. (Participant), Kuosmanen, A. (Participant), Kurki, V. (Participant), Kuusela, S. (Participant), Kücükel, H. (Participant), Langohr, L. (Participant), Lavikka, K. A. (Participant), Le Joncour, V. (Participant), Lehto, T.-P. (Participant), Leivonen, S.-K. (Participant), Liljeström, M. (Participant), Lindfors, I. S. (Participant), Lindgren, H. (Participant), Luck, T. J. (Participant), Lähdeniemi, I. A. K. (Participant), Maarala, A. I. (Participant), Maljanen, K. J. (Participant), Marchi, G. (Participant), Martikainen, E. M. (Participant), Meriranta, L. (Participant), Metsäranta, N. A. C. (Participant), Miihkinen, M. S. (Participant), Moradi, N. (Participant), Nader, K. M. (Participant), Nagaraj, A. (Participant), Nguyen, M. (Participant), Niemeyer, F. (Participant), Niemiec, I. (Participant), Nylén, M. M. (Participant), Palin, K. (Participant), Palva, A. (Participant), Parsons, A. O. (Participant), Perez Villatoro, F. R. (Participant), Pietiäinen, V. (Participant), Pirinen, I. E. (Participant), Pirttikoski, A. A. (Participant), Pitko, I. M. (Participant), Polianskyte-Prause, Z. (Participant), Puhka, M. (Participant), Quintero, I. B. (Participant), Rachidi, S. E. (Participant), Rajalaakso, M. T. (Participant), Rodosthenous, R. (Participant), Saad, J. (Participant), Sanjaya, P. (Participant), Seppälä, T. T. (Participant), Seref Vujaklija, C. (Participant), Shah, S. (Participant), Sorri, S. P. (Participant), Suni, V. (Participant), Suutala, A. (Participant), Suvela, M. (Participant), Sysivirta, L. K. M. (Participant), Udayani, J. E. (Participant), Verkasalo, H. M. (Participant), Viiri, L. E. (Participant), Vilkkavaara Cancocak, Y. (Participant), Vähärautio, A. (Participant), Vänttinen, I. M. (Participant), Västrik, I. (Participant), Väänänen, J. (Participant), Wang, W. (Participant) & Zhang, X. (Participant)
Suomen Akatemia Projektilaskutus, Academy of Finland
01/09/2022 → 31/12/2026
Project: Research Council of Finland: Finnish Flagship Programme
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Neurodevelopmental features of the Neopl
Le Joncour, V. (Project manager)
06/03/2023 → 05/04/2024
Project: Foundations (Private Foundations, Non-Profit Foundations, Charitable Trusts)
Prizes
Activities
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Finnish Brain Tumor Research Association Annual Meeting: FiBTRA 2019
Laakkonen, P. (Member of organizing committee), Le Joncour, V. (Member of organizing committee) & Filppu, P. (Member of organizing committee)
31 Oct 2019 → 1 Nov 2019Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
File -
Oral presentation to FiBTRA 2017
Le Joncour, V. (Speaker)
27 Oct 2017Activity: Talk or presentation types › Oral presentation
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Presentation to the Magic Bullet Network Meeting
Le Joncour, V. (Speaker)
19 Jul 2016Activity: Talk or presentation types › Invited talk
File -
Finnish Brain Tumor Research Association Annual Meeting
Le Joncour, V. (Member of organizing committee), Laakkonen, P. M. (Member of organizing committee), Filppu, P. I. (Attendee), Tanjore Ramanathan, J. (Attendee), Ayo, A. O. (Attendee), Ylä-Hertttuala, S. (Speaker: Keynote) & Westermarck, J. (Member of organizing committee)
1 Nov 2016 → 2 Nov 2016Activity: Participating in or organising an event types › Organisation and participation in conferences, workshops, courses, seminars
Press/Media
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Cover of the EMBO Molecular Medicine journal
07/06/2019
1 item of Media coverage
Press/Media: Press / Media
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Exploiting a Chink in the Armor of Brain Tumor Cells
Laakkonen, P. & Le Joncour, V.
13/05/2019
1 item of Media coverage
Press/Media: Press / Media
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-UNIVERSITY OF HELSINKI: Researchers discover the Achilles' heel of an aggressive brain cancer - could antihistamine be a potential aid in defeating cancerous cells?
Sihto, H., Joensuu, H., Laakkonen, P. & Le Joncour, V.
13/05/2019
1 item of Media coverage
Press/Media: Press / Media
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Researchers discover the Achilles' heel of an aggressive brain cancer
Sihto, H., Joensuu, H., Laakkonen, P. & Le Joncour, V.
10/05/2019 → 13/05/2019
8 items of Media coverage
Press/Media: Press / Media